Amino acid dipepetide frequency for Candidatus Methylopumilus planktonicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.437AlaAla: 5.437 ± 0.162
0.73AlaCys: 0.73 ± 0.041
3.463AlaAsp: 3.463 ± 0.098
4.143AlaGlu: 4.143 ± 0.119
3.342AlaPhe: 3.342 ± 0.101
4.686AlaGly: 4.686 ± 0.163
1.743AlaHis: 1.743 ± 0.073
6.555AlaIle: 6.555 ± 0.14
5.649AlaLys: 5.649 ± 0.132
8.134AlaLeu: 8.134 ± 0.155
2.153AlaMet: 2.153 ± 0.075
3.094AlaAsn: 3.094 ± 0.083
2.286AlaPro: 2.286 ± 0.075
2.583AlaGln: 2.583 ± 0.081
3.023AlaArg: 3.023 ± 0.09
5.185AlaSer: 5.185 ± 0.118
3.513AlaThr: 3.513 ± 0.111
4.253AlaVal: 4.253 ± 0.102
0.83AlaTrp: 0.83 ± 0.048
2.219AlaTyr: 2.219 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
0.599CysAla: 0.599 ± 0.031
0.109CysCys: 0.109 ± 0.019
0.495CysAsp: 0.495 ± 0.03
0.587CysGlu: 0.587 ± 0.036
0.409CysPhe: 0.409 ± 0.032
0.79CysGly: 0.79 ± 0.046
0.35CysHis: 0.35 ± 0.028
0.642CysIle: 0.642 ± 0.036
0.473CysLys: 0.473 ± 0.036
0.835CysLeu: 0.835 ± 0.041
0.159CysMet: 0.159 ± 0.017
0.371CysAsn: 0.371 ± 0.028
0.49CysPro: 0.49 ± 0.034
0.274CysGln: 0.274 ± 0.031
0.333CysArg: 0.333 ± 0.03
0.618CysSer: 0.618 ± 0.044
0.431CysThr: 0.431 ± 0.029
0.523CysVal: 0.523 ± 0.039
0.09CysTrp: 0.09 ± 0.016
0.29CysTyr: 0.29 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
4.001AspAla: 4.001 ± 0.106
0.452AspCys: 0.452 ± 0.033
2.595AspAsp: 2.595 ± 0.08
3.713AspGlu: 3.713 ± 0.098
2.666AspPhe: 2.666 ± 0.086
3.335AspGly: 3.335 ± 0.087
1.223AspHis: 1.223 ± 0.052
4.698AspIle: 4.698 ± 0.115
3.751AspLys: 3.751 ± 0.102
6.022AspLeu: 6.022 ± 0.122
1.325AspMet: 1.325 ± 0.063
1.972AspAsn: 1.972 ± 0.068
2.065AspPro: 2.065 ± 0.067
2.214AspGln: 2.214 ± 0.075
2.34AspArg: 2.34 ± 0.068
2.857AspSer: 2.857 ± 0.084
2.469AspThr: 2.469 ± 0.084
3.577AspVal: 3.577 ± 0.089
0.735AspTrp: 0.735 ± 0.042
1.95AspTyr: 1.95 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
5.387GluAla: 5.387 ± 0.123
0.478GluCys: 0.478 ± 0.035
3.19GluAsp: 3.19 ± 0.091
3.856GluGlu: 3.856 ± 0.113
2.421GluPhe: 2.421 ± 0.076
3.682GluGly: 3.682 ± 0.098
1.41GluHis: 1.41 ± 0.07
5.808GluIle: 5.808 ± 0.118
5.532GluLys: 5.532 ± 0.115
5.708GluLeu: 5.708 ± 0.11
1.584GluMet: 1.584 ± 0.066
3.056GluAsn: 3.056 ± 0.088
1.701GluPro: 1.701 ± 0.076
1.674GluGln: 1.674 ± 0.073
2.545GluArg: 2.545 ± 0.084
4.089GluSer: 4.089 ± 0.112
2.99GluThr: 2.99 ± 0.084
4.262GluVal: 4.262 ± 0.106
0.618GluTrp: 0.618 ± 0.042
1.663GluTyr: 1.663 ± 0.068
0.0GluXaa: 0.0 ± 0.0
Phe
3.09PheAla: 3.09 ± 0.088
0.49PheCys: 0.49 ± 0.035
2.868PheAsp: 2.868 ± 0.076
2.662PheGlu: 2.662 ± 0.079
2.364PhePhe: 2.364 ± 0.091
3.182PheGly: 3.182 ± 0.097
0.944PheHis: 0.944 ± 0.061
3.986PheIle: 3.986 ± 0.109
3.494PheLys: 3.494 ± 0.092
4.319PheLeu: 4.319 ± 0.128
1.111PheMet: 1.111 ± 0.052
2.769PheAsn: 2.769 ± 0.085
1.489PhePro: 1.489 ± 0.061
1.315PheGln: 1.315 ± 0.059
1.444PheArg: 1.444 ± 0.047
3.377PheSer: 3.377 ± 0.098
2.041PheThr: 2.041 ± 0.073
2.757PheVal: 2.757 ± 0.078
0.507PheTrp: 0.507 ± 0.045
1.663PheTyr: 1.663 ± 0.074
0.0PheXaa: 0.0 ± 0.0
Gly
4.888GlyAla: 4.888 ± 0.157
0.773GlyCys: 0.773 ± 0.043
3.263GlyAsp: 3.263 ± 0.097
3.622GlyGlu: 3.622 ± 0.098
3.235GlyPhe: 3.235 ± 0.085
5.1GlyGly: 5.1 ± 0.351
1.546GlyHis: 1.546 ± 0.066
5.613GlyIle: 5.613 ± 0.121
4.614GlyLys: 4.614 ± 0.116
6.465GlyLeu: 6.465 ± 0.152
1.82GlyMet: 1.82 ± 0.069
2.685GlyAsn: 2.685 ± 0.115
1.701GlyPro: 1.701 ± 0.065
2.245GlyGln: 2.245 ± 0.082
2.835GlyArg: 2.835 ± 0.097
4.248GlySer: 4.248 ± 0.139
3.149GlyThr: 3.149 ± 0.158
4.277GlyVal: 4.277 ± 0.116
0.771GlyTrp: 0.771 ± 0.042
2.214GlyTyr: 2.214 ± 0.08
0.0GlyXaa: 0.0 ± 0.0
His
1.741HisAla: 1.741 ± 0.068
0.238HisCys: 0.238 ± 0.024
1.154HisAsp: 1.154 ± 0.051
1.32HisGlu: 1.32 ± 0.06
1.218HisPhe: 1.218 ± 0.06
1.539HisGly: 1.539 ± 0.059
0.768HisHis: 0.768 ± 0.053
1.85HisIle: 1.85 ± 0.076
1.344HisLys: 1.344 ± 0.055
2.557HisLeu: 2.557 ± 0.082
0.587HisMet: 0.587 ± 0.035
0.968HisAsn: 0.968 ± 0.046
1.223HisPro: 1.223 ± 0.06
1.07HisGln: 1.07 ± 0.049
0.93HisArg: 0.93 ± 0.054
1.337HisSer: 1.337 ± 0.067
1.039HisThr: 1.039 ± 0.044
1.427HisVal: 1.427 ± 0.055
0.281HisTrp: 0.281 ± 0.026
0.823HisTyr: 0.823 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
6.627IleAla: 6.627 ± 0.133
0.661IleCys: 0.661 ± 0.047
5.425IleAsp: 5.425 ± 0.116
6.332IleGlu: 6.332 ± 0.146
3.634IlePhe: 3.634 ± 0.109
5.53IleGly: 5.53 ± 0.129
2.06IleHis: 2.06 ± 0.076
5.528IleIle: 5.528 ± 0.145
7.15IleLys: 7.15 ± 0.166
7.511IleLeu: 7.511 ± 0.174
1.677IleMet: 1.677 ± 0.068
4.288IleAsn: 4.288 ± 0.112
3.287IlePro: 3.287 ± 0.085
3.385IleGln: 3.385 ± 0.11
3.149IleArg: 3.149 ± 0.094
5.892IleSer: 5.892 ± 0.123
4.3IleThr: 4.3 ± 0.122
4.759IleVal: 4.759 ± 0.114
0.706IleTrp: 0.706 ± 0.044
2.471IleTyr: 2.471 ± 0.092
0.0IleXaa: 0.0 ± 0.0
Lys
5.48LysAla: 5.48 ± 0.128
0.416LysCys: 0.416 ± 0.031
4.36LysAsp: 4.36 ± 0.103
5.378LysGlu: 5.378 ± 0.107
2.581LysPhe: 2.581 ± 0.089
4.046LysGly: 4.046 ± 0.117
1.632LysHis: 1.632 ± 0.054
6.945LysIle: 6.945 ± 0.168
7.868LysLys: 7.868 ± 0.204
7.307LysLeu: 7.307 ± 0.136
1.929LysMet: 1.929 ± 0.07
5.147LysAsn: 5.147 ± 0.147
2.983LysPro: 2.983 ± 0.091
2.528LysGln: 2.528 ± 0.086
3.116LysArg: 3.116 ± 0.089
5.138LysSer: 5.138 ± 0.137
4.448LysThr: 4.448 ± 0.105
4.419LysVal: 4.419 ± 0.124
0.504LysTrp: 0.504 ± 0.03
2.015LysTyr: 2.015 ± 0.071
0.0LysXaa: 0.0 ± 0.0
Leu
7.266LeuAla: 7.266 ± 0.14
0.899LeuCys: 0.899 ± 0.051
5.344LeuAsp: 5.344 ± 0.106
5.758LeuGlu: 5.758 ± 0.15
4.571LeuPhe: 4.571 ± 0.109
6.529LeuGly: 6.529 ± 0.138
1.991LeuHis: 1.991 ± 0.071
8.627LeuIle: 8.627 ± 0.139
8.598LeuLys: 8.598 ± 0.166
9.381LeuLeu: 9.381 ± 0.175
2.559LeuMet: 2.559 ± 0.088
5.637LeuAsn: 5.637 ± 0.121
4.101LeuPro: 4.101 ± 0.103
2.933LeuGln: 2.933 ± 0.095
3.929LeuArg: 3.929 ± 0.115
7.68LeuSer: 7.68 ± 0.14
5.387LeuThr: 5.387 ± 0.116
5.475LeuVal: 5.475 ± 0.129
0.987LeuTrp: 0.987 ± 0.056
2.557LeuTyr: 2.557 ± 0.085
0.0LeuXaa: 0.0 ± 0.0
Met
2.076MetAla: 2.076 ± 0.08
0.171MetCys: 0.171 ± 0.023
1.227MetAsp: 1.227 ± 0.057
1.375MetGlu: 1.375 ± 0.057
0.904MetPhe: 0.904 ± 0.048
1.727MetGly: 1.727 ± 0.066
0.628MetHis: 0.628 ± 0.038
2.015MetIle: 2.015 ± 0.079
2.072MetLys: 2.072 ± 0.073
2.331MetLeu: 2.331 ± 0.081
0.84MetMet: 0.84 ± 0.058
1.408MetAsn: 1.408 ± 0.055
1.199MetPro: 1.199 ± 0.058
1.03MetGln: 1.03 ± 0.052
1.123MetArg: 1.123 ± 0.057
1.755MetSer: 1.755 ± 0.063
1.515MetThr: 1.515 ± 0.061
1.382MetVal: 1.382 ± 0.066
0.14MetTrp: 0.14 ± 0.02
0.466MetTyr: 0.466 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
3.416AsnAla: 3.416 ± 0.111
0.378AsnCys: 0.378 ± 0.026
2.578AsnAsp: 2.578 ± 0.071
3.104AsnGlu: 3.104 ± 0.092
2.379AsnPhe: 2.379 ± 0.082
2.75AsnGly: 2.75 ± 0.142
1.258AsnHis: 1.258 ± 0.06
4.296AsnIle: 4.296 ± 0.11
3.813AsnLys: 3.813 ± 0.111
5.059AsnLeu: 5.059 ± 0.115
1.096AsnMet: 1.096 ± 0.056
2.331AsnAsn: 2.331 ± 0.084
2.307AsnPro: 2.307 ± 0.072
2.543AsnGln: 2.543 ± 0.082
1.879AsnArg: 1.879 ± 0.073
2.742AsnSer: 2.742 ± 0.118
2.467AsnThr: 2.467 ± 0.082
2.669AsnVal: 2.669 ± 0.081
0.533AsnTrp: 0.533 ± 0.032
1.556AsnTyr: 1.556 ± 0.068
0.0AsnXaa: 0.0 ± 0.0
Pro
2.355ProAla: 2.355 ± 0.083
0.304ProCys: 0.304 ± 0.025
2.107ProAsp: 2.107 ± 0.08
2.623ProGlu: 2.623 ± 0.092
1.741ProPhe: 1.741 ± 0.071
2.402ProGly: 2.402 ± 0.086
0.963ProHis: 0.963 ± 0.045
3.285ProIle: 3.285 ± 0.086
2.866ProLys: 2.866 ± 0.077
3.596ProLeu: 3.596 ± 0.102
0.959ProMet: 0.959 ± 0.045
1.927ProAsn: 1.927 ± 0.08
1.232ProPro: 1.232 ± 0.065
1.406ProGln: 1.406 ± 0.067
1.263ProArg: 1.263 ± 0.057
2.612ProSer: 2.612 ± 0.067
1.879ProThr: 1.879 ± 0.065
2.324ProVal: 2.324 ± 0.073
0.385ProTrp: 0.385 ± 0.03
1.287ProTyr: 1.287 ± 0.061
0.0ProXaa: 0.0 ± 0.0
Gln
2.507GlnAla: 2.507 ± 0.077
0.319GlnCys: 0.319 ± 0.03
2.007GlnAsp: 2.007 ± 0.067
2.093GlnGlu: 2.093 ± 0.076
1.786GlnPhe: 1.786 ± 0.066
2.155GlnGly: 2.155 ± 0.07
0.913GlnHis: 0.913 ± 0.05
2.814GlnIle: 2.814 ± 0.095
3.128GlnLys: 3.128 ± 0.09
3.513GlnLeu: 3.513 ± 0.104
0.961GlnMet: 0.961 ± 0.047
1.732GlnAsn: 1.732 ± 0.078
1.165GlnPro: 1.165 ± 0.053
1.085GlnGln: 1.085 ± 0.053
1.375GlnArg: 1.375 ± 0.069
2.612GlnSer: 2.612 ± 0.087
1.789GlnThr: 1.789 ± 0.066
2.05GlnVal: 2.05 ± 0.073
0.433GlnTrp: 0.433 ± 0.031
1.175GlnTyr: 1.175 ± 0.057
0.0GlnXaa: 0.0 ± 0.0
Arg
2.907ArgAla: 2.907 ± 0.08
0.338ArgCys: 0.338 ± 0.03
2.26ArgAsp: 2.26 ± 0.078
2.659ArgGlu: 2.659 ± 0.085
2.015ArgPhe: 2.015 ± 0.078
2.474ArgGly: 2.474 ± 0.078
0.897ArgHis: 0.897 ± 0.045
3.287ArgIle: 3.287 ± 0.095
2.581ArgLys: 2.581 ± 0.083
4.139ArgLeu: 4.139 ± 0.104
1.137ArgMet: 1.137 ± 0.054
1.81ArgAsn: 1.81 ± 0.06
1.413ArgPro: 1.413 ± 0.058
1.451ArgGln: 1.451 ± 0.061
1.834ArgArg: 1.834 ± 0.081
2.495ArgSer: 2.495 ± 0.078
1.755ArgThr: 1.755 ± 0.068
2.614ArgVal: 2.614 ± 0.095
0.414ArgTrp: 0.414 ± 0.029
1.479ArgTyr: 1.479 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
4.369SerAla: 4.369 ± 0.122
0.59SerCys: 0.59 ± 0.038
3.62SerAsp: 3.62 ± 0.094
3.894SerGlu: 3.894 ± 0.1
3.394SerPhe: 3.394 ± 0.096
4.733SerGly: 4.733 ± 0.17
1.827SerHis: 1.827 ± 0.072
6.206SerIle: 6.206 ± 0.118
4.783SerLys: 4.783 ± 0.105
7.262SerLeu: 7.262 ± 0.123
1.803SerMet: 1.803 ± 0.075
3.085SerAsn: 3.085 ± 0.085
2.497SerPro: 2.497 ± 0.074
2.514SerGln: 2.514 ± 0.079
2.702SerArg: 2.702 ± 0.086
4.745SerSer: 4.745 ± 0.194
2.971SerThr: 2.971 ± 0.094
3.691SerVal: 3.691 ± 0.098
0.763SerTrp: 0.763 ± 0.041
2.131SerTyr: 2.131 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
3.297ThrAla: 3.297 ± 0.102
0.428ThrCys: 0.428 ± 0.035
2.459ThrAsp: 2.459 ± 0.083
2.697ThrGlu: 2.697 ± 0.083
2.533ThrPhe: 2.533 ± 0.082
3.592ThrGly: 3.592 ± 0.116
1.296ThrHis: 1.296 ± 0.061
3.989ThrIle: 3.989 ± 0.111
3.354ThrLys: 3.354 ± 0.093
5.692ThrLeu: 5.692 ± 0.144
1.108ThrMet: 1.108 ± 0.057
2.333ThrAsn: 2.333 ± 0.096
2.462ThrPro: 2.462 ± 0.077
1.884ThrGln: 1.884 ± 0.072
1.822ThrArg: 1.822 ± 0.074
3.596ThrSer: 3.596 ± 0.106
2.436ThrThr: 2.436 ± 0.097
2.823ThrVal: 2.823 ± 0.09
0.464ThrTrp: 0.464 ± 0.037
1.632ThrTyr: 1.632 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
4.681ValAla: 4.681 ± 0.127
0.628ValCys: 0.628 ± 0.043
3.42ValAsp: 3.42 ± 0.092
3.487ValGlu: 3.487 ± 0.101
2.512ValPhe: 2.512 ± 0.076
4.186ValGly: 4.186 ± 0.123
1.049ValHis: 1.049 ± 0.046
5.399ValIle: 5.399 ± 0.111
4.334ValLys: 4.334 ± 0.112
5.601ValLeu: 5.601 ± 0.129
1.724ValMet: 1.724 ± 0.063
2.928ValAsn: 2.928 ± 0.083
2.238ValPro: 2.238 ± 0.077
1.563ValGln: 1.563 ± 0.065
2.307ValArg: 2.307 ± 0.083
4.084ValSer: 4.084 ± 0.101
3.449ValThr: 3.449 ± 0.081
4.029ValVal: 4.029 ± 0.115
0.571ValTrp: 0.571 ± 0.036
1.506ValTyr: 1.506 ± 0.067
0.0ValXaa: 0.0 ± 0.0
Trp
0.687TrpAla: 0.687 ± 0.035
0.124TrpCys: 0.124 ± 0.018
0.497TrpAsp: 0.497 ± 0.037
0.488TrpGlu: 0.488 ± 0.034
0.535TrpPhe: 0.535 ± 0.041
0.597TrpGly: 0.597 ± 0.039
0.29TrpHis: 0.29 ± 0.029
0.852TrpIle: 0.852 ± 0.059
0.714TrpLys: 0.714 ± 0.038
1.363TrpLeu: 1.363 ± 0.062
0.228TrpMet: 0.228 ± 0.022
0.45TrpAsn: 0.45 ± 0.032
0.331TrpPro: 0.331 ± 0.031
0.452TrpGln: 0.452 ± 0.033
0.502TrpArg: 0.502 ± 0.038
0.583TrpSer: 0.583 ± 0.038
0.433TrpThr: 0.433 ± 0.031
0.661TrpVal: 0.661 ± 0.041
0.126TrpTrp: 0.126 ± 0.019
0.333TrpTyr: 0.333 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.212TyrAla: 2.212 ± 0.072
0.343TyrCys: 0.343 ± 0.027
1.625TyrAsp: 1.625 ± 0.069
1.865TyrGlu: 1.865 ± 0.069
1.632TyrPhe: 1.632 ± 0.071
2.031TyrGly: 2.031 ± 0.072
0.626TyrHis: 0.626 ± 0.04
1.979TyrIle: 1.979 ± 0.074
2.122TyrLys: 2.122 ± 0.074
3.416TyrLeu: 3.416 ± 0.102
0.621TyrMet: 0.621 ± 0.04
1.161TyrAsn: 1.161 ± 0.055
1.349TyrPro: 1.349 ± 0.059
1.463TyrGln: 1.463 ± 0.063
1.506TyrArg: 1.506 ± 0.062
1.938TyrSer: 1.938 ± 0.075
1.437TyrThr: 1.437 ± 0.062
1.722TyrVal: 1.722 ± 0.067
0.385TyrTrp: 0.385 ± 0.034
0.859TyrTyr: 0.859 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1376 proteins (420434 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski