Amino acid dipepetide frequency for Corticibacter populi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.339AlaAla: 18.339 ± 0.221	1.28AlaCys: 1.28 ± 0.035	6.412AlaAsp: 6.412 ± 0.075	6.855AlaGlu: 6.855 ± 0.096	3.881AlaPhe: 3.881 ± 0.054	11.066AlaGly: 11.066 ± 0.131	2.826AlaHis: 2.826 ± 0.059	5.618AlaIle: 5.618 ± 0.083	3.097AlaLys: 3.097 ± 0.069	15.447AlaLeu: 15.447 ± 0.174	3.387AlaMet: 3.387 ± 0.06	2.808AlaAsn: 2.808 ± 0.051	6.431AlaPro: 6.431 ± 0.101	6.641AlaGln: 6.641 ± 0.096	9.053AlaArg: 9.053 ± 0.101	7.396AlaSer: 7.396 ± 0.091	5.965AlaThr: 5.965 ± 0.077	8.522AlaVal: 8.522 ± 0.089	2.047AlaTrp: 2.047 ± 0.05	2.525AlaTyr: 2.525 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.042CysAla: 1.042 ± 0.035	0.124CysCys: 0.124 ± 0.009	0.438CysAsp: 0.438 ± 0.021	0.453CysGlu: 0.453 ± 0.021	0.297CysPhe: 0.297 ± 0.016	0.883CysGly: 0.883 ± 0.032	0.277CysHis: 0.277 ± 0.016	0.425CysIle: 0.425 ± 0.021	0.169CysLys: 0.169 ± 0.012	0.851CysLeu: 0.851 ± 0.027	0.236CysMet: 0.236 ± 0.014	0.212CysAsn: 0.212 ± 0.014	0.455CysPro: 0.455 ± 0.021	0.352CysGln: 0.352 ± 0.015	0.551CysArg: 0.551 ± 0.023	0.508CysSer: 0.508 ± 0.023	0.468CysThr: 0.468 ± 0.02	0.59CysVal: 0.59 ± 0.023	0.132CysTrp: 0.132 ± 0.01	0.171CysTyr: 0.171 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.435AspAla: 7.435 ± 0.099	0.416AspCys: 0.416 ± 0.021	2.767AspAsp: 2.767 ± 0.054	3.035AspGlu: 3.035 ± 0.055	1.977AspPhe: 1.977 ± 0.043	4.723AspGly: 4.723 ± 0.073	1.026AspHis: 1.026 ± 0.033	2.481AspIle: 2.481 ± 0.055	1.486AspLys: 1.486 ± 0.042	4.941AspLeu: 4.941 ± 0.066	1.222AspMet: 1.222 ± 0.033	1.153AspAsn: 1.153 ± 0.035	2.691AspPro: 2.691 ± 0.055	1.668AspGln: 1.668 ± 0.04	2.91AspArg: 2.91 ± 0.051	2.315AspSer: 2.315 ± 0.052	2.399AspThr: 2.399 ± 0.054	3.844AspVal: 3.844 ± 0.063	1.081AspTrp: 1.081 ± 0.031	1.475AspTyr: 1.475 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.776GluAla: 6.776 ± 0.097	0.35GluCys: 0.35 ± 0.016	2.391GluAsp: 2.391 ± 0.044	2.523GluGlu: 2.523 ± 0.059	1.586GluPhe: 1.586 ± 0.036	3.65GluGly: 3.65 ± 0.06	1.358GluHis: 1.358 ± 0.041	2.503GluIle: 2.503 ± 0.054	1.767GluLys: 1.767 ± 0.052	5.936GluLeu: 5.936 ± 0.068	1.122GluMet: 1.122 ± 0.031	1.32GluAsn: 1.32 ± 0.038	2.632GluPro: 2.632 ± 0.045	3.154GluGln: 3.154 ± 0.058	4.594GluArg: 4.594 ± 0.07	2.382GluSer: 2.382 ± 0.043	2.491GluThr: 2.491 ± 0.052	3.812GluVal: 3.812 ± 0.057	0.762GluTrp: 0.762 ± 0.026	1.099GluTyr: 1.099 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.987PheAla: 3.987 ± 0.068	0.354PheCys: 0.354 ± 0.017	2.34PheAsp: 2.34 ± 0.055	1.957PheGlu: 1.957 ± 0.039	1.375PhePhe: 1.375 ± 0.042	3.228PheGly: 3.228 ± 0.057	0.69PheHis: 0.69 ± 0.025	1.613PheIle: 1.613 ± 0.04	1.006PheLys: 1.006 ± 0.032	2.954PheLeu: 2.954 ± 0.048	0.772PheMet: 0.772 ± 0.027	1.085PheAsn: 1.085 ± 0.032	1.429PhePro: 1.429 ± 0.033	1.14PheGln: 1.14 ± 0.029	1.708PheArg: 1.708 ± 0.04	2.1PheSer: 2.1 ± 0.046	1.774PheThr: 1.774 ± 0.04	2.472PheVal: 2.472 ± 0.054	0.573PheTrp: 0.573 ± 0.023	0.846PheTyr: 0.846 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.025GlyAla: 9.025 ± 0.105	0.831GlyCys: 0.831 ± 0.032	3.897GlyAsp: 3.897 ± 0.065	4.328GlyGlu: 4.328 ± 0.067	3.156GlyPhe: 3.156 ± 0.054	6.76GlyGly: 6.76 ± 0.094	2.068GlyHis: 2.068 ± 0.046	4.33GlyIle: 4.33 ± 0.058	2.983GlyLys: 2.983 ± 0.064	9.232GlyLeu: 9.232 ± 0.11	2.258GlyMet: 2.258 ± 0.041	2.265GlyAsn: 2.265 ± 0.053	2.997GlyPro: 2.997 ± 0.055	4.187GlyGln: 4.187 ± 0.066	5.586GlyArg: 5.586 ± 0.073	4.986GlySer: 4.986 ± 0.079	4.387GlyThr: 4.387 ± 0.076	5.933GlyVal: 5.933 ± 0.073	1.536GlyTrp: 1.536 ± 0.042	2.287GlyTyr: 2.287 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	3.234HisAla: 3.234 ± 0.058	0.286HisCys: 0.286 ± 0.017	1.272HisAsp: 1.272 ± 0.027	1.143HisGlu: 1.143 ± 0.032	0.894HisPhe: 0.894 ± 0.029	2.332HisGly: 2.332 ± 0.049	0.642HisHis: 0.642 ± 0.025	1.098HisIle: 1.098 ± 0.03	0.526HisLys: 0.526 ± 0.022	2.34HisLeu: 2.34 ± 0.042	0.508HisMet: 0.508 ± 0.019	0.523HisAsn: 0.523 ± 0.023	1.522HisPro: 1.522 ± 0.038	0.955HisGln: 0.955 ± 0.027	1.489HisArg: 1.489 ± 0.035	1.132HisSer: 1.132 ± 0.029	1.12HisThr: 1.12 ± 0.029	1.599HisVal: 1.599 ± 0.041	0.529HisTrp: 0.529 ± 0.02	0.664HisTyr: 0.664 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.324IleAla: 6.324 ± 0.082	0.407IleCys: 0.407 ± 0.02	3.077IleAsp: 3.077 ± 0.048	3.274IleGlu: 3.274 ± 0.058	1.363IlePhe: 1.363 ± 0.036	4.35IleGly: 4.35 ± 0.065	1.002IleHis: 1.002 ± 0.028	1.817IleIle: 1.817 ± 0.046	1.289IleLys: 1.289 ± 0.04	3.691IleLeu: 3.691 ± 0.068	0.778IleMet: 0.778 ± 0.029	1.469IleAsn: 1.469 ± 0.041	2.103IlePro: 2.103 ± 0.042	1.553IleGln: 1.553 ± 0.037	2.757IleArg: 2.757 ± 0.051	2.528IleSer: 2.528 ± 0.051	2.486IleThr: 2.486 ± 0.05	3.375IleVal: 3.375 ± 0.062	0.581IleTrp: 0.581 ± 0.023	1.075IleTyr: 1.075 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.509LysAla: 3.509 ± 0.079	0.137LysCys: 0.137 ± 0.011	1.386LysAsp: 1.386 ± 0.042	1.354LysGlu: 1.354 ± 0.043	0.677LysPhe: 0.677 ± 0.023	2.173LysGly: 2.173 ± 0.05	0.547LysHis: 0.547 ± 0.023	1.256LysIle: 1.256 ± 0.042	1.086LysLys: 1.086 ± 0.041	2.864LysLeu: 2.864 ± 0.067	0.555LysMet: 0.555 ± 0.026	0.884LysAsn: 0.884 ± 0.033	1.813LysPro: 1.813 ± 0.047	1.11LysGln: 1.11 ± 0.038	1.837LysArg: 1.837 ± 0.048	1.525LysSer: 1.525 ± 0.041	1.668LysThr: 1.668 ± 0.048	2.13LysVal: 2.13 ± 0.057	0.309LysTrp: 0.309 ± 0.017	0.603LysTyr: 0.603 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	15.681LeuAla: 15.681 ± 0.171	0.99LeuCys: 0.99 ± 0.028	5.888LeuAsp: 5.888 ± 0.066	5.387LeuGlu: 5.387 ± 0.077	3.387LeuPhe: 3.387 ± 0.062	8.986LeuGly: 8.986 ± 0.109	2.647LeuHis: 2.647 ± 0.046	4.27LeuIle: 4.27 ± 0.069	2.868LeuLys: 2.868 ± 0.06	12.776LeuLeu: 12.776 ± 0.179	2.314LeuMet: 2.314 ± 0.051	2.535LeuAsn: 2.535 ± 0.042	6.635LeuPro: 6.635 ± 0.083	5.862LeuGln: 5.862 ± 0.088	8.209LeuArg: 8.209 ± 0.1	5.882LeuSer: 5.882 ± 0.082	5.213LeuThr: 5.213 ± 0.077	7.831LeuVal: 7.831 ± 0.084	1.455LeuTrp: 1.455 ± 0.043	2.131LeuTyr: 2.131 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.013MetAla: 3.013 ± 0.056	0.137MetCys: 0.137 ± 0.011	1.019MetAsp: 1.019 ± 0.03	0.993MetGlu: 0.993 ± 0.029	0.648MetPhe: 0.648 ± 0.023	1.76MetGly: 1.76 ± 0.042	0.534MetHis: 0.534 ± 0.021	0.871MetIle: 0.871 ± 0.026	0.685MetLys: 0.685 ± 0.028	2.761MetLeu: 2.761 ± 0.057	0.485MetMet: 0.485 ± 0.021	0.749MetAsn: 0.749 ± 0.021	1.551MetPro: 1.551 ± 0.036	1.236MetGln: 1.236 ± 0.034	1.664MetArg: 1.664 ± 0.037	1.404MetSer: 1.404 ± 0.04	1.412MetThr: 1.412 ± 0.031	1.654MetVal: 1.654 ± 0.041	0.189MetTrp: 0.189 ± 0.012	0.321MetTyr: 0.321 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.161AsnAla: 3.161 ± 0.053	0.206AsnCys: 0.206 ± 0.013	1.233AsnAsp: 1.233 ± 0.035	1.116AsnGlu: 1.116 ± 0.032	0.846AsnPhe: 0.846 ± 0.03	2.247AsnGly: 2.247 ± 0.053	0.542AsnHis: 0.542 ± 0.021	1.304AsnIle: 1.304 ± 0.039	0.686AsnLys: 0.686 ± 0.025	2.656AsnLeu: 2.656 ± 0.047	0.553AsnMet: 0.553 ± 0.023	0.709AsnAsn: 0.709 ± 0.025	1.832AsnPro: 1.832 ± 0.043	1.03AsnGln: 1.03 ± 0.033	1.686AsnArg: 1.686 ± 0.04	1.204AsnSer: 1.204 ± 0.037	1.416AsnThr: 1.416 ± 0.037	1.809AsnVal: 1.809 ± 0.038	0.436AsnTrp: 0.436 ± 0.017	0.688AsnTyr: 0.688 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	7.669ProAla: 7.669 ± 0.118	0.36ProCys: 0.36 ± 0.017	3.08ProAsp: 3.08 ± 0.054	3.407ProGlu: 3.407 ± 0.052	1.752ProPhe: 1.752 ± 0.042	4.635ProGly: 4.635 ± 0.072	1.238ProHis: 1.238 ± 0.036	2.035ProIle: 2.035 ± 0.04	1.22ProLys: 1.22 ± 0.04	5.605ProLeu: 5.605 ± 0.083	1.23ProMet: 1.23 ± 0.027	1.195ProAsn: 1.195 ± 0.035	2.813ProPro: 2.813 ± 0.069	2.696ProGln: 2.696 ± 0.048	3.117ProArg: 3.117 ± 0.056	2.991ProSer: 2.991 ± 0.051	2.421ProThr: 2.421 ± 0.046	4.164ProVal: 4.164 ± 0.07	0.892ProTrp: 0.892 ± 0.027	1.193ProTyr: 1.193 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	7.354GlnAla: 7.354 ± 0.108	0.335GlnCys: 0.335 ± 0.018	2.06GlnAsp: 2.06 ± 0.04	2.134GlnGlu: 2.134 ± 0.046	1.397GlnPhe: 1.397 ± 0.035	3.646GlnGly: 3.646 ± 0.055	1.282GlnHis: 1.282 ± 0.037	1.991GlnIle: 1.991 ± 0.041	1.16GlnLys: 1.16 ± 0.034	5.053GlnLeu: 5.053 ± 0.064	1.007GlnMet: 1.007 ± 0.029	1.014GlnAsn: 1.014 ± 0.032	2.917GlnPro: 2.917 ± 0.057	3.074GlnGln: 3.074 ± 0.061	4.057GlnArg: 4.057 ± 0.064	2.452GlnSer: 2.452 ± 0.049	2.259GlnThr: 2.259 ± 0.046	3.406GlnVal: 3.406 ± 0.056	0.981GlnTrp: 0.981 ± 0.03	0.946GlnTyr: 0.946 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	7.389ArgAla: 7.389 ± 0.096	0.568ArgCys: 0.568 ± 0.022	3.294ArgAsp: 3.294 ± 0.058	3.869ArgGlu: 3.869 ± 0.062	2.619ArgPhe: 2.619 ± 0.052	4.317ArgGly: 4.317 ± 0.062	2.165ArgHis: 2.165 ± 0.049	3.884ArgIle: 3.884 ± 0.061	1.989ArgLys: 1.989 ± 0.052	8.434ArgLeu: 8.434 ± 0.109	1.829ArgMet: 1.829 ± 0.038	1.904ArgAsn: 1.904 ± 0.04	3.422ArgPro: 3.422 ± 0.058	4.164ArgGln: 4.164 ± 0.069	5.248ArgArg: 5.248 ± 0.085	3.589ArgSer: 3.589 ± 0.057	3.139ArgThr: 3.139 ± 0.047	4.437ArgVal: 4.437 ± 0.077	1.233ArgTrp: 1.233 ± 0.035	1.86ArgTyr: 1.86 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	6.589SerAla: 6.589 ± 0.073	0.43SerCys: 0.43 ± 0.023	2.586SerAsp: 2.586 ± 0.054	2.476SerGlu: 2.476 ± 0.045	1.964SerPhe: 1.964 ± 0.043	5.458SerGly: 5.458 ± 0.096	1.308SerHis: 1.308 ± 0.031	2.704SerIle: 2.704 ± 0.056	1.406SerLys: 1.406 ± 0.039	5.736SerLeu: 5.736 ± 0.078	1.331SerMet: 1.331 ± 0.033	1.448SerAsn: 1.448 ± 0.043	2.887SerPro: 2.887 ± 0.047	2.142SerGln: 2.142 ± 0.05	3.551SerArg: 3.551 ± 0.056	3.292SerSer: 3.292 ± 0.07	3.013SerThr: 3.013 ± 0.065	3.763SerVal: 3.763 ± 0.055	0.79SerTrp: 0.79 ± 0.03	1.371SerTyr: 1.371 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.032ThrAla: 6.032 ± 0.084	0.383ThrCys: 0.383 ± 0.018	2.413ThrAsp: 2.413 ± 0.042	2.395ThrGlu: 2.395 ± 0.046	1.531ThrPhe: 1.531 ± 0.038	4.683ThrGly: 4.683 ± 0.068	1.138ThrHis: 1.138 ± 0.032	2.299ThrIle: 2.299 ± 0.056	1.088ThrLys: 1.088 ± 0.036	6.062ThrLeu: 6.062 ± 0.098	1.003ThrMet: 1.003 ± 0.027	1.216ThrAsn: 1.216 ± 0.037	3.528ThrPro: 3.528 ± 0.065	1.96ThrGln: 1.96 ± 0.042	3.226ThrArg: 3.226 ± 0.047	2.766ThrSer: 2.766 ± 0.059	2.704ThrThr: 2.704 ± 0.053	3.886ThrVal: 3.886 ± 0.074	0.646ThrTrp: 0.646 ± 0.02	1.059ThrTyr: 1.059 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.976ValAla: 8.976 ± 0.095	0.633ValCys: 0.633 ± 0.025	3.66ValAsp: 3.66 ± 0.062	3.695ValGlu: 3.695 ± 0.059	2.584ValPhe: 2.584 ± 0.047	5.061ValGly: 5.061 ± 0.072	1.571ValHis: 1.571 ± 0.034	3.329ValIle: 3.329 ± 0.06	1.938ValLys: 1.938 ± 0.054	8.603ValLeu: 8.603 ± 0.101	1.676ValMet: 1.676 ± 0.037	1.853ValAsn: 1.853 ± 0.041	4.054ValPro: 4.054 ± 0.066	3.349ValGln: 3.349 ± 0.053	4.934ValArg: 4.934 ± 0.057	3.734ValSer: 3.734 ± 0.057	3.788ValThr: 3.788 ± 0.053	5.746ValVal: 5.746 ± 0.07	0.989ValTrp: 0.989 ± 0.031	1.507ValTyr: 1.507 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.351TrpAla: 1.351 ± 0.037	0.171TrpCys: 0.171 ± 0.012	0.624TrpAsp: 0.624 ± 0.024	0.553TrpGlu: 0.553 ± 0.02	0.548TrpPhe: 0.548 ± 0.021	1.021TrpGly: 1.021 ± 0.029	0.464TrpHis: 0.464 ± 0.018	0.663TrpIle: 0.663 ± 0.024	0.381TrpLys: 0.381 ± 0.02	2.57TrpLeu: 2.57 ± 0.058	0.404TrpMet: 0.404 ± 0.019	0.429TrpAsn: 0.429 ± 0.019	0.892TrpPro: 0.892 ± 0.03	1.206TrpGln: 1.206 ± 0.04	1.404TrpArg: 1.404 ± 0.042	0.853TrpSer: 0.853 ± 0.028	0.697TrpThr: 0.697 ± 0.026	0.998TrpVal: 0.998 ± 0.036	0.308TrpTrp: 0.308 ± 0.023	0.319TrpTyr: 0.319 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.71TyrAla: 2.71 ± 0.047	0.238TyrCys: 0.238 ± 0.014	1.208TyrAsp: 1.208 ± 0.033	1.263TyrGlu: 1.263 ± 0.039	0.92TyrPhe: 0.92 ± 0.032	2.054TyrGly: 2.054 ± 0.04	0.483TyrHis: 0.483 ± 0.019	0.807TyrIle: 0.807 ± 0.027	0.594TyrLys: 0.594 ± 0.025	2.436TyrLeu: 2.436 ± 0.046	0.415TyrMet: 0.415 ± 0.021	0.588TyrAsn: 0.588 ± 0.023	1.109TyrPro: 1.109 ± 0.031	1.046TyrGln: 1.046 ± 0.03	1.771TyrArg: 1.771 ± 0.039	1.207TyrSer: 1.207 ± 0.035	1.198TyrThr: 1.198 ± 0.035	1.71TyrVal: 1.71 ± 0.042	0.388TyrTrp: 0.388 ± 0.019	0.615TyrTyr: 0.615 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3638 proteins (1229857 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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