Amino acid dipepetide frequency for Pedobacter antarcticus 4BY

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.702AlaAla: 6.702 ± 0.09	0.644AlaCys: 0.644 ± 0.022	4.501AlaAsp: 4.501 ± 0.064	4.893AlaGlu: 4.893 ± 0.069	3.453AlaPhe: 3.453 ± 0.053	5.948AlaGly: 5.948 ± 0.076	1.241AlaHis: 1.241 ± 0.033	5.368AlaIle: 5.368 ± 0.074	4.552AlaLys: 4.552 ± 0.067	7.065AlaLeu: 7.065 ± 0.068	1.794AlaMet: 1.794 ± 0.043	3.424AlaAsn: 3.424 ± 0.066	2.182AlaPro: 2.182 ± 0.046	2.862AlaGln: 2.862 ± 0.053	2.544AlaArg: 2.544 ± 0.053	4.454AlaSer: 4.454 ± 0.057	3.652AlaThr: 3.652 ± 0.051	5.138AlaVal: 5.138 ± 0.069	0.77AlaTrp: 0.77 ± 0.027	2.854AlaTyr: 2.854 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.521CysAla: 0.521 ± 0.025	0.145CysCys: 0.145 ± 0.01	0.369CysAsp: 0.369 ± 0.017	0.355CysGlu: 0.355 ± 0.016	0.395CysPhe: 0.395 ± 0.015	0.637CysGly: 0.637 ± 0.025	0.185CysHis: 0.185 ± 0.013	0.606CysIle: 0.606 ± 0.021	0.485CysLys: 0.485 ± 0.02	0.782CysLeu: 0.782 ± 0.026	0.185CysMet: 0.185 ± 0.012	0.349CysAsn: 0.349 ± 0.019	0.33CysPro: 0.33 ± 0.02	0.22CysGln: 0.22 ± 0.014	0.298CysArg: 0.298 ± 0.016	0.513CysSer: 0.513 ± 0.023	0.415CysThr: 0.415 ± 0.018	0.427CysVal: 0.427 ± 0.015	0.069CysTrp: 0.069 ± 0.007	0.288CysTyr: 0.288 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.686AspAla: 3.686 ± 0.06	0.364AspCys: 0.364 ± 0.016	2.373AspAsp: 2.373 ± 0.047	3.256AspGlu: 3.256 ± 0.053	3.153AspPhe: 3.153 ± 0.054	3.543AspGly: 3.543 ± 0.066	1.047AspHis: 1.047 ± 0.032	3.972AspIle: 3.972 ± 0.054	3.704AspLys: 3.704 ± 0.057	5.327AspLeu: 5.327 ± 0.069	1.217AspMet: 1.217 ± 0.029	2.477AspAsn: 2.477 ± 0.046	2.095AspPro: 2.095 ± 0.044	2.26AspGln: 2.26 ± 0.045	2.223AspArg: 2.223 ± 0.04	2.826AspSer: 2.826 ± 0.046	2.54AspThr: 2.54 ± 0.049	3.208AspVal: 3.208 ± 0.053	0.726AspTrp: 0.726 ± 0.024	2.49AspTyr: 2.49 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	4.104GluAla: 4.104 ± 0.064	0.326GluCys: 0.326 ± 0.017	2.889GluAsp: 2.889 ± 0.052	4.056GluGlu: 4.056 ± 0.073	2.613GluPhe: 2.613 ± 0.041	3.283GluGly: 3.283 ± 0.051	1.113GluHis: 1.113 ± 0.027	4.787GluIle: 4.787 ± 0.067	5.002GluLys: 5.002 ± 0.08	6.418GluLeu: 6.418 ± 0.083	1.57GluMet: 1.57 ± 0.038	3.616GluAsn: 3.616 ± 0.059	1.631GluPro: 1.631 ± 0.038	2.778GluGln: 2.778 ± 0.05	2.666GluArg: 2.666 ± 0.05	3.127GluSer: 3.127 ± 0.049	3.138GluThr: 3.138 ± 0.05	3.798GluVal: 3.798 ± 0.056	0.627GluTrp: 0.627 ± 0.023	2.023GluTyr: 2.023 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.364PheAla: 3.364 ± 0.053	0.454PheCys: 0.454 ± 0.019	2.783PheAsp: 2.783 ± 0.049	2.746PheGlu: 2.746 ± 0.054	2.532PhePhe: 2.532 ± 0.055	3.538PheGly: 3.538 ± 0.048	0.881PheHis: 0.881 ± 0.032	3.74PheIle: 3.74 ± 0.072	3.288PheLys: 3.288 ± 0.049	4.51PheLeu: 4.51 ± 0.074	1.103PheMet: 1.103 ± 0.03	2.906PheAsn: 2.906 ± 0.054	1.741PhePro: 1.741 ± 0.037	1.525PheGln: 1.525 ± 0.037	2.048PheArg: 2.048 ± 0.041	3.904PheSer: 3.904 ± 0.065	3.002PheThr: 3.002 ± 0.049	2.728PheVal: 2.728 ± 0.043	0.547PheTrp: 0.547 ± 0.025	2.083PheTyr: 2.083 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.494GlyAla: 4.494 ± 0.078	0.582GlyCys: 0.582 ± 0.024	3.164GlyAsp: 3.164 ± 0.052	3.457GlyGlu: 3.457 ± 0.056	3.677GlyPhe: 3.677 ± 0.06	4.792GlyGly: 4.792 ± 0.083	1.222GlyHis: 1.222 ± 0.036	5.686GlyIle: 5.686 ± 0.069	5.503GlyLys: 5.503 ± 0.065	6.727GlyLeu: 6.727 ± 0.076	1.755GlyMet: 1.755 ± 0.038	3.58GlyAsn: 3.58 ± 0.063	1.598GlyPro: 1.598 ± 0.035	2.364GlyGln: 2.364 ± 0.046	2.616GlyArg: 2.616 ± 0.052	4.48GlySer: 4.48 ± 0.076	4.009GlyThr: 4.009 ± 0.076	4.381GlyVal: 4.381 ± 0.067	0.876GlyTrp: 0.876 ± 0.028	3.092GlyTyr: 3.092 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.188HisAla: 1.188 ± 0.028	0.199HisCys: 0.199 ± 0.013	0.849HisAsp: 0.849 ± 0.024	1.009HisGlu: 1.009 ± 0.028	1.132HisPhe: 1.132 ± 0.032	1.12HisGly: 1.12 ± 0.032	0.513HisHis: 0.513 ± 0.02	1.399HisIle: 1.399 ± 0.034	1.006HisLys: 1.006 ± 0.029	1.923HisLeu: 1.923 ± 0.044	0.364HisMet: 0.364 ± 0.017	0.838HisAsn: 0.838 ± 0.027	0.951HisPro: 0.951 ± 0.026	0.859HisGln: 0.859 ± 0.028	0.765HisArg: 0.765 ± 0.025	1.06HisSer: 1.06 ± 0.032	1.055HisThr: 1.055 ± 0.029	0.908HisVal: 0.908 ± 0.031	0.251HisTrp: 0.251 ± 0.014	0.826HisTyr: 0.826 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.083IleAla: 6.083 ± 0.07	0.766IleCys: 0.766 ± 0.024	4.07IleAsp: 4.07 ± 0.055	4.326IleGlu: 4.326 ± 0.065	3.28IlePhe: 3.28 ± 0.065	4.981IleGly: 4.981 ± 0.068	1.369IleHis: 1.369 ± 0.034	5.262IleIle: 5.262 ± 0.076	4.887IleLys: 4.887 ± 0.065	6.946IleLeu: 6.946 ± 0.092	1.471IleMet: 1.471 ± 0.039	4.137IleAsn: 4.137 ± 0.058	3.322IlePro: 3.322 ± 0.043	2.656IleGln: 2.656 ± 0.043	3.314IleArg: 3.314 ± 0.055	5.646IleSer: 5.646 ± 0.08	4.426IleThr: 4.426 ± 0.065	4.251IleVal: 4.251 ± 0.071	0.746IleTrp: 0.746 ± 0.022	2.8IleTyr: 2.8 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	5.02LysAla: 5.02 ± 0.068	0.304LysCys: 0.304 ± 0.016	4.131LysAsp: 4.131 ± 0.062	4.693LysGlu: 4.693 ± 0.076	2.737LysPhe: 2.737 ± 0.05	4.594LysGly: 4.594 ± 0.068	1.217LysHis: 1.217 ± 0.033	5.306LysIle: 5.306 ± 0.066	5.326LysLys: 5.326 ± 0.078	6.256LysLeu: 6.256 ± 0.074	1.908LysMet: 1.908 ± 0.036	4.173LysAsn: 4.173 ± 0.06	2.686LysPro: 2.686 ± 0.049	2.79LysGln: 2.79 ± 0.051	2.681LysArg: 2.681 ± 0.049	4.305LysSer: 4.305 ± 0.059	4.024LysThr: 4.024 ± 0.058	4.339LysVal: 4.339 ± 0.062	0.747LysTrp: 0.747 ± 0.023	2.709LysTyr: 2.709 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	6.94LeuAla: 6.94 ± 0.082	0.826LeuCys: 0.826 ± 0.026	4.928LeuAsp: 4.928 ± 0.062	5.553LeuGlu: 5.553 ± 0.088	4.814LeuPhe: 4.814 ± 0.069	5.838LeuGly: 5.838 ± 0.067	1.777LeuHis: 1.777 ± 0.036	7.466LeuIle: 7.466 ± 0.094	7.625LeuLys: 7.625 ± 0.086	10.122LeuLeu: 10.122 ± 0.115	2.402LeuMet: 2.402 ± 0.041	5.789LeuAsn: 5.789 ± 0.077	4.061LeuPro: 4.061 ± 0.054	3.979LeuGln: 3.979 ± 0.066	3.818LeuArg: 3.818 ± 0.06	7.371LeuSer: 7.371 ± 0.074	5.388LeuThr: 5.388 ± 0.062	5.61LeuVal: 5.61 ± 0.074	0.917LeuTrp: 0.917 ± 0.027	3.358LeuTyr: 3.358 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	1.81MetAla: 1.81 ± 0.042	0.127MetCys: 0.127 ± 0.01	1.289MetAsp: 1.289 ± 0.031	1.643MetGlu: 1.643 ± 0.036	0.813MetPhe: 0.813 ± 0.024	1.576MetGly: 1.576 ± 0.037	0.45MetHis: 0.45 ± 0.02	1.654MetIle: 1.654 ± 0.034	2.042MetLys: 2.042 ± 0.04	2.298MetLeu: 2.298 ± 0.04	0.627MetMet: 0.627 ± 0.025	1.415MetAsn: 1.415 ± 0.037	1.001MetPro: 1.001 ± 0.031	0.958MetGln: 0.958 ± 0.028	0.955MetArg: 0.955 ± 0.026	1.434MetSer: 1.434 ± 0.029	1.125MetThr: 1.125 ± 0.028	1.476MetVal: 1.476 ± 0.036	0.174MetTrp: 0.174 ± 0.012	0.623MetTyr: 0.623 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.804AsnAla: 3.804 ± 0.059	0.35AsnCys: 0.35 ± 0.017	2.567AsnAsp: 2.567 ± 0.038	2.962AsnGlu: 2.962 ± 0.056	2.776AsnPhe: 2.776 ± 0.049	3.82AsnGly: 3.82 ± 0.06	0.937AsnHis: 0.937 ± 0.029	3.992AsnIle: 3.992 ± 0.06	3.567AsnLys: 3.567 ± 0.055	5.234AsnLeu: 5.234 ± 0.063	1.162AsnMet: 1.162 ± 0.029	2.96AsnAsn: 2.96 ± 0.056	2.657AsnPro: 2.657 ± 0.044	2.177AsnGln: 2.177 ± 0.048	2.275AsnArg: 2.275 ± 0.046	3.468AsnSer: 3.468 ± 0.058	3.166AsnThr: 3.166 ± 0.051	2.927AsnVal: 2.927 ± 0.061	0.735AsnTrp: 0.735 ± 0.025	2.472AsnTyr: 2.472 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	3.265ProAla: 3.265 ± 0.058	0.212ProCys: 0.212 ± 0.012	2.486ProAsp: 2.486 ± 0.05	3.194ProGlu: 3.194 ± 0.052	1.889ProPhe: 1.889 ± 0.04	2.913ProGly: 2.913 ± 0.045	0.615ProHis: 0.615 ± 0.022	2.127ProIle: 2.127 ± 0.047	2.1ProLys: 2.1 ± 0.043	3.414ProLeu: 3.414 ± 0.052	0.778ProMet: 0.778 ± 0.026	1.674ProAsn: 1.674 ± 0.038	0.932ProPro: 0.932 ± 0.029	1.35ProGln: 1.35 ± 0.032	1.066ProArg: 1.066 ± 0.028	2.147ProSer: 2.147 ± 0.043	1.658ProThr: 1.658 ± 0.04	3.506ProVal: 3.506 ± 0.053	0.363ProTrp: 0.363 ± 0.018	1.544ProTyr: 1.544 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	2.825GlnAla: 2.825 ± 0.051	0.186GlnCys: 0.186 ± 0.012	1.908GlnAsp: 1.908 ± 0.04	2.434GlnGlu: 2.434 ± 0.051	1.72GlnPhe: 1.72 ± 0.036	2.196GlnGly: 2.196 ± 0.037	0.842GlnHis: 0.842 ± 0.029	2.91GlnIle: 2.91 ± 0.05	2.695GlnLys: 2.695 ± 0.038	4.191GlnLeu: 4.191 ± 0.064	0.941GlnMet: 0.941 ± 0.027	2.044GlnAsn: 2.044 ± 0.049	1.371GlnPro: 1.371 ± 0.029	2.326GlnGln: 2.326 ± 0.062	1.601GlnArg: 1.601 ± 0.047	2.23GlnSer: 2.23 ± 0.042	2.225GlnThr: 2.225 ± 0.04	2.479GlnVal: 2.479 ± 0.047	0.387GlnTrp: 0.387 ± 0.019	1.437GlnTyr: 1.437 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.561ArgAla: 2.561 ± 0.052	0.22ArgCys: 0.22 ± 0.013	1.993ArgAsp: 1.993 ± 0.04	2.439ArgGlu: 2.439 ± 0.047	2.137ArgPhe: 2.137 ± 0.041	2.114ArgGly: 2.114 ± 0.046	0.685ArgHis: 0.685 ± 0.023	3.357ArgIle: 3.357 ± 0.056	3.192ArgLys: 3.192 ± 0.054	4.074ArgLeu: 4.074 ± 0.056	1.111ArgMet: 1.111 ± 0.027	2.379ArgAsn: 2.379 ± 0.042	1.364ArgPro: 1.364 ± 0.033	1.538ArgGln: 1.538 ± 0.043	1.618ArgArg: 1.618 ± 0.037	2.54ArgSer: 2.54 ± 0.055	2.193ArgThr: 2.193 ± 0.045	2.368ArgVal: 2.368 ± 0.037	0.464ArgTrp: 0.464 ± 0.019	1.706ArgTyr: 1.706 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.074SerAla: 5.074 ± 0.067	0.569SerCys: 0.569 ± 0.024	3.205SerAsp: 3.205 ± 0.052	3.323SerGlu: 3.323 ± 0.054	3.631SerPhe: 3.631 ± 0.062	5.324SerGly: 5.324 ± 0.069	1.134SerHis: 1.134 ± 0.029	4.704SerIle: 4.704 ± 0.063	4.084SerLys: 4.084 ± 0.059	6.506SerLeu: 6.506 ± 0.065	1.472SerMet: 1.472 ± 0.033	3.179SerAsn: 3.179 ± 0.052	2.447SerPro: 2.447 ± 0.049	2.088SerGln: 2.088 ± 0.045	2.8SerArg: 2.8 ± 0.053	4.401SerSer: 4.401 ± 0.067	3.498SerThr: 3.498 ± 0.061	4.313SerVal: 4.313 ± 0.061	0.785SerTrp: 0.785 ± 0.023	2.702SerTyr: 2.702 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.756ThrAla: 4.756 ± 0.064	0.323ThrCys: 0.323 ± 0.016	3.211ThrAsp: 3.211 ± 0.048	3.112ThrGlu: 3.112 ± 0.048	2.648ThrPhe: 2.648 ± 0.055	4.801ThrGly: 4.801 ± 0.064	0.914ThrHis: 0.914 ± 0.026	4.127ThrIle: 4.127 ± 0.059	2.978ThrLys: 2.978 ± 0.05	5.334ThrLeu: 5.334 ± 0.069	1.012ThrMet: 1.012 ± 0.029	2.613ThrAsn: 2.613 ± 0.056	2.439ThrPro: 2.439 ± 0.043	1.812ThrGln: 1.812 ± 0.043	2.061ThrArg: 2.061 ± 0.04	3.364ThrSer: 3.364 ± 0.062	3.107ThrThr: 3.107 ± 0.054	3.808ThrVal: 3.808 ± 0.049	0.558ThrTrp: 0.558 ± 0.022	2.216ThrTyr: 2.216 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	4.4ValAla: 4.4 ± 0.066	0.534ValCys: 0.534 ± 0.024	3.137ValAsp: 3.137 ± 0.049	3.451ValGlu: 3.451 ± 0.05	3.272ValPhe: 3.272 ± 0.052	3.611ValGly: 3.611 ± 0.06	1.05ValHis: 1.05 ± 0.029	4.926ValIle: 4.926 ± 0.068	4.484ValLys: 4.484 ± 0.067	6.256ValLeu: 6.256 ± 0.069	1.491ValMet: 1.491 ± 0.043	3.554ValAsn: 3.554 ± 0.067	2.507ValPro: 2.507 ± 0.045	2.127ValGln: 2.127 ± 0.043	2.441ValArg: 2.441 ± 0.045	4.611ValSer: 4.611 ± 0.071	3.482ValThr: 3.482 ± 0.055	3.979ValVal: 3.979 ± 0.059	0.677ValTrp: 0.677 ± 0.024	2.405ValTyr: 2.405 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.699TrpAla: 0.699 ± 0.023	0.105TrpCys: 0.105 ± 0.009	0.592TrpAsp: 0.592 ± 0.022	0.63TrpGlu: 0.63 ± 0.023	0.592TrpPhe: 0.592 ± 0.021	0.742TrpGly: 0.742 ± 0.024	0.215TrpHis: 0.215 ± 0.013	0.766TrpIle: 0.766 ± 0.027	0.808TrpLys: 0.808 ± 0.026	1.155TrpLeu: 1.155 ± 0.03	0.342TrpMet: 0.342 ± 0.017	0.647TrpAsn: 0.647 ± 0.022	0.313TrpPro: 0.313 ± 0.016	0.434TrpGln: 0.434 ± 0.019	0.444TrpArg: 0.444 ± 0.017	0.687TrpSer: 0.687 ± 0.021	0.587TrpThr: 0.587 ± 0.02	0.678TrpVal: 0.678 ± 0.027	0.166TrpTrp: 0.166 ± 0.013	0.441TrpTyr: 0.441 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.743TyrAla: 2.743 ± 0.053	0.337TyrCys: 0.337 ± 0.018	2.042TyrAsp: 2.042 ± 0.04	2.032TyrGlu: 2.032 ± 0.043	2.161TyrPhe: 2.161 ± 0.046	2.685TyrGly: 2.685 ± 0.048	0.81TyrHis: 0.81 ± 0.025	2.582TyrIle: 2.582 ± 0.047	2.619TyrLys: 2.619 ± 0.05	4.043TyrLeu: 4.043 ± 0.063	0.784TyrMet: 0.784 ± 0.026	2.254TyrAsn: 2.254 ± 0.049	1.603TyrPro: 1.603 ± 0.04	1.848TyrGln: 1.848 ± 0.036	1.819TyrArg: 1.819 ± 0.042	2.671TyrSer: 2.671 ± 0.045	2.504TyrThr: 2.504 ± 0.048	2.073TyrVal: 2.073 ± 0.038	0.457TyrTrp: 0.457 ± 0.018	1.705TyrTyr: 1.705 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3836 proteins (1283354 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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