Amino acid dipepetide frequency for Methanoculleus bourgensis (strain ATCC 43281 / DSM 3045 / OCM 15 / MS2) (Methanogenium bourgense)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.516AlaAla: 11.516 ± 0.168
1.348AlaCys: 1.348 ± 0.049
5.487AlaAsp: 5.487 ± 0.09
6.344AlaGlu: 6.344 ± 0.104
3.521AlaPhe: 3.521 ± 0.077
9.818AlaGly: 9.818 ± 0.139
1.639AlaHis: 1.639 ± 0.052
6.014AlaIle: 6.014 ± 0.101
2.964AlaLys: 2.964 ± 0.07
10.224AlaLeu: 10.224 ± 0.153
2.551AlaMet: 2.551 ± 0.058
2.252AlaAsn: 2.252 ± 0.065
4.07AlaPro: 4.07 ± 0.075
1.838AlaGln: 1.838 ± 0.049
6.737AlaArg: 6.737 ± 0.11
4.83AlaSer: 4.83 ± 0.094
5.07AlaThr: 5.07 ± 0.112
9.038AlaVal: 9.038 ± 0.123
1.112AlaTrp: 1.112 ± 0.049
2.643AlaTyr: 2.643 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
1.077CysAla: 1.077 ± 0.042
0.252CysCys: 0.252 ± 0.02
0.767CysAsp: 0.767 ± 0.03
0.649CysGlu: 0.649 ± 0.027
0.377CysPhe: 0.377 ± 0.019
1.522CysGly: 1.522 ± 0.039
0.326CysHis: 0.326 ± 0.021
0.853CysIle: 0.853 ± 0.034
0.302CysLys: 0.302 ± 0.02
0.974CysLeu: 0.974 ± 0.036
0.323CysMet: 0.323 ± 0.019
0.355CysAsn: 0.355 ± 0.024
0.953CysPro: 0.953 ± 0.037
0.234CysGln: 0.234 ± 0.016
1.16CysArg: 1.16 ± 0.04
0.784CysSer: 0.784 ± 0.034
0.898CysThr: 0.898 ± 0.034
0.766CysVal: 0.766 ± 0.037
0.134CysTrp: 0.134 ± 0.012
0.431CysTyr: 0.431 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
6.054AspAla: 6.054 ± 0.09
0.705AspCys: 0.705 ± 0.035
3.299AspAsp: 3.299 ± 0.091
4.182AspGlu: 4.182 ± 0.075
1.737AspPhe: 1.737 ± 0.05
4.576AspGly: 4.576 ± 0.103
1.205AspHis: 1.205 ± 0.038
3.947AspIle: 3.947 ± 0.081
1.216AspLys: 1.216 ± 0.043
7.098AspLeu: 7.098 ± 0.113
1.262AspMet: 1.262 ± 0.04
1.13AspAsn: 1.13 ± 0.042
3.667AspPro: 3.667 ± 0.071
1.345AspGln: 1.345 ± 0.036
4.294AspArg: 4.294 ± 0.078
2.103AspSer: 2.103 ± 0.065
2.85AspThr: 2.85 ± 0.07
4.486AspVal: 4.486 ± 0.084
0.579AspTrp: 0.579 ± 0.025
1.917AspTyr: 1.917 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
6.63GluAla: 6.63 ± 0.106
0.727GluCys: 0.727 ± 0.028
3.638GluAsp: 3.638 ± 0.076
6.205GluGlu: 6.205 ± 0.128
2.308GluPhe: 2.308 ± 0.053
5.117GluGly: 5.117 ± 0.086
1.476GluHis: 1.476 ± 0.047
4.743GluIle: 4.743 ± 0.08
3.152GluLys: 3.152 ± 0.072
4.948GluLeu: 4.948 ± 0.093
1.884GluMet: 1.884 ± 0.058
2.267GluAsn: 2.267 ± 0.055
2.984GluPro: 2.984 ± 0.065
2.093GluGln: 2.093 ± 0.057
5.556GluArg: 5.556 ± 0.084
3.05GluSer: 3.05 ± 0.066
3.931GluThr: 3.931 ± 0.083
5.854GluVal: 5.854 ± 0.093
0.67GluTrp: 0.67 ± 0.031
2.116GluTyr: 2.116 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
3.614PheAla: 3.614 ± 0.085
0.514PheCys: 0.514 ± 0.027
2.24PheAsp: 2.24 ± 0.06
2.244PheGlu: 2.244 ± 0.055
1.474PhePhe: 1.474 ± 0.053
3.17PheGly: 3.17 ± 0.067
0.646PheHis: 0.646 ± 0.031
2.163PheIle: 2.163 ± 0.055
0.843PheLys: 0.843 ± 0.033
3.383PheLeu: 3.383 ± 0.079
0.708PheMet: 0.708 ± 0.028
0.955PheAsn: 0.955 ± 0.046
1.541PhePro: 1.541 ± 0.046
0.817PheGln: 0.817 ± 0.033
2.261PheArg: 2.261 ± 0.057
2.644PheSer: 2.644 ± 0.061
2.034PheThr: 2.034 ± 0.069
2.716PheVal: 2.716 ± 0.068
0.407PheTrp: 0.407 ± 0.022
1.048PheTyr: 1.048 ± 0.038
0.0PheXaa: 0.0 ± 0.0
Gly
7.47GlyAla: 7.47 ± 0.133
1.303GlyCys: 1.303 ± 0.05
4.931GlyAsp: 4.931 ± 0.085
6.015GlyGlu: 6.015 ± 0.099
3.026GlyPhe: 3.026 ± 0.063
6.8GlyGly: 6.8 ± 0.135
1.553GlyHis: 1.553 ± 0.053
6.317GlyIle: 6.317 ± 0.102
3.503GlyLys: 3.503 ± 0.076
7.042GlyLeu: 7.042 ± 0.123
2.546GlyMet: 2.546 ± 0.061
2.478GlyAsn: 2.478 ± 0.074
2.875GlyPro: 2.875 ± 0.061
1.76GlyGln: 1.76 ± 0.043
5.997GlyArg: 5.997 ± 0.098
4.949GlySer: 4.949 ± 0.091
5.47GlyThr: 5.47 ± 0.107
6.78GlyVal: 6.78 ± 0.108
0.974GlyTrp: 0.974 ± 0.037
2.903GlyTyr: 2.903 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.746HisAla: 1.746 ± 0.043
0.321HisCys: 0.321 ± 0.02
1.164HisAsp: 1.164 ± 0.039
1.121HisGlu: 1.121 ± 0.037
0.699HisPhe: 0.699 ± 0.034
1.639HisGly: 1.639 ± 0.052
0.546HisHis: 0.546 ± 0.032
1.203HisIle: 1.203 ± 0.037
0.432HisLys: 0.432 ± 0.024
2.167HisLeu: 2.167 ± 0.052
0.389HisMet: 0.389 ± 0.023
0.55HisAsn: 0.55 ± 0.031
1.472HisPro: 1.472 ± 0.041
0.609HisGln: 0.609 ± 0.025
1.458HisArg: 1.458 ± 0.046
0.873HisSer: 0.873 ± 0.037
1.099HisThr: 1.099 ± 0.038
1.348HisVal: 1.348 ± 0.044
0.215HisTrp: 0.215 ± 0.017
0.618HisTyr: 0.618 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.854IleAla: 6.854 ± 0.099
0.801IleCys: 0.801 ± 0.035
3.971IleAsp: 3.971 ± 0.073
4.425IleGlu: 4.425 ± 0.079
2.193IlePhe: 2.193 ± 0.058
5.341IleGly: 5.341 ± 0.091
1.173IleHis: 1.173 ± 0.046
3.677IleIle: 3.677 ± 0.079
1.724IleLys: 1.724 ± 0.059
5.852IleLeu: 5.852 ± 0.1
1.124IleMet: 1.124 ± 0.044
1.725IleAsn: 1.725 ± 0.058
3.685IlePro: 3.685 ± 0.063
1.56IleGln: 1.56 ± 0.053
4.722IleArg: 4.722 ± 0.078
3.499IleSer: 3.499 ± 0.084
3.904IleThr: 3.904 ± 0.081
4.745IleVal: 4.745 ± 0.078
0.535IleTrp: 0.535 ± 0.023
1.838IleTyr: 1.838 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
2.829LysAla: 2.829 ± 0.065
0.371LysCys: 0.371 ± 0.022
1.921LysAsp: 1.921 ± 0.057
2.66LysGlu: 2.66 ± 0.072
0.94LysPhe: 0.94 ± 0.045
2.466LysGly: 2.466 ± 0.067
0.641LysHis: 0.641 ± 0.028
2.204LysIle: 2.204 ± 0.062
2.034LysLys: 2.034 ± 0.07
2.272LysLeu: 2.272 ± 0.061
0.878LysMet: 0.878 ± 0.033
1.339LysAsn: 1.339 ± 0.052
1.669LysPro: 1.669 ± 0.047
1.037LysGln: 1.037 ± 0.035
2.351LysArg: 2.351 ± 0.055
1.721LysSer: 1.721 ± 0.051
2.21LysThr: 2.21 ± 0.055
2.626LysVal: 2.626 ± 0.062
0.319LysTrp: 0.319 ± 0.025
1.035LysTyr: 1.035 ± 0.042
0.0LysXaa: 0.0 ± 0.0
Leu
10.607LeuAla: 10.607 ± 0.157
1.091LeuCys: 1.091 ± 0.039
5.612LeuAsp: 5.612 ± 0.087
5.831LeuGlu: 5.831 ± 0.103
3.651LeuPhe: 3.651 ± 0.087
7.114LeuGly: 7.114 ± 0.114
1.85LeuHis: 1.85 ± 0.054
5.933LeuIle: 5.933 ± 0.102
3.239LeuLys: 3.239 ± 0.074
9.587LeuLeu: 9.587 ± 0.17
2.093LeuMet: 2.093 ± 0.058
2.435LeuAsn: 2.435 ± 0.056
4.835LeuPro: 4.835 ± 0.079
2.65LeuGln: 2.65 ± 0.064
6.214LeuArg: 6.214 ± 0.112
5.582LeuSer: 5.582 ± 0.098
4.895LeuThr: 4.895 ± 0.09
7.323LeuVal: 7.323 ± 0.115
0.878LeuTrp: 0.878 ± 0.036
2.598LeuTyr: 2.598 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
2.297MetAla: 2.297 ± 0.068
0.203MetCys: 0.203 ± 0.015
1.264MetAsp: 1.264 ± 0.04
1.661MetGlu: 1.661 ± 0.053
0.584MetPhe: 0.584 ± 0.028
1.886MetGly: 1.886 ± 0.058
0.498MetHis: 0.498 ± 0.025
1.423MetIle: 1.423 ± 0.051
1.246MetLys: 1.246 ± 0.042
2.358MetLeu: 2.358 ± 0.059
0.662MetMet: 0.662 ± 0.028
0.849MetAsn: 0.849 ± 0.032
1.198MetPro: 1.198 ± 0.042
0.805MetGln: 0.805 ± 0.03
1.82MetArg: 1.82 ± 0.046
1.138MetSer: 1.138 ± 0.04
1.604MetThr: 1.604 ± 0.046
1.919MetVal: 1.919 ± 0.051
0.165MetTrp: 0.165 ± 0.014
0.5MetTyr: 0.5 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
2.552AsnAla: 2.552 ± 0.072
0.389AsnCys: 0.389 ± 0.031
1.396AsnAsp: 1.396 ± 0.044
1.59AsnGlu: 1.59 ± 0.048
0.875AsnPhe: 0.875 ± 0.037
2.184AsnGly: 2.184 ± 0.066
0.544AsnHis: 0.544 ± 0.032
1.845AsnIle: 1.845 ± 0.051
0.77AsnLys: 0.77 ± 0.034
2.92AsnLeu: 2.92 ± 0.059
0.52AsnMet: 0.52 ± 0.028
0.834AsnAsn: 0.834 ± 0.042
2.059AsnPro: 2.059 ± 0.054
0.752AsnGln: 0.752 ± 0.035
2.003AsnArg: 2.003 ± 0.053
1.145AsnSer: 1.145 ± 0.046
1.561AsnThr: 1.561 ± 0.047
2.252AsnVal: 2.252 ± 0.065
0.294AsnTrp: 0.294 ± 0.02
0.899AsnTyr: 0.899 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
5.288ProAla: 5.288 ± 0.098
0.683ProCys: 0.683 ± 0.034
3.689ProAsp: 3.689 ± 0.074
4.631ProGlu: 4.631 ± 0.086
1.86ProPhe: 1.86 ± 0.057
5.488ProGly: 5.488 ± 0.106
0.999ProHis: 0.999 ± 0.04
2.261ProIle: 2.261 ± 0.06
1.398ProLys: 1.398 ± 0.043
4.471ProLeu: 4.471 ± 0.079
1.025ProMet: 1.025 ± 0.035
1.084ProAsn: 1.084 ± 0.034
2.694ProPro: 2.694 ± 0.074
1.065ProGln: 1.065 ± 0.037
2.697ProArg: 2.697 ± 0.064
2.3ProSer: 2.3 ± 0.054
2.496ProThr: 2.496 ± 0.082
4.758ProVal: 4.758 ± 0.083
0.494ProTrp: 0.494 ± 0.026
1.505ProTyr: 1.505 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
2.361GlnAla: 2.361 ± 0.051
0.265GlnCys: 0.265 ± 0.02
1.333GlnAsp: 1.333 ± 0.041
1.923GlnGlu: 1.923 ± 0.052
0.844GlnPhe: 0.844 ± 0.036
1.895GlnGly: 1.895 ± 0.053
0.581GlnHis: 0.581 ± 0.03
1.658GlnIle: 1.658 ± 0.052
1.342GlnLys: 1.342 ± 0.043
1.58GlnLeu: 1.58 ± 0.047
0.778GlnMet: 0.778 ± 0.035
0.878GlnAsn: 0.878 ± 0.034
1.037GlnPro: 1.037 ± 0.034
0.94GlnGln: 0.94 ± 0.038
1.856GlnArg: 1.856 ± 0.054
1.232GlnSer: 1.232 ± 0.044
1.257GlnThr: 1.257 ± 0.038
2.214GlnVal: 2.214 ± 0.052
0.298GlnTrp: 0.298 ± 0.023
0.805GlnTyr: 0.805 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
6.063ArgAla: 6.063 ± 0.102
1.016ArgCys: 1.016 ± 0.037
4.369ArgAsp: 4.369 ± 0.087
6.145ArgGlu: 6.145 ± 0.104
2.728ArgPhe: 2.728 ± 0.066
5.245ArgGly: 5.245 ± 0.093
1.436ArgHis: 1.436 ± 0.05
4.507ArgIle: 4.507 ± 0.075
2.751ArgLys: 2.751 ± 0.073
6.192ArgLeu: 6.192 ± 0.097
2.105ArgMet: 2.105 ± 0.048
1.998ArgAsn: 1.998 ± 0.049
3.043ArgPro: 3.043 ± 0.062
2.034ArgGln: 2.034 ± 0.06
5.537ArgArg: 5.537 ± 0.105
3.668ArgSer: 3.668 ± 0.076
3.387ArgThr: 3.387 ± 0.067
5.367ArgVal: 5.367 ± 0.095
0.823ArgTrp: 0.823 ± 0.033
2.671ArgTyr: 2.671 ± 0.069
0.0ArgXaa: 0.0 ± 0.0
Ser
4.731SerAla: 4.731 ± 0.073
0.662SerCys: 0.662 ± 0.03
2.736SerAsp: 2.736 ± 0.062
2.94SerGlu: 2.94 ± 0.065
1.869SerPhe: 1.869 ± 0.055
5.628SerGly: 5.628 ± 0.101
1.106SerHis: 1.106 ± 0.038
3.356SerIle: 3.356 ± 0.066
1.31SerLys: 1.31 ± 0.047
5.044SerLeu: 5.044 ± 0.094
1.25SerMet: 1.25 ± 0.045
1.24SerAsn: 1.24 ± 0.05
3.044SerPro: 3.044 ± 0.068
1.055SerGln: 1.055 ± 0.039
3.936SerArg: 3.936 ± 0.081
3.044SerSer: 3.044 ± 0.07
2.949SerThr: 2.949 ± 0.066
4.148SerVal: 4.148 ± 0.074
0.598SerTrp: 0.598 ± 0.03
1.458SerTyr: 1.458 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
5.579ThrAla: 5.579 ± 0.123
0.727ThrCys: 0.727 ± 0.035
2.92ThrAsp: 2.92 ± 0.068
3.123ThrGlu: 3.123 ± 0.07
2.204ThrPhe: 2.204 ± 0.053
5.779ThrGly: 5.779 ± 0.115
1.035ThrHis: 1.035 ± 0.039
3.701ThrIle: 3.701 ± 0.078
1.543ThrLys: 1.543 ± 0.042
5.677ThrLeu: 5.677 ± 0.081
1.172ThrMet: 1.172 ± 0.039
1.415ThrAsn: 1.415 ± 0.052
3.659ThrPro: 3.659 ± 0.095
1.012ThrGln: 1.012 ± 0.04
3.273ThrArg: 3.273 ± 0.062
2.736ThrSer: 2.736 ± 0.069
3.398ThrThr: 3.398 ± 0.097
5.455ThrVal: 5.455 ± 0.126
0.626ThrTrp: 0.626 ± 0.035
1.753ThrTyr: 1.753 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
8.061ValAla: 8.061 ± 0.107
1.173ValCys: 1.173 ± 0.04
4.518ValAsp: 4.518 ± 0.087
5.203ValGlu: 5.203 ± 0.089
3.08ValPhe: 3.08 ± 0.063
5.674ValGly: 5.674 ± 0.109
1.53ValHis: 1.53 ± 0.047
5.132ValIle: 5.132 ± 0.096
2.531ValLys: 2.531 ± 0.068
7.999ValLeu: 7.999 ± 0.096
1.973ValMet: 1.973 ± 0.049
2.25ValAsn: 2.25 ± 0.063
4.391ValPro: 4.391 ± 0.068
2.115ValGln: 2.115 ± 0.056
5.946ValArg: 5.946 ± 0.087
4.593ValSer: 4.593 ± 0.085
5.348ValThr: 5.348 ± 0.118
7.127ValVal: 7.127 ± 0.121
0.842ValTrp: 0.842 ± 0.042
2.331ValTyr: 2.331 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.797TrpAla: 0.797 ± 0.033
0.16TrpCys: 0.16 ± 0.015
0.62TrpAsp: 0.62 ± 0.029
0.706TrpGlu: 0.706 ± 0.037
0.382TrpPhe: 0.382 ± 0.022
0.74TrpGly: 0.74 ± 0.04
0.207TrpHis: 0.207 ± 0.016
0.606TrpIle: 0.606 ± 0.026
0.513TrpLys: 0.513 ± 0.027
1.016TrpLeu: 1.016 ± 0.041
0.294TrpMet: 0.294 ± 0.019
0.424TrpAsn: 0.424 ± 0.027
0.31TrpPro: 0.31 ± 0.019
0.395TrpGln: 0.395 ± 0.025
0.758TrpArg: 0.758 ± 0.038
0.633TrpSer: 0.633 ± 0.031
0.537TrpThr: 0.537 ± 0.031
0.833TrpVal: 0.833 ± 0.041
0.169TrpTrp: 0.169 ± 0.014
0.367TrpTyr: 0.367 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.89TyrAla: 2.89 ± 0.067
0.427TyrCys: 0.427 ± 0.024
1.776TyrAsp: 1.776 ± 0.055
1.751TyrGlu: 1.751 ± 0.046
1.071TyrPhe: 1.071 ± 0.044
2.608TyrGly: 2.608 ± 0.066
0.676TyrHis: 0.676 ± 0.032
1.807TyrIle: 1.807 ± 0.058
0.71TyrLys: 0.71 ± 0.038
3.21TyrLeu: 3.21 ± 0.068
0.545TyrMet: 0.545 ± 0.028
0.925TyrAsn: 0.925 ± 0.04
1.699TyrPro: 1.699 ± 0.054
0.963TyrGln: 0.963 ± 0.039
2.512TyrArg: 2.512 ± 0.058
1.579TyrSer: 1.579 ± 0.046
1.89TyrThr: 1.89 ± 0.055
2.062TyrVal: 2.062 ± 0.061
0.337TyrTrp: 0.337 ± 0.022
1.045TyrTyr: 1.045 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2575 proteins (768769 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski