Amino acid dipepetide frequency for Thauera sp. 63

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.643AlaAla: 17.643 ± 0.168
1.409AlaCys: 1.409 ± 0.034
7.04AlaAsp: 7.04 ± 0.08
7.97AlaGlu: 7.97 ± 0.104
4.179AlaPhe: 4.179 ± 0.06
11.007AlaGly: 11.007 ± 0.103
2.735AlaHis: 2.735 ± 0.046
5.511AlaIle: 5.511 ± 0.066
3.305AlaLys: 3.305 ± 0.067
14.887AlaLeu: 14.887 ± 0.128
3.41AlaMet: 3.41 ± 0.056
2.822AlaAsn: 2.822 ± 0.052
5.742AlaPro: 5.742 ± 0.074
4.705AlaGln: 4.705 ± 0.066
10.02AlaArg: 10.02 ± 0.113
6.161AlaSer: 6.161 ± 0.074
5.855AlaThr: 5.855 ± 0.08
8.982AlaVal: 8.982 ± 0.1
1.794AlaTrp: 1.794 ± 0.047
2.474AlaTyr: 2.474 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
1.207CysAla: 1.207 ± 0.029
0.136CysCys: 0.136 ± 0.011
0.607CysAsp: 0.607 ± 0.018
0.541CysGlu: 0.541 ± 0.02
0.328CysPhe: 0.328 ± 0.015
1.039CysGly: 1.039 ± 0.031
0.312CysHis: 0.312 ± 0.019
0.434CysIle: 0.434 ± 0.018
0.213CysLys: 0.213 ± 0.012
0.887CysLeu: 0.887 ± 0.025
0.203CysMet: 0.203 ± 0.014
0.262CysAsn: 0.262 ± 0.014
0.539CysPro: 0.539 ± 0.021
0.247CysGln: 0.247 ± 0.014
0.711CysArg: 0.711 ± 0.025
0.501CysSer: 0.501 ± 0.02
0.483CysThr: 0.483 ± 0.021
0.759CysVal: 0.759 ± 0.027
0.114CysTrp: 0.114 ± 0.011
0.238CysTyr: 0.238 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.431AspAla: 7.431 ± 0.097
0.5AspCys: 0.5 ± 0.02
3.084AspAsp: 3.084 ± 0.058
3.841AspGlu: 3.841 ± 0.058
2.26AspPhe: 2.26 ± 0.042
4.848AspGly: 4.848 ± 0.069
1.181AspHis: 1.181 ± 0.029
2.687AspIle: 2.687 ± 0.048
1.673AspLys: 1.673 ± 0.036
5.489AspLeu: 5.489 ± 0.065
1.253AspMet: 1.253 ± 0.032
1.251AspAsn: 1.251 ± 0.033
3.051AspPro: 3.051 ± 0.046
1.479AspGln: 1.479 ± 0.035
3.868AspArg: 3.868 ± 0.061
2.311AspSer: 2.311 ± 0.042
2.73AspThr: 2.73 ± 0.043
3.994AspVal: 3.994 ± 0.06
1.064AspTrp: 1.064 ± 0.026
1.508AspTyr: 1.508 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
7.974GluAla: 7.974 ± 0.099
0.458GluCys: 0.458 ± 0.018
2.778GluAsp: 2.778 ± 0.05
2.885GluGlu: 2.885 ± 0.055
1.842GluPhe: 1.842 ± 0.042
4.436GluGly: 4.436 ± 0.065
1.538GluHis: 1.538 ± 0.037
3.225GluIle: 3.225 ± 0.057
1.876GluLys: 1.876 ± 0.044
6.59GluLeu: 6.59 ± 0.076
1.36GluMet: 1.36 ± 0.032
1.323GluAsn: 1.323 ± 0.029
2.601GluPro: 2.601 ± 0.058
2.5GluGln: 2.5 ± 0.044
5.59GluArg: 5.59 ± 0.071
2.676GluSer: 2.676 ± 0.048
2.988GluThr: 2.988 ± 0.068
4.52GluVal: 4.52 ± 0.069
0.805GluTrp: 0.805 ± 0.03
1.12GluTyr: 1.12 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
4.564PheAla: 4.564 ± 0.055
0.406PheCys: 0.406 ± 0.02
2.637PheAsp: 2.637 ± 0.046
2.308PheGlu: 2.308 ± 0.04
1.373PhePhe: 1.373 ± 0.032
3.489PheGly: 3.489 ± 0.051
0.795PheHis: 0.795 ± 0.028
1.62PheIle: 1.62 ± 0.037
0.991PheLys: 0.991 ± 0.029
3.155PheLeu: 3.155 ± 0.056
0.782PheMet: 0.782 ± 0.027
1.042PheAsn: 1.042 ± 0.031
1.498PhePro: 1.498 ± 0.035
0.942PheGln: 0.942 ± 0.029
2.319PheArg: 2.319 ± 0.053
2.033PheSer: 2.033 ± 0.045
1.687PheThr: 1.687 ± 0.036
2.945PheVal: 2.945 ± 0.054
0.52PheTrp: 0.52 ± 0.022
0.8PheTyr: 0.8 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
8.993GlyAla: 8.993 ± 0.105
0.985GlyCys: 0.985 ± 0.031
4.276GlyAsp: 4.276 ± 0.055
5.396GlyGlu: 5.396 ± 0.073
3.458GlyPhe: 3.458 ± 0.056
7.043GlyGly: 7.043 ± 0.111
1.901GlyHis: 1.901 ± 0.035
4.146GlyIle: 4.146 ± 0.064
3.099GlyLys: 3.099 ± 0.053
9.228GlyLeu: 9.228 ± 0.082
2.38GlyMet: 2.38 ± 0.05
2.055GlyAsn: 2.055 ± 0.045
2.758GlyPro: 2.758 ± 0.051
2.851GlyGln: 2.851 ± 0.045
6.385GlyArg: 6.385 ± 0.073
4.224GlySer: 4.224 ± 0.069
4.143GlyThr: 4.143 ± 0.071
6.753GlyVal: 6.753 ± 0.088
1.448GlyTrp: 1.448 ± 0.037
2.129GlyTyr: 2.129 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
2.915HisAla: 2.915 ± 0.044
0.283HisCys: 0.283 ± 0.016
1.317HisAsp: 1.317 ± 0.034
1.219HisGlu: 1.219 ± 0.03
0.99HisPhe: 0.99 ± 0.029
2.131HisGly: 2.131 ± 0.037
0.703HisHis: 0.703 ± 0.024
0.974HisIle: 0.974 ± 0.027
0.588HisLys: 0.588 ± 0.021
2.369HisLeu: 2.369 ± 0.044
0.464HisMet: 0.464 ± 0.02
0.501HisAsn: 0.501 ± 0.02
1.54HisPro: 1.54 ± 0.037
0.666HisGln: 0.666 ± 0.023
1.672HisArg: 1.672 ± 0.037
0.952HisSer: 0.952 ± 0.03
1.018HisThr: 1.018 ± 0.027
1.569HisVal: 1.569 ± 0.035
0.374HisTrp: 0.374 ± 0.019
0.677HisTyr: 0.677 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
6.509IleAla: 6.509 ± 0.081
0.438IleCys: 0.438 ± 0.018
3.447IleAsp: 3.447 ± 0.055
3.616IleGlu: 3.616 ± 0.056
1.355IlePhe: 1.355 ± 0.039
4.495IleGly: 4.495 ± 0.06
0.965IleHis: 0.965 ± 0.027
1.766IleIle: 1.766 ± 0.041
1.372IleLys: 1.372 ± 0.032
3.8IleLeu: 3.8 ± 0.061
0.821IleMet: 0.821 ± 0.027
1.426IleAsn: 1.426 ± 0.035
2.192IlePro: 2.192 ± 0.045
1.255IleGln: 1.255 ± 0.03
3.176IleArg: 3.176 ± 0.057
2.304IleSer: 2.304 ± 0.045
2.435IleThr: 2.435 ± 0.05
3.754IleVal: 3.754 ± 0.055
0.453IleTrp: 0.453 ± 0.018
0.983IleTyr: 0.983 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
3.767LysAla: 3.767 ± 0.072
0.187LysCys: 0.187 ± 0.011
1.519LysAsp: 1.519 ± 0.032
1.458LysGlu: 1.458 ± 0.038
0.832LysPhe: 0.832 ± 0.026
2.295LysGly: 2.295 ± 0.046
0.653LysHis: 0.653 ± 0.024
1.385LysIle: 1.385 ± 0.035
1.151LysLys: 1.151 ± 0.032
3.264LysLeu: 3.264 ± 0.059
0.752LysMet: 0.752 ± 0.022
0.833LysAsn: 0.833 ± 0.027
1.817LysPro: 1.817 ± 0.045
1.09LysGln: 1.09 ± 0.033
2.26LysArg: 2.26 ± 0.043
1.469LysSer: 1.469 ± 0.039
1.539LysThr: 1.539 ± 0.036
2.452LysVal: 2.452 ± 0.052
0.34LysTrp: 0.34 ± 0.016
0.671LysTyr: 0.671 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
15.26LeuAla: 15.26 ± 0.143
1.024LeuCys: 1.024 ± 0.027
6.399LeuAsp: 6.399 ± 0.081
5.936LeuGlu: 5.936 ± 0.073
3.748LeuPhe: 3.748 ± 0.055
8.929LeuGly: 8.929 ± 0.094
2.401LeuHis: 2.401 ± 0.051
4.819LeuIle: 4.819 ± 0.07
3.407LeuLys: 3.407 ± 0.065
11.564LeuLeu: 11.564 ± 0.135
2.498LeuMet: 2.498 ± 0.048
2.669LeuAsn: 2.669 ± 0.047
6.247LeuPro: 6.247 ± 0.074
3.746LeuGln: 3.746 ± 0.054
8.202LeuArg: 8.202 ± 0.091
5.977LeuSer: 5.977 ± 0.073
5.159LeuThr: 5.159 ± 0.068
7.763LeuVal: 7.763 ± 0.085
1.221LeuTrp: 1.221 ± 0.033
2.098LeuTyr: 2.098 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
2.744MetAla: 2.744 ± 0.048
0.18MetCys: 0.18 ± 0.01
1.199MetAsp: 1.199 ± 0.032
1.117MetGlu: 1.117 ± 0.029
0.7MetPhe: 0.7 ± 0.024
1.726MetGly: 1.726 ± 0.039
0.508MetHis: 0.508 ± 0.018
1.136MetIle: 1.136 ± 0.03
1.04MetLys: 1.04 ± 0.029
2.721MetLeu: 2.721 ± 0.044
0.634MetMet: 0.634 ± 0.025
0.847MetAsn: 0.847 ± 0.023
1.406MetPro: 1.406 ± 0.038
0.983MetGln: 0.983 ± 0.028
1.854MetArg: 1.854 ± 0.034
1.654MetSer: 1.654 ± 0.039
1.426MetThr: 1.426 ± 0.034
1.705MetVal: 1.705 ± 0.034
0.22MetTrp: 0.22 ± 0.013
0.354MetTyr: 0.354 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.209AsnAla: 3.209 ± 0.054
0.294AsnCys: 0.294 ± 0.016
1.205AsnAsp: 1.205 ± 0.029
1.221AsnGlu: 1.221 ± 0.035
0.9AsnPhe: 0.9 ± 0.026
2.111AsnGly: 2.111 ± 0.048
0.484AsnHis: 0.484 ± 0.019
1.189AsnIle: 1.189 ± 0.033
0.716AsnLys: 0.716 ± 0.026
2.663AsnLeu: 2.663 ± 0.05
0.54AsnMet: 0.54 ± 0.02
0.678AsnAsn: 0.678 ± 0.026
1.812AsnPro: 1.812 ± 0.044
0.77AsnGln: 0.77 ± 0.023
1.764AsnArg: 1.764 ± 0.037
1.045AsnSer: 1.045 ± 0.032
1.313AsnThr: 1.313 ± 0.034
1.845AsnVal: 1.845 ± 0.044
0.377AsnTrp: 0.377 ± 0.017
0.642AsnTyr: 0.642 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
6.914ProAla: 6.914 ± 0.084
0.405ProCys: 0.405 ± 0.02
3.318ProAsp: 3.318 ± 0.053
3.597ProGlu: 3.597 ± 0.057
1.736ProPhe: 1.736 ± 0.039
4.43ProGly: 4.43 ± 0.06
1.093ProHis: 1.093 ± 0.031
2.061ProIle: 2.061 ± 0.043
1.348ProLys: 1.348 ± 0.038
5.284ProLeu: 5.284 ± 0.076
1.163ProMet: 1.163 ± 0.031
1.192ProAsn: 1.192 ± 0.029
2.607ProPro: 2.607 ± 0.058
1.827ProGln: 1.827 ± 0.038
3.062ProArg: 3.062 ± 0.056
2.404ProSer: 2.404 ± 0.045
2.3ProThr: 2.3 ± 0.045
4.174ProVal: 4.174 ± 0.065
0.731ProTrp: 0.731 ± 0.027
1.102ProTyr: 1.102 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
4.815GlnAla: 4.815 ± 0.074
0.268GlnCys: 0.268 ± 0.014
1.497GlnAsp: 1.497 ± 0.033
1.514GlnGlu: 1.514 ± 0.038
1.092GlnPhe: 1.092 ± 0.03
2.64GlnGly: 2.64 ± 0.047
0.898GlnHis: 0.898 ± 0.031
1.635GlnIle: 1.635 ± 0.037
0.963GlnLys: 0.963 ± 0.028
3.722GlnLeu: 3.722 ± 0.054
0.878GlnMet: 0.878 ± 0.024
0.756GlnAsn: 0.756 ± 0.027
1.964GlnPro: 1.964 ± 0.043
1.554GlnGln: 1.554 ± 0.038
3.132GlnArg: 3.132 ± 0.054
1.624GlnSer: 1.624 ± 0.044
1.681GlnThr: 1.681 ± 0.043
2.626GlnVal: 2.626 ± 0.046
0.504GlnTrp: 0.504 ± 0.021
0.662GlnTyr: 0.662 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
8.483ArgAla: 8.483 ± 0.098
0.721ArgCys: 0.721 ± 0.025
4.095ArgAsp: 4.095 ± 0.05
4.903ArgGlu: 4.903 ± 0.072
3.261ArgPhe: 3.261 ± 0.051
5.1ArgGly: 5.1 ± 0.058
2.131ArgHis: 2.131 ± 0.042
4.221ArgIle: 4.221 ± 0.054
2.186ArgLys: 2.186 ± 0.043
8.997ArgLeu: 8.997 ± 0.096
2.038ArgMet: 2.038 ± 0.041
2.03ArgAsn: 2.03 ± 0.044
3.507ArgPro: 3.507 ± 0.051
2.767ArgGln: 2.767 ± 0.054
6.029ArgArg: 6.029 ± 0.077
3.609ArgSer: 3.609 ± 0.053
3.267ArgThr: 3.267 ± 0.051
5.449ArgVal: 5.449 ± 0.071
1.075ArgTrp: 1.075 ± 0.031
1.988ArgTyr: 1.988 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
6.218SerAla: 6.218 ± 0.066
0.463SerCys: 0.463 ± 0.021
2.516SerAsp: 2.516 ± 0.046
2.533SerGlu: 2.533 ± 0.054
1.979SerPhe: 1.979 ± 0.046
4.931SerGly: 4.931 ± 0.066
1.114SerHis: 1.114 ± 0.029
2.385SerIle: 2.385 ± 0.048
1.34SerLys: 1.34 ± 0.034
5.438SerLeu: 5.438 ± 0.075
1.265SerMet: 1.265 ± 0.031
1.228SerAsn: 1.228 ± 0.034
2.647SerPro: 2.647 ± 0.054
1.559SerGln: 1.559 ± 0.037
3.688SerArg: 3.688 ± 0.057
2.57SerSer: 2.57 ± 0.056
2.488SerThr: 2.488 ± 0.05
3.767SerVal: 3.767 ± 0.057
0.645SerTrp: 0.645 ± 0.021
1.089SerTyr: 1.089 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
5.645ThrAla: 5.645 ± 0.076
0.419ThrCys: 0.419 ± 0.017
2.548ThrAsp: 2.548 ± 0.048
2.622ThrGlu: 2.622 ± 0.065
1.551ThrPhe: 1.551 ± 0.034
4.407ThrGly: 4.407 ± 0.082
1.179ThrHis: 1.179 ± 0.032
2.166ThrIle: 2.166 ± 0.041
1.1ThrLys: 1.1 ± 0.035
6.206ThrLeu: 6.206 ± 0.081
0.99ThrMet: 0.99 ± 0.032
1.094ThrAsn: 1.094 ± 0.029
3.224ThrPro: 3.224 ± 0.049
1.622ThrGln: 1.622 ± 0.042
3.472ThrArg: 3.472 ± 0.054
2.231ThrSer: 2.231 ± 0.045
2.493ThrThr: 2.493 ± 0.056
4.015ThrVal: 4.015 ± 0.086
0.648ThrTrp: 0.648 ± 0.024
0.965ThrTyr: 0.965 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
9.543ValAla: 9.543 ± 0.104
0.786ValCys: 0.786 ± 0.025
4.207ValAsp: 4.207 ± 0.062
4.683ValGlu: 4.683 ± 0.055
2.921ValPhe: 2.921 ± 0.055
5.791ValGly: 5.791 ± 0.073
1.482ValHis: 1.482 ± 0.035
3.702ValIle: 3.702 ± 0.053
2.304ValLys: 2.304 ± 0.048
8.347ValLeu: 8.347 ± 0.083
1.918ValMet: 1.918 ± 0.038
1.793ValAsn: 1.793 ± 0.041
3.838ValPro: 3.838 ± 0.052
2.396ValGln: 2.396 ± 0.048
5.545ValArg: 5.545 ± 0.071
4.292ValSer: 4.292 ± 0.058
3.848ValThr: 3.848 ± 0.077
6.439ValVal: 6.439 ± 0.087
0.962ValTrp: 0.962 ± 0.031
1.348ValTyr: 1.348 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.252TrpAla: 1.252 ± 0.036
0.161TrpCys: 0.161 ± 0.012
0.627TrpAsp: 0.627 ± 0.025
0.609TrpGlu: 0.609 ± 0.022
0.522TrpPhe: 0.522 ± 0.022
0.866TrpGly: 0.866 ± 0.03
0.368TrpHis: 0.368 ± 0.02
0.708TrpIle: 0.708 ± 0.024
0.458TrpLys: 0.458 ± 0.018
2.029TrpLeu: 2.029 ± 0.047
0.414TrpMet: 0.414 ± 0.019
0.393TrpAsn: 0.393 ± 0.018
0.674TrpPro: 0.674 ± 0.025
0.708TrpGln: 0.708 ± 0.025
1.21TrpArg: 1.21 ± 0.035
0.734TrpSer: 0.734 ± 0.025
0.626TrpThr: 0.626 ± 0.024
1.008TrpVal: 1.008 ± 0.029
0.233TrpTrp: 0.233 ± 0.014
0.278TrpTyr: 0.278 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.566TyrAla: 2.566 ± 0.049
0.242TyrCys: 0.242 ± 0.015
1.187TyrAsp: 1.187 ± 0.035
1.116TyrGlu: 1.116 ± 0.029
0.878TyrPhe: 0.878 ± 0.028
1.935TyrGly: 1.935 ± 0.042
0.479TyrHis: 0.479 ± 0.019
0.791TyrIle: 0.791 ± 0.025
0.601TyrLys: 0.601 ± 0.025
2.426TyrLeu: 2.426 ± 0.042
0.39TyrMet: 0.39 ± 0.018
0.585TyrAsn: 0.585 ± 0.024
1.085TyrPro: 1.085 ± 0.03
0.76TyrGln: 0.76 ± 0.023
1.898TyrArg: 1.898 ± 0.037
1.092TyrSer: 1.092 ± 0.029
1.12TyrThr: 1.12 ± 0.027
1.625TyrVal: 1.625 ± 0.038
0.35TyrTrp: 0.35 ± 0.016
0.577TyrTyr: 0.577 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3951 proteins (1270611 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski