Amino acid dipepetide frequency for Alistipes indistinctus YIT 12060

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.21AlaAla: 9.21 ± 0.135	1.044AlaCys: 1.044 ± 0.035	4.952AlaAsp: 4.952 ± 0.078	5.479AlaGlu: 5.479 ± 0.089	3.3AlaPhe: 3.3 ± 0.073	7.466AlaGly: 7.466 ± 0.092	1.368AlaHis: 1.368 ± 0.044	4.725AlaIle: 4.725 ± 0.096	3.956AlaLys: 3.956 ± 0.085	8.435AlaLeu: 8.435 ± 0.129	2.145AlaMet: 2.145 ± 0.056	2.874AlaAsn: 2.874 ± 0.062	3.413AlaPro: 3.413 ± 0.07	3.035AlaGln: 3.035 ± 0.057	4.578AlaArg: 4.578 ± 0.073	4.864AlaSer: 4.864 ± 0.086	4.546AlaThr: 4.546 ± 0.081	6.457AlaVal: 6.457 ± 0.106	0.931AlaTrp: 0.931 ± 0.033	2.947AlaTyr: 2.947 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.906CysAla: 0.906 ± 0.035	0.232CysCys: 0.232 ± 0.02	0.695CysAsp: 0.695 ± 0.033	0.596CysGlu: 0.596 ± 0.023	0.482CysPhe: 0.482 ± 0.022	1.244CysGly: 1.244 ± 0.042	0.255CysHis: 0.255 ± 0.017	0.687CysIle: 0.687 ± 0.029	0.507CysLys: 0.507 ± 0.022	0.836CysLeu: 0.836 ± 0.031	0.29CysMet: 0.29 ± 0.019	0.534CysAsn: 0.534 ± 0.026	0.556CysPro: 0.556 ± 0.027	0.261CysGln: 0.261 ± 0.018	0.785CysArg: 0.785 ± 0.033	0.758CysSer: 0.758 ± 0.032	0.715CysThr: 0.715 ± 0.033	0.715CysVal: 0.715 ± 0.031	0.131CysTrp: 0.131 ± 0.012	0.412CysTyr: 0.412 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.264AspAla: 4.264 ± 0.089	0.59AspCys: 0.59 ± 0.027	2.7AspAsp: 2.7 ± 0.063	3.412AspGlu: 3.412 ± 0.074	2.735AspPhe: 2.735 ± 0.064	4.473AspGly: 4.473 ± 0.083	0.859AspHis: 0.859 ± 0.033	3.483AspIle: 3.483 ± 0.065	3.043AspLys: 3.043 ± 0.063	4.672AspLeu: 4.672 ± 0.074	1.432AspMet: 1.432 ± 0.042	2.331AspAsn: 2.331 ± 0.05	2.789AspPro: 2.789 ± 0.062	1.424AspGln: 1.424 ± 0.044	3.568AspArg: 3.568 ± 0.074	3.201AspSer: 3.201 ± 0.071	3.072AspThr: 3.072 ± 0.064	3.34AspVal: 3.34 ± 0.071	0.738AspTrp: 0.738 ± 0.031	2.745AspTyr: 2.745 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	5.447GluAla: 5.447 ± 0.086	0.528GluCys: 0.528 ± 0.031	2.363GluAsp: 2.363 ± 0.052	3.915GluGlu: 3.915 ± 0.084	2.211GluPhe: 2.211 ± 0.054	4.143GluGly: 4.143 ± 0.082	1.173GluHis: 1.173 ± 0.039	4.086GluIle: 4.086 ± 0.083	3.767GluLys: 3.767 ± 0.074	5.977GluLeu: 5.977 ± 0.082	1.93GluMet: 1.93 ± 0.051	2.641GluAsn: 2.641 ± 0.059	2.051GluPro: 2.051 ± 0.049	2.683GluGln: 2.683 ± 0.067	3.85GluArg: 3.85 ± 0.077	2.987GluSer: 2.987 ± 0.065	3.331GluThr: 3.331 ± 0.064	4.306GluVal: 4.306 ± 0.071	0.798GluTrp: 0.798 ± 0.031	2.205GluTyr: 2.205 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.646PheAla: 3.646 ± 0.061	0.62PheCys: 0.62 ± 0.028	2.878PheAsp: 2.878 ± 0.047	2.214PheGlu: 2.214 ± 0.051	1.889PhePhe: 1.889 ± 0.055	3.592PheGly: 3.592 ± 0.072	0.727PheHis: 0.727 ± 0.031	2.598PheIle: 2.598 ± 0.061	1.739PheLys: 1.739 ± 0.048	3.586PheLeu: 3.586 ± 0.072	1.013PheMet: 1.013 ± 0.033	1.847PheAsn: 1.847 ± 0.053	1.842PhePro: 1.842 ± 0.046	0.949PheGln: 0.949 ± 0.034	2.564PheArg: 2.564 ± 0.057	2.968PheSer: 2.968 ± 0.065	2.686PheThr: 2.686 ± 0.062	2.965PheVal: 2.965 ± 0.065	0.525PheTrp: 0.525 ± 0.027	1.615PheTyr: 1.615 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	6.053GlyAla: 6.053 ± 0.093	1.067GlyCys: 1.067 ± 0.041	4.041GlyAsp: 4.041 ± 0.091	4.736GlyGlu: 4.736 ± 0.081	3.367GlyPhe: 3.367 ± 0.066	6.25GlyGly: 6.25 ± 0.116	1.529GlyHis: 1.529 ± 0.049	5.5GlyIle: 5.5 ± 0.078	4.518GlyLys: 4.518 ± 0.075	6.645GlyLeu: 6.645 ± 0.112	2.275GlyMet: 2.275 ± 0.051	3.235GlyAsn: 3.235 ± 0.071	2.013GlyPro: 2.013 ± 0.051	2.319GlyGln: 2.319 ± 0.055	4.498GlyArg: 4.498 ± 0.083	4.72GlySer: 4.72 ± 0.096	4.933GlyThr: 4.933 ± 0.095	5.743GlyVal: 5.743 ± 0.085	1.109GlyTrp: 1.109 ± 0.047	3.431GlyTyr: 3.431 ± 0.073	0.0GlyXaa: 0.0 ± 0.0
His	1.376HisAla: 1.376 ± 0.041	0.269HisCys: 0.269 ± 0.019	0.988HisAsp: 0.988 ± 0.034	0.945HisGlu: 0.945 ± 0.037	0.901HisPhe: 0.901 ± 0.035	1.362HisGly: 1.362 ± 0.039	0.448HisHis: 0.448 ± 0.02	1.243HisIle: 1.243 ± 0.048	0.878HisLys: 0.878 ± 0.031	1.718HisLeu: 1.718 ± 0.053	0.381HisMet: 0.381 ± 0.022	0.769HisAsn: 0.769 ± 0.027	1.163HisPro: 1.163 ± 0.04	0.47HisGln: 0.47 ± 0.022	1.149HisArg: 1.149 ± 0.042	1.091HisSer: 1.091 ± 0.036	1.134HisThr: 1.134 ± 0.034	1.014HisVal: 1.014 ± 0.033	0.268HisTrp: 0.268 ± 0.017	0.848HisTyr: 0.848 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.802IleAla: 5.802 ± 0.094	0.763IleCys: 0.763 ± 0.031	4.225IleAsp: 4.225 ± 0.08	3.984IleGlu: 3.984 ± 0.076	2.412IlePhe: 2.412 ± 0.063	4.844IleGly: 4.844 ± 0.091	1.161IleHis: 1.161 ± 0.037	3.265IleIle: 3.265 ± 0.076	2.776IleLys: 2.776 ± 0.072	5.435IleLeu: 5.435 ± 0.112	1.214IleMet: 1.214 ± 0.041	2.378IleAsn: 2.378 ± 0.065	3.336IlePro: 3.336 ± 0.072	1.557IleGln: 1.557 ± 0.045	4.119IleArg: 4.119 ± 0.079	3.807IleSer: 3.807 ± 0.074	3.62IleThr: 3.62 ± 0.062	4.44IleVal: 4.44 ± 0.078	0.555IleTrp: 0.555 ± 0.026	2.257IleTyr: 2.257 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	4.21LysAla: 4.21 ± 0.078	0.362LysCys: 0.362 ± 0.022	2.443LysAsp: 2.443 ± 0.063	3.633LysGlu: 3.633 ± 0.072	1.751LysPhe: 1.751 ± 0.046	3.651LysGly: 3.651 ± 0.069	0.876LysHis: 0.876 ± 0.034	3.579LysIle: 3.579 ± 0.074	3.097LysLys: 3.097 ± 0.068	4.593LysLeu: 4.593 ± 0.078	1.702LysMet: 1.702 ± 0.045	2.317LysAsn: 2.317 ± 0.055	2.115LysPro: 2.115 ± 0.055	1.938LysGln: 1.938 ± 0.051	2.836LysArg: 2.836 ± 0.059	2.645LysSer: 2.645 ± 0.052	2.761LysThr: 2.761 ± 0.059	3.437LysVal: 3.437 ± 0.069	0.573LysTrp: 0.573 ± 0.026	2.059LysTyr: 2.059 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	7.902LeuAla: 7.902 ± 0.106	1.311LeuCys: 1.311 ± 0.035	4.953LeuAsp: 4.953 ± 0.086	4.965LeuGlu: 4.965 ± 0.084	4.426LeuPhe: 4.426 ± 0.092	6.565LeuGly: 6.565 ± 0.098	1.867LeuHis: 1.867 ± 0.053	5.398LeuIle: 5.398 ± 0.098	4.782LeuLys: 4.782 ± 0.088	9.722LeuLeu: 9.722 ± 0.156	2.388LeuMet: 2.388 ± 0.057	3.775LeuAsn: 3.775 ± 0.062	4.493LeuPro: 4.493 ± 0.079	3.192LeuGln: 3.192 ± 0.069	5.434LeuArg: 5.434 ± 0.086	6.751LeuSer: 6.751 ± 0.107	5.481LeuThr: 5.481 ± 0.081	5.71LeuVal: 5.71 ± 0.104	1.126LeuTrp: 1.126 ± 0.043	3.419LeuTyr: 3.419 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.215MetAla: 2.215 ± 0.058	0.214MetCys: 0.214 ± 0.014	1.329MetAsp: 1.329 ± 0.039	1.58MetGlu: 1.58 ± 0.043	0.985MetPhe: 0.985 ± 0.034	1.831MetGly: 1.831 ± 0.049	0.439MetHis: 0.439 ± 0.023	1.585MetIle: 1.585 ± 0.044	1.865MetLys: 1.865 ± 0.05	2.624MetLeu: 2.624 ± 0.061	0.692MetMet: 0.692 ± 0.031	1.142MetAsn: 1.142 ± 0.038	1.303MetPro: 1.303 ± 0.041	1.031MetGln: 1.031 ± 0.038	1.581MetArg: 1.581 ± 0.043	1.553MetSer: 1.553 ± 0.04	1.537MetThr: 1.537 ± 0.043	1.541MetVal: 1.541 ± 0.045	0.258MetTrp: 0.258 ± 0.019	0.708MetTyr: 0.708 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.073AsnAla: 3.073 ± 0.064	0.385AsnCys: 0.385 ± 0.023	2.165AsnAsp: 2.165 ± 0.058	2.097AsnGlu: 2.097 ± 0.048	1.729AsnPhe: 1.729 ± 0.052	3.402AsnGly: 3.402 ± 0.08	0.716AsnHis: 0.716 ± 0.029	2.878AsnIle: 2.878 ± 0.069	1.938AsnLys: 1.938 ± 0.05	3.778AsnLeu: 3.778 ± 0.079	1.011AsnMet: 1.011 ± 0.037	1.831AsnAsn: 1.831 ± 0.049	2.466AsnPro: 2.466 ± 0.057	1.19AsnGln: 1.19 ± 0.044	2.632AsnArg: 2.632 ± 0.066	2.218AsnSer: 2.218 ± 0.062	2.361AsnThr: 2.361 ± 0.058	2.67AsnVal: 2.67 ± 0.066	0.485AsnTrp: 0.485 ± 0.026	1.793AsnTyr: 1.793 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	4.545ProAla: 4.545 ± 0.081	0.434ProCys: 0.434 ± 0.023	3.194ProAsp: 3.194 ± 0.066	3.676ProGlu: 3.676 ± 0.065	1.847ProPhe: 1.847 ± 0.046	3.684ProGly: 3.684 ± 0.083	0.875ProHis: 0.875 ± 0.031	2.046ProIle: 2.046 ± 0.055	1.813ProLys: 1.813 ± 0.046	3.952ProLeu: 3.952 ± 0.063	0.997ProMet: 0.997 ± 0.039	1.5ProAsn: 1.5 ± 0.047	1.358ProPro: 1.358 ± 0.046	1.878ProGln: 1.878 ± 0.05	1.896ProArg: 1.896 ± 0.046	2.557ProSer: 2.557 ± 0.059	2.116ProThr: 2.116 ± 0.061	3.958ProVal: 3.958 ± 0.073	0.529ProTrp: 0.529 ± 0.029	1.783ProTyr: 1.783 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	2.805GlnAla: 2.805 ± 0.06	0.285GlnCys: 0.285 ± 0.018	1.353GlnAsp: 1.353 ± 0.044	1.937GlnGlu: 1.937 ± 0.046	1.21GlnPhe: 1.21 ± 0.045	2.345GlnGly: 2.345 ± 0.058	0.609GlnHis: 0.609 ± 0.027	2.168GlnIle: 2.168 ± 0.055	1.823GlnLys: 1.823 ± 0.052	3.138GlnLeu: 3.138 ± 0.072	1.061GlnMet: 1.061 ± 0.039	1.524GlnAsn: 1.524 ± 0.048	1.553GlnPro: 1.553 ± 0.054	1.828GlnGln: 1.828 ± 0.049	2.025GlnArg: 2.025 ± 0.052	1.89GlnSer: 1.89 ± 0.046	1.936GlnThr: 1.936 ± 0.041	2.265GlnVal: 2.265 ± 0.06	0.403GlnTrp: 0.403 ± 0.022	1.362GlnTyr: 1.362 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	3.94ArgAla: 3.94 ± 0.077	0.577ArgCys: 0.577 ± 0.025	2.921ArgAsp: 2.921 ± 0.061	4.041ArgGlu: 4.041 ± 0.084	2.846ArgPhe: 2.846 ± 0.062	3.528ArgGly: 3.528 ± 0.068	1.271ArgHis: 1.271 ± 0.039	4.385ArgIle: 4.385 ± 0.072	3.215ArgLys: 3.215 ± 0.066	5.541ArgLeu: 5.541 ± 0.091	1.787ArgMet: 1.787 ± 0.047	2.628ArgAsn: 2.628 ± 0.058	2.436ArgPro: 2.436 ± 0.052	2.247ArgGln: 2.247 ± 0.059	3.726ArgArg: 3.726 ± 0.083	3.312ArgSer: 3.312 ± 0.069	3.252ArgThr: 3.252 ± 0.063	3.529ArgVal: 3.529 ± 0.079	0.788ArgTrp: 0.788 ± 0.032	2.807ArgTyr: 2.807 ± 0.068	0.0ArgXaa: 0.0 ± 0.0
Ser	5.167SerAla: 5.167 ± 0.078	0.74SerCys: 0.74 ± 0.028	3.348SerAsp: 3.348 ± 0.059	3.299SerGlu: 3.299 ± 0.063	2.772SerPhe: 2.772 ± 0.065	5.533SerGly: 5.533 ± 0.102	1.056SerHis: 1.056 ± 0.037	3.455SerIle: 3.455 ± 0.069	2.657SerLys: 2.657 ± 0.072	5.855SerLeu: 5.855 ± 0.101	1.456SerMet: 1.456 ± 0.04	2.083SerAsn: 2.083 ± 0.059	2.743SerPro: 2.743 ± 0.06	1.94SerGln: 1.94 ± 0.043	3.293SerArg: 3.293 ± 0.067	3.583SerSer: 3.583 ± 0.086	3.007SerThr: 3.007 ± 0.073	4.52SerVal: 4.52 ± 0.081	0.734SerTrp: 0.734 ± 0.028	2.421SerTyr: 2.421 ± 0.064	0.0SerXaa: 0.0 ± 0.0
Thr	5.232ThrAla: 5.232 ± 0.084	0.516ThrCys: 0.516 ± 0.029	3.354ThrAsp: 3.354 ± 0.064	3.049ThrGlu: 3.049 ± 0.063	2.456ThrPhe: 2.456 ± 0.055	5.263ThrGly: 5.263 ± 0.105	1.031ThrHis: 1.031 ± 0.035	3.478ThrIle: 3.478 ± 0.066	2.222ThrLys: 2.222 ± 0.057	5.832ThrLeu: 5.832 ± 0.086	1.187ThrMet: 1.187 ± 0.043	1.959ThrAsn: 1.959 ± 0.052	3.436ThrPro: 3.436 ± 0.071	1.691ThrGln: 1.691 ± 0.042	2.763ThrArg: 2.763 ± 0.061	3.04ThrSer: 3.04 ± 0.067	3.21ThrThr: 3.21 ± 0.071	4.866ThrVal: 4.866 ± 0.074	0.592ThrTrp: 0.592 ± 0.027	2.086ThrTyr: 2.086 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	6.111ValAla: 6.111 ± 0.097	0.982ValCys: 0.982 ± 0.037	3.702ValAsp: 3.702 ± 0.077	4.095ValGlu: 4.095 ± 0.08	2.761ValPhe: 2.761 ± 0.056	4.788ValGly: 4.788 ± 0.083	1.185ValHis: 1.185 ± 0.038	4.411ValIle: 4.411 ± 0.091	3.541ValLys: 3.541 ± 0.076	6.242ValLeu: 6.242 ± 0.093	1.738ValMet: 1.738 ± 0.05	2.885ValAsn: 2.885 ± 0.071	3.255ValPro: 3.255 ± 0.069	2.236ValGln: 2.236 ± 0.056	4.142ValArg: 4.142 ± 0.077	4.685ValSer: 4.685 ± 0.08	4.48ValThr: 4.48 ± 0.084	5.328ValVal: 5.328 ± 0.094	0.791ValTrp: 0.791 ± 0.032	2.53ValTyr: 2.53 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.8TrpAla: 0.8 ± 0.033	0.175TrpCys: 0.175 ± 0.016	0.684TrpAsp: 0.684 ± 0.028	0.673TrpGlu: 0.673 ± 0.03	0.555TrpPhe: 0.555 ± 0.028	0.951TrpGly: 0.951 ± 0.04	0.255TrpHis: 0.255 ± 0.019	0.818TrpIle: 0.818 ± 0.028	0.645TrpLys: 0.645 ± 0.032	1.205TrpLeu: 1.205 ± 0.041	0.413TrpMet: 0.413 ± 0.025	0.637TrpAsn: 0.637 ± 0.031	0.385TrpPro: 0.385 ± 0.022	0.455TrpGln: 0.455 ± 0.026	0.636TrpArg: 0.636 ± 0.028	0.74TrpSer: 0.74 ± 0.029	0.656TrpThr: 0.656 ± 0.032	0.716TrpVal: 0.716 ± 0.029	0.243TrpTrp: 0.243 ± 0.017	0.466TrpTyr: 0.466 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.022TyrAla: 3.022 ± 0.067	0.504TyrCys: 0.504 ± 0.027	2.58TyrAsp: 2.58 ± 0.057	2.069TyrGlu: 2.069 ± 0.055	1.827TyrPhe: 1.827 ± 0.055	3.069TyrGly: 3.069 ± 0.071	0.716TyrHis: 0.716 ± 0.031	2.162TyrIle: 2.162 ± 0.051	1.793TyrLys: 1.793 ± 0.053	3.874TyrLeu: 3.874 ± 0.069	0.9TyrMet: 0.9 ± 0.03	1.93TyrAsn: 1.93 ± 0.066	1.935TyrPro: 1.935 ± 0.05	1.192TyrGln: 1.192 ± 0.038	2.703TyrArg: 2.703 ± 0.069	2.288TyrSer: 2.288 ± 0.057	2.429TyrThr: 2.429 ± 0.063	2.37TyrVal: 2.37 ± 0.056	0.531TyrTrp: 0.531 ± 0.026	1.785TyrTyr: 1.785 ± 0.054	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2348 proteins (832160 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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