Amino acid dipepetide frequency for Candidatus Aquiluna sp. 15G-AUS-rot

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.805AlaAla: 12.805 ± 0.268
0.482AlaCys: 0.482 ± 0.034
5.069AlaAsp: 5.069 ± 0.099
7.177AlaGlu: 7.177 ± 0.189
3.811AlaPhe: 3.811 ± 0.111
9.127AlaGly: 9.127 ± 0.165
1.756AlaHis: 1.756 ± 0.058
6.658AlaIle: 6.658 ± 0.121
5.839AlaLys: 5.839 ± 0.147
12.111AlaLeu: 12.111 ± 0.207
2.699AlaMet: 2.699 ± 0.082
3.466AlaAsn: 3.466 ± 0.093
3.867AlaPro: 3.867 ± 0.115
4.053AlaGln: 4.053 ± 0.093
5.504AlaArg: 5.504 ± 0.122
6.823AlaSer: 6.823 ± 0.13
5.735AlaThr: 5.735 ± 0.141
8.18AlaVal: 8.18 ± 0.166
1.191AlaTrp: 1.191 ± 0.054
2.089AlaTyr: 2.089 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
0.512CysAla: 0.512 ± 0.034
0.042CysCys: 0.042 ± 0.009
0.342CysAsp: 0.342 ± 0.028
0.416CysGlu: 0.416 ± 0.034
0.191CysPhe: 0.191 ± 0.02
0.586CysGly: 0.586 ± 0.034
0.107CysHis: 0.107 ± 0.016
0.221CysIle: 0.221 ± 0.019
0.165CysLys: 0.165 ± 0.02
0.482CysLeu: 0.482 ± 0.032
0.07CysMet: 0.07 ± 0.013
0.158CysAsn: 0.158 ± 0.019
0.286CysPro: 0.286 ± 0.03
0.174CysGln: 0.174 ± 0.019
0.263CysArg: 0.263 ± 0.024
0.423CysSer: 0.423 ± 0.031
0.282CysThr: 0.282 ± 0.026
0.379CysVal: 0.379 ± 0.032
0.056CysTrp: 0.056 ± 0.011
0.121CysTyr: 0.121 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
5.323AspAla: 5.323 ± 0.126
0.344AspCys: 0.344 ± 0.031
2.159AspAsp: 2.159 ± 0.084
3.52AspGlu: 3.52 ± 0.108
2.41AspPhe: 2.41 ± 0.075
4.148AspGly: 4.148 ± 0.1
0.952AspHis: 0.952 ± 0.048
2.457AspIle: 2.457 ± 0.086
1.677AspLys: 1.677 ± 0.071
6.205AspLeu: 6.205 ± 0.115
0.898AspMet: 0.898 ± 0.044
1.156AspAsn: 1.156 ± 0.053
3.141AspPro: 3.141 ± 0.091
2.247AspGln: 2.247 ± 0.072
2.983AspArg: 2.983 ± 0.085
3.35AspSer: 3.35 ± 0.097
2.133AspThr: 2.133 ± 0.067
3.843AspVal: 3.843 ± 0.104
0.803AspTrp: 0.803 ± 0.043
1.503AspTyr: 1.503 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
6.612GluAla: 6.612 ± 0.143
0.263GluCys: 0.263 ± 0.028
2.852GluAsp: 2.852 ± 0.088
3.459GluGlu: 3.459 ± 0.123
2.708GluPhe: 2.708 ± 0.077
3.969GluGly: 3.969 ± 0.108
1.305GluHis: 1.305 ± 0.057
4.59GluIle: 4.59 ± 0.106
2.796GluLys: 2.796 ± 0.1
8.84GluLeu: 8.84 ± 0.189
1.284GluMet: 1.284 ± 0.061
2.35GluAsn: 2.35 ± 0.077
2.587GluPro: 2.587 ± 0.084
2.964GluGln: 2.964 ± 0.086
4.19GluArg: 4.19 ± 0.108
4.008GluSer: 4.008 ± 0.103
3.103GluThr: 3.103 ± 0.1
5.835GluVal: 5.835 ± 0.139
0.596GluTrp: 0.596 ± 0.035
1.431GluTyr: 1.431 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
4.357PheAla: 4.357 ± 0.119
0.216PheCys: 0.216 ± 0.021
2.734PheAsp: 2.734 ± 0.083
2.978PheGlu: 2.978 ± 0.092
1.459PhePhe: 1.459 ± 0.071
4.209PheGly: 4.209 ± 0.106
0.593PheHis: 0.593 ± 0.041
1.866PheIle: 1.866 ± 0.075
1.296PheLys: 1.296 ± 0.059
3.436PheLeu: 3.436 ± 0.099
0.656PheMet: 0.656 ± 0.042
1.196PheAsn: 1.196 ± 0.058
1.545PhePro: 1.545 ± 0.067
1.198PheGln: 1.198 ± 0.049
1.819PheArg: 1.819 ± 0.075
2.752PheSer: 2.752 ± 0.085
2.14PheThr: 2.14 ± 0.084
2.966PheVal: 2.966 ± 0.098
0.575PheTrp: 0.575 ± 0.044
0.961PheTyr: 0.961 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
7.74GlyAla: 7.74 ± 0.172
0.556GlyCys: 0.556 ± 0.043
3.827GlyAsp: 3.827 ± 0.096
5.009GlyGlu: 5.009 ± 0.122
3.862GlyPhe: 3.862 ± 0.099
6.03GlyGly: 6.03 ± 0.173
1.598GlyHis: 1.598 ± 0.061
5.162GlyIle: 5.162 ± 0.113
4.104GlyLys: 4.104 ± 0.105
8.929GlyLeu: 8.929 ± 0.154
1.91GlyMet: 1.91 ± 0.072
2.415GlyAsn: 2.415 ± 0.078
3.008GlyPro: 3.008 ± 0.084
2.78GlyGln: 2.78 ± 0.076
4.074GlyArg: 4.074 ± 0.113
5.59GlySer: 5.59 ± 0.117
4.169GlyThr: 4.169 ± 0.107
6.628GlyVal: 6.628 ± 0.115
1.245GlyTrp: 1.245 ± 0.055
2.368GlyTyr: 2.368 ± 0.088
0.0GlyXaa: 0.0 ± 0.0
His
1.626HisAla: 1.626 ± 0.068
0.121HisCys: 0.121 ± 0.018
0.996HisAsp: 0.996 ± 0.055
1.173HisGlu: 1.173 ± 0.054
0.679HisPhe: 0.679 ± 0.038
1.51HisGly: 1.51 ± 0.055
0.491HisHis: 0.491 ± 0.038
0.968HisIle: 0.968 ± 0.051
0.556HisLys: 0.556 ± 0.033
1.831HisLeu: 1.831 ± 0.07
0.335HisMet: 0.335 ± 0.026
0.526HisAsn: 0.526 ± 0.033
1.226HisPro: 1.226 ± 0.056
0.71HisGln: 0.71 ± 0.047
1.068HisArg: 1.068 ± 0.05
1.163HisSer: 1.163 ± 0.059
0.882HisThr: 0.882 ± 0.046
1.161HisVal: 1.161 ± 0.055
0.237HisTrp: 0.237 ± 0.025
0.5HisTyr: 0.5 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
7.331IleAla: 7.331 ± 0.134
0.321IleCys: 0.321 ± 0.031
3.497IleAsp: 3.497 ± 0.093
4.22IleGlu: 4.22 ± 0.111
1.987IlePhe: 1.987 ± 0.077
5.148IleGly: 5.148 ± 0.118
0.898IleHis: 0.898 ± 0.041
2.438IleIle: 2.438 ± 0.09
1.971IleLys: 1.971 ± 0.072
4.792IleLeu: 4.792 ± 0.114
0.831IleMet: 0.831 ± 0.044
1.563IleAsn: 1.563 ± 0.061
2.896IlePro: 2.896 ± 0.078
1.796IleGln: 1.796 ± 0.06
3.241IleArg: 3.241 ± 0.086
4.453IleSer: 4.453 ± 0.102
3.432IleThr: 3.432 ± 0.093
3.978IleVal: 3.978 ± 0.111
0.81IleTrp: 0.81 ± 0.039
1.168IleTyr: 1.168 ± 0.058
0.0IleXaa: 0.0 ± 0.0
Lys
4.481LysAla: 4.481 ± 0.121
0.142LysCys: 0.142 ± 0.019
1.966LysAsp: 1.966 ± 0.071
2.161LysGlu: 2.161 ± 0.075
1.454LysPhe: 1.454 ± 0.055
2.652LysGly: 2.652 ± 0.096
0.798LysHis: 0.798 ± 0.039
2.336LysIle: 2.336 ± 0.075
1.919LysLys: 1.919 ± 0.083
4.874LysLeu: 4.874 ± 0.105
0.931LysMet: 0.931 ± 0.046
1.538LysAsn: 1.538 ± 0.055
2.359LysPro: 2.359 ± 0.086
1.601LysGln: 1.601 ± 0.053
2.657LysArg: 2.657 ± 0.073
2.789LysSer: 2.789 ± 0.083
2.61LysThr: 2.61 ± 0.07
3.499LysVal: 3.499 ± 0.106
0.484LysTrp: 0.484 ± 0.031
0.917LysTyr: 0.917 ± 0.043
0.0LysXaa: 0.0 ± 0.0
Leu
12.989LeuAla: 12.989 ± 0.194
0.468LeuCys: 0.468 ± 0.032
5.746LeuAsp: 5.746 ± 0.122
7.519LeuGlu: 7.519 ± 0.177
3.522LeuPhe: 3.522 ± 0.098
9.438LeuGly: 9.438 ± 0.178
1.708LeuHis: 1.708 ± 0.068
6.063LeuIle: 6.063 ± 0.126
4.26LeuLys: 4.26 ± 0.107
10.343LeuLeu: 10.343 ± 0.24
2.271LeuMet: 2.271 ± 0.074
3.322LeuAsn: 3.322 ± 0.091
5.207LeuPro: 5.207 ± 0.11
3.257LeuGln: 3.257 ± 0.096
5.835LeuArg: 5.835 ± 0.129
7.815LeuSer: 7.815 ± 0.149
5.721LeuThr: 5.721 ± 0.117
9.194LeuVal: 9.194 ± 0.177
1.196LeuTrp: 1.196 ± 0.049
1.975LeuTyr: 1.975 ± 0.068
0.0LeuXaa: 0.0 ± 0.0
Met
2.561MetAla: 2.561 ± 0.085
0.116MetCys: 0.116 ± 0.017
1.026MetAsp: 1.026 ± 0.043
0.979MetGlu: 0.979 ± 0.05
0.677MetPhe: 0.677 ± 0.045
1.656MetGly: 1.656 ± 0.072
0.349MetHis: 0.349 ± 0.027
1.089MetIle: 1.089 ± 0.05
0.879MetLys: 0.879 ± 0.043
2.14MetLeu: 2.14 ± 0.076
0.375MetMet: 0.375 ± 0.032
0.7MetAsn: 0.7 ± 0.043
1.091MetPro: 1.091 ± 0.052
0.803MetGln: 0.803 ± 0.042
1.287MetArg: 1.287 ± 0.053
1.67MetSer: 1.67 ± 0.062
1.277MetThr: 1.277 ± 0.052
1.647MetVal: 1.647 ± 0.062
0.205MetTrp: 0.205 ± 0.021
0.314MetTyr: 0.314 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
2.959AsnAla: 2.959 ± 0.077
0.216AsnCys: 0.216 ± 0.025
1.345AsnAsp: 1.345 ± 0.056
1.587AsnGlu: 1.587 ± 0.058
1.412AsnPhe: 1.412 ± 0.066
2.224AsnGly: 2.224 ± 0.068
0.619AsnHis: 0.619 ± 0.035
1.435AsnIle: 1.435 ± 0.054
1.0AsnLys: 1.0 ± 0.048
3.955AsnLeu: 3.955 ± 0.113
0.635AsnMet: 0.635 ± 0.039
0.807AsnAsn: 0.807 ± 0.044
2.35AsnPro: 2.35 ± 0.078
1.503AsnGln: 1.503 ± 0.061
1.903AsnArg: 1.903 ± 0.064
1.994AsnSer: 1.994 ± 0.071
1.463AsnThr: 1.463 ± 0.057
2.131AsnVal: 2.131 ± 0.069
0.561AsnTrp: 0.561 ± 0.038
0.926AsnTyr: 0.926 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
4.804ProAla: 4.804 ± 0.112
0.193ProCys: 0.193 ± 0.023
2.645ProAsp: 2.645 ± 0.087
3.897ProGlu: 3.897 ± 0.089
1.605ProPhe: 1.605 ± 0.062
3.699ProGly: 3.699 ± 0.105
0.828ProHis: 0.828 ± 0.048
2.606ProIle: 2.606 ± 0.089
2.34ProLys: 2.34 ± 0.079
4.097ProLeu: 4.097 ± 0.091
0.947ProMet: 0.947 ± 0.051
1.724ProAsn: 1.724 ± 0.058
1.154ProPro: 1.154 ± 0.053
1.629ProGln: 1.629 ± 0.06
2.14ProArg: 2.14 ± 0.085
2.875ProSer: 2.875 ± 0.091
2.634ProThr: 2.634 ± 0.098
3.676ProVal: 3.676 ± 0.099
0.649ProTrp: 0.649 ± 0.044
1.024ProTyr: 1.024 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
4.011GlnAla: 4.011 ± 0.088
0.161GlnCys: 0.161 ± 0.02
1.738GlnAsp: 1.738 ± 0.056
2.224GlnGlu: 2.224 ± 0.068
1.273GlnPhe: 1.273 ± 0.057
2.585GlnGly: 2.585 ± 0.093
0.714GlnHis: 0.714 ± 0.044
2.426GlnIle: 2.426 ± 0.074
1.417GlnLys: 1.417 ± 0.061
4.537GlnLeu: 4.537 ± 0.121
0.796GlnMet: 0.796 ± 0.046
1.14GlnAsn: 1.14 ± 0.048
1.531GlnPro: 1.531 ± 0.059
1.582GlnGln: 1.582 ± 0.072
2.254GlnArg: 2.254 ± 0.079
2.082GlnSer: 2.082 ± 0.076
1.845GlnThr: 1.845 ± 0.063
3.155GlnVal: 3.155 ± 0.085
0.489GlnTrp: 0.489 ± 0.034
0.717GlnTyr: 0.717 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
5.449ArgAla: 5.449 ± 0.133
0.291ArgCys: 0.291 ± 0.027
2.952ArgAsp: 2.952 ± 0.08
3.974ArgGlu: 3.974 ± 0.109
2.489ArgPhe: 2.489 ± 0.077
3.85ArgGly: 3.85 ± 0.096
0.989ArgHis: 0.989 ± 0.048
3.331ArgIle: 3.331 ± 0.085
2.396ArgLys: 2.396 ± 0.079
5.67ArgLeu: 5.67 ± 0.119
1.335ArgMet: 1.335 ± 0.054
1.712ArgAsn: 1.712 ± 0.07
2.308ArgPro: 2.308 ± 0.075
2.005ArgGln: 2.005 ± 0.065
3.334ArgArg: 3.334 ± 0.116
3.527ArgSer: 3.527 ± 0.097
2.643ArgThr: 2.643 ± 0.076
4.581ArgVal: 4.581 ± 0.1
0.786ArgTrp: 0.786 ± 0.043
1.431ArgTyr: 1.431 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
7.179SerAla: 7.179 ± 0.165
0.382SerCys: 0.382 ± 0.034
3.527SerAsp: 3.527 ± 0.096
4.83SerGlu: 4.83 ± 0.131
2.766SerPhe: 2.766 ± 0.084
6.437SerGly: 6.437 ± 0.123
1.21SerHis: 1.21 ± 0.053
3.406SerIle: 3.406 ± 0.101
3.031SerLys: 3.031 ± 0.089
6.933SerLeu: 6.933 ± 0.134
1.508SerMet: 1.508 ± 0.055
2.024SerAsn: 2.024 ± 0.065
2.738SerPro: 2.738 ± 0.086
2.543SerGln: 2.543 ± 0.079
3.529SerArg: 3.529 ± 0.103
4.732SerSer: 4.732 ± 0.123
3.338SerThr: 3.338 ± 0.099
5.251SerVal: 5.251 ± 0.121
0.945SerTrp: 0.945 ± 0.051
1.656SerTyr: 1.656 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
5.469ThrAla: 5.469 ± 0.133
0.258ThrCys: 0.258 ± 0.021
2.65ThrAsp: 2.65 ± 0.083
3.299ThrGlu: 3.299 ± 0.106
1.973ThrPhe: 1.973 ± 0.067
4.695ThrGly: 4.695 ± 0.128
0.933ThrHis: 0.933 ± 0.05
2.962ThrIle: 2.962 ± 0.083
2.401ThrLys: 2.401 ± 0.079
5.649ThrLeu: 5.649 ± 0.127
0.961ThrMet: 0.961 ± 0.043
1.78ThrAsn: 1.78 ± 0.07
2.894ThrPro: 2.894 ± 0.091
1.775ThrGln: 1.775 ± 0.063
2.659ThrArg: 2.659 ± 0.083
3.452ThrSer: 3.452 ± 0.1
2.838ThrThr: 2.838 ± 0.098
4.036ThrVal: 4.036 ± 0.105
0.621ThrTrp: 0.621 ± 0.039
1.196ThrTyr: 1.196 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
8.864ValAla: 8.864 ± 0.166
0.454ValCys: 0.454 ± 0.032
4.223ValAsp: 4.223 ± 0.102
5.179ValGlu: 5.179 ± 0.121
2.985ValPhe: 2.985 ± 0.084
6.221ValGly: 6.221 ± 0.126
1.291ValHis: 1.291 ± 0.055
5.132ValIle: 5.132 ± 0.115
2.945ValLys: 2.945 ± 0.088
8.443ValLeu: 8.443 ± 0.159
1.805ValMet: 1.805 ± 0.064
2.34ValAsn: 2.34 ± 0.084
3.366ValPro: 3.366 ± 0.093
2.396ValGln: 2.396 ± 0.072
4.074ValArg: 4.074 ± 0.1
6.046ValSer: 6.046 ± 0.123
4.592ValThr: 4.592 ± 0.132
7.175ValVal: 7.175 ± 0.147
0.861ValTrp: 0.861 ± 0.04
1.563ValTyr: 1.563 ± 0.071
0.0ValXaa: 0.0 ± 0.0
Trp
1.254TrpAla: 1.254 ± 0.045
0.086TrpCys: 0.086 ± 0.014
0.649TrpAsp: 0.649 ± 0.04
0.735TrpGlu: 0.735 ± 0.034
0.633TrpPhe: 0.633 ± 0.042
0.933TrpGly: 0.933 ± 0.043
0.235TrpHis: 0.235 ± 0.023
0.733TrpIle: 0.733 ± 0.049
0.421TrpLys: 0.421 ± 0.031
1.78TrpLeu: 1.78 ± 0.068
0.286TrpMet: 0.286 ± 0.025
0.437TrpAsn: 0.437 ± 0.033
0.491TrpPro: 0.491 ± 0.032
0.547TrpGln: 0.547 ± 0.031
0.742TrpArg: 0.742 ± 0.041
0.814TrpSer: 0.814 ± 0.046
0.589TrpThr: 0.589 ± 0.037
1.017TrpVal: 1.017 ± 0.049
0.295TrpTrp: 0.295 ± 0.027
0.279TrpTyr: 0.279 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.117TyrAla: 2.117 ± 0.082
0.165TyrCys: 0.165 ± 0.021
1.31TyrAsp: 1.31 ± 0.051
1.408TyrGlu: 1.408 ± 0.063
1.056TyrPhe: 1.056 ± 0.052
1.887TyrGly: 1.887 ± 0.071
0.384TyrHis: 0.384 ± 0.028
0.891TyrIle: 0.891 ± 0.048
0.751TyrLys: 0.751 ± 0.04
2.801TyrLeu: 2.801 ± 0.09
0.309TyrMet: 0.309 ± 0.026
0.67TyrAsn: 0.67 ± 0.045
1.121TyrPro: 1.121 ± 0.057
1.112TyrGln: 1.112 ± 0.048
1.501TyrArg: 1.501 ± 0.067
1.603TyrSer: 1.603 ± 0.063
1.075TyrThr: 1.075 ± 0.056
1.624TyrVal: 1.624 ± 0.065
0.354TyrTrp: 0.354 ± 0.03
0.512TyrTyr: 0.512 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1370 proteins (429841 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski