Amino acid dipepetide frequency for Actinomyces bovis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.584AlaAla: 20.584 ± 0.295	1.242AlaCys: 1.242 ± 0.049	6.994AlaAsp: 6.994 ± 0.149	8.49AlaGlu: 8.49 ± 0.174	3.079AlaPhe: 3.079 ± 0.057	11.881AlaGly: 11.881 ± 0.167	2.312AlaHis: 2.312 ± 0.059	4.444AlaIle: 4.444 ± 0.087	3.992AlaLys: 3.992 ± 0.149	14.07AlaLeu: 14.07 ± 0.199	2.665AlaMet: 2.665 ± 0.054	2.663AlaAsn: 2.663 ± 0.068	7.249AlaPro: 7.249 ± 0.147	5.585AlaGln: 5.585 ± 0.109	8.497AlaArg: 8.497 ± 0.141	7.746AlaSer: 7.746 ± 0.133	8.066AlaThr: 8.066 ± 0.129	11.086AlaVal: 11.086 ± 0.137	1.94AlaTrp: 1.94 ± 0.059	2.404AlaTyr: 2.404 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.001CysAla: 1.001 ± 0.037	0.1CysCys: 0.1 ± 0.012	0.444CysAsp: 0.444 ± 0.023	0.453CysGlu: 0.453 ± 0.029	0.236CysPhe: 0.236 ± 0.02	0.926CysGly: 0.926 ± 0.035	0.178CysHis: 0.178 ± 0.016	0.215CysIle: 0.215 ± 0.016	0.179CysLys: 0.179 ± 0.016	0.92CysLeu: 0.92 ± 0.038	0.126CysMet: 0.126 ± 0.013	0.152CysAsn: 0.152 ± 0.014	0.512CysPro: 0.512 ± 0.029	0.328CysGln: 0.328 ± 0.019	0.489CysArg: 0.489 ± 0.026	0.503CysSer: 0.503 ± 0.027	0.561CysThr: 0.561 ± 0.031	0.625CysVal: 0.625 ± 0.03	0.138CysTrp: 0.138 ± 0.014	0.187CysTyr: 0.187 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	7.104AspAla: 7.104 ± 0.135	0.499AspCys: 0.499 ± 0.027	2.819AspAsp: 2.819 ± 0.064	3.311AspGlu: 3.311 ± 0.081	1.469AspPhe: 1.469 ± 0.043	5.092AspGly: 5.092 ± 0.095	1.083AspHis: 1.083 ± 0.041	1.736AspIle: 1.736 ± 0.055	1.3AspLys: 1.3 ± 0.048	5.9AspLeu: 5.9 ± 0.088	0.79AspMet: 0.79 ± 0.035	1.004AspAsn: 1.004 ± 0.038	3.806AspPro: 3.806 ± 0.075	1.807AspGln: 1.807 ± 0.052	3.085AspArg: 3.085 ± 0.065	2.931AspSer: 2.931 ± 0.068	2.641AspThr: 2.641 ± 0.067	4.522AspVal: 4.522 ± 0.101	0.861AspTrp: 0.861 ± 0.034	1.235AspTyr: 1.235 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	8.46GluAla: 8.46 ± 0.243	0.388GluCys: 0.388 ± 0.023	2.832GluAsp: 2.832 ± 0.073	3.517GluGlu: 3.517 ± 0.085	1.18GluPhe: 1.18 ± 0.039	4.225GluGly: 4.225 ± 0.08	1.478GluHis: 1.478 ± 0.048	2.335GluIle: 2.335 ± 0.063	1.433GluLys: 1.433 ± 0.055	6.963GluLeu: 6.963 ± 0.117	1.026GluMet: 1.026 ± 0.044	1.167GluAsn: 1.167 ± 0.042	3.177GluPro: 3.177 ± 0.081	2.804GluGln: 2.804 ± 0.069	4.754GluArg: 4.754 ± 0.099	2.747GluSer: 2.747 ± 0.068	2.758GluThr: 2.758 ± 0.071	5.327GluVal: 5.327 ± 0.111	0.622GluTrp: 0.622 ± 0.028	1.01GluTyr: 1.01 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	2.801PheAla: 2.801 ± 0.056	0.245PheCys: 0.245 ± 0.022	1.581PheAsp: 1.581 ± 0.047	1.328PheGlu: 1.328 ± 0.051	0.814PhePhe: 0.814 ± 0.039	2.376PheGly: 2.376 ± 0.061	0.498PheHis: 0.498 ± 0.027	1.04PheIle: 1.04 ± 0.039	0.779PheLys: 0.779 ± 0.034	2.543PheLeu: 2.543 ± 0.072	0.508PheMet: 0.508 ± 0.029	0.707PheAsn: 0.707 ± 0.035	1.23PhePro: 1.23 ± 0.042	0.734PheGln: 0.734 ± 0.03	1.347PheArg: 1.347 ± 0.047	1.763PheSer: 1.763 ± 0.05	1.953PheThr: 1.953 ± 0.053	1.922PheVal: 1.922 ± 0.05	0.377PheTrp: 0.377 ± 0.025	0.608PheTyr: 0.608 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	10.752GlyAla: 10.752 ± 0.138	0.749GlyCys: 0.749 ± 0.032	3.928GlyAsp: 3.928 ± 0.081	4.799GlyGlu: 4.799 ± 0.087	2.534GlyPhe: 2.534 ± 0.064	7.44GlyGly: 7.44 ± 0.125	1.834GlyHis: 1.834 ± 0.05	3.4GlyIle: 3.4 ± 0.07	2.963GlyLys: 2.963 ± 0.082	9.18GlyLeu: 9.18 ± 0.128	1.936GlyMet: 1.936 ± 0.052	1.886GlyAsn: 1.886 ± 0.051	3.977GlyPro: 3.977 ± 0.08	3.474GlyGln: 3.474 ± 0.073	5.982GlyArg: 5.982 ± 0.098	5.435GlySer: 5.435 ± 0.102	5.828GlyThr: 5.828 ± 0.101	7.343GlyVal: 7.343 ± 0.108	1.626GlyTrp: 1.626 ± 0.054	2.054GlyTyr: 2.054 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	2.294HisAla: 2.294 ± 0.06	0.2HisCys: 0.2 ± 0.015	1.093HisAsp: 1.093 ± 0.042	1.091HisGlu: 1.091 ± 0.04	0.468HisPhe: 0.468 ± 0.024	1.767HisGly: 1.767 ± 0.051	0.49HisHis: 0.49 ± 0.025	0.652HisIle: 0.652 ± 0.029	0.473HisLys: 0.473 ± 0.029	2.388HisLeu: 2.388 ± 0.066	0.385HisMet: 0.385 ± 0.022	0.453HisAsn: 0.453 ± 0.028	1.47HisPro: 1.47 ± 0.046	0.69HisGln: 0.69 ± 0.03	1.492HisArg: 1.492 ± 0.046	1.082HisSer: 1.082 ± 0.04	1.087HisThr: 1.087 ± 0.035	1.463HisVal: 1.463 ± 0.044	0.305HisTrp: 0.305 ± 0.02	0.444HisTyr: 0.444 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	4.8IleAla: 4.8 ± 0.088	0.396IleCys: 0.396 ± 0.024	2.527IleAsp: 2.527 ± 0.061	2.164IleGlu: 2.164 ± 0.065	0.963IlePhe: 0.963 ± 0.044	3.546IleGly: 3.546 ± 0.079	0.676IleHis: 0.676 ± 0.031	1.545IleIle: 1.545 ± 0.052	1.104IleLys: 1.104 ± 0.038	3.11IleLeu: 3.11 ± 0.07	0.686IleMet: 0.686 ± 0.031	0.979IleAsn: 0.979 ± 0.037	1.953IlePro: 1.953 ± 0.056	0.956IleGln: 0.956 ± 0.038	2.008IleArg: 2.008 ± 0.052	2.366IleSer: 2.366 ± 0.06	2.607IleThr: 2.607 ± 0.067	3.001IleVal: 3.001 ± 0.075	0.482IleTrp: 0.482 ± 0.027	0.709IleTyr: 0.709 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.722LysAla: 3.722 ± 0.114	0.147LysCys: 0.147 ± 0.015	1.659LysAsp: 1.659 ± 0.054	1.605LysGlu: 1.605 ± 0.058	0.494LysPhe: 0.494 ± 0.029	2.257LysGly: 2.257 ± 0.065	0.618LysHis: 0.618 ± 0.035	1.019LysIle: 1.019 ± 0.041	0.937LysLys: 0.937 ± 0.047	2.307LysLeu: 2.307 ± 0.064	0.474LysMet: 0.474 ± 0.028	0.675LysAsn: 0.675 ± 0.032	1.807LysPro: 1.807 ± 0.178	1.083LysGln: 1.083 ± 0.044	1.788LysArg: 1.788 ± 0.054	1.458LysSer: 1.458 ± 0.057	1.75LysThr: 1.75 ± 0.065	2.38LysVal: 2.38 ± 0.066	0.333LysTrp: 0.333 ± 0.023	0.51LysTyr: 0.51 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	15.27LeuAla: 15.27 ± 0.179	0.786LeuCys: 0.786 ± 0.032	6.109LeuAsp: 6.109 ± 0.109	5.886LeuGlu: 5.886 ± 0.102	2.24LeuPhe: 2.24 ± 0.06	9.549LeuGly: 9.549 ± 0.155	1.855LeuHis: 1.855 ± 0.047	3.487LeuIle: 3.487 ± 0.088	2.37LeuLys: 2.37 ± 0.061	11.459LeuLeu: 11.459 ± 0.188	1.824LeuMet: 1.824 ± 0.052	2.055LeuAsn: 2.055 ± 0.05	6.199LeuPro: 6.199 ± 0.112	2.746LeuGln: 2.746 ± 0.074	7.83LeuArg: 7.83 ± 0.129	6.41LeuSer: 6.41 ± 0.102	6.637LeuThr: 6.637 ± 0.098	9.436LeuVal: 9.436 ± 0.126	1.28LeuTrp: 1.28 ± 0.048	1.478LeuTyr: 1.478 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.272MetAla: 2.272 ± 0.055	0.117MetCys: 0.117 ± 0.012	0.912MetAsp: 0.912 ± 0.036	0.912MetGlu: 0.912 ± 0.035	0.445MetPhe: 0.445 ± 0.025	1.479MetGly: 1.479 ± 0.046	0.358MetHis: 0.358 ± 0.02	0.753MetIle: 0.753 ± 0.034	0.457MetLys: 0.457 ± 0.027	2.015MetLeu: 2.015 ± 0.058	0.321MetMet: 0.321 ± 0.024	0.499MetAsn: 0.499 ± 0.025	1.238MetPro: 1.238 ± 0.044	0.536MetGln: 0.536 ± 0.029	1.48MetArg: 1.48 ± 0.045	1.568MetSer: 1.568 ± 0.041	1.589MetThr: 1.589 ± 0.041	1.52MetVal: 1.52 ± 0.047	0.202MetTrp: 0.202 ± 0.017	0.262MetTyr: 0.262 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.534AsnAla: 2.534 ± 0.063	0.195AsnCys: 0.195 ± 0.017	1.133AsnAsp: 1.133 ± 0.043	1.065AsnGlu: 1.065 ± 0.044	0.537AsnPhe: 0.537 ± 0.029	2.04AsnGly: 2.04 ± 0.071	0.485AsnHis: 0.485 ± 0.025	0.855AsnIle: 0.855 ± 0.03	0.542AsnLys: 0.542 ± 0.03	2.362AsnLeu: 2.362 ± 0.059	0.405AsnMet: 0.405 ± 0.022	0.572AsnAsn: 0.572 ± 0.031	1.75AsnPro: 1.75 ± 0.049	0.908AsnGln: 0.908 ± 0.036	1.47AsnArg: 1.47 ± 0.05	1.217AsnSer: 1.217 ± 0.045	1.335AsnThr: 1.335 ± 0.048	1.463AsnVal: 1.463 ± 0.044	0.384AsnTrp: 0.384 ± 0.03	0.494AsnTyr: 0.494 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	8.332ProAla: 8.332 ± 0.145	0.317ProCys: 0.317 ± 0.018	3.109ProAsp: 3.109 ± 0.077	4.525ProGlu: 4.525 ± 0.145	1.339ProPhe: 1.339 ± 0.039	5.589ProGly: 5.589 ± 0.096	1.066ProHis: 1.066 ± 0.041	1.664ProIle: 1.664 ± 0.049	1.538ProLys: 1.538 ± 0.044	4.855ProLeu: 4.855 ± 0.081	0.994ProMet: 0.994 ± 0.036	1.255ProAsn: 1.255 ± 0.042	2.388ProPro: 2.388 ± 0.082	2.409ProGln: 2.409 ± 0.06	3.166ProArg: 3.166 ± 0.086	3.671ProSer: 3.671 ± 0.075	4.073ProThr: 4.073 ± 0.099	5.103ProVal: 5.103 ± 0.093	0.844ProTrp: 0.844 ± 0.034	1.07ProTyr: 1.07 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	5.928GlnAla: 5.928 ± 0.143	0.259GlnCys: 0.259 ± 0.022	1.9GlnAsp: 1.9 ± 0.049	2.163GlnGlu: 2.163 ± 0.057	0.66GlnPhe: 0.66 ± 0.03	2.806GlnGly: 2.806 ± 0.063	0.676GlnHis: 0.676 ± 0.032	1.473GlnIle: 1.473 ± 0.048	0.752GlnLys: 0.752 ± 0.032	3.641GlnLeu: 3.641 ± 0.082	0.679GlnMet: 0.679 ± 0.03	0.658GlnAsn: 0.658 ± 0.036	2.092GlnPro: 2.092 ± 0.063	1.499GlnGln: 1.499 ± 0.055	2.638GlnArg: 2.638 ± 0.072	1.6GlnSer: 1.6 ± 0.054	1.859GlnThr: 1.859 ± 0.052	3.891GlnVal: 3.891 ± 0.077	0.507GlnTrp: 0.507 ± 0.029	0.54GlnTyr: 0.54 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	8.299ArgAla: 8.299 ± 0.138	0.529ArgCys: 0.529 ± 0.026	3.197ArgAsp: 3.197 ± 0.081	4.074ArgGlu: 4.074 ± 0.094	1.894ArgPhe: 1.894 ± 0.054	4.682ArgGly: 4.682 ± 0.086	1.547ArgHis: 1.547 ± 0.053	2.598ArgIle: 2.598 ± 0.06	1.7ArgLys: 1.7 ± 0.051	7.652ArgLeu: 7.652 ± 0.138	1.564ArgMet: 1.564 ± 0.048	1.386ArgAsn: 1.386 ± 0.041	3.82ArgPro: 3.82 ± 0.09	2.582ArgGln: 2.582 ± 0.064	6.331ArgArg: 6.331 ± 0.131	4.419ArgSer: 4.419 ± 0.1	3.935ArgThr: 3.935 ± 0.076	5.281ArgVal: 5.281 ± 0.094	1.09ArgTrp: 1.09 ± 0.039	1.412ArgTyr: 1.412 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	7.89SerAla: 7.89 ± 0.144	0.532SerCys: 0.532 ± 0.027	2.535SerAsp: 2.535 ± 0.065	2.817SerGlu: 2.817 ± 0.066	1.78SerPhe: 1.78 ± 0.053	5.848SerGly: 5.848 ± 0.105	1.124SerHis: 1.124 ± 0.038	2.062SerIle: 2.062 ± 0.059	1.763SerLys: 1.763 ± 0.058	6.071SerLeu: 6.071 ± 0.098	1.197SerMet: 1.197 ± 0.037	1.415SerAsn: 1.415 ± 0.049	3.626SerPro: 3.626 ± 0.074	2.409SerGln: 2.409 ± 0.066	3.913SerArg: 3.913 ± 0.082	4.243SerSer: 4.243 ± 0.095	4.027SerThr: 4.027 ± 0.074	4.493SerVal: 4.493 ± 0.081	1.148SerTrp: 1.148 ± 0.039	1.293SerTyr: 1.293 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	8.376ThrAla: 8.376 ± 0.134	0.494ThrCys: 0.494 ± 0.025	3.231ThrAsp: 3.231 ± 0.065	3.05ThrGlu: 3.05 ± 0.062	1.647ThrPhe: 1.647 ± 0.054	6.105ThrGly: 6.105 ± 0.101	1.152ThrHis: 1.152 ± 0.037	2.635ThrIle: 2.635 ± 0.067	1.744ThrLys: 1.744 ± 0.061	5.872ThrLeu: 5.872 ± 0.096	1.066ThrMet: 1.066 ± 0.042	1.415ThrAsn: 1.415 ± 0.045	4.361ThrPro: 4.361 ± 0.085	2.002ThrGln: 2.002 ± 0.049	3.637ThrArg: 3.637 ± 0.084	3.806ThrSer: 3.806 ± 0.075	4.302ThrThr: 4.302 ± 0.103	5.517ThrVal: 5.517 ± 0.102	1.107ThrTrp: 1.107 ± 0.041	1.319ThrTyr: 1.319 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	10.719ValAla: 10.719 ± 0.139	0.74ValCys: 0.74 ± 0.032	4.998ValAsp: 4.998 ± 0.082	5.04ValGlu: 5.04 ± 0.093	2.338ValPhe: 2.338 ± 0.06	6.62ValGly: 6.62 ± 0.095	1.628ValHis: 1.628 ± 0.047	3.499ValIle: 3.499 ± 0.082	2.137ValLys: 2.137 ± 0.098	9.769ValLeu: 9.769 ± 0.153	1.652ValMet: 1.652 ± 0.051	1.871ValAsn: 1.871 ± 0.055	4.973ValPro: 4.973 ± 0.076	2.24ValGln: 2.24 ± 0.055	5.488ValArg: 5.488 ± 0.104	5.154ValSer: 5.154 ± 0.099	5.733ValThr: 5.733 ± 0.097	8.477ValVal: 8.477 ± 0.115	0.959ValTrp: 0.959 ± 0.036	1.475ValTyr: 1.475 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.67TrpAla: 1.67 ± 0.046	0.179TrpCys: 0.179 ± 0.015	0.846TrpAsp: 0.846 ± 0.036	0.748TrpGlu: 0.748 ± 0.031	0.453TrpPhe: 0.453 ± 0.025	1.107TrpGly: 1.107 ± 0.042	0.341TrpHis: 0.341 ± 0.021	0.54TrpIle: 0.54 ± 0.027	0.358TrpLys: 0.358 ± 0.023	1.656TrpLeu: 1.656 ± 0.053	0.321TrpMet: 0.321 ± 0.021	0.457TrpAsn: 0.457 ± 0.028	0.688TrpPro: 0.688 ± 0.038	0.66TrpGln: 0.66 ± 0.029	1.217TrpArg: 1.217 ± 0.045	0.938TrpSer: 0.938 ± 0.033	0.879TrpThr: 0.879 ± 0.037	1.145TrpVal: 1.145 ± 0.034	0.375TrpTrp: 0.375 ± 0.023	0.314TrpTyr: 0.314 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.181TyrAla: 2.181 ± 0.062	0.157TyrCys: 0.157 ± 0.015	1.149TyrAsp: 1.149 ± 0.041	1.165TyrGlu: 1.165 ± 0.042	0.586TyrPhe: 0.586 ± 0.029	1.784TyrGly: 1.784 ± 0.052	0.39TyrHis: 0.39 ± 0.022	0.629TyrIle: 0.629 ± 0.031	0.5TyrLys: 0.5 ± 0.027	2.175TyrLeu: 2.175 ± 0.061	0.313TyrMet: 0.313 ± 0.023	0.477TyrAsn: 0.477 ± 0.027	0.99TyrPro: 0.99 ± 0.043	0.768TyrGln: 0.768 ± 0.034	1.381TyrArg: 1.381 ± 0.049	1.131TyrSer: 1.131 ± 0.046	1.214TyrThr: 1.214 ± 0.042	1.514TyrVal: 1.514 ± 0.05	0.314TyrTrp: 0.314 ± 0.023	0.523TyrTyr: 0.523 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2148 proteins (763328 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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