Amino acid dipepetide frequency for Pseudooceanicola atlanticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.765AlaAla: 15.765 ± 0.152	1.063AlaCys: 1.063 ± 0.027	7.262AlaAsp: 7.262 ± 0.082	8.521AlaGlu: 8.521 ± 0.091	4.221AlaPhe: 4.221 ± 0.068	10.451AlaGly: 10.451 ± 0.115	2.211AlaHis: 2.211 ± 0.046	5.927AlaIle: 5.927 ± 0.065	3.752AlaLys: 3.752 ± 0.059	13.242AlaLeu: 13.242 ± 0.131	3.893AlaMet: 3.893 ± 0.059	2.676AlaAsn: 2.676 ± 0.049	5.595AlaPro: 5.595 ± 0.08	4.261AlaGln: 4.261 ± 0.064	8.488AlaArg: 8.488 ± 0.1	5.476AlaSer: 5.476 ± 0.067	5.874AlaThr: 5.874 ± 0.073	8.051AlaVal: 8.051 ± 0.094	1.466AlaTrp: 1.466 ± 0.039	2.496AlaTyr: 2.496 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.962CysAla: 0.962 ± 0.027	0.1CysCys: 0.1 ± 0.009	0.615CysAsp: 0.615 ± 0.022	0.427CysGlu: 0.427 ± 0.021	0.328CysPhe: 0.328 ± 0.014	0.901CysGly: 0.901 ± 0.029	0.258CysHis: 0.258 ± 0.015	0.395CysIle: 0.395 ± 0.018	0.188CysLys: 0.188 ± 0.012	0.799CysLeu: 0.799 ± 0.021	0.178CysMet: 0.178 ± 0.01	0.207CysAsn: 0.207 ± 0.012	0.501CysPro: 0.501 ± 0.02	0.249CysGln: 0.249 ± 0.013	0.534CysArg: 0.534 ± 0.022	0.418CysSer: 0.418 ± 0.017	0.429CysThr: 0.429 ± 0.02	0.622CysVal: 0.622 ± 0.024	0.112CysTrp: 0.112 ± 0.01	0.214CysTyr: 0.214 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.288AspAla: 7.288 ± 0.087	0.521AspCys: 0.521 ± 0.022	3.809AspAsp: 3.809 ± 0.086	3.777AspGlu: 3.777 ± 0.058	2.483AspPhe: 2.483 ± 0.064	6.003AspGly: 6.003 ± 0.093	1.627AspHis: 1.627 ± 0.042	3.329AspIle: 3.329 ± 0.049	1.806AspLys: 1.806 ± 0.041	6.757AspLeu: 6.757 ± 0.099	1.894AspMet: 1.894 ± 0.037	1.405AspAsn: 1.405 ± 0.041	3.903AspPro: 3.903 ± 0.067	2.022AspGln: 2.022 ± 0.044	4.961AspArg: 4.961 ± 0.074	2.275AspSer: 2.275 ± 0.055	3.424AspThr: 3.424 ± 0.086	4.416AspVal: 4.416 ± 0.061	1.151AspTrp: 1.151 ± 0.03	1.654AspTyr: 1.654 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	8.543GluAla: 8.543 ± 0.094	0.368GluCys: 0.368 ± 0.017	3.948GluAsp: 3.948 ± 0.055	4.081GluGlu: 4.081 ± 0.069	1.851GluPhe: 1.851 ± 0.036	5.343GluGly: 5.343 ± 0.069	1.02GluHis: 1.02 ± 0.028	3.811GluIle: 3.811 ± 0.054	2.312GluLys: 2.312 ± 0.057	5.229GluLeu: 5.229 ± 0.07	1.999GluMet: 1.999 ± 0.05	1.753GluAsn: 1.753 ± 0.037	2.591GluPro: 2.591 ± 0.05	1.891GluGln: 1.891 ± 0.038	4.117GluArg: 4.117 ± 0.059	2.13GluSer: 2.13 ± 0.041	4.055GluThr: 4.055 ± 0.056	4.607GluVal: 4.607 ± 0.06	0.703GluTrp: 0.703 ± 0.019	1.096GluTyr: 1.096 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.329PheAla: 4.329 ± 0.051	0.428PheCys: 0.428 ± 0.019	2.968PheAsp: 2.968 ± 0.057	2.23PheGlu: 2.23 ± 0.041	1.396PhePhe: 1.396 ± 0.033	3.827PheGly: 3.827 ± 0.066	0.727PheHis: 0.727 ± 0.024	1.579PheIle: 1.579 ± 0.04	0.922PheLys: 0.922 ± 0.028	3.43PheLeu: 3.43 ± 0.068	0.842PheMet: 0.842 ± 0.024	1.01PheAsn: 1.01 ± 0.031	1.558PhePro: 1.558 ± 0.036	1.011PheGln: 1.011 ± 0.028	2.231PheArg: 2.231 ± 0.043	2.077PheSer: 2.077 ± 0.049	2.012PheThr: 2.012 ± 0.048	2.683PheVal: 2.683 ± 0.049	0.521PheTrp: 0.521 ± 0.022	0.933PheTyr: 0.933 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.974GlyAla: 9.974 ± 0.113	0.815GlyCys: 0.815 ± 0.032	5.264GlyAsp: 5.264 ± 0.116	5.132GlyGlu: 5.132 ± 0.067	3.682GlyPhe: 3.682 ± 0.056	7.964GlyGly: 7.964 ± 0.135	1.961GlyHis: 1.961 ± 0.037	4.708GlyIle: 4.708 ± 0.059	3.055GlyLys: 3.055 ± 0.051	9.27GlyLeu: 9.27 ± 0.098	2.777GlyMet: 2.777 ± 0.049	2.306GlyAsn: 2.306 ± 0.075	3.937GlyPro: 3.937 ± 0.057	3.309GlyGln: 3.309 ± 0.056	5.77GlyArg: 5.77 ± 0.083	4.443GlySer: 4.443 ± 0.076	4.927GlyThr: 4.927 ± 0.067	6.257GlyVal: 6.257 ± 0.072	1.487GlyTrp: 1.487 ± 0.039	2.422GlyTyr: 2.422 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.29HisAla: 2.29 ± 0.045	0.213HisCys: 0.213 ± 0.013	1.29HisAsp: 1.29 ± 0.034	1.084HisGlu: 1.084 ± 0.029	0.805HisPhe: 0.805 ± 0.026	1.89HisGly: 1.89 ± 0.038	0.624HisHis: 0.624 ± 0.029	0.96HisIle: 0.96 ± 0.025	0.527HisLys: 0.527 ± 0.02	2.013HisLeu: 2.013 ± 0.036	0.567HisMet: 0.567 ± 0.024	0.44HisAsn: 0.44 ± 0.018	1.404HisPro: 1.404 ± 0.037	0.537HisGln: 0.537 ± 0.019	1.263HisArg: 1.263 ± 0.034	0.873HisSer: 0.873 ± 0.031	0.831HisThr: 0.831 ± 0.028	1.57HisVal: 1.57 ± 0.038	0.359HisTrp: 0.359 ± 0.016	0.533HisTyr: 0.533 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.107IleAla: 7.107 ± 0.074	0.604IleCys: 0.604 ± 0.023	3.728IleAsp: 3.728 ± 0.065	3.681IleGlu: 3.681 ± 0.043	1.827IlePhe: 1.827 ± 0.04	5.157IleGly: 5.157 ± 0.064	0.927IleHis: 0.927 ± 0.026	2.216IleIle: 2.216 ± 0.045	1.374IleLys: 1.374 ± 0.035	4.978IleLeu: 4.978 ± 0.073	1.093IleMet: 1.093 ± 0.03	1.35IleAsn: 1.35 ± 0.035	2.37IlePro: 2.37 ± 0.039	1.224IleGln: 1.224 ± 0.034	3.325IleArg: 3.325 ± 0.055	2.846IleSer: 2.846 ± 0.042	2.948IleThr: 2.948 ± 0.058	3.963IleVal: 3.963 ± 0.06	0.665IleTrp: 0.665 ± 0.026	1.19IleTyr: 1.19 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.903LysAla: 3.903 ± 0.059	0.171LysCys: 0.171 ± 0.01	1.8LysAsp: 1.8 ± 0.041	1.651LysGlu: 1.651 ± 0.043	0.919LysPhe: 0.919 ± 0.03	2.778LysGly: 2.778 ± 0.054	0.576LysHis: 0.576 ± 0.021	1.607LysIle: 1.607 ± 0.043	1.133LysLys: 1.133 ± 0.041	2.886LysLeu: 2.886 ± 0.052	0.918LysMet: 0.918 ± 0.031	0.773LysAsn: 0.773 ± 0.027	1.735LysPro: 1.735 ± 0.04	0.841LysGln: 0.841 ± 0.028	2.129LysArg: 2.129 ± 0.046	1.736LysSer: 1.736 ± 0.038	1.905LysThr: 1.905 ± 0.046	2.398LysVal: 2.398 ± 0.048	0.371LysTrp: 0.371 ± 0.018	0.638LysTyr: 0.638 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.379LeuAla: 12.379 ± 0.123	0.851LeuCys: 0.851 ± 0.023	6.449LeuAsp: 6.449 ± 0.085	5.203LeuGlu: 5.203 ± 0.062	3.499LeuPhe: 3.499 ± 0.07	8.386LeuGly: 8.386 ± 0.091	1.817LeuHis: 1.817 ± 0.041	5.367LeuIle: 5.367 ± 0.071	3.151LeuLys: 3.151 ± 0.05	8.491LeuLeu: 8.491 ± 0.098	2.674LeuMet: 2.674 ± 0.047	2.688LeuAsn: 2.688 ± 0.052	5.394LeuPro: 5.394 ± 0.076	2.594LeuGln: 2.594 ± 0.044	6.76LeuArg: 6.76 ± 0.076	6.626LeuSer: 6.626 ± 0.075	6.327LeuThr: 6.327 ± 0.066	6.694LeuVal: 6.694 ± 0.083	1.237LeuTrp: 1.237 ± 0.033	1.961LeuTyr: 1.961 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.635MetAla: 3.635 ± 0.059	0.186MetCys: 0.186 ± 0.012	1.51MetAsp: 1.51 ± 0.037	1.564MetGlu: 1.564 ± 0.032	0.847MetPhe: 0.847 ± 0.025	2.364MetGly: 2.364 ± 0.044	0.486MetHis: 0.486 ± 0.019	1.683MetIle: 1.683 ± 0.04	1.075MetLys: 1.075 ± 0.03	2.637MetLeu: 2.637 ± 0.051	0.864MetMet: 0.864 ± 0.029	0.851MetAsn: 0.851 ± 0.026	1.536MetPro: 1.536 ± 0.033	1.042MetGln: 1.042 ± 0.032	1.942MetArg: 1.942 ± 0.037	1.916MetSer: 1.916 ± 0.036	2.224MetThr: 2.224 ± 0.045	1.944MetVal: 1.944 ± 0.038	0.255MetTrp: 0.255 ± 0.013	0.337MetTyr: 0.337 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.147AsnAla: 3.147 ± 0.049	0.237AsnCys: 0.237 ± 0.015	1.546AsnAsp: 1.546 ± 0.064	1.226AsnGlu: 1.226 ± 0.031	0.953AsnPhe: 0.953 ± 0.029	2.495AsnGly: 2.495 ± 0.063	0.483AsnHis: 0.483 ± 0.02	1.392AsnIle: 1.392 ± 0.029	0.616AsnLys: 0.616 ± 0.022	2.494AsnLeu: 2.494 ± 0.047	0.737AsnMet: 0.737 ± 0.026	0.675AsnAsn: 0.675 ± 0.028	1.821AsnPro: 1.821 ± 0.039	0.705AsnGln: 0.705 ± 0.027	1.77AsnArg: 1.77 ± 0.033	1.203AsnSer: 1.203 ± 0.03	1.277AsnThr: 1.277 ± 0.032	1.848AsnVal: 1.848 ± 0.042	0.405AsnTrp: 0.405 ± 0.02	0.648AsnTyr: 0.648 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.454ProAla: 5.454 ± 0.076	0.336ProCys: 0.336 ± 0.015	4.309ProAsp: 4.309 ± 0.065	4.346ProGlu: 4.346 ± 0.068	1.879ProPhe: 1.879 ± 0.039	4.643ProGly: 4.643 ± 0.059	1.031ProHis: 1.031 ± 0.029	2.301ProIle: 2.301 ± 0.04	1.6ProLys: 1.6 ± 0.041	4.563ProLeu: 4.563 ± 0.065	1.324ProMet: 1.324 ± 0.031	1.206ProAsn: 1.206 ± 0.032	2.223ProPro: 2.223 ± 0.046	1.587ProGln: 1.587 ± 0.036	2.839ProArg: 2.839 ± 0.049	2.463ProSer: 2.463 ± 0.045	2.415ProThr: 2.415 ± 0.044	4.273ProVal: 4.273 ± 0.074	0.62ProTrp: 0.62 ± 0.025	1.13ProTyr: 1.13 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.016GlnAla: 4.016 ± 0.061	0.197GlnCys: 0.197 ± 0.012	1.775GlnAsp: 1.775 ± 0.034	1.635GlnGlu: 1.635 ± 0.032	1.047GlnPhe: 1.047 ± 0.027	2.646GlnGly: 2.646 ± 0.054	0.546GlnHis: 0.546 ± 0.02	2.005GlnIle: 2.005 ± 0.037	1.071GlnLys: 1.071 ± 0.033	2.74GlnLeu: 2.74 ± 0.041	1.093GlnMet: 1.093 ± 0.032	0.881GlnAsn: 0.881 ± 0.031	1.533GlnPro: 1.533 ± 0.035	1.067GlnGln: 1.067 ± 0.033	2.024GlnArg: 2.024 ± 0.044	1.738GlnSer: 1.738 ± 0.042	1.765GlnThr: 1.765 ± 0.038	2.471GlnVal: 2.471 ± 0.046	0.375GlnTrp: 0.375 ± 0.018	0.567GlnTyr: 0.567 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.749ArgAla: 7.749 ± 0.106	0.431ArgCys: 0.431 ± 0.017	4.665ArgAsp: 4.665 ± 0.068	3.87ArgGlu: 3.87 ± 0.061	2.628ArgPhe: 2.628 ± 0.041	4.675ArgGly: 4.675 ± 0.059	1.455ArgHis: 1.455 ± 0.037	3.939ArgIle: 3.939 ± 0.06	2.27ArgLys: 2.27 ± 0.049	7.078ArgLeu: 7.078 ± 0.088	2.051ArgMet: 2.051 ± 0.039	1.839ArgAsn: 1.839 ± 0.04	3.283ArgPro: 3.283 ± 0.058	2.239ArgGln: 2.239 ± 0.043	4.798ArgArg: 4.798 ± 0.071	3.285ArgSer: 3.285 ± 0.045	2.989ArgThr: 2.989 ± 0.043	4.675ArgVal: 4.675 ± 0.07	0.845ArgTrp: 0.845 ± 0.023	1.567ArgTyr: 1.567 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.657SerAla: 5.657 ± 0.074	0.423SerCys: 0.423 ± 0.021	3.526SerAsp: 3.526 ± 0.06	2.955SerGlu: 2.955 ± 0.051	2.145SerPhe: 2.145 ± 0.047	5.55SerGly: 5.55 ± 0.087	1.036SerHis: 1.036 ± 0.029	2.404SerIle: 2.404 ± 0.046	1.383SerLys: 1.383 ± 0.035	4.943SerLeu: 4.943 ± 0.057	1.465SerMet: 1.465 ± 0.035	1.335SerAsn: 1.335 ± 0.032	2.395SerPro: 2.395 ± 0.043	1.542SerGln: 1.542 ± 0.035	3.123SerArg: 3.123 ± 0.05	2.522SerSer: 2.522 ± 0.048	2.475SerThr: 2.475 ± 0.05	3.74SerVal: 3.74 ± 0.053	0.703SerTrp: 0.703 ± 0.025	1.292SerTyr: 1.292 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	6.16ThrAla: 6.16 ± 0.071	0.505ThrCys: 0.505 ± 0.02	3.426ThrAsp: 3.426 ± 0.059	3.33ThrGlu: 3.33 ± 0.052	2.058ThrPhe: 2.058 ± 0.041	5.775ThrGly: 5.775 ± 0.077	1.13ThrHis: 1.13 ± 0.027	2.912ThrIle: 2.912 ± 0.058	1.475ThrLys: 1.475 ± 0.039	5.969ThrLeu: 5.969 ± 0.078	1.347ThrMet: 1.347 ± 0.036	1.325ThrAsn: 1.325 ± 0.037	3.444ThrPro: 3.444 ± 0.05	1.633ThrGln: 1.633 ± 0.038	3.609ThrArg: 3.609 ± 0.058	2.652ThrSer: 2.652 ± 0.045	2.901ThrThr: 2.901 ± 0.052	3.991ThrVal: 3.991 ± 0.062	0.695ThrTrp: 0.695 ± 0.025	1.345ThrTyr: 1.345 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.489ValAla: 8.489 ± 0.093	0.601ValCys: 0.601 ± 0.024	4.146ValAsp: 4.146 ± 0.062	4.713ValGlu: 4.713 ± 0.062	2.741ValPhe: 2.741 ± 0.049	5.371ValGly: 5.371 ± 0.074	1.297ValHis: 1.297 ± 0.037	4.388ValIle: 4.388 ± 0.067	2.126ValLys: 2.126 ± 0.054	7.209ValLeu: 7.209 ± 0.09	2.23ValMet: 2.23 ± 0.04	1.96ValAsn: 1.96 ± 0.038	3.591ValPro: 3.591 ± 0.055	2.215ValGln: 2.215 ± 0.042	4.12ValArg: 4.12 ± 0.048	4.058ValSer: 4.058 ± 0.054	4.992ValThr: 4.992 ± 0.065	5.416ValVal: 5.416 ± 0.081	0.871ValTrp: 0.871 ± 0.029	1.458ValTyr: 1.458 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.301TrpAla: 1.301 ± 0.032	0.139TrpCys: 0.139 ± 0.011	0.765TrpAsp: 0.765 ± 0.024	0.663TrpGlu: 0.663 ± 0.024	0.526TrpPhe: 0.526 ± 0.021	0.991TrpGly: 0.991 ± 0.026	0.338TrpHis: 0.338 ± 0.016	0.712TrpIle: 0.712 ± 0.025	0.451TrpLys: 0.451 ± 0.02	1.538TrpLeu: 1.538 ± 0.036	0.433TrpMet: 0.433 ± 0.019	0.404TrpAsn: 0.404 ± 0.018	0.682TrpPro: 0.682 ± 0.024	0.567TrpGln: 0.567 ± 0.018	0.981TrpArg: 0.981 ± 0.027	0.754TrpSer: 0.754 ± 0.024	0.815TrpThr: 0.815 ± 0.03	0.844TrpVal: 0.844 ± 0.025	0.209TrpTrp: 0.209 ± 0.012	0.277TrpTyr: 0.277 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.541TyrAla: 2.541 ± 0.042	0.247TyrCys: 0.247 ± 0.013	1.701TyrAsp: 1.701 ± 0.037	1.362TyrGlu: 1.362 ± 0.03	0.881TyrPhe: 0.881 ± 0.027	2.248TyrGly: 2.248 ± 0.044	0.524TyrHis: 0.524 ± 0.021	0.941TyrIle: 0.941 ± 0.026	0.581TyrLys: 0.581 ± 0.021	2.284TyrLeu: 2.284 ± 0.046	0.517TyrMet: 0.517 ± 0.021	0.592TyrAsn: 0.592 ± 0.02	1.047TyrPro: 1.047 ± 0.03	0.653TyrGln: 0.653 ± 0.025	1.55TyrArg: 1.55 ± 0.04	1.123TyrSer: 1.123 ± 0.029	1.096TyrThr: 1.096 ± 0.025	1.528TyrVal: 1.528 ± 0.031	0.34TyrTrp: 0.34 ± 0.017	0.61TyrTyr: 0.61 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4202 proteins (1327093 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---