Amino acid dipepetide frequency for Frigoribacterium sp. Leaf164

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.082AlaAla: 22.082 ± 0.259	0.607AlaCys: 0.607 ± 0.027	9.062AlaAsp: 9.062 ± 0.13	8.065AlaGlu: 8.065 ± 0.118	3.659AlaPhe: 3.659 ± 0.068	13.328AlaGly: 13.328 ± 0.162	2.303AlaHis: 2.303 ± 0.059	3.965AlaIle: 3.965 ± 0.081	2.084AlaLys: 2.084 ± 0.062	14.705AlaLeu: 14.705 ± 0.155	2.275AlaMet: 2.275 ± 0.049	1.772AlaAsn: 1.772 ± 0.045	7.728AlaPro: 7.728 ± 0.142	3.41AlaGln: 3.41 ± 0.068	9.702AlaArg: 9.702 ± 0.15	8.397AlaSer: 8.397 ± 0.114	8.439AlaThr: 8.439 ± 0.123	13.843AlaVal: 13.843 ± 0.169	1.922AlaTrp: 1.922 ± 0.049	2.118AlaTyr: 2.118 ± 0.047	0.002AlaXaa: 0.002 ± 0.001
Cys	0.488CysAla: 0.488 ± 0.025	0.031CysCys: 0.031 ± 0.006	0.26CysAsp: 0.26 ± 0.017	0.189CysGlu: 0.189 ± 0.015	0.133CysPhe: 0.133 ± 0.011	0.502CysGly: 0.502 ± 0.025	0.113CysHis: 0.113 ± 0.012	0.117CysIle: 0.117 ± 0.01	0.038CysLys: 0.038 ± 0.005	0.422CysLeu: 0.422 ± 0.023	0.055CysMet: 0.055 ± 0.007	0.072CysAsn: 0.072 ± 0.008	0.229CysPro: 0.229 ± 0.018	0.095CysGln: 0.095 ± 0.011	0.294CysArg: 0.294 ± 0.022	0.322CysSer: 0.322 ± 0.021	0.287CysThr: 0.287 ± 0.019	0.419CysVal: 0.419 ± 0.019	0.05CysTrp: 0.05 ± 0.008	0.074CysTyr: 0.074 ± 0.008	0.001CysXaa: 0.001 ± 0.001
Asp	9.134AspAla: 9.134 ± 0.124	0.203AspCys: 0.203 ± 0.014	5.835AspAsp: 5.835 ± 0.117	4.827AspGlu: 4.827 ± 0.094	1.59AspPhe: 1.59 ± 0.045	6.575AspGly: 6.575 ± 0.105	1.322AspHis: 1.322 ± 0.044	1.566AspIle: 1.566 ± 0.051	0.791AspLys: 0.791 ± 0.034	6.87AspLeu: 6.87 ± 0.094	0.678AspMet: 0.678 ± 0.029	0.712AspAsn: 0.712 ± 0.03	4.388AspPro: 4.388 ± 0.087	1.745AspGln: 1.745 ± 0.046	4.818AspArg: 4.818 ± 0.091	2.775AspSer: 2.775 ± 0.061	2.908AspThr: 2.908 ± 0.057	6.791AspVal: 6.791 ± 0.099	0.91AspTrp: 0.91 ± 0.031	1.146AspTyr: 1.146 ± 0.037	0.002AspXaa: 0.002 ± 0.001
Glu	7.794GluAla: 7.794 ± 0.111	0.198GluCys: 0.198 ± 0.017	1.723GluAsp: 1.723 ± 0.05	2.454GluGlu: 2.454 ± 0.062	1.574GluPhe: 1.574 ± 0.049	4.47GluGly: 4.47 ± 0.085	1.521GluHis: 1.521 ± 0.047	2.158GluIle: 2.158 ± 0.06	1.232GluLys: 1.232 ± 0.048	6.328GluLeu: 6.328 ± 0.108	0.799GluMet: 0.799 ± 0.032	0.965GluAsn: 0.965 ± 0.04	3.009GluPro: 3.009 ± 0.072	2.282GluGln: 2.282 ± 0.052	4.768GluArg: 4.768 ± 0.093	2.781GluSer: 2.781 ± 0.076	3.038GluThr: 3.038 ± 0.069	4.94GluVal: 4.94 ± 0.094	0.74GluTrp: 0.74 ± 0.031	0.946GluTyr: 0.946 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.725PheAla: 3.725 ± 0.069	0.14PheCys: 0.14 ± 0.012	2.21PheAsp: 2.21 ± 0.058	1.525PheGlu: 1.525 ± 0.049	0.97PhePhe: 0.97 ± 0.047	3.061PheGly: 3.061 ± 0.059	0.455PheHis: 0.455 ± 0.024	0.821PheIle: 0.821 ± 0.037	0.387PheLys: 0.387 ± 0.02	2.528PheLeu: 2.528 ± 0.062	0.385PheMet: 0.385 ± 0.021	0.471PheAsn: 0.471 ± 0.024	1.263PhePro: 1.263 ± 0.04	0.704PheGln: 0.704 ± 0.028	1.711PheArg: 1.711 ± 0.046	1.829PheSer: 1.829 ± 0.044	1.969PheThr: 1.969 ± 0.051	3.114PheVal: 3.114 ± 0.068	0.451PheTrp: 0.451 ± 0.026	0.599PheTyr: 0.599 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	12.049GlyAla: 12.049 ± 0.168	0.491GlyCys: 0.491 ± 0.025	6.046GlyAsp: 6.046 ± 0.087	4.698GlyGlu: 4.698 ± 0.082	2.933GlyPhe: 2.933 ± 0.066	8.487GlyGly: 8.487 ± 0.118	1.885GlyHis: 1.885 ± 0.045	3.355GlyIle: 3.355 ± 0.071	1.785GlyLys: 1.785 ± 0.049	9.802GlyLeu: 9.802 ± 0.133	1.53GlyMet: 1.53 ± 0.04	1.398GlyAsn: 1.398 ± 0.048	4.297GlyPro: 4.297 ± 0.074	2.69GlyGln: 2.69 ± 0.067	7.162GlyArg: 7.162 ± 0.102	6.167GlySer: 6.167 ± 0.097	6.387GlyThr: 6.387 ± 0.14	9.28GlyVal: 9.28 ± 0.115	1.599GlyTrp: 1.599 ± 0.042	1.948GlyTyr: 1.948 ± 0.051	0.001GlyXaa: 0.001 ± 0.001
His	2.255HisAla: 2.255 ± 0.058	0.079HisCys: 0.079 ± 0.009	1.649HisAsp: 1.649 ± 0.047	1.115HisGlu: 1.115 ± 0.037	0.492HisPhe: 0.492 ± 0.026	2.046HisGly: 2.046 ± 0.057	0.498HisHis: 0.498 ± 0.024	0.421HisIle: 0.421 ± 0.024	0.202HisLys: 0.202 ± 0.016	2.004HisLeu: 2.004 ± 0.047	0.241HisMet: 0.241 ± 0.017	0.245HisAsn: 0.245 ± 0.016	1.357HisPro: 1.357 ± 0.04	0.502HisGln: 0.502 ± 0.025	1.645HisArg: 1.645 ± 0.046	0.817HisSer: 0.817 ± 0.032	0.841HisThr: 0.841 ± 0.026	2.005HisVal: 2.005 ± 0.049	0.257HisTrp: 0.257 ± 0.015	0.354HisTyr: 0.354 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	4.79IleAla: 4.79 ± 0.091	0.191IleCys: 0.191 ± 0.014	2.553IleAsp: 2.553 ± 0.069	1.909IleGlu: 1.909 ± 0.05	0.789IlePhe: 0.789 ± 0.034	3.614IleGly: 3.614 ± 0.078	0.487IleHis: 0.487 ± 0.024	1.059IleIle: 1.059 ± 0.043	0.641IleLys: 0.641 ± 0.038	2.225IleLeu: 2.225 ± 0.058	0.476IleMet: 0.476 ± 0.026	0.651IleAsn: 0.651 ± 0.03	1.383IlePro: 1.383 ± 0.039	0.675IleGln: 0.675 ± 0.03	1.896IleArg: 1.896 ± 0.055	1.876IleSer: 1.876 ± 0.053	2.114IleThr: 2.114 ± 0.057	3.646IleVal: 3.646 ± 0.084	0.372IleTrp: 0.372 ± 0.022	0.587IleTyr: 0.587 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	2.075LysAla: 2.075 ± 0.063	0.043LysCys: 0.043 ± 0.007	0.838LysAsp: 0.838 ± 0.036	0.808LysGlu: 0.808 ± 0.034	0.441LysPhe: 0.441 ± 0.022	1.472LysGly: 1.472 ± 0.056	0.358LysHis: 0.358 ± 0.02	0.743LysIle: 0.743 ± 0.04	0.686LysLys: 0.686 ± 0.035	1.467LysLeu: 1.467 ± 0.053	0.32LysMet: 0.32 ± 0.022	0.417LysAsn: 0.417 ± 0.025	0.862LysPro: 0.862 ± 0.034	0.604LysGln: 0.604 ± 0.028	1.2LysArg: 1.2 ± 0.041	1.02LysSer: 1.02 ± 0.038	1.095LysThr: 1.095 ± 0.04	1.573LysVal: 1.573 ± 0.046	0.154LysTrp: 0.154 ± 0.012	0.353LysTyr: 0.353 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.853LeuAla: 14.853 ± 0.153	0.394LeuCys: 0.394 ± 0.022	7.474LeuAsp: 7.474 ± 0.106	4.999LeuGlu: 4.999 ± 0.084	2.703LeuPhe: 2.703 ± 0.07	9.738LeuGly: 9.738 ± 0.127	1.84LeuHis: 1.84 ± 0.052	2.99LeuIle: 2.99 ± 0.072	1.426LeuLys: 1.426 ± 0.047	10.451LeuLeu: 10.451 ± 0.154	1.409LeuMet: 1.409 ± 0.044	1.334LeuAsn: 1.334 ± 0.04	5.763LeuPro: 5.763 ± 0.09	2.354LeuGln: 2.354 ± 0.053	7.725LeuArg: 7.725 ± 0.112	5.687LeuSer: 5.687 ± 0.09	6.379LeuThr: 6.379 ± 0.089	11.466LeuVal: 11.466 ± 0.141	1.19LeuTrp: 1.19 ± 0.041	1.554LeuTyr: 1.554 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	1.818MetAla: 1.818 ± 0.046	0.077MetCys: 0.077 ± 0.01	0.633MetAsp: 0.633 ± 0.028	0.52MetGlu: 0.52 ± 0.027	0.408MetPhe: 0.408 ± 0.024	1.087MetGly: 1.087 ± 0.039	0.295MetHis: 0.295 ± 0.019	0.675MetIle: 0.675 ± 0.03	0.325MetLys: 0.325 ± 0.019	1.562MetLeu: 1.562 ± 0.048	0.236MetMet: 0.236 ± 0.018	0.35MetAsn: 0.35 ± 0.018	0.974MetPro: 0.974 ± 0.031	0.419MetGln: 0.419 ± 0.02	1.114MetArg: 1.114 ± 0.033	1.203MetSer: 1.203 ± 0.039	1.694MetThr: 1.694 ± 0.04	1.283MetVal: 1.283 ± 0.044	0.148MetTrp: 0.148 ± 0.013	0.205MetTyr: 0.205 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	1.845AsnAla: 1.845 ± 0.051	0.078AsnCys: 0.078 ± 0.01	1.026AsnAsp: 1.026 ± 0.037	0.723AsnGlu: 0.723 ± 0.03	0.499AsnPhe: 0.499 ± 0.029	1.51AsnGly: 1.51 ± 0.044	0.279AsnHis: 0.279 ± 0.017	0.574AsnIle: 0.574 ± 0.029	0.303AsnLys: 0.303 ± 0.021	1.379AsnLeu: 1.379 ± 0.041	0.265AsnMet: 0.265 ± 0.019	0.348AsnAsn: 0.348 ± 0.02	1.048AsnPro: 1.048 ± 0.032	0.439AsnGln: 0.439 ± 0.025	0.959AsnArg: 0.959 ± 0.034	0.789AsnSer: 0.789 ± 0.036	0.872AsnThr: 0.872 ± 0.034	1.53AsnVal: 1.53 ± 0.052	0.241AsnTrp: 0.241 ± 0.016	0.372AsnTyr: 0.372 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	8.402ProAla: 8.402 ± 0.144	0.164ProCys: 0.164 ± 0.014	3.882ProAsp: 3.882 ± 0.074	3.676ProGlu: 3.676 ± 0.071	1.554ProPhe: 1.554 ± 0.046	5.791ProGly: 5.791 ± 0.095	0.981ProHis: 0.981 ± 0.035	1.449ProIle: 1.449 ± 0.041	0.737ProLys: 0.737 ± 0.033	4.97ProLeu: 4.97 ± 0.073	0.766ProMet: 0.766 ± 0.029	0.742ProAsn: 0.742 ± 0.029	2.347ProPro: 2.347 ± 0.073	1.396ProGln: 1.396 ± 0.042	3.753ProArg: 3.753 ± 0.074	3.362ProSer: 3.362 ± 0.07	3.87ProThr: 3.87 ± 0.076	5.874ProVal: 5.874 ± 0.114	0.898ProTrp: 0.898 ± 0.034	0.946ProTyr: 0.946 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.47GlnAla: 3.47 ± 0.073	0.078GlnCys: 0.078 ± 0.011	1.014GlnAsp: 1.014 ± 0.034	1.2GlnGlu: 1.2 ± 0.036	0.79GlnPhe: 0.79 ± 0.031	2.313GlnGly: 2.313 ± 0.055	0.645GlnHis: 0.645 ± 0.026	1.096GlnIle: 1.096 ± 0.038	0.585GlnLys: 0.585 ± 0.027	3.298GlnLeu: 3.298 ± 0.066	0.414GlnMet: 0.414 ± 0.022	0.486GlnAsn: 0.486 ± 0.028	1.553GlnPro: 1.553 ± 0.05	1.245GlnGln: 1.245 ± 0.04	2.152GlnArg: 2.152 ± 0.057	1.39GlnSer: 1.39 ± 0.035	1.477GlnThr: 1.477 ± 0.051	2.676GlnVal: 2.676 ± 0.059	0.365GlnTrp: 0.365 ± 0.02	0.565GlnTyr: 0.565 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	9.536ArgAla: 9.536 ± 0.134	0.285ArgCys: 0.285 ± 0.02	4.63ArgAsp: 4.63 ± 0.086	4.214ArgGlu: 4.214 ± 0.088	2.11ArgPhe: 2.11 ± 0.061	5.885ArgGly: 5.885 ± 0.091	1.641ArgHis: 1.641 ± 0.051	2.339ArgIle: 2.339 ± 0.055	1.049ArgLys: 1.049 ± 0.039	7.643ArgLeu: 7.643 ± 0.107	1.375ArgMet: 1.375 ± 0.043	0.948ArgAsn: 0.948 ± 0.037	4.208ArgPro: 4.208 ± 0.072	1.987ArgGln: 1.987 ± 0.05	7.419ArgArg: 7.419 ± 0.132	4.455ArgSer: 4.455 ± 0.081	4.11ArgThr: 4.11 ± 0.07	6.913ArgVal: 6.913 ± 0.088	1.271ArgTrp: 1.271 ± 0.035	1.348ArgTyr: 1.348 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	7.56SerAla: 7.56 ± 0.111	0.291SerCys: 0.291 ± 0.016	3.402SerAsp: 3.402 ± 0.071	2.451SerGlu: 2.451 ± 0.058	1.93SerPhe: 1.93 ± 0.047	6.075SerGly: 6.075 ± 0.087	1.0SerHis: 1.0 ± 0.034	2.17SerIle: 2.17 ± 0.062	1.045SerLys: 1.045 ± 0.035	5.631SerLeu: 5.631 ± 0.084	1.14SerMet: 1.14 ± 0.04	0.959SerAsn: 0.959 ± 0.028	3.622SerPro: 3.622 ± 0.057	1.387SerGln: 1.387 ± 0.041	4.032SerArg: 4.032 ± 0.072	4.148SerSer: 4.148 ± 0.099	4.41SerThr: 4.41 ± 0.088	5.504SerVal: 5.504 ± 0.088	1.071SerTrp: 1.071 ± 0.035	1.266SerTyr: 1.266 ± 0.034	0.001SerXaa: 0.001 ± 0.001
Thr	8.881ThrAla: 8.881 ± 0.133	0.242ThrCys: 0.242 ± 0.016	3.781ThrAsp: 3.781 ± 0.078	2.835ThrGlu: 2.835 ± 0.059	1.775ThrPhe: 1.775 ± 0.045	6.343ThrGly: 6.343 ± 0.122	0.98ThrHis: 0.98 ± 0.03	2.358ThrIle: 2.358 ± 0.059	1.139ThrLys: 1.139 ± 0.042	5.911ThrLeu: 5.911 ± 0.086	0.84ThrMet: 0.84 ± 0.033	1.029ThrAsn: 1.029 ± 0.035	4.16ThrPro: 4.16 ± 0.073	1.367ThrGln: 1.367 ± 0.042	3.943ThrArg: 3.943 ± 0.066	4.036ThrSer: 4.036 ± 0.092	4.932ThrThr: 4.932 ± 0.115	7.203ThrVal: 7.203 ± 0.182	1.018ThrTrp: 1.018 ± 0.037	1.139ThrTyr: 1.139 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	14.839ValAla: 14.839 ± 0.176	0.406ValCys: 0.406 ± 0.02	7.609ValAsp: 7.609 ± 0.117	5.898ValGlu: 5.898 ± 0.101	2.817ValPhe: 2.817 ± 0.071	8.87ValGly: 8.87 ± 0.133	1.868ValHis: 1.868 ± 0.052	3.183ValIle: 3.183 ± 0.082	1.53ValLys: 1.53 ± 0.044	10.81ValLeu: 10.81 ± 0.135	1.362ValMet: 1.362 ± 0.042	1.499ValAsn: 1.499 ± 0.05	5.782ValPro: 5.782 ± 0.089	2.388ValGln: 2.388 ± 0.061	6.47ValArg: 6.47 ± 0.101	5.822ValSer: 5.822 ± 0.095	7.152ValThr: 7.152 ± 0.15	13.772ValVal: 13.772 ± 0.253	1.077ValTrp: 1.077 ± 0.038	1.501ValTyr: 1.501 ± 0.044	0.001ValXaa: 0.001 ± 0.001
Trp	1.751TrpAla: 1.751 ± 0.045	0.091TrpCys: 0.091 ± 0.009	0.617TrpAsp: 0.617 ± 0.029	0.57TrpGlu: 0.57 ± 0.023	0.563TrpPhe: 0.563 ± 0.028	1.095TrpGly: 1.095 ± 0.042	0.291TrpHis: 0.291 ± 0.018	0.471TrpIle: 0.471 ± 0.025	0.207TrpLys: 0.207 ± 0.015	1.753TrpLeu: 1.753 ± 0.054	0.27TrpMet: 0.27 ± 0.016	0.324TrpAsn: 0.324 ± 0.019	0.726TrpPro: 0.726 ± 0.026	0.558TrpGln: 0.558 ± 0.027	1.263TrpArg: 1.263 ± 0.041	1.182TrpSer: 1.182 ± 0.042	0.866TrpThr: 0.866 ± 0.032	1.15TrpVal: 1.15 ± 0.04	0.348TrpTrp: 0.348 ± 0.021	0.245TrpTyr: 0.245 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.118TyrAla: 2.118 ± 0.044	0.101TyrCys: 0.101 ± 0.011	1.342TyrAsp: 1.342 ± 0.04	1.041TyrGlu: 1.041 ± 0.042	0.592TyrPhe: 0.592 ± 0.029	1.728TyrGly: 1.728 ± 0.051	0.265TyrHis: 0.265 ± 0.018	0.421TyrIle: 0.421 ± 0.023	0.336TyrLys: 0.336 ± 0.024	1.969TyrLeu: 1.969 ± 0.043	0.191TyrMet: 0.191 ± 0.016	0.355TyrAsn: 0.355 ± 0.021	0.862TyrPro: 0.862 ± 0.034	0.565TyrGln: 0.565 ± 0.025	1.339TyrArg: 1.339 ± 0.041	1.036TyrSer: 1.036 ± 0.031	1.069TyrThr: 1.069 ± 0.038	1.674TyrVal: 1.674 ± 0.042	0.261TyrTrp: 0.261 ± 0.018	0.375TyrTyr: 0.375 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.002XaaThr: 0.002 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 2793 proteins (897636 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---