Amino acid dipepetide frequency for Pontibacter oryzae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.593AlaAla: 7.593 ± 0.111	0.689AlaCys: 0.689 ± 0.027	4.2AlaAsp: 4.2 ± 0.059	5.213AlaGlu: 5.213 ± 0.072	3.675AlaPhe: 3.675 ± 0.072	6.119AlaGly: 6.119 ± 0.085	1.461AlaHis: 1.461 ± 0.035	5.127AlaIle: 5.127 ± 0.079	4.682AlaLys: 4.682 ± 0.067	8.245AlaLeu: 8.245 ± 0.112	2.083AlaMet: 2.083 ± 0.044	3.533AlaAsn: 3.533 ± 0.052	3.009AlaPro: 3.009 ± 0.061	3.648AlaGln: 3.648 ± 0.066	3.276AlaArg: 3.276 ± 0.057	5.027AlaSer: 5.027 ± 0.077	4.876AlaThr: 4.876 ± 0.093	5.435AlaVal: 5.435 ± 0.073	0.855AlaTrp: 0.855 ± 0.023	3.189AlaTyr: 3.189 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.578CysAla: 0.578 ± 0.026	0.115CysCys: 0.115 ± 0.009	0.356CysAsp: 0.356 ± 0.017	0.4CysGlu: 0.4 ± 0.018	0.319CysPhe: 0.319 ± 0.018	0.635CysGly: 0.635 ± 0.026	0.189CysHis: 0.189 ± 0.011	0.458CysIle: 0.458 ± 0.018	0.304CysLys: 0.304 ± 0.017	0.706CysLeu: 0.706 ± 0.025	0.166CysMet: 0.166 ± 0.011	0.308CysAsn: 0.308 ± 0.015	0.342CysPro: 0.342 ± 0.02	0.299CysGln: 0.299 ± 0.016	0.305CysArg: 0.305 ± 0.019	0.533CysSer: 0.533 ± 0.022	0.43CysThr: 0.43 ± 0.019	0.419CysVal: 0.419 ± 0.018	0.067CysTrp: 0.067 ± 0.008	0.263CysTyr: 0.263 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.247AspAla: 4.247 ± 0.064	0.351AspCys: 0.351 ± 0.017	2.394AspAsp: 2.394 ± 0.055	3.458AspGlu: 3.458 ± 0.057	2.866AspPhe: 2.866 ± 0.054	3.527AspGly: 3.527 ± 0.069	0.865AspHis: 0.865 ± 0.026	3.414AspIle: 3.414 ± 0.059	3.517AspLys: 3.517 ± 0.064	4.939AspLeu: 4.939 ± 0.073	1.312AspMet: 1.312 ± 0.034	2.395AspAsn: 2.395 ± 0.047	1.955AspPro: 1.955 ± 0.042	1.726AspGln: 1.726 ± 0.044	2.226AspArg: 2.226 ± 0.051	2.716AspSer: 2.716 ± 0.046	2.644AspThr: 2.644 ± 0.05	3.554AspVal: 3.554 ± 0.059	0.688AspTrp: 0.688 ± 0.025	2.345AspTyr: 2.345 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	5.688GluAla: 5.688 ± 0.087	0.295GluCys: 0.295 ± 0.017	3.136GluAsp: 3.136 ± 0.06	4.947GluGlu: 4.947 ± 0.081	2.337GluPhe: 2.337 ± 0.047	4.008GluGly: 4.008 ± 0.067	1.391GluHis: 1.391 ± 0.037	3.782GluIle: 3.782 ± 0.072	4.341GluLys: 4.341 ± 0.069	6.851GluLeu: 6.851 ± 0.084	1.553GluMet: 1.553 ± 0.035	3.153GluAsn: 3.153 ± 0.044	2.171GluPro: 2.171 ± 0.043	3.621GluGln: 3.621 ± 0.065	3.223GluArg: 3.223 ± 0.052	3.073GluSer: 3.073 ± 0.047	3.1GluThr: 3.1 ± 0.055	4.898GluVal: 4.898 ± 0.064	0.649GluTrp: 0.649 ± 0.028	2.095GluTyr: 2.095 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.432PheAla: 3.432 ± 0.061	0.378PheCys: 0.378 ± 0.017	2.564PheAsp: 2.564 ± 0.047	2.799PheGlu: 2.799 ± 0.046	2.155PhePhe: 2.155 ± 0.052	3.377PheGly: 3.377 ± 0.052	0.737PheHis: 0.737 ± 0.027	2.858PheIle: 2.858 ± 0.059	2.501PheLys: 2.501 ± 0.05	4.11PheLeu: 4.11 ± 0.074	1.141PheMet: 1.141 ± 0.03	2.273PheAsn: 2.273 ± 0.045	1.571PhePro: 1.571 ± 0.039	1.352PheGln: 1.352 ± 0.033	1.995PheArg: 1.995 ± 0.038	3.302PheSer: 3.302 ± 0.052	2.866PheThr: 2.866 ± 0.059	2.963PheVal: 2.963 ± 0.047	0.608PheTrp: 0.608 ± 0.03	1.915PheTyr: 1.915 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	5.226GlyAla: 5.226 ± 0.076	0.613GlyCys: 0.613 ± 0.027	3.167GlyAsp: 3.167 ± 0.059	3.944GlyGlu: 3.944 ± 0.06	3.402GlyPhe: 3.402 ± 0.058	4.995GlyGly: 4.995 ± 0.088	1.343GlyHis: 1.343 ± 0.034	4.776GlyIle: 4.776 ± 0.076	4.767GlyLys: 4.767 ± 0.075	6.527GlyLeu: 6.527 ± 0.083	1.813GlyMet: 1.813 ± 0.042	3.401GlyAsn: 3.401 ± 0.064	1.839GlyPro: 1.839 ± 0.046	2.701GlyGln: 2.701 ± 0.052	2.863GlyArg: 2.863 ± 0.042	4.425GlySer: 4.425 ± 0.07	4.316GlyThr: 4.316 ± 0.081	4.717GlyVal: 4.717 ± 0.066	0.828GlyTrp: 0.828 ± 0.034	3.042GlyTyr: 3.042 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.422HisAla: 1.422 ± 0.034	0.171HisCys: 0.171 ± 0.01	0.969HisAsp: 0.969 ± 0.031	1.205HisGlu: 1.205 ± 0.035	1.064HisPhe: 1.064 ± 0.028	1.317HisGly: 1.317 ± 0.035	0.573HisHis: 0.573 ± 0.029	1.32HisIle: 1.32 ± 0.034	1.069HisLys: 1.069 ± 0.03	2.084HisLeu: 2.084 ± 0.049	0.493HisMet: 0.493 ± 0.021	0.932HisAsn: 0.932 ± 0.031	1.067HisPro: 1.067 ± 0.032	0.885HisGln: 0.885 ± 0.029	0.91HisArg: 0.91 ± 0.026	1.096HisSer: 1.096 ± 0.034	1.357HisThr: 1.357 ± 0.04	1.211HisVal: 1.211 ± 0.032	0.245HisTrp: 0.245 ± 0.016	0.874HisTyr: 0.874 ± 0.028	0.001HisXaa: 0.001 ± 0.001
Ile	5.065IleAla: 5.065 ± 0.076	0.546IleCys: 0.546 ± 0.024	3.28IleAsp: 3.28 ± 0.056	3.683IleGlu: 3.683 ± 0.067	2.445IlePhe: 2.445 ± 0.06	4.455IleGly: 4.455 ± 0.063	1.082IleHis: 1.082 ± 0.03	3.784IleIle: 3.784 ± 0.067	3.652IleLys: 3.652 ± 0.057	6.163IleLeu: 6.163 ± 0.087	1.208IleMet: 1.208 ± 0.031	3.242IleAsn: 3.242 ± 0.048	2.649IlePro: 2.649 ± 0.049	2.082IleGln: 2.082 ± 0.051	2.803IleArg: 2.803 ± 0.05	4.404IleSer: 4.404 ± 0.065	3.983IleThr: 3.983 ± 0.077	3.804IleVal: 3.804 ± 0.066	0.56IleTrp: 0.56 ± 0.023	2.125IleTyr: 2.125 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	5.144LysAla: 5.144 ± 0.079	0.245LysCys: 0.245 ± 0.014	3.115LysAsp: 3.115 ± 0.06	4.219LysGlu: 4.219 ± 0.081	1.958LysPhe: 1.958 ± 0.042	3.89LysGly: 3.89 ± 0.059	1.246LysHis: 1.246 ± 0.033	3.454LysIle: 3.454 ± 0.055	4.005LysLys: 4.005 ± 0.068	6.132LysLeu: 6.132 ± 0.074	1.49LysMet: 1.49 ± 0.037	2.826LysAsn: 2.826 ± 0.05	2.703LysPro: 2.703 ± 0.05	2.802LysGln: 2.802 ± 0.053	2.799LysArg: 2.799 ± 0.053	3.365LysSer: 3.365 ± 0.055	3.148LysThr: 3.148 ± 0.049	4.347LysVal: 4.347 ± 0.058	0.57LysTrp: 0.57 ± 0.022	2.888LysTyr: 2.888 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	8.293LeuAla: 8.293 ± 0.11	0.796LeuCys: 0.796 ± 0.027	5.0LeuAsp: 5.0 ± 0.067	6.188LeuGlu: 6.188 ± 0.085	4.336LeuPhe: 4.336 ± 0.071	6.462LeuGly: 6.462 ± 0.089	2.199LeuHis: 2.199 ± 0.048	5.571LeuIle: 5.571 ± 0.094	6.127LeuLys: 6.127 ± 0.081	11.179LeuLeu: 11.179 ± 0.156	2.397LeuMet: 2.397 ± 0.043	4.841LeuAsn: 4.841 ± 0.068	4.7LeuPro: 4.7 ± 0.067	5.217LeuGln: 5.217 ± 0.09	4.818LeuArg: 4.818 ± 0.067	6.578LeuSer: 6.578 ± 0.075	5.665LeuThr: 5.665 ± 0.076	6.582LeuVal: 6.582 ± 0.091	0.975LeuTrp: 0.975 ± 0.029	3.63LeuTyr: 3.63 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	2.328MetAla: 2.328 ± 0.05	0.117MetCys: 0.117 ± 0.009	1.192MetAsp: 1.192 ± 0.033	1.466MetGlu: 1.466 ± 0.03	0.845MetPhe: 0.845 ± 0.031	1.547MetGly: 1.547 ± 0.038	0.597MetHis: 0.597 ± 0.022	1.301MetIle: 1.301 ± 0.031	1.687MetLys: 1.687 ± 0.035	2.628MetLeu: 2.628 ± 0.048	0.565MetMet: 0.565 ± 0.022	1.071MetAsn: 1.071 ± 0.027	1.167MetPro: 1.167 ± 0.033	1.299MetGln: 1.299 ± 0.028	1.236MetArg: 1.236 ± 0.031	1.329MetSer: 1.329 ± 0.036	1.056MetThr: 1.056 ± 0.034	1.636MetVal: 1.636 ± 0.038	0.197MetTrp: 0.197 ± 0.013	0.725MetTyr: 0.725 ± 0.024	0.001MetXaa: 0.001 ± 0.001
Asn	3.54AsnAla: 3.54 ± 0.057	0.318AsnCys: 0.318 ± 0.016	2.216AsnAsp: 2.216 ± 0.049	2.718AsnGlu: 2.718 ± 0.057	2.166AsnPhe: 2.166 ± 0.047	3.532AsnGly: 3.532 ± 0.068	0.892AsnHis: 0.892 ± 0.028	3.112AsnIle: 3.112 ± 0.054	2.76AsnLys: 2.76 ± 0.053	4.853AsnLeu: 4.853 ± 0.069	1.14AsnMet: 1.14 ± 0.031	2.509AsnAsn: 2.509 ± 0.067	2.577AsnPro: 2.577 ± 0.043	1.87AsnGln: 1.87 ± 0.044	2.269AsnArg: 2.269 ± 0.046	2.917AsnSer: 2.917 ± 0.063	2.867AsnThr: 2.867 ± 0.062	2.951AsnVal: 2.951 ± 0.055	0.64AsnTrp: 0.64 ± 0.023	2.196AsnTyr: 2.196 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	3.707ProAla: 3.707 ± 0.075	0.211ProCys: 0.211 ± 0.015	2.729ProAsp: 2.729 ± 0.046	3.565ProGlu: 3.565 ± 0.052	1.795ProPhe: 1.795 ± 0.042	2.653ProGly: 2.653 ± 0.049	0.811ProHis: 0.811 ± 0.027	2.231ProIle: 2.231 ± 0.043	2.155ProLys: 2.155 ± 0.043	3.681ProLeu: 3.681 ± 0.052	0.856ProMet: 0.856 ± 0.027	1.95ProAsn: 1.95 ± 0.042	1.126ProPro: 1.126 ± 0.038	1.752ProGln: 1.752 ± 0.039	1.377ProArg: 1.377 ± 0.036	2.273ProSer: 2.273 ± 0.046	2.223ProThr: 2.223 ± 0.054	3.148ProVal: 3.148 ± 0.057	0.41ProTrp: 0.41 ± 0.019	1.688ProTyr: 1.688 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.736GlnAla: 3.736 ± 0.062	0.194GlnCys: 0.194 ± 0.011	2.184GlnAsp: 2.184 ± 0.04	3.304GlnGlu: 3.304 ± 0.066	1.524GlnPhe: 1.524 ± 0.031	2.516GlnGly: 2.516 ± 0.049	1.19GlnHis: 1.19 ± 0.038	2.181GlnIle: 2.181 ± 0.046	2.639GlnLys: 2.639 ± 0.057	4.791GlnLeu: 4.791 ± 0.077	0.982GlnMet: 0.982 ± 0.032	2.137GlnAsn: 2.137 ± 0.047	1.931GlnPro: 1.931 ± 0.043	3.106GlnGln: 3.106 ± 0.074	2.153GlnArg: 2.153 ± 0.052	2.157GlnSer: 2.157 ± 0.054	2.206GlnThr: 2.206 ± 0.042	3.269GlnVal: 3.269 ± 0.053	0.442GlnTrp: 0.442 ± 0.022	1.356GlnTyr: 1.356 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.047ArgAla: 3.047 ± 0.052	0.246ArgCys: 0.246 ± 0.014	2.18ArgAsp: 2.18 ± 0.048	3.118ArgGlu: 3.118 ± 0.049	2.307ArgPhe: 2.307 ± 0.041	2.557ArgGly: 2.557 ± 0.05	1.062ArgHis: 1.062 ± 0.03	2.972ArgIle: 2.972 ± 0.054	2.835ArgLys: 2.835 ± 0.057	4.605ArgLeu: 4.605 ± 0.068	1.282ArgMet: 1.282 ± 0.032	2.314ArgAsn: 2.314 ± 0.042	1.571ArgPro: 1.571 ± 0.041	2.173ArgGln: 2.173 ± 0.049	2.085ArgArg: 2.085 ± 0.046	2.417ArgSer: 2.417 ± 0.054	2.313ArgThr: 2.313 ± 0.04	3.009ArgVal: 3.009 ± 0.052	0.549ArgTrp: 0.549 ± 0.023	1.925ArgTyr: 1.925 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	4.623SerAla: 4.623 ± 0.07	0.569SerCys: 0.569 ± 0.024	3.113SerAsp: 3.113 ± 0.058	3.645SerGlu: 3.645 ± 0.058	3.134SerPhe: 3.134 ± 0.051	4.846SerGly: 4.846 ± 0.074	1.122SerHis: 1.122 ± 0.035	4.202SerIle: 4.202 ± 0.073	3.471SerLys: 3.471 ± 0.053	5.817SerLeu: 5.817 ± 0.067	1.573SerMet: 1.573 ± 0.038	2.884SerAsn: 2.884 ± 0.057	2.372SerPro: 2.372 ± 0.049	2.175SerGln: 2.175 ± 0.041	2.516SerArg: 2.516 ± 0.051	4.003SerSer: 4.003 ± 0.084	3.44SerThr: 3.44 ± 0.073	4.012SerVal: 4.012 ± 0.067	0.688SerTrp: 0.688 ± 0.023	2.675SerTyr: 2.675 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	4.875ThrAla: 4.875 ± 0.083	0.386ThrCys: 0.386 ± 0.018	3.195ThrAsp: 3.195 ± 0.054	3.348ThrGlu: 3.348 ± 0.054	2.786ThrPhe: 2.786 ± 0.045	4.436ThrGly: 4.436 ± 0.079	1.092ThrHis: 1.092 ± 0.03	3.68ThrIle: 3.68 ± 0.07	2.728ThrLys: 2.728 ± 0.052	5.865ThrLeu: 5.865 ± 0.072	1.086ThrMet: 1.086 ± 0.029	2.444ThrAsn: 2.444 ± 0.051	2.808ThrPro: 2.808 ± 0.057	2.107ThrGln: 2.107 ± 0.043	2.132ThrArg: 2.132 ± 0.045	3.609ThrSer: 3.609 ± 0.071	3.416ThrThr: 3.416 ± 0.077	4.113ThrVal: 4.113 ± 0.087	0.691ThrTrp: 0.691 ± 0.032	2.47ThrTyr: 2.47 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	5.679ValAla: 5.679 ± 0.069	0.576ValCys: 0.576 ± 0.022	3.365ValAsp: 3.365 ± 0.053	4.182ValGlu: 4.182 ± 0.064	3.092ValPhe: 3.092 ± 0.046	4.371ValGly: 4.371 ± 0.07	1.292ValHis: 1.292 ± 0.037	4.115ValIle: 4.115 ± 0.068	3.983ValLys: 3.983 ± 0.052	7.016ValLeu: 7.016 ± 0.086	1.693ValMet: 1.693 ± 0.041	3.108ValAsn: 3.108 ± 0.051	2.879ValPro: 2.879 ± 0.056	2.903ValGln: 2.903 ± 0.051	2.99ValArg: 2.99 ± 0.056	4.495ValSer: 4.495 ± 0.072	3.841ValThr: 3.841 ± 0.084	4.998ValVal: 4.998 ± 0.069	0.768ValTrp: 0.768 ± 0.025	2.78ValTyr: 2.78 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.817TrpAla: 0.817 ± 0.029	0.086TrpCys: 0.086 ± 0.007	0.56TrpAsp: 0.56 ± 0.023	0.672TrpGlu: 0.672 ± 0.027	0.512TrpPhe: 0.512 ± 0.027	0.704TrpGly: 0.704 ± 0.026	0.281TrpHis: 0.281 ± 0.015	0.536TrpIle: 0.536 ± 0.025	0.589TrpLys: 0.589 ± 0.023	1.279TrpLeu: 1.279 ± 0.041	0.313TrpMet: 0.313 ± 0.017	0.517TrpAsn: 0.517 ± 0.021	0.354TrpPro: 0.354 ± 0.019	0.685TrpGln: 0.685 ± 0.027	0.574TrpArg: 0.574 ± 0.022	0.64TrpSer: 0.64 ± 0.027	0.529TrpThr: 0.529 ± 0.025	0.799TrpVal: 0.799 ± 0.025	0.164TrpTrp: 0.164 ± 0.014	0.427TrpTyr: 0.427 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.895TyrAla: 2.895 ± 0.051	0.29TyrCys: 0.29 ± 0.017	2.225TyrAsp: 2.225 ± 0.058	2.239TyrGlu: 2.239 ± 0.052	2.182TyrPhe: 2.182 ± 0.048	2.758TyrGly: 2.758 ± 0.061	0.838TyrHis: 0.838 ± 0.027	2.142TyrIle: 2.142 ± 0.048	2.534TyrLys: 2.534 ± 0.053	4.083TyrLeu: 4.083 ± 0.063	0.841TyrMet: 0.841 ± 0.026	2.208TyrAsn: 2.208 ± 0.045	1.547TyrPro: 1.547 ± 0.035	1.593TyrGln: 1.593 ± 0.033	2.017TyrArg: 2.017 ± 0.05	2.52TyrSer: 2.52 ± 0.048	2.991TyrThr: 2.991 ± 0.066	2.258TyrVal: 2.258 ± 0.049	0.446TyrTrp: 0.446 ± 0.02	1.782TyrTyr: 1.782 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3576 proteins (1225943 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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