Amino acid dipepetide frequency for Alkalihalobacillus krulwichiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.456AlaAla: 5.456 ± 0.078	0.675AlaCys: 0.675 ± 0.024	3.157AlaAsp: 3.157 ± 0.052	4.758AlaGlu: 4.758 ± 0.069	3.296AlaPhe: 3.296 ± 0.054	5.031AlaGly: 5.031 ± 0.066	1.313AlaHis: 1.313 ± 0.034	6.105AlaIle: 6.105 ± 0.076	4.494AlaLys: 4.494 ± 0.068	7.302AlaLeu: 7.302 ± 0.076	2.01AlaMet: 2.01 ± 0.042	2.911AlaAsn: 2.911 ± 0.048	1.981AlaPro: 1.981 ± 0.049	2.271AlaGln: 2.271 ± 0.051	2.699AlaArg: 2.699 ± 0.044	4.032AlaSer: 4.032 ± 0.064	3.863AlaThr: 3.863 ± 0.056	5.122AlaVal: 5.122 ± 0.073	0.584AlaTrp: 0.584 ± 0.023	2.221AlaTyr: 2.221 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.429CysAla: 0.429 ± 0.019	0.107CysCys: 0.107 ± 0.009	0.43CysAsp: 0.43 ± 0.018	0.488CysGlu: 0.488 ± 0.021	0.312CysPhe: 0.312 ± 0.016	0.682CysGly: 0.682 ± 0.025	0.201CysHis: 0.201 ± 0.013	0.503CysIle: 0.503 ± 0.018	0.402CysLys: 0.402 ± 0.02	0.688CysLeu: 0.688 ± 0.023	0.185CysMet: 0.185 ± 0.011	0.298CysAsn: 0.298 ± 0.015	0.345CysPro: 0.345 ± 0.017	0.271CysGln: 0.271 ± 0.015	0.311CysArg: 0.311 ± 0.018	0.505CysSer: 0.505 ± 0.022	0.403CysThr: 0.403 ± 0.016	0.419CysVal: 0.419 ± 0.019	0.074CysTrp: 0.074 ± 0.008	0.258CysTyr: 0.258 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.017AspAla: 3.017 ± 0.052	0.363AspCys: 0.363 ± 0.017	2.375AspAsp: 2.375 ± 0.046	4.454AspGlu: 4.454 ± 0.067	2.33AspPhe: 2.33 ± 0.041	3.177AspGly: 3.177 ± 0.053	1.259AspHis: 1.259 ± 0.03	3.782AspIle: 3.782 ± 0.048	2.712AspLys: 2.712 ± 0.046	5.326AspLeu: 5.326 ± 0.069	1.236AspMet: 1.236 ± 0.029	1.653AspAsn: 1.653 ± 0.04	1.964AspPro: 1.964 ± 0.05	2.321AspGln: 2.321 ± 0.045	2.359AspArg: 2.359 ± 0.041	2.54AspSer: 2.54 ± 0.055	2.233AspThr: 2.233 ± 0.043	3.993AspVal: 3.993 ± 0.066	0.593AspTrp: 0.593 ± 0.022	1.994AspTyr: 1.994 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.678GluAla: 5.678 ± 0.08	0.411GluCys: 0.411 ± 0.02	3.859GluAsp: 3.859 ± 0.057	7.845GluGlu: 7.845 ± 0.106	2.588GluPhe: 2.588 ± 0.043	4.595GluGly: 4.595 ± 0.07	1.673GluHis: 1.673 ± 0.045	5.544GluIle: 5.544 ± 0.075	6.212GluLys: 6.212 ± 0.073	7.815GluLeu: 7.815 ± 0.085	2.364GluMet: 2.364 ± 0.041	3.45GluAsn: 3.45 ± 0.052	2.118GluPro: 2.118 ± 0.044	3.972GluGln: 3.972 ± 0.066	4.1GluArg: 4.1 ± 0.062	3.59GluSer: 3.59 ± 0.053	4.015GluThr: 4.015 ± 0.065	5.757GluVal: 5.757 ± 0.066	0.794GluTrp: 0.794 ± 0.027	2.169GluTyr: 2.169 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.033PheAla: 3.033 ± 0.055	0.337PheCys: 0.337 ± 0.015	2.351PheAsp: 2.351 ± 0.047	2.929PheGlu: 2.929 ± 0.045	2.326PhePhe: 2.326 ± 0.061	3.362PheGly: 3.362 ± 0.062	0.961PheHis: 0.961 ± 0.029	3.876PheIle: 3.876 ± 0.072	2.259PheLys: 2.259 ± 0.049	4.683PheLeu: 4.683 ± 0.077	1.118PheMet: 1.118 ± 0.03	1.855PheAsn: 1.855 ± 0.04	1.625PhePro: 1.625 ± 0.04	1.687PheGln: 1.687 ± 0.038	1.576PheArg: 1.576 ± 0.035	3.19PheSer: 3.19 ± 0.053	2.547PheThr: 2.547 ± 0.047	3.255PheVal: 3.255 ± 0.05	0.486PheTrp: 0.486 ± 0.022	1.606PheTyr: 1.606 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.94GlyAla: 4.94 ± 0.076	0.606GlyCys: 0.606 ± 0.023	3.091GlyAsp: 3.091 ± 0.054	4.635GlyGlu: 4.635 ± 0.063	3.454GlyPhe: 3.454 ± 0.057	4.692GlyGly: 4.692 ± 0.08	1.428GlyHis: 1.428 ± 0.036	5.678GlyIle: 5.678 ± 0.08	4.424GlyLys: 4.424 ± 0.058	6.712GlyLeu: 6.712 ± 0.082	2.096GlyMet: 2.096 ± 0.043	2.489GlyAsn: 2.489 ± 0.046	1.813GlyPro: 1.813 ± 0.042	2.358GlyGln: 2.358 ± 0.043	2.706GlyArg: 2.706 ± 0.055	3.793GlySer: 3.793 ± 0.068	3.87GlyThr: 3.87 ± 0.054	5.292GlyVal: 5.292 ± 0.072	0.779GlyTrp: 0.779 ± 0.026	2.663GlyTyr: 2.663 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.277HisAla: 1.277 ± 0.034	0.219HisCys: 0.219 ± 0.012	1.05HisAsp: 1.05 ± 0.03	1.467HisGlu: 1.467 ± 0.036	1.134HisPhe: 1.134 ± 0.031	1.287HisGly: 1.287 ± 0.036	0.67HisHis: 0.67 ± 0.028	1.505HisIle: 1.505 ± 0.032	0.985HisLys: 0.985 ± 0.032	2.347HisLeu: 2.347 ± 0.044	0.508HisMet: 0.508 ± 0.02	0.783HisAsn: 0.783 ± 0.026	1.082HisPro: 1.082 ± 0.029	0.897HisGln: 0.897 ± 0.031	0.89HisArg: 0.89 ± 0.029	1.29HisSer: 1.29 ± 0.038	1.062HisThr: 1.062 ± 0.029	1.563HisVal: 1.563 ± 0.035	0.234HisTrp: 0.234 ± 0.015	0.872HisTyr: 0.872 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.974IleAla: 5.974 ± 0.076	0.636IleCys: 0.636 ± 0.023	4.485IleAsp: 4.485 ± 0.066	6.303IleGlu: 6.303 ± 0.081	3.076IlePhe: 3.076 ± 0.06	6.104IleGly: 6.104 ± 0.082	1.674IleHis: 1.674 ± 0.037	5.821IleIle: 5.821 ± 0.086	4.373IleLys: 4.373 ± 0.063	6.752IleLeu: 6.752 ± 0.09	1.848IleMet: 1.848 ± 0.039	3.281IleAsn: 3.281 ± 0.052	3.274IlePro: 3.274 ± 0.054	2.939IleGln: 2.939 ± 0.045	3.248IleArg: 3.248 ± 0.055	4.879IleSer: 4.879 ± 0.068	4.326IleThr: 4.326 ± 0.06	5.8IleVal: 5.8 ± 0.078	0.69IleTrp: 0.69 ± 0.024	2.369IleTyr: 2.369 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.433LysAla: 4.433 ± 0.062	0.33LysCys: 0.33 ± 0.018	3.316LysAsp: 3.316 ± 0.058	6.725LysGlu: 6.725 ± 0.074	1.701LysPhe: 1.701 ± 0.04	4.388LysGly: 4.388 ± 0.06	1.38LysHis: 1.38 ± 0.033	4.158LysIle: 4.158 ± 0.069	5.677LysLys: 5.677 ± 0.083	5.596LysLeu: 5.596 ± 0.069	2.038LysMet: 2.038 ± 0.045	2.652LysAsn: 2.652 ± 0.055	2.073LysPro: 2.073 ± 0.046	3.316LysGln: 3.316 ± 0.051	3.611LysArg: 3.611 ± 0.054	3.277LysSer: 3.277 ± 0.054	3.175LysThr: 3.175 ± 0.064	4.762LysVal: 4.762 ± 0.062	0.8LysTrp: 0.8 ± 0.027	1.835LysTyr: 1.835 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	7.493LeuAla: 7.493 ± 0.099	0.703LeuCys: 0.703 ± 0.024	4.863LeuAsp: 4.863 ± 0.059	7.213LeuGlu: 7.213 ± 0.086	5.048LeuPhe: 5.048 ± 0.083	6.425LeuGly: 6.425 ± 0.074	2.015LeuHis: 2.015 ± 0.041	7.437LeuIle: 7.437 ± 0.102	6.389LeuLys: 6.389 ± 0.077	10.758LeuLeu: 10.758 ± 0.143	2.564LeuMet: 2.564 ± 0.05	4.195LeuAsn: 4.195 ± 0.062	3.85LeuPro: 3.85 ± 0.062	3.608LeuGln: 3.608 ± 0.061	3.88LeuArg: 3.88 ± 0.067	6.753LeuSer: 6.753 ± 0.079	5.87LeuThr: 5.87 ± 0.063	6.82LeuVal: 6.82 ± 0.081	0.809LeuTrp: 0.809 ± 0.031	3.039LeuTyr: 3.039 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	1.925MetAla: 1.925 ± 0.042	0.128MetCys: 0.128 ± 0.011	1.347MetAsp: 1.347 ± 0.033	1.852MetGlu: 1.852 ± 0.043	1.12MetPhe: 1.12 ± 0.031	1.688MetGly: 1.688 ± 0.037	0.406MetHis: 0.406 ± 0.018	2.283MetIle: 2.283 ± 0.046	2.448MetLys: 2.448 ± 0.042	2.561MetLeu: 2.561 ± 0.043	0.858MetMet: 0.858 ± 0.029	1.618MetAsn: 1.618 ± 0.034	0.952MetPro: 0.952 ± 0.034	0.921MetGln: 0.921 ± 0.027	1.106MetArg: 1.106 ± 0.03	1.787MetSer: 1.787 ± 0.04	1.709MetThr: 1.709 ± 0.037	1.807MetVal: 1.807 ± 0.042	0.199MetTrp: 0.199 ± 0.012	0.787MetTyr: 0.787 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.482AsnAla: 2.482 ± 0.045	0.318AsnCys: 0.318 ± 0.014	2.181AsnAsp: 2.181 ± 0.044	3.848AsnGlu: 3.848 ± 0.064	1.47AsnPhe: 1.47 ± 0.035	3.099AsnGly: 3.099 ± 0.06	1.079AsnHis: 1.079 ± 0.032	3.129AsnIle: 3.129 ± 0.049	2.756AsnLys: 2.756 ± 0.047	3.62AsnLeu: 3.62 ± 0.056	1.155AsnMet: 1.155 ± 0.029	1.913AsnAsn: 1.913 ± 0.046	1.994AsnPro: 1.994 ± 0.041	2.189AsnGln: 2.189 ± 0.049	2.04AsnArg: 2.04 ± 0.042	2.169AsnSer: 2.169 ± 0.04	1.994AsnThr: 1.994 ± 0.046	3.199AsnVal: 3.199 ± 0.05	0.536AsnTrp: 0.536 ± 0.024	1.489AsnTyr: 1.489 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	2.178ProAla: 2.178 ± 0.047	0.227ProCys: 0.227 ± 0.014	1.825ProAsp: 1.825 ± 0.037	2.806ProGlu: 2.806 ± 0.053	1.964ProPhe: 1.964 ± 0.049	2.217ProGly: 2.217 ± 0.046	0.753ProHis: 0.753 ± 0.022	3.003ProIle: 3.003 ± 0.053	2.065ProLys: 2.065 ± 0.043	3.57ProLeu: 3.57 ± 0.056	0.826ProMet: 0.826 ± 0.029	1.752ProAsn: 1.752 ± 0.042	1.002ProPro: 1.002 ± 0.035	1.095ProGln: 1.095 ± 0.03	1.175ProArg: 1.175 ± 0.034	2.212ProSer: 2.212 ± 0.047	2.185ProThr: 2.185 ± 0.042	2.79ProVal: 2.79 ± 0.044	0.383ProTrp: 0.383 ± 0.018	1.386ProTyr: 1.386 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.957GlnAla: 2.957 ± 0.059	0.219GlnCys: 0.219 ± 0.014	1.587GlnAsp: 1.587 ± 0.034	3.095GlnGlu: 3.095 ± 0.06	1.753GlnPhe: 1.753 ± 0.037	2.23GlnGly: 2.23 ± 0.041	0.789GlnHis: 0.789 ± 0.025	2.795GlnIle: 2.795 ± 0.048	2.604GlnLys: 2.604 ± 0.042	4.554GlnLeu: 4.554 ± 0.076	1.208GlnMet: 1.208 ± 0.033	1.585GlnAsn: 1.585 ± 0.037	1.331GlnPro: 1.331 ± 0.04	2.009GlnGln: 2.009 ± 0.063	1.694GlnArg: 1.694 ± 0.039	2.368GlnSer: 2.368 ± 0.047	2.227GlnThr: 2.227 ± 0.045	2.819GlnVal: 2.819 ± 0.051	0.426GlnTrp: 0.426 ± 0.017	1.297GlnTyr: 1.297 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.621ArgAla: 2.621 ± 0.053	0.267ArgCys: 0.267 ± 0.015	2.196ArgAsp: 2.196 ± 0.045	3.489ArgGlu: 3.489 ± 0.051	2.029ArgPhe: 2.029 ± 0.037	2.533ArgGly: 2.533 ± 0.045	0.822ArgHis: 0.822 ± 0.031	3.165ArgIle: 3.165 ± 0.056	3.258ArgLys: 3.258 ± 0.057	4.175ArgLeu: 4.175 ± 0.06	1.329ArgMet: 1.329 ± 0.031	2.064ArgAsn: 2.064 ± 0.044	1.41ArgPro: 1.41 ± 0.035	1.679ArgGln: 1.679 ± 0.04	2.004ArgArg: 2.004 ± 0.043	2.468ArgSer: 2.468 ± 0.048	2.207ArgThr: 2.207 ± 0.044	2.865ArgVal: 2.865 ± 0.049	0.462ArgTrp: 0.462 ± 0.019	1.588ArgTyr: 1.588 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	3.567SerAla: 3.567 ± 0.068	0.414SerCys: 0.414 ± 0.019	2.773SerAsp: 2.773 ± 0.054	4.071SerGlu: 4.071 ± 0.06	3.289SerPhe: 3.289 ± 0.053	4.112SerGly: 4.112 ± 0.067	1.22SerHis: 1.22 ± 0.029	5.17SerIle: 5.17 ± 0.067	3.638SerLys: 3.638 ± 0.054	6.269SerLeu: 6.269 ± 0.081	1.751SerMet: 1.751 ± 0.032	2.634SerAsn: 2.634 ± 0.046	2.039SerPro: 2.039 ± 0.044	2.024SerGln: 2.024 ± 0.038	2.361SerArg: 2.361 ± 0.046	3.964SerSer: 3.964 ± 0.063	3.203SerThr: 3.203 ± 0.048	4.095SerVal: 4.095 ± 0.056	0.621SerTrp: 0.621 ± 0.023	2.208SerTyr: 2.208 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	3.78ThrAla: 3.78 ± 0.054	0.373ThrCys: 0.373 ± 0.018	2.734ThrAsp: 2.734 ± 0.05	3.75ThrGlu: 3.75 ± 0.066	2.749ThrPhe: 2.749 ± 0.052	3.972ThrGly: 3.972 ± 0.061	1.066ThrHis: 1.066 ± 0.03	4.725ThrIle: 4.725 ± 0.066	3.346ThrLys: 3.346 ± 0.059	5.432ThrLeu: 5.432 ± 0.071	1.369ThrMet: 1.369 ± 0.034	2.524ThrAsn: 2.524 ± 0.045	2.234ThrPro: 2.234 ± 0.043	1.46ThrGln: 1.46 ± 0.032	1.926ThrArg: 1.926 ± 0.04	3.28ThrSer: 3.28 ± 0.051	3.146ThrThr: 3.146 ± 0.056	4.351ThrVal: 4.351 ± 0.066	0.536ThrTrp: 0.536 ± 0.021	1.911ThrTyr: 1.911 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	5.407ValAla: 5.407 ± 0.072	0.591ValCys: 0.591 ± 0.023	3.78ValAsp: 3.78 ± 0.058	5.623ValGlu: 5.623 ± 0.077	3.2ValPhe: 3.2 ± 0.06	4.944ValGly: 4.944 ± 0.07	1.389ValHis: 1.389 ± 0.036	6.112ValIle: 6.112 ± 0.074	4.556ValLys: 4.556 ± 0.063	6.886ValLeu: 6.886 ± 0.077	1.899ValMet: 1.899 ± 0.042	3.154ValAsn: 3.154 ± 0.055	2.724ValPro: 2.724 ± 0.047	2.484ValGln: 2.484 ± 0.047	2.944ValArg: 2.944 ± 0.052	4.6ValSer: 4.6 ± 0.057	4.484ValThr: 4.484 ± 0.07	5.479ValVal: 5.479 ± 0.087	0.589ValTrp: 0.589 ± 0.021	2.273ValTyr: 2.273 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.62TrpAla: 0.62 ± 0.023	0.078TrpCys: 0.078 ± 0.008	0.473TrpAsp: 0.473 ± 0.023	0.658TrpGlu: 0.658 ± 0.025	0.498TrpPhe: 0.498 ± 0.021	0.658TrpGly: 0.658 ± 0.024	0.194TrpHis: 0.194 ± 0.014	0.754TrpIle: 0.754 ± 0.025	0.733TrpLys: 0.733 ± 0.025	1.252TrpLeu: 1.252 ± 0.035	0.324TrpMet: 0.324 ± 0.015	0.508TrpAsn: 0.508 ± 0.021	0.258TrpPro: 0.258 ± 0.015	0.39TrpGln: 0.39 ± 0.018	0.428TrpArg: 0.428 ± 0.02	0.635TrpSer: 0.635 ± 0.025	0.515TrpThr: 0.515 ± 0.022	0.669TrpVal: 0.669 ± 0.023	0.144TrpTrp: 0.144 ± 0.01	0.294TrpTyr: 0.294 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.01TyrAla: 2.01 ± 0.043	0.307TyrCys: 0.307 ± 0.017	1.809TyrAsp: 1.809 ± 0.035	2.543TyrGlu: 2.543 ± 0.047	1.724TyrPhe: 1.724 ± 0.041	2.325TyrGly: 2.325 ± 0.045	0.83TyrHis: 0.83 ± 0.028	2.304TyrIle: 2.304 ± 0.047	1.909TyrLys: 1.909 ± 0.039	3.435TyrLeu: 3.435 ± 0.052	0.816TyrMet: 0.816 ± 0.026	1.344TyrAsn: 1.344 ± 0.035	1.348TyrPro: 1.348 ± 0.032	1.657TyrGln: 1.657 ± 0.04	1.574TyrArg: 1.574 ± 0.04	2.091TyrSer: 2.091 ± 0.045	1.631TyrThr: 1.631 ± 0.037	2.26TyrVal: 2.26 ± 0.039	0.345TyrTrp: 0.345 ± 0.016	1.341TyrTyr: 1.341 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4515 proteins (1230270 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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