Amino acid dipepetide frequency for Endozoicomonas montiporae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.547AlaAla: 7.547 ± 0.1	1.077AlaCys: 1.077 ± 0.035	4.807AlaAsp: 4.807 ± 0.093	5.495AlaGlu: 5.495 ± 0.077	3.405AlaPhe: 3.405 ± 0.058	6.861AlaGly: 6.861 ± 0.117	1.553AlaHis: 1.553 ± 0.037	5.213AlaIle: 5.213 ± 0.081	3.697AlaLys: 3.697 ± 0.06	9.072AlaLeu: 9.072 ± 0.098	2.647AlaMet: 2.647 ± 0.054	2.879AlaAsn: 2.879 ± 0.057	2.798AlaPro: 2.798 ± 0.047	2.9AlaGln: 2.9 ± 0.047	4.653AlaArg: 4.653 ± 0.079	5.506AlaSer: 5.506 ± 0.073	4.257AlaThr: 4.257 ± 0.062	5.878AlaVal: 5.878 ± 0.083	0.864AlaTrp: 0.864 ± 0.026	2.204AlaTyr: 2.204 ± 0.045	0.002AlaXaa: 0.002 ± 0.001
Cys	0.77CysAla: 0.77 ± 0.025	0.191CysCys: 0.191 ± 0.013	0.655CysAsp: 0.655 ± 0.025	0.645CysGlu: 0.645 ± 0.024	0.457CysPhe: 0.457 ± 0.019	0.885CysGly: 0.885 ± 0.028	0.381CysHis: 0.381 ± 0.02	0.586CysIle: 0.586 ± 0.023	0.536CysLys: 0.536 ± 0.022	1.153CysLeu: 1.153 ± 0.037	0.274CysMet: 0.274 ± 0.014	0.422CysAsn: 0.422 ± 0.02	0.565CysPro: 0.565 ± 0.024	0.576CysGln: 0.576 ± 0.022	0.66CysArg: 0.66 ± 0.023	0.847CysSer: 0.847 ± 0.031	0.513CysThr: 0.513 ± 0.022	0.618CysVal: 0.618 ± 0.023	0.15CysTrp: 0.15 ± 0.01	0.359CysTyr: 0.359 ± 0.019	0.001CysXaa: 0.001 ± 0.001
Asp	4.379AspAla: 4.379 ± 0.069	0.661AspCys: 0.661 ± 0.025	3.662AspAsp: 3.662 ± 0.101	3.92AspGlu: 3.92 ± 0.061	2.427AspPhe: 2.427 ± 0.042	4.14AspGly: 4.14 ± 0.137	1.375AspHis: 1.375 ± 0.037	3.968AspIle: 3.968 ± 0.059	2.96AspLys: 2.96 ± 0.048	5.342AspLeu: 5.342 ± 0.08	1.43AspMet: 1.43 ± 0.035	2.53AspAsn: 2.53 ± 0.049	2.31AspPro: 2.31 ± 0.05	2.557AspGln: 2.557 ± 0.049	3.082AspArg: 3.082 ± 0.056	3.724AspSer: 3.724 ± 0.072	3.103AspThr: 3.103 ± 0.24	3.626AspVal: 3.626 ± 0.062	0.882AspTrp: 0.882 ± 0.027	2.178AspTyr: 2.178 ± 0.05	0.001AspXaa: 0.001 ± 0.001
Glu	5.9GluAla: 5.9 ± 0.076	0.605GluCys: 0.605 ± 0.023	3.189GluAsp: 3.189 ± 0.061	4.121GluGlu: 4.121 ± 0.075	2.213GluPhe: 2.213 ± 0.038	4.153GluGly: 4.153 ± 0.074	1.625GluHis: 1.625 ± 0.039	3.323GluIle: 3.323 ± 0.052	3.779GluLys: 3.779 ± 0.068	7.201GluLeu: 7.201 ± 0.11	1.674GluMet: 1.674 ± 0.039	2.666GluAsn: 2.666 ± 0.058	2.425GluPro: 2.425 ± 0.044	4.062GluGln: 4.062 ± 0.078	3.642GluArg: 3.642 ± 0.054	3.985GluSer: 3.985 ± 0.061	3.341GluThr: 3.341 ± 0.057	4.245GluVal: 4.245 ± 0.07	0.79GluTrp: 0.79 ± 0.027	1.809GluTyr: 1.809 ± 0.044	0.001GluXaa: 0.001 ± 0.001
Phe	3.071PheAla: 3.071 ± 0.062	0.54PheCys: 0.54 ± 0.021	2.566PheAsp: 2.566 ± 0.045	2.334PheGlu: 2.334 ± 0.047	1.569PhePhe: 1.569 ± 0.043	2.902PheGly: 2.902 ± 0.062	0.829PheHis: 0.829 ± 0.029	2.36PheIle: 2.36 ± 0.046	1.821PheLys: 1.821 ± 0.041	3.449PheLeu: 3.449 ± 0.062	1.082PheMet: 1.082 ± 0.033	1.823PheAsn: 1.823 ± 0.036	1.527PhePro: 1.527 ± 0.04	1.366PheGln: 1.366 ± 0.035	1.994PheArg: 1.994 ± 0.041	3.161PheSer: 3.161 ± 0.059	2.23PheThr: 2.23 ± 0.048	2.477PheVal: 2.477 ± 0.046	0.502PheTrp: 0.502 ± 0.022	1.31PheTyr: 1.31 ± 0.03	0.002PheXaa: 0.002 ± 0.001
Gly	5.321GlyAla: 5.321 ± 0.129	0.961GlyCys: 0.961 ± 0.028	3.972GlyAsp: 3.972 ± 0.171	4.323GlyGlu: 4.323 ± 0.066	3.138GlyPhe: 3.138 ± 0.056	5.269GlyGly: 5.269 ± 0.25	1.642GlyHis: 1.642 ± 0.041	4.67GlyIle: 4.67 ± 0.066	4.141GlyLys: 4.141 ± 0.071	7.118GlyLeu: 7.118 ± 0.095	2.208GlyMet: 2.208 ± 0.047	2.836GlyAsn: 2.836 ± 0.122	1.575GlyPro: 1.575 ± 0.039	3.09GlyGln: 3.09 ± 0.056	3.727GlyArg: 3.727 ± 0.049	4.825GlySer: 4.825 ± 0.13	3.731GlyThr: 3.731 ± 0.08	5.082GlyVal: 5.082 ± 0.068	1.085GlyTrp: 1.085 ± 0.031	2.548GlyTyr: 2.548 ± 0.047	0.002GlyXaa: 0.002 ± 0.001
His	1.561HisAla: 1.561 ± 0.036	0.379HisCys: 0.379 ± 0.02	1.232HisAsp: 1.232 ± 0.033	1.267HisGlu: 1.267 ± 0.035	1.069HisPhe: 1.069 ± 0.033	1.51HisGly: 1.51 ± 0.036	0.729HisHis: 0.729 ± 0.031	1.259HisIle: 1.259 ± 0.031	1.086HisLys: 1.086 ± 0.031	2.397HisLeu: 2.397 ± 0.047	0.56HisMet: 0.56 ± 0.022	0.906HisAsn: 0.906 ± 0.027	1.275HisPro: 1.275 ± 0.037	1.204HisGln: 1.204 ± 0.035	1.3HisArg: 1.3 ± 0.026	1.549HisSer: 1.549 ± 0.037	1.117HisThr: 1.117 ± 0.031	1.184HisVal: 1.184 ± 0.033	0.376HisTrp: 0.376 ± 0.019	0.931HisTyr: 0.931 ± 0.028	0.001HisXaa: 0.001 ± 0.001
Ile	5.253IleAla: 5.253 ± 0.079	0.65IleCys: 0.65 ± 0.023	3.772IleAsp: 3.772 ± 0.059	4.006IleGlu: 4.006 ± 0.066	1.813IlePhe: 1.813 ± 0.045	3.932IleGly: 3.932 ± 0.071	1.287IleHis: 1.287 ± 0.033	3.199IleIle: 3.199 ± 0.057	3.092IleLys: 3.092 ± 0.06	4.876IleLeu: 4.876 ± 0.064	1.289IleMet: 1.289 ± 0.035	2.85IleAsn: 2.85 ± 0.047	2.749IlePro: 2.749 ± 0.052	2.231IleGln: 2.231 ± 0.041	3.333IleArg: 3.333 ± 0.06	3.95IleSer: 3.95 ± 0.061	3.48IleThr: 3.48 ± 0.06	3.55IleVal: 3.55 ± 0.06	0.553IleTrp: 0.553 ± 0.024	1.46IleTyr: 1.46 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	5.04LysAla: 5.04 ± 0.082	0.343LysCys: 0.343 ± 0.019	2.88LysAsp: 2.88 ± 0.055	3.461LysGlu: 3.461 ± 0.076	1.277LysPhe: 1.277 ± 0.032	3.588LysGly: 3.588 ± 0.058	1.242LysHis: 1.242 ± 0.036	2.539LysIle: 2.539 ± 0.044	3.319LysLys: 3.319 ± 0.074	4.961LysLeu: 4.961 ± 0.078	1.251LysMet: 1.251 ± 0.029	2.09LysAsn: 2.09 ± 0.046	2.649LysPro: 2.649 ± 0.052	2.682LysGln: 2.682 ± 0.05	2.852LysArg: 2.852 ± 0.046	3.073LysSer: 3.073 ± 0.059	3.09LysThr: 3.09 ± 0.057	3.601LysVal: 3.601 ± 0.057	0.471LysTrp: 0.471 ± 0.02	1.17LysTyr: 1.17 ± 0.033	0.003LysXaa: 0.003 ± 0.002
Leu	8.887LeuAla: 8.887 ± 0.094	1.164LeuCys: 1.164 ± 0.033	5.98LeuAsp: 5.98 ± 0.079	6.598LeuGlu: 6.598 ± 0.103	4.049LeuPhe: 4.049 ± 0.079	6.693LeuGly: 6.693 ± 0.087	2.036LeuHis: 2.036 ± 0.048	5.593LeuIle: 5.593 ± 0.073	6.041LeuLys: 6.041 ± 0.083	10.536LeuLeu: 10.536 ± 0.14	2.88LeuMet: 2.88 ± 0.057	4.455LeuAsn: 4.455 ± 0.065	5.112LeuPro: 5.112 ± 0.081	4.222LeuGln: 4.222 ± 0.069	4.875LeuArg: 4.875 ± 0.078	7.745LeuSer: 7.745 ± 0.077	5.933LeuThr: 5.933 ± 0.085	6.571LeuVal: 6.571 ± 0.091	1.054LeuTrp: 1.054 ± 0.028	2.594LeuTyr: 2.594 ± 0.046	0.004LeuXaa: 0.004 ± 0.002
Met	2.672MetAla: 2.672 ± 0.049	0.196MetCys: 0.196 ± 0.013	1.515MetAsp: 1.515 ± 0.034	1.509MetGlu: 1.509 ± 0.035	0.838MetPhe: 0.838 ± 0.029	1.912MetGly: 1.912 ± 0.044	0.513MetHis: 0.513 ± 0.021	1.508MetIle: 1.508 ± 0.039	1.47MetLys: 1.47 ± 0.037	2.748MetLeu: 2.748 ± 0.058	0.821MetMet: 0.821 ± 0.031	1.186MetAsn: 1.186 ± 0.029	1.386MetPro: 1.386 ± 0.034	1.049MetGln: 1.049 ± 0.031	1.165MetArg: 1.165 ± 0.03	2.0MetSer: 2.0 ± 0.048	1.796MetThr: 1.796 ± 0.044	1.894MetVal: 1.894 ± 0.043	0.166MetTrp: 0.166 ± 0.011	0.474MetTyr: 0.474 ± 0.02	0.002MetXaa: 0.002 ± 0.001
Asn	3.145AsnAla: 3.145 ± 0.055	0.401AsnCys: 0.401 ± 0.017	2.492AsnAsp: 2.492 ± 0.119	2.401AsnGlu: 2.401 ± 0.044	1.335AsnPhe: 1.335 ± 0.033	2.848AsnGly: 2.848 ± 0.067	1.04AsnHis: 1.04 ± 0.035	2.425AsnIle: 2.425 ± 0.058	2.025AsnLys: 2.025 ± 0.045	3.899AsnLeu: 3.899 ± 0.056	0.889AsnMet: 0.889 ± 0.026	1.81AsnAsn: 1.81 ± 0.046	2.345AsnPro: 2.345 ± 0.052	1.871AsnGln: 1.871 ± 0.044	2.418AsnArg: 2.418 ± 0.049	2.514AsnSer: 2.514 ± 0.051	2.251AsnThr: 2.251 ± 0.042	2.34AsnVal: 2.34 ± 0.051	0.603AsnTrp: 0.603 ± 0.021	1.168AsnTyr: 1.168 ± 0.032	0.002AsnXaa: 0.002 ± 0.001
Pro	3.809ProAla: 3.809 ± 0.062	0.384ProCys: 0.384 ± 0.018	3.338ProAsp: 3.338 ± 0.066	4.248ProGlu: 4.248 ± 0.07	1.683ProPhe: 1.683 ± 0.036	3.056ProGly: 3.056 ± 0.06	0.86ProHis: 0.86 ± 0.03	1.836ProIle: 1.836 ± 0.041	1.821ProLys: 1.821 ± 0.048	4.103ProLeu: 4.103 ± 0.061	1.092ProMet: 1.092 ± 0.03	1.357ProAsn: 1.357 ± 0.034	1.511ProPro: 1.511 ± 0.05	1.405ProGln: 1.405 ± 0.037	1.581ProArg: 1.581 ± 0.036	2.502ProSer: 2.502 ± 0.049	1.827ProThr: 1.827 ± 0.041	4.137ProVal: 4.137 ± 0.06	0.515ProTrp: 0.515 ± 0.022	1.207ProTyr: 1.207 ± 0.035	0.002ProXaa: 0.002 ± 0.001
Gln	4.034GlnAla: 4.034 ± 0.062	0.425GlnCys: 0.425 ± 0.017	1.944GlnAsp: 1.944 ± 0.042	2.661GlnGlu: 2.661 ± 0.058	1.626GlnPhe: 1.626 ± 0.037	2.855GlnGly: 2.855 ± 0.05	1.087GlnHis: 1.087 ± 0.031	2.132GlnIle: 2.132 ± 0.045	2.4GlnLys: 2.4 ± 0.057	5.046GlnLeu: 5.046 ± 0.091	1.133GlnMet: 1.133 ± 0.032	1.527GlnAsn: 1.527 ± 0.039	2.103GlnPro: 2.103 ± 0.048	2.848GlnGln: 2.848 ± 0.075	2.415GlnArg: 2.415 ± 0.049	2.954GlnSer: 2.954 ± 0.054	2.241GlnThr: 2.241 ± 0.049	2.9GlnVal: 2.9 ± 0.051	0.725GlnTrp: 0.725 ± 0.026	1.216GlnTyr: 1.216 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.632ArgAla: 3.632 ± 0.056	0.554ArgCys: 0.554 ± 0.025	2.692ArgAsp: 2.692 ± 0.052	3.548ArgGlu: 3.548 ± 0.066	2.619ArgPhe: 2.619 ± 0.05	2.844ArgGly: 2.844 ± 0.051	1.456ArgHis: 1.456 ± 0.034	3.284ArgIle: 3.284 ± 0.051	3.093ArgLys: 3.093 ± 0.055	5.975ArgLeu: 5.975 ± 0.087	1.552ArgMet: 1.552 ± 0.031	2.066ArgAsn: 2.066 ± 0.045	2.026ArgPro: 2.026 ± 0.045	2.958ArgGln: 2.958 ± 0.06	3.035ArgArg: 3.035 ± 0.058	3.322ArgSer: 3.322 ± 0.049	2.555ArgThr: 2.555 ± 0.046	3.415ArgVal: 3.415 ± 0.06	0.729ArgTrp: 0.729 ± 0.025	1.91ArgTyr: 1.91 ± 0.045	0.001ArgXaa: 0.001 ± 0.001
Ser	5.304SerAla: 5.304 ± 0.089	0.732SerCys: 0.732 ± 0.028	4.166SerAsp: 4.166 ± 0.08	4.367SerGlu: 4.367 ± 0.077	2.684SerPhe: 2.684 ± 0.048	5.904SerGly: 5.904 ± 0.114	1.626SerHis: 1.626 ± 0.034	3.796SerIle: 3.796 ± 0.064	2.975SerLys: 2.975 ± 0.054	7.207SerLeu: 7.207 ± 0.088	1.809SerMet: 1.809 ± 0.041	2.556SerAsn: 2.556 ± 0.057	2.682SerPro: 2.682 ± 0.055	2.745SerGln: 2.745 ± 0.05	3.622SerArg: 3.622 ± 0.049	4.883SerSer: 4.883 ± 0.087	3.233SerThr: 3.233 ± 0.066	4.701SerVal: 4.701 ± 0.075	0.869SerTrp: 0.869 ± 0.025	1.957SerTyr: 1.957 ± 0.042	0.002SerXaa: 0.002 ± 0.001
Thr	4.514ThrAla: 4.514 ± 0.073	0.542ThrCys: 0.542 ± 0.023	3.145ThrAsp: 3.145 ± 0.081	3.295ThrGlu: 3.295 ± 0.058	2.075ThrPhe: 2.075 ± 0.043	4.804ThrGly: 4.804 ± 0.105	1.135ThrHis: 1.135 ± 0.031	3.214ThrIle: 3.214 ± 0.055	1.884ThrLys: 1.884 ± 0.045	6.337ThrLeu: 6.337 ± 0.155	1.243ThrMet: 1.243 ± 0.035	1.762ThrAsn: 1.762 ± 0.044	2.787ThrPro: 2.787 ± 0.053	1.796ThrGln: 1.796 ± 0.041	2.811ThrArg: 2.811 ± 0.054	3.383ThrSer: 3.383 ± 0.06	2.913ThrThr: 2.913 ± 0.054	4.04ThrVal: 4.04 ± 0.071	0.531ThrTrp: 0.531 ± 0.023	1.385ThrTyr: 1.385 ± 0.035	0.001ThrXaa: 0.001 ± 0.001
Val	5.713ValAla: 5.713 ± 0.088	0.834ValCys: 0.834 ± 0.028	4.01ValAsp: 4.01 ± 0.068	4.289ValGlu: 4.289 ± 0.066	2.767ValPhe: 2.767 ± 0.052	4.221ValGly: 4.221 ± 0.072	1.372ValHis: 1.372 ± 0.035	4.315ValIle: 4.315 ± 0.067	3.413ValLys: 3.413 ± 0.066	6.655ValLeu: 6.655 ± 0.082	1.987ValMet: 1.987 ± 0.044	2.894ValAsn: 2.894 ± 0.059	2.674ValPro: 2.674 ± 0.041	2.386ValGln: 2.386 ± 0.049	3.514ValArg: 3.514 ± 0.06	4.979ValSer: 4.979 ± 0.069	4.013ValThr: 4.013 ± 0.068	5.157ValVal: 5.157 ± 0.072	0.783ValTrp: 0.783 ± 0.028	1.859ValTyr: 1.859 ± 0.037	0.002ValXaa: 0.002 ± 0.001
Trp	0.74TrpAla: 0.74 ± 0.027	0.151TrpCys: 0.151 ± 0.013	0.55TrpAsp: 0.55 ± 0.022	0.649TrpGlu: 0.649 ± 0.022	0.564TrpPhe: 0.564 ± 0.022	0.761TrpGly: 0.761 ± 0.027	0.361TrpHis: 0.361 ± 0.019	0.62TrpIle: 0.62 ± 0.026	0.641TrpLys: 0.641 ± 0.025	1.808TrpLeu: 1.808 ± 0.048	0.358TrpMet: 0.358 ± 0.02	0.501TrpAsn: 0.501 ± 0.022	0.462TrpPro: 0.462 ± 0.019	0.789TrpGln: 0.789 ± 0.03	0.632TrpArg: 0.632 ± 0.022	0.836TrpSer: 0.836 ± 0.029	0.53TrpThr: 0.53 ± 0.02	0.763TrpVal: 0.763 ± 0.025	0.156TrpTrp: 0.156 ± 0.013	0.35TrpTyr: 0.35 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.021TyrAla: 2.021 ± 0.04	0.455TyrCys: 0.455 ± 0.018	1.691TyrAsp: 1.691 ± 0.039	1.611TyrGlu: 1.611 ± 0.034	1.304TyrPhe: 1.304 ± 0.038	2.126TyrGly: 2.126 ± 0.044	0.744TyrHis: 0.744 ± 0.026	1.486TyrIle: 1.486 ± 0.032	1.389TyrLys: 1.389 ± 0.039	3.135TyrLeu: 3.135 ± 0.059	0.637TyrMet: 0.637 ± 0.023	1.101TyrAsn: 1.101 ± 0.034	1.31TyrPro: 1.31 ± 0.038	1.532TyrGln: 1.532 ± 0.029	1.951TyrArg: 1.951 ± 0.039	2.086TyrSer: 2.086 ± 0.051	1.442TyrThr: 1.442 ± 0.036	1.654TyrVal: 1.654 ± 0.039	0.414TyrTrp: 0.414 ± 0.019	0.985TyrTyr: 0.985 ± 0.031	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.002XaaGlu: 0.002 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.002XaaLys: 0.002 ± 0.001	0.005XaaLeu: 0.005 ± 0.002	0.002XaaMet: 0.002 ± 0.001	0.003XaaAsn: 0.003 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.002XaaGln: 0.002 ± 0.001	0.002XaaArg: 0.002 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3948 proteins (1238042 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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