Amino acid dipepetide frequency for Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.835AlaAla: 14.835 ± 0.172	0.966AlaCys: 0.966 ± 0.027	5.946AlaAsp: 5.946 ± 0.071	6.651AlaGlu: 6.651 ± 0.097	3.52AlaPhe: 3.52 ± 0.054	8.916AlaGly: 8.916 ± 0.112	2.144AlaHis: 2.144 ± 0.044	6.949AlaIle: 6.949 ± 0.08	1.726AlaLys: 1.726 ± 0.043	13.655AlaLeu: 13.655 ± 0.142	2.54AlaMet: 2.54 ± 0.044	2.864AlaAsn: 2.864 ± 0.065	5.19AlaPro: 5.19 ± 0.083	4.815AlaGln: 4.815 ± 0.085	8.112AlaArg: 8.112 ± 0.086	4.793AlaSer: 4.793 ± 0.078	6.951AlaThr: 6.951 ± 0.105	7.848AlaVal: 7.848 ± 0.096	1.557AlaTrp: 1.557 ± 0.046	2.774AlaTyr: 2.774 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.896CysAla: 0.896 ± 0.031	0.096CysCys: 0.096 ± 0.009	0.482CysAsp: 0.482 ± 0.019	0.366CysGlu: 0.366 ± 0.018	0.289CysPhe: 0.289 ± 0.013	0.854CysGly: 0.854 ± 0.027	0.238CysHis: 0.238 ± 0.014	0.383CysIle: 0.383 ± 0.015	0.127CysLys: 0.127 ± 0.01	0.756CysLeu: 0.756 ± 0.023	0.138CysMet: 0.138 ± 0.01	0.232CysAsn: 0.232 ± 0.015	0.505CysPro: 0.505 ± 0.021	0.296CysGln: 0.296 ± 0.016	0.616CysArg: 0.616 ± 0.023	0.451CysSer: 0.451 ± 0.016	0.507CysThr: 0.507 ± 0.019	0.5CysVal: 0.5 ± 0.02	0.155CysTrp: 0.155 ± 0.014	0.295CysTyr: 0.295 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.765AspAla: 4.765 ± 0.079	0.358AspCys: 0.358 ± 0.018	2.909AspAsp: 2.909 ± 0.068	3.42AspGlu: 3.42 ± 0.053	1.586AspPhe: 1.586 ± 0.04	4.316AspGly: 4.316 ± 0.088	1.228AspHis: 1.228 ± 0.029	2.581AspIle: 2.581 ± 0.043	0.783AspLys: 0.783 ± 0.027	6.491AspLeu: 6.491 ± 0.078	0.834AspMet: 0.834 ± 0.023	1.21AspAsn: 1.21 ± 0.043	3.8AspPro: 3.8 ± 0.058	2.411AspGln: 2.411 ± 0.048	3.711AspArg: 3.711 ± 0.054	1.993AspSer: 1.993 ± 0.064	2.575AspThr: 2.575 ± 0.045	3.807AspVal: 3.807 ± 0.062	0.898AspTrp: 0.898 ± 0.03	1.515AspTyr: 1.515 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	6.144GluAla: 6.144 ± 0.102	0.317GluCys: 0.317 ± 0.017	1.868GluAsp: 1.868 ± 0.04	3.186GluGlu: 3.186 ± 0.083	1.568GluPhe: 1.568 ± 0.04	3.291GluGly: 3.291 ± 0.056	1.255GluHis: 1.255 ± 0.031	2.968GluIle: 2.968 ± 0.054	1.094GluLys: 1.094 ± 0.035	6.602GluLeu: 6.602 ± 0.094	1.234GluMet: 1.234 ± 0.032	1.054GluAsn: 1.054 ± 0.031	2.923GluPro: 2.923 ± 0.059	3.348GluGln: 3.348 ± 0.061	5.924GluArg: 5.924 ± 0.08	2.005GluSer: 2.005 ± 0.04	2.928GluThr: 2.928 ± 0.049	4.072GluVal: 4.072 ± 0.066	0.908GluTrp: 0.908 ± 0.03	1.32GluTyr: 1.32 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.039PheAla: 4.039 ± 0.055	0.366PheCys: 0.366 ± 0.019	1.991PheAsp: 1.991 ± 0.042	1.595PheGlu: 1.595 ± 0.038	1.445PhePhe: 1.445 ± 0.037	3.095PheGly: 3.095 ± 0.066	0.676PheHis: 0.676 ± 0.023	1.84PheIle: 1.84 ± 0.043	0.553PheLys: 0.553 ± 0.022	3.254PheLeu: 3.254 ± 0.055	0.509PheMet: 0.509 ± 0.019	1.104PheAsn: 1.104 ± 0.031	1.599PhePro: 1.599 ± 0.038	1.081PheGln: 1.081 ± 0.027	2.162PheArg: 2.162 ± 0.041	2.028PheSer: 2.028 ± 0.046	2.205PheThr: 2.205 ± 0.054	2.761PheVal: 2.761 ± 0.053	0.639PheTrp: 0.639 ± 0.025	1.059PheTyr: 1.059 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	6.972GlyAla: 6.972 ± 0.101	0.81GlyCys: 0.81 ± 0.026	3.919GlyAsp: 3.919 ± 0.071	4.27GlyGlu: 4.27 ± 0.076	2.834GlyPhe: 2.834 ± 0.051	6.07GlyGly: 6.07 ± 0.092	1.553GlyHis: 1.553 ± 0.037	4.704GlyIle: 4.704 ± 0.066	2.055GlyLys: 2.055 ± 0.051	8.262GlyLeu: 8.262 ± 0.096	2.018GlyMet: 2.018 ± 0.04	2.22GlyAsn: 2.22 ± 0.071	3.125GlyPro: 3.125 ± 0.055	3.389GlyGln: 3.389 ± 0.058	5.461GlyArg: 5.461 ± 0.068	4.295GlySer: 4.295 ± 0.073	4.191GlyThr: 4.191 ± 0.075	6.021GlyVal: 6.021 ± 0.083	1.626GlyTrp: 1.626 ± 0.04	2.533GlyTyr: 2.533 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.981HisAla: 1.981 ± 0.042	0.227HisCys: 0.227 ± 0.014	1.144HisAsp: 1.144 ± 0.027	1.194HisGlu: 1.194 ± 0.034	0.735HisPhe: 0.735 ± 0.024	1.68HisGly: 1.68 ± 0.04	0.711HisHis: 0.711 ± 0.029	1.176HisIle: 1.176 ± 0.033	0.306HisLys: 0.306 ± 0.017	2.612HisLeu: 2.612 ± 0.049	0.332HisMet: 0.332 ± 0.015	0.584HisAsn: 0.584 ± 0.023	1.65HisPro: 1.65 ± 0.04	0.871HisGln: 0.871 ± 0.029	1.525HisArg: 1.525 ± 0.041	0.958HisSer: 0.958 ± 0.028	1.132HisThr: 1.132 ± 0.029	1.374HisVal: 1.374 ± 0.032	0.364HisTrp: 0.364 ± 0.017	0.684HisTyr: 0.684 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.541IleAla: 7.541 ± 0.09	0.575IleCys: 0.575 ± 0.022	3.915IleAsp: 3.915 ± 0.054	3.827IleGlu: 3.827 ± 0.068	2.067IlePhe: 2.067 ± 0.044	5.618IleGly: 5.618 ± 0.082	1.111IleHis: 1.111 ± 0.029	3.328IleIle: 3.328 ± 0.05	1.16IleLys: 1.16 ± 0.033	5.022IleLeu: 5.022 ± 0.073	0.852IleMet: 0.852 ± 0.028	1.793IleAsn: 1.793 ± 0.035	3.115IlePro: 3.115 ± 0.06	1.696IleGln: 1.696 ± 0.039	3.642IleArg: 3.642 ± 0.054	2.986IleSer: 2.986 ± 0.048	3.799IleThr: 3.799 ± 0.055	5.008IleVal: 5.008 ± 0.073	0.862IleTrp: 0.862 ± 0.033	1.512IleTyr: 1.512 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	1.854LysAla: 1.854 ± 0.044	0.097LysCys: 0.097 ± 0.011	0.773LysAsp: 0.773 ± 0.029	1.015LysGlu: 1.015 ± 0.036	0.487LysPhe: 0.487 ± 0.019	1.299LysGly: 1.299 ± 0.034	0.399LysHis: 0.399 ± 0.018	1.06LysIle: 1.06 ± 0.039	0.485LysLys: 0.485 ± 0.022	1.888LysLeu: 1.888 ± 0.045	0.429LysMet: 0.429 ± 0.017	0.484LysAsn: 0.484 ± 0.02	1.246LysPro: 1.246 ± 0.033	0.817LysGln: 0.817 ± 0.027	1.49LysArg: 1.49 ± 0.04	0.838LysSer: 0.838 ± 0.025	1.058LysThr: 1.058 ± 0.033	1.411LysVal: 1.411 ± 0.035	0.209LysTrp: 0.209 ± 0.012	0.475LysTyr: 0.475 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.223LeuAla: 14.223 ± 0.157	0.963LeuCys: 0.963 ± 0.029	5.345LeuAsp: 5.345 ± 0.065	5.195LeuGlu: 5.195 ± 0.093	3.822LeuPhe: 3.822 ± 0.069	7.608LeuGly: 7.608 ± 0.085	2.402LeuHis: 2.402 ± 0.048	7.381LeuIle: 7.381 ± 0.094	1.941LeuLys: 1.941 ± 0.042	12.855LeuLeu: 12.855 ± 0.145	2.076LeuMet: 2.076 ± 0.035	3.103LeuAsn: 3.103 ± 0.054	7.162LeuPro: 7.162 ± 0.076	4.111LeuGln: 4.111 ± 0.06	9.232LeuArg: 9.232 ± 0.1	6.462LeuSer: 6.462 ± 0.069	6.937LeuThr: 6.937 ± 0.079	8.086LeuVal: 8.086 ± 0.09	1.511LeuTrp: 1.511 ± 0.038	2.634LeuTyr: 2.634 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.376MetAla: 2.376 ± 0.041	0.132MetCys: 0.132 ± 0.009	0.659MetAsp: 0.659 ± 0.023	0.852MetGlu: 0.852 ± 0.026	0.497MetPhe: 0.497 ± 0.021	1.222MetGly: 1.222 ± 0.031	0.43MetHis: 0.43 ± 0.018	1.325MetIle: 1.325 ± 0.029	0.525MetLys: 0.525 ± 0.018	2.4MetLeu: 2.4 ± 0.051	0.475MetMet: 0.475 ± 0.02	0.651MetAsn: 0.651 ± 0.022	1.252MetPro: 1.252 ± 0.034	0.896MetGln: 0.896 ± 0.023	1.554MetArg: 1.554 ± 0.039	1.195MetSer: 1.195 ± 0.03	1.389MetThr: 1.389 ± 0.031	1.614MetVal: 1.614 ± 0.035	0.217MetTrp: 0.217 ± 0.013	0.398MetTyr: 0.398 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.769AsnAla: 2.769 ± 0.049	0.19AsnCys: 0.19 ± 0.011	1.544AsnAsp: 1.544 ± 0.043	1.513AsnGlu: 1.513 ± 0.037	0.792AsnPhe: 0.792 ± 0.025	2.669AsnGly: 2.669 ± 0.088	0.558AsnHis: 0.558 ± 0.019	1.412AsnIle: 1.412 ± 0.032	0.405AsnLys: 0.405 ± 0.019	3.072AsnLeu: 3.072 ± 0.057	0.374AsnMet: 0.374 ± 0.019	0.972AsnAsn: 0.972 ± 0.041	2.081AsnPro: 2.081 ± 0.05	1.122AsnGln: 1.122 ± 0.03	2.069AsnArg: 2.069 ± 0.046	1.14AsnSer: 1.14 ± 0.034	1.534AsnThr: 1.534 ± 0.075	1.926AsnVal: 1.926 ± 0.045	0.439AsnTrp: 0.439 ± 0.018	0.743AsnTyr: 0.743 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.163ProAla: 7.163 ± 0.118	0.332ProCys: 0.332 ± 0.017	3.945ProAsp: 3.945 ± 0.062	3.337ProGlu: 3.337 ± 0.067	2.164ProPhe: 2.164 ± 0.044	4.389ProGly: 4.389 ± 0.074	1.271ProHis: 1.271 ± 0.036	2.948ProIle: 2.948 ± 0.048	0.827ProLys: 0.827 ± 0.025	6.427ProLeu: 6.427 ± 0.07	0.953ProMet: 0.953 ± 0.028	1.616ProAsn: 1.616 ± 0.04	4.24ProPro: 4.24 ± 0.079	2.22ProGln: 2.22 ± 0.044	3.265ProArg: 3.265 ± 0.054	2.649ProSer: 2.649 ± 0.066	4.352ProThr: 4.352 ± 0.111	4.713ProVal: 4.713 ± 0.058	0.837ProTrp: 0.837 ± 0.023	1.448ProTyr: 1.448 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	5.145GlnAla: 5.145 ± 0.082	0.248GlnCys: 0.248 ± 0.014	1.17GlnAsp: 1.17 ± 0.036	1.92GlnGlu: 1.92 ± 0.042	1.224GlnPhe: 1.224 ± 0.033	2.456GlnGly: 2.456 ± 0.047	0.975GlnHis: 0.975 ± 0.026	2.995GlnIle: 2.995 ± 0.048	0.704GlnLys: 0.704 ± 0.024	4.442GlnLeu: 4.442 ± 0.06	1.024GlnMet: 1.024 ± 0.03	0.853GlnAsn: 0.853 ± 0.027	3.114GlnPro: 3.114 ± 0.059	2.466GlnGln: 2.466 ± 0.062	4.243GlnArg: 4.243 ± 0.071	2.05GlnSer: 2.05 ± 0.039	2.456GlnThr: 2.456 ± 0.045	3.177GlnVal: 3.177 ± 0.056	0.617GlnTrp: 0.617 ± 0.023	0.981GlnTyr: 0.981 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.329ArgAla: 7.329 ± 0.094	0.612ArgCys: 0.612 ± 0.021	3.862ArgAsp: 3.862 ± 0.058	4.524ArgGlu: 4.524 ± 0.08	2.871ArgPhe: 2.871 ± 0.046	4.622ArgGly: 4.622 ± 0.063	1.781ArgHis: 1.781 ± 0.04	4.479ArgIle: 4.479 ± 0.065	1.425ArgLys: 1.425 ± 0.045	9.389ArgLeu: 9.389 ± 0.087	1.778ArgMet: 1.778 ± 0.033	2.077ArgAsn: 2.077 ± 0.044	3.87ArgPro: 3.87 ± 0.06	3.878ArgGln: 3.878 ± 0.064	6.653ArgArg: 6.653 ± 0.1	3.864ArgSer: 3.864 ± 0.058	3.671ArgThr: 3.671 ± 0.052	4.938ArgVal: 4.938 ± 0.063	1.56ArgTrp: 1.56 ± 0.042	2.666ArgTyr: 2.666 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.21SerAla: 5.21 ± 0.069	0.363SerCys: 0.363 ± 0.016	2.823SerAsp: 2.823 ± 0.062	2.47SerGlu: 2.47 ± 0.042	1.935SerPhe: 1.935 ± 0.034	4.803SerGly: 4.803 ± 0.084	1.015SerHis: 1.015 ± 0.026	2.655SerIle: 2.655 ± 0.043	0.76SerLys: 0.76 ± 0.026	5.438SerLeu: 5.438 ± 0.074	0.964SerMet: 0.964 ± 0.023	1.324SerAsn: 1.324 ± 0.043	3.218SerPro: 3.218 ± 0.058	1.773SerGln: 1.773 ± 0.032	3.346SerArg: 3.346 ± 0.055	2.809SerSer: 2.809 ± 0.057	2.891SerThr: 2.891 ± 0.056	3.361SerVal: 3.361 ± 0.053	0.79SerTrp: 0.79 ± 0.029	1.334SerTyr: 1.334 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.885ThrAla: 6.885 ± 0.105	0.472ThrCys: 0.472 ± 0.021	2.965ThrAsp: 2.965 ± 0.068	2.38ThrGlu: 2.38 ± 0.042	2.297ThrPhe: 2.297 ± 0.051	4.662ThrGly: 4.662 ± 0.073	1.036ThrHis: 1.036 ± 0.031	4.219ThrIle: 4.219 ± 0.071	0.837ThrLys: 0.837 ± 0.027	7.099ThrLeu: 7.099 ± 0.089	1.15ThrMet: 1.15 ± 0.023	1.771ThrAsn: 1.771 ± 0.074	4.767ThrPro: 4.767 ± 0.121	1.746ThrGln: 1.746 ± 0.039	3.31ThrArg: 3.31 ± 0.051	2.761ThrSer: 2.761 ± 0.053	4.391ThrThr: 4.391 ± 0.108	5.04ThrVal: 5.04 ± 0.088	0.788ThrTrp: 0.788 ± 0.028	1.516ThrTyr: 1.516 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	8.612ValAla: 8.612 ± 0.079	0.686ValCys: 0.686 ± 0.023	3.721ValAsp: 3.721 ± 0.056	4.068ValGlu: 4.068 ± 0.063	2.405ValPhe: 2.405 ± 0.047	5.416ValGly: 5.416 ± 0.058	1.325ValHis: 1.325 ± 0.031	4.956ValIle: 4.956 ± 0.064	1.426ValLys: 1.426 ± 0.036	7.842ValLeu: 7.842 ± 0.092	1.623ValMet: 1.623 ± 0.037	2.105ValAsn: 2.105 ± 0.037	3.944ValPro: 3.944 ± 0.057	2.937ValGln: 2.937 ± 0.047	5.52ValArg: 5.52 ± 0.076	3.982ValSer: 3.982 ± 0.058	4.769ValThr: 4.769 ± 0.08	6.524ValVal: 6.524 ± 0.072	1.142ValTrp: 1.142 ± 0.039	1.985ValTyr: 1.985 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.307TrpAla: 1.307 ± 0.034	0.121TrpCys: 0.121 ± 0.009	0.629TrpAsp: 0.629 ± 0.031	0.754TrpGlu: 0.754 ± 0.025	0.569TrpPhe: 0.569 ± 0.02	1.012TrpGly: 1.012 ± 0.027	0.407TrpHis: 0.407 ± 0.017	0.786TrpIle: 0.786 ± 0.026	0.277TrpLys: 0.277 ± 0.015	2.378TrpLeu: 2.378 ± 0.073	0.376TrpMet: 0.376 ± 0.018	0.473TrpAsn: 0.473 ± 0.025	0.864TrpPro: 0.864 ± 0.025	1.15TrpGln: 1.15 ± 0.031	1.473TrpArg: 1.473 ± 0.035	0.847TrpSer: 0.847 ± 0.028	0.714TrpThr: 0.714 ± 0.023	0.999TrpVal: 0.999 ± 0.027	0.388TrpTrp: 0.388 ± 0.02	0.426TrpTyr: 0.426 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.705TyrAla: 2.705 ± 0.053	0.253TyrCys: 0.253 ± 0.012	1.582TyrAsp: 1.582 ± 0.04	1.47TyrGlu: 1.47 ± 0.035	0.894TyrPhe: 0.894 ± 0.027	2.333TyrGly: 2.333 ± 0.042	0.723TyrHis: 0.723 ± 0.023	1.283TyrIle: 1.283 ± 0.031	0.398TyrLys: 0.398 ± 0.018	3.164TyrLeu: 3.164 ± 0.047	0.382TyrMet: 0.382 ± 0.017	0.834TyrAsn: 0.834 ± 0.028	1.428TyrPro: 1.428 ± 0.036	1.235TyrGln: 1.235 ± 0.034	2.54TyrArg: 2.54 ± 0.043	1.174TyrSer: 1.174 ± 0.033	1.643TyrThr: 1.643 ± 0.041	1.808TyrVal: 1.808 ± 0.038	0.447TyrTrp: 0.447 ± 0.02	0.826TyrTyr: 0.826 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3850 proteins (1405705 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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