Amino acid dipepetide frequency for Besnoitia besnoiti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.777AlaAla: 21.777 ± 0.153	2.56AlaCys: 2.56 ± 0.027	5.635AlaAsp: 5.635 ± 0.031	9.184AlaGlu: 9.184 ± 0.071	3.876AlaPhe: 3.876 ± 0.032	10.591AlaGly: 10.591 ± 0.079	2.321AlaHis: 2.321 ± 0.021	2.134AlaIle: 2.134 ± 0.025	3.844AlaLys: 3.844 ± 0.058	10.241AlaLeu: 10.241 ± 0.065	1.365AlaMet: 1.365 ± 0.016	2.074AlaAsn: 2.074 ± 0.019	9.198AlaPro: 9.198 ± 0.073	4.218AlaGln: 4.218 ± 0.029	9.174AlaArg: 9.174 ± 0.077	15.529AlaSer: 15.529 ± 0.111	5.738AlaThr: 5.738 ± 0.029	6.76AlaVal: 6.76 ± 0.052	1.144AlaTrp: 1.144 ± 0.016	1.558AlaTyr: 1.558 ± 0.017	0.0AlaXaa: 0.0 ± 0.0
Cys	2.324CysAla: 2.324 ± 0.024	0.592CysCys: 0.592 ± 0.012	0.828CysAsp: 0.828 ± 0.016	1.127CysGlu: 1.127 ± 0.016	0.704CysPhe: 0.704 ± 0.011	1.744CysGly: 1.744 ± 0.021	0.356CysHis: 0.356 ± 0.009	0.546CysIle: 0.546 ± 0.01	0.552CysLys: 0.552 ± 0.012	1.919CysLeu: 1.919 ± 0.021	0.29CysMet: 0.29 ± 0.007	0.339CysAsn: 0.339 ± 0.008	1.262CysPro: 1.262 ± 0.032	0.568CysGln: 0.568 ± 0.01	1.574CysArg: 1.574 ± 0.02	1.902CysSer: 1.902 ± 0.023	0.854CysThr: 0.854 ± 0.015	1.366CysVal: 1.366 ± 0.018	0.213CysTrp: 0.213 ± 0.007	0.324CysTyr: 0.324 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	7.239AspAla: 7.239 ± 0.046	0.842AspCys: 0.842 ± 0.013	3.187AspAsp: 3.187 ± 0.038	4.535AspGlu: 4.535 ± 0.036	1.586AspPhe: 1.586 ± 0.017	4.425AspGly: 4.425 ± 0.038	0.617AspHis: 0.617 ± 0.012	1.326AspIle: 1.326 ± 0.018	1.537AspLys: 1.537 ± 0.021	3.724AspLeu: 3.724 ± 0.033	0.696AspMet: 0.696 ± 0.012	0.854AspAsn: 0.854 ± 0.014	2.372AspPro: 2.372 ± 0.02	1.162AspGln: 1.162 ± 0.016	3.223AspArg: 3.223 ± 0.025	4.155AspSer: 4.155 ± 0.029	2.0AspThr: 2.0 ± 0.022	2.909AspVal: 2.909 ± 0.02	0.504AspTrp: 0.504 ± 0.009	0.7AspTyr: 0.7 ± 0.012	0.0AspXaa: 0.0 ± 0.0
Glu	9.816GluAla: 9.816 ± 0.082	0.932GluCys: 0.932 ± 0.017	4.619GluAsp: 4.619 ± 0.038	8.465GluGlu: 8.465 ± 0.084	1.446GluPhe: 1.446 ± 0.019	6.691GluGly: 6.691 ± 0.053	1.074GluHis: 1.074 ± 0.016	1.733GluIle: 1.733 ± 0.022	3.945GluLys: 3.945 ± 0.045	4.757GluLeu: 4.757 ± 0.042	1.025GluMet: 1.025 ± 0.018	1.768GluAsn: 1.768 ± 0.022	3.126GluPro: 3.126 ± 0.033	2.57GluGln: 2.57 ± 0.022	6.449GluArg: 6.449 ± 0.052	4.885GluSer: 4.885 ± 0.035	4.079GluThr: 4.079 ± 0.031	3.31GluVal: 3.31 ± 0.029	0.579GluTrp: 0.579 ± 0.011	0.755GluTyr: 0.755 ± 0.012	0.0GluXaa: 0.0 ± 0.0
Phe	3.513PheAla: 3.513 ± 0.027	0.772PheCys: 0.772 ± 0.015	1.409PheAsp: 1.409 ± 0.019	1.636PheGlu: 1.636 ± 0.019	1.794PhePhe: 1.794 ± 0.022	2.07PheGly: 2.07 ± 0.03	0.738PheHis: 0.738 ± 0.012	0.885PheIle: 0.885 ± 0.016	0.815PheLys: 0.815 ± 0.015	3.738PheLeu: 3.738 ± 0.033	0.465PheMet: 0.465 ± 0.008	0.625PheAsn: 0.625 ± 0.013	2.164PhePro: 2.164 ± 0.02	0.992PheGln: 0.992 ± 0.014	1.934PheArg: 1.934 ± 0.018	3.758PheSer: 3.758 ± 0.026	1.282PheThr: 1.282 ± 0.018	2.123PheVal: 2.123 ± 0.026	0.389PheTrp: 0.389 ± 0.008	0.714PheTyr: 0.714 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	11.051GlyAla: 11.051 ± 0.084	1.451GlyCys: 1.451 ± 0.018	5.162GlyAsp: 5.162 ± 0.04	6.644GlyGlu: 6.644 ± 0.059	2.116GlyPhe: 2.116 ± 0.023	10.109GlyGly: 10.109 ± 0.091	1.368GlyHis: 1.368 ± 0.02	1.642GlyIle: 1.642 ± 0.022	2.85GlyLys: 2.85 ± 0.029	5.776GlyLeu: 5.776 ± 0.04	1.003GlyMet: 1.003 ± 0.017	1.653GlyAsn: 1.653 ± 0.018	3.648GlyPro: 3.648 ± 0.045	2.201GlyGln: 2.201 ± 0.021	6.763GlyArg: 6.763 ± 0.052	7.389GlySer: 7.389 ± 0.053	3.435GlyThr: 3.435 ± 0.028	4.664GlyVal: 4.664 ± 0.03	0.739GlyTrp: 0.739 ± 0.011	1.064GlyTyr: 1.064 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	2.943HisAla: 2.943 ± 0.024	0.373HisCys: 0.373 ± 0.008	0.873HisAsp: 0.873 ± 0.015	1.246HisGlu: 1.246 ± 0.016	0.771HisPhe: 0.771 ± 0.013	1.57HisGly: 1.57 ± 0.019	0.577HisHis: 0.577 ± 0.014	0.599HisIle: 0.599 ± 0.01	0.561HisLys: 0.561 ± 0.01	2.033HisLeu: 2.033 ± 0.019	0.338HisMet: 0.338 ± 0.007	0.364HisAsn: 0.364 ± 0.008	1.514HisPro: 1.514 ± 0.018	0.8HisGln: 0.8 ± 0.013	1.634HisArg: 1.634 ± 0.016	1.842HisSer: 1.842 ± 0.02	0.99HisThr: 0.99 ± 0.019	1.308HisVal: 1.308 ± 0.014	0.209HisTrp: 0.209 ± 0.005	0.347HisTyr: 0.347 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	2.114IleAla: 2.114 ± 0.021	0.571IleCys: 0.571 ± 0.011	1.209IleAsp: 1.209 ± 0.018	1.484IleGlu: 1.484 ± 0.02	1.01IlePhe: 1.01 ± 0.017	1.387IleGly: 1.387 ± 0.02	0.595IleHis: 0.595 ± 0.011	0.762IleIle: 0.762 ± 0.016	0.854IleLys: 0.854 ± 0.016	2.409IleLeu: 2.409 ± 0.026	0.362IleMet: 0.362 ± 0.01	0.579IleAsn: 0.579 ± 0.012	1.449IlePro: 1.449 ± 0.02	1.008IleGln: 1.008 ± 0.015	1.668IleArg: 1.668 ± 0.021	1.958IleSer: 1.958 ± 0.022	0.965IleThr: 0.965 ± 0.018	1.514IleVal: 1.514 ± 0.02	0.27IleTrp: 0.27 ± 0.008	0.525IleTyr: 0.525 ± 0.01	0.0IleXaa: 0.0 ± 0.0
Lys	3.992LysAla: 3.992 ± 0.105	0.561LysCys: 0.561 ± 0.011	1.763LysAsp: 1.763 ± 0.019	3.063LysGlu: 3.063 ± 0.035	0.829LysPhe: 0.829 ± 0.016	2.523LysGly: 2.523 ± 0.027	0.785LysHis: 0.785 ± 0.013	1.07LysIle: 1.07 ± 0.018	2.943LysLys: 2.943 ± 0.045	2.843LysLeu: 2.843 ± 0.037	0.609LysMet: 0.609 ± 0.013	1.05LysAsn: 1.05 ± 0.015	1.811LysPro: 1.811 ± 0.023	1.664LysGln: 1.664 ± 0.021	3.45LysArg: 3.45 ± 0.037	2.286LysSer: 2.286 ± 0.021	2.025LysThr: 2.025 ± 0.023	1.726LysVal: 1.726 ± 0.024	0.329LysTrp: 0.329 ± 0.008	0.579LysTyr: 0.579 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	9.63LeuAla: 9.63 ± 0.06	1.868LeuCys: 1.868 ± 0.021	3.568LeuAsp: 3.568 ± 0.027	5.296LeuGlu: 5.296 ± 0.046	3.393LeuPhe: 3.393 ± 0.035	5.229LeuGly: 5.229 ± 0.034	2.468LeuHis: 2.468 ± 0.021	2.019LeuIle: 2.019 ± 0.028	3.131LeuLys: 3.131 ± 0.035	10.754LeuLeu: 10.754 ± 0.093	1.224LeuMet: 1.224 ± 0.018	1.743LeuAsn: 1.743 ± 0.021	7.16LeuPro: 7.16 ± 0.044	4.523LeuGln: 4.523 ± 0.043	7.579LeuArg: 7.579 ± 0.047	9.145LeuSer: 9.145 ± 0.057	3.697LeuThr: 3.697 ± 0.028	4.847LeuVal: 4.847 ± 0.045	0.992LeuTrp: 0.992 ± 0.014	1.583LeuTyr: 1.583 ± 0.02	0.0LeuXaa: 0.0 ± 0.0
Met	1.306MetAla: 1.306 ± 0.017	0.232MetCys: 0.232 ± 0.007	0.589MetAsp: 0.589 ± 0.012	0.962MetGlu: 0.962 ± 0.015	0.373MetPhe: 0.373 ± 0.009	0.8MetGly: 0.8 ± 0.015	0.358MetHis: 0.358 ± 0.007	0.384MetIle: 0.384 ± 0.01	0.691MetLys: 0.691 ± 0.014	1.294MetLeu: 1.294 ± 0.017	0.301MetMet: 0.301 ± 0.009	0.386MetAsn: 0.386 ± 0.008	0.889MetPro: 0.889 ± 0.015	0.738MetGln: 0.738 ± 0.011	1.169MetArg: 1.169 ± 0.015	1.024MetSer: 1.024 ± 0.015	0.741MetThr: 0.741 ± 0.017	0.619MetVal: 0.619 ± 0.013	0.15MetTrp: 0.15 ± 0.005	0.283MetTyr: 0.283 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.503AsnAla: 2.503 ± 0.022	0.402AsnCys: 0.402 ± 0.007	0.951AsnAsp: 0.951 ± 0.014	1.418AsnGlu: 1.418 ± 0.019	0.723AsnPhe: 0.723 ± 0.013	1.655AsnGly: 1.655 ± 0.019	0.346AsnHis: 0.346 ± 0.008	0.644AsnIle: 0.644 ± 0.013	0.762AsnLys: 0.762 ± 0.013	1.738AsnLeu: 1.738 ± 0.024	0.341AsnMet: 0.341 ± 0.008	0.481AsnAsn: 0.481 ± 0.01	1.306AsnPro: 1.306 ± 0.019	0.66AsnGln: 0.66 ± 0.011	1.376AsnArg: 1.376 ± 0.016	1.64AsnSer: 1.64 ± 0.019	0.915AsnThr: 0.915 ± 0.013	1.3AsnVal: 1.3 ± 0.017	0.228AsnTrp: 0.228 ± 0.006	0.389AsnTyr: 0.389 ± 0.009	0.0AsnXaa: 0.0 ± 0.0
Pro	9.237ProAla: 9.237 ± 0.069	1.282ProCys: 1.282 ± 0.021	2.426ProAsp: 2.426 ± 0.022	3.85ProGlu: 3.85 ± 0.03	2.273ProPhe: 2.273 ± 0.02	4.749ProGly: 4.749 ± 0.051	1.602ProHis: 1.602 ± 0.018	1.041ProIle: 1.041 ± 0.016	1.611ProLys: 1.611 ± 0.037	6.348ProLeu: 6.348 ± 0.043	0.62ProMet: 0.62 ± 0.015	1.066ProAsn: 1.066 ± 0.018	7.804ProPro: 7.804 ± 0.087	2.727ProGln: 2.727 ± 0.022	5.368ProArg: 5.368 ± 0.049	9.164ProSer: 9.164 ± 0.081	2.938ProThr: 2.938 ± 0.027	3.715ProVal: 3.715 ± 0.027	0.637ProTrp: 0.637 ± 0.01	0.911ProTyr: 0.911 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	4.376GlnAla: 4.376 ± 0.031	0.526GlnCys: 0.526 ± 0.011	1.548GlnAsp: 1.548 ± 0.015	2.816GlnGlu: 2.816 ± 0.026	0.88GlnPhe: 0.88 ± 0.013	2.783GlnGly: 2.783 ± 0.024	0.969GlnHis: 0.969 ± 0.014	0.977GlnIle: 0.977 ± 0.015	1.782GlnLys: 1.782 ± 0.021	3.612GlnLeu: 3.612 ± 0.033	0.672GlnMet: 0.672 ± 0.012	0.89GlnAsn: 0.89 ± 0.015	2.351GlnPro: 2.351 ± 0.024	2.54GlnGln: 2.54 ± 0.038	3.781GlnArg: 3.781 ± 0.031	2.691GlnSer: 2.691 ± 0.023	2.114GlnThr: 2.114 ± 0.019	1.857GlnVal: 1.857 ± 0.017	0.373GlnTrp: 0.373 ± 0.008	0.495GlnTyr: 0.495 ± 0.011	0.0GlnXaa: 0.0 ± 0.0
Arg	8.927ArgAla: 8.927 ± 0.064	1.399ArgCys: 1.399 ± 0.017	4.157ArgAsp: 4.157 ± 0.033	6.83ArgGlu: 6.83 ± 0.055	2.12ArgPhe: 2.12 ± 0.022	7.636ArgGly: 7.636 ± 0.065	1.953ArgHis: 1.953 ± 0.02	1.756ArgIle: 1.756 ± 0.021	3.207ArgLys: 3.207 ± 0.032	7.455ArgLeu: 7.455 ± 0.052	1.144ArgMet: 1.144 ± 0.014	1.611ArgAsn: 1.611 ± 0.019	4.684ArgPro: 4.684 ± 0.04	3.744ArgGln: 3.744 ± 0.033	10.119ArgArg: 10.119 ± 0.095	6.533ArgSer: 6.533 ± 0.049	3.295ArgThr: 3.295 ± 0.024	4.171ArgVal: 4.171 ± 0.031	0.788ArgTrp: 0.788 ± 0.011	1.042ArgTyr: 1.042 ± 0.013	0.0ArgXaa: 0.0 ± 0.0
Ser	13.606SerAla: 13.606 ± 0.086	2.082SerCys: 2.082 ± 0.024	3.71SerAsp: 3.71 ± 0.026	5.125SerGlu: 5.125 ± 0.038	3.48SerPhe: 3.48 ± 0.032	7.477SerGly: 7.477 ± 0.056	1.981SerHis: 1.981 ± 0.02	1.806SerIle: 1.806 ± 0.021	2.257SerLys: 2.257 ± 0.025	9.581SerLeu: 9.581 ± 0.059	0.987SerMet: 0.987 ± 0.014	1.471SerAsn: 1.471 ± 0.017	9.935SerPro: 9.935 ± 0.094	3.209SerGln: 3.209 ± 0.025	7.735SerArg: 7.735 ± 0.062	15.784SerSer: 15.784 ± 0.156	4.155SerThr: 4.155 ± 0.031	5.179SerVal: 5.179 ± 0.036	0.937SerTrp: 0.937 ± 0.013	1.168SerTyr: 1.168 ± 0.017	0.0SerXaa: 0.0 ± 0.0
Thr	5.541ThrAla: 5.541 ± 0.035	0.968ThrCys: 0.968 ± 0.016	2.034ThrAsp: 2.034 ± 0.021	3.075ThrGlu: 3.075 ± 0.028	1.353ThrPhe: 1.353 ± 0.016	3.738ThrGly: 3.738 ± 0.033	1.035ThrHis: 1.035 ± 0.017	1.068ThrIle: 1.068 ± 0.016	1.542ThrLys: 1.542 ± 0.018	4.015ThrLeu: 4.015 ± 0.034	0.551ThrMet: 0.551 ± 0.01	0.946ThrAsn: 0.946 ± 0.015	3.702ThrPro: 3.702 ± 0.037	1.806ThrGln: 1.806 ± 0.017	3.547ThrArg: 3.547 ± 0.029	4.263ThrSer: 4.263 ± 0.026	2.297ThrThr: 2.297 ± 0.031	2.699ThrVal: 2.699 ± 0.027	0.474ThrTrp: 0.474 ± 0.01	0.738ThrTyr: 0.738 ± 0.015	0.0ThrXaa: 0.0 ± 0.0
Val	6.686ValAla: 6.686 ± 0.043	1.413ValCys: 1.413 ± 0.018	2.782ValAsp: 2.782 ± 0.028	3.795ValGlu: 3.795 ± 0.046	2.181ValPhe: 2.181 ± 0.021	3.672ValGly: 3.672 ± 0.029	1.223ValHis: 1.223 ± 0.015	1.401ValIle: 1.401 ± 0.02	1.995ValLys: 1.995 ± 0.025	5.095ValLeu: 5.095 ± 0.039	0.788ValMet: 0.788 ± 0.014	1.22ValAsn: 1.22 ± 0.015	3.668ValPro: 3.668 ± 0.032	1.971ValGln: 1.971 ± 0.019	3.704ValArg: 3.704 ± 0.026	5.656ValSer: 5.656 ± 0.035	2.525ValThr: 2.525 ± 0.025	3.552ValVal: 3.552 ± 0.035	0.657ValTrp: 0.657 ± 0.012	1.155ValTyr: 1.155 ± 0.016	0.0ValXaa: 0.0 ± 0.0
Trp	0.828TrpAla: 0.828 ± 0.013	0.198TrpCys: 0.198 ± 0.006	0.409TrpAsp: 0.409 ± 0.008	0.568TrpGlu: 0.568 ± 0.01	0.275TrpPhe: 0.275 ± 0.008	0.731TrpGly: 0.731 ± 0.011	0.204TrpHis: 0.204 ± 0.006	0.361TrpIle: 0.361 ± 0.008	0.495TrpLys: 0.495 ± 0.01	1.043TrpLeu: 1.043 ± 0.015	0.228TrpMet: 0.228 ± 0.005	0.28TrpAsn: 0.28 ± 0.007	0.474TrpPro: 0.474 ± 0.009	0.433TrpGln: 0.433 ± 0.009	1.186TrpArg: 1.186 ± 0.016	0.841TrpSer: 0.841 ± 0.012	0.579TrpThr: 0.579 ± 0.01	0.49TrpVal: 0.49 ± 0.009	0.187TrpTrp: 0.187 ± 0.006	0.172TrpTyr: 0.172 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.511TyrAla: 1.511 ± 0.02	0.361TyrCys: 0.361 ± 0.021	0.734TyrAsp: 0.734 ± 0.013	0.906TyrGlu: 0.906 ± 0.014	0.633TyrPhe: 0.633 ± 0.011	1.147TyrGly: 1.147 ± 0.02	0.321TyrHis: 0.321 ± 0.008	0.539TyrIle: 0.539 ± 0.011	0.525TyrLys: 0.525 ± 0.012	1.473TyrLeu: 1.473 ± 0.019	0.279TyrMet: 0.279 ± 0.008	0.379TyrAsn: 0.379 ± 0.01	0.851TyrPro: 0.851 ± 0.014	0.502TyrGln: 0.502 ± 0.01	1.139TyrArg: 1.139 ± 0.015	1.223TyrSer: 1.223 ± 0.017	0.769TyrThr: 0.769 ± 0.014	1.028TyrVal: 1.028 ± 0.016	0.182TyrTrp: 0.182 ± 0.006	0.48TyrTyr: 0.48 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8036 proteins (6780256 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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