Amino acid dipepetide frequency for Human papillomavirus 134

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.874AlaAla: 2.874 ± 0.462
2.053AlaCys: 2.053 ± 0.792
2.874AlaAsp: 2.874 ± 0.699
2.874AlaGlu: 2.874 ± 0.934
2.874AlaPhe: 2.874 ± 0.761
2.874AlaGly: 2.874 ± 1.413
0.821AlaHis: 0.821 ± 0.685
2.463AlaIle: 2.463 ± 1.0
3.284AlaLys: 3.284 ± 1.099
5.337AlaLeu: 5.337 ± 1.03
1.232AlaMet: 1.232 ± 0.753
1.642AlaAsn: 1.642 ± 1.075
1.642AlaPro: 1.642 ± 1.072
2.053AlaGln: 2.053 ± 1.188
2.463AlaArg: 2.463 ± 0.881
2.463AlaSer: 2.463 ± 0.506
4.516AlaThr: 4.516 ± 1.762
3.284AlaVal: 3.284 ± 0.999
0.821AlaTrp: 0.821 ± 0.386
0.821AlaTyr: 0.821 ± 0.686
0.0AlaXaa: 0.0 ± 0.0
Cys
1.232CysAla: 1.232 ± 0.556
1.232CysCys: 1.232 ± 0.818
2.053CysAsp: 2.053 ± 0.774
1.232CysGlu: 1.232 ± 0.645
0.0CysPhe: 0.0 ± 0.0
0.411CysGly: 0.411 ± 0.456
0.411CysHis: 0.411 ± 0.544
0.411CysIle: 0.411 ± 0.343
2.463CysLys: 2.463 ± 0.879
1.642CysLeu: 1.642 ± 2.177
0.411CysMet: 0.411 ± 0.544
1.232CysAsn: 1.232 ± 1.029
1.642CysPro: 1.642 ± 0.81
1.232CysGln: 1.232 ± 1.029
2.053CysArg: 2.053 ± 2.16
1.642CysSer: 1.642 ± 1.042
0.411CysThr: 0.411 ± 0.544
1.232CysVal: 1.232 ± 0.559
1.232CysTrp: 1.232 ± 0.417
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.284AspAla: 3.284 ± 0.478
2.053AspCys: 2.053 ± 1.408
4.516AspAsp: 4.516 ± 1.379
3.695AspGlu: 3.695 ± 1.801
2.053AspPhe: 2.053 ± 1.364
4.105AspGly: 4.105 ± 1.244
1.232AspHis: 1.232 ± 0.497
4.926AspIle: 4.926 ± 1.589
3.695AspLys: 3.695 ± 1.805
4.516AspLeu: 4.516 ± 1.872
0.411AspMet: 0.411 ± 0.342
2.463AspAsn: 2.463 ± 1.564
2.874AspPro: 2.874 ± 1.261
2.463AspGln: 2.463 ± 0.89
2.463AspArg: 2.463 ± 0.885
4.926AspSer: 4.926 ± 1.882
2.463AspThr: 2.463 ± 0.543
3.284AspVal: 3.284 ± 0.81
0.0AspTrp: 0.0 ± 0.0
1.232AspTyr: 1.232 ± 0.421
0.0AspXaa: 0.0 ± 0.0
Glu
3.695GluAla: 3.695 ± 1.014
0.411GluCys: 0.411 ± 0.456
4.516GluAsp: 4.516 ± 1.511
6.568GluGlu: 6.568 ± 1.502
3.284GluPhe: 3.284 ± 0.857
5.337GluGly: 5.337 ± 2.664
0.821GluHis: 0.821 ± 0.406
2.874GluIle: 2.874 ± 0.869
2.463GluLys: 2.463 ± 0.649
6.568GluLeu: 6.568 ± 1.093
2.874GluMet: 2.874 ± 1.907
5.747GluAsn: 5.747 ± 1.738
2.463GluPro: 2.463 ± 0.592
2.463GluGln: 2.463 ± 0.543
2.463GluArg: 2.463 ± 1.146
6.158GluSer: 6.158 ± 2.164
2.874GluThr: 2.874 ± 0.462
3.695GluVal: 3.695 ± 0.923
1.642GluTrp: 1.642 ± 1.373
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
2.053PheAla: 2.053 ± 0.768
1.232PheCys: 1.232 ± 0.818
2.874PheAsp: 2.874 ± 0.662
2.053PheGlu: 2.053 ± 0.839
2.053PhePhe: 2.053 ± 1.006
3.695PheGly: 3.695 ± 0.946
0.411PheHis: 0.411 ± 0.342
2.463PheIle: 2.463 ± 0.896
4.105PheLys: 4.105 ± 1.392
3.284PheLeu: 3.284 ± 0.82
1.232PheMet: 1.232 ± 0.674
1.232PheAsn: 1.232 ± 0.346
1.642PhePro: 1.642 ± 0.562
1.232PheGln: 1.232 ± 0.645
0.821PheArg: 0.821 ± 0.686
2.053PheSer: 2.053 ± 0.839
2.463PheThr: 2.463 ± 0.505
2.874PheVal: 2.874 ± 1.384
0.821PheTrp: 0.821 ± 0.386
1.232PheTyr: 1.232 ± 0.346
0.0PheXaa: 0.0 ± 0.0
Gly
2.053GlyAla: 2.053 ± 0.653
0.821GlyCys: 0.821 ± 0.601
2.874GlyAsp: 2.874 ± 1.169
4.926GlyGlu: 4.926 ± 1.616
0.821GlyPhe: 0.821 ± 0.398
4.926GlyGly: 4.926 ± 2.103
1.642GlyHis: 1.642 ± 0.841
5.337GlyIle: 5.337 ± 0.893
4.926GlyLys: 4.926 ± 1.297
3.695GlyLeu: 3.695 ± 0.919
0.0GlyMet: 0.0 ± 0.0
2.463GlyAsn: 2.463 ± 0.724
2.463GlyPro: 2.463 ± 0.643
1.232GlyGln: 1.232 ± 0.648
3.695GlyArg: 3.695 ± 1.403
8.21GlySer: 8.21 ± 2.367
4.516GlyThr: 4.516 ± 2.178
2.874GlyVal: 2.874 ± 0.683
0.0GlyTrp: 0.0 ± 0.0
0.821GlyTyr: 0.821 ± 0.668
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.821HisCys: 0.821 ± 0.386
0.821HisAsp: 0.821 ± 0.386
0.0HisGlu: 0.0 ± 0.0
1.642HisPhe: 1.642 ± 0.56
0.821HisGly: 0.821 ± 0.601
0.411HisHis: 0.411 ± 0.375
0.411HisIle: 0.411 ± 0.456
1.642HisLys: 1.642 ± 0.715
1.642HisLeu: 1.642 ± 1.118
0.411HisMet: 0.411 ± 0.343
1.232HisAsn: 1.232 ± 0.559
2.874HisPro: 2.874 ± 0.931
0.821HisGln: 0.821 ± 0.604
1.232HisArg: 1.232 ± 0.782
1.232HisSer: 1.232 ± 0.361
0.411HisThr: 0.411 ± 0.375
0.821HisVal: 0.821 ± 0.406
0.411HisTrp: 0.411 ± 0.342
1.232HisTyr: 1.232 ± 0.417
0.0HisXaa: 0.0 ± 0.0
Ile
2.053IleAla: 2.053 ± 0.945
1.232IleCys: 1.232 ± 0.644
3.284IleAsp: 3.284 ± 1.274
4.516IleGlu: 4.516 ± 1.215
1.642IlePhe: 1.642 ± 0.56
3.284IleGly: 3.284 ± 0.723
0.0IleHis: 0.0 ± 0.0
2.463IleIle: 2.463 ± 0.886
1.642IleLys: 1.642 ± 0.576
3.695IleLeu: 3.695 ± 1.081
0.821IleMet: 0.821 ± 0.414
2.053IleAsn: 2.053 ± 0.854
2.463IlePro: 2.463 ± 0.925
0.411IleGln: 0.411 ± 0.343
2.463IleArg: 2.463 ± 0.844
6.568IleSer: 6.568 ± 1.123
4.516IleThr: 4.516 ± 1.225
3.695IleVal: 3.695 ± 0.563
0.411IleTrp: 0.411 ± 0.544
2.053IleTyr: 2.053 ± 0.823
0.0IleXaa: 0.0 ± 0.0
Lys
2.874LysAla: 2.874 ± 1.36
1.642LysCys: 1.642 ± 0.978
2.463LysAsp: 2.463 ± 0.649
2.463LysGlu: 2.463 ± 1.264
2.053LysPhe: 2.053 ± 1.071
3.695LysGly: 3.695 ± 1.312
1.642LysHis: 1.642 ± 0.842
2.463LysIle: 2.463 ± 0.701
2.874LysLys: 2.874 ± 0.905
4.516LysLeu: 4.516 ± 1.86
1.232LysMet: 1.232 ± 0.775
4.105LysAsn: 4.105 ± 1.313
2.463LysPro: 2.463 ± 0.957
3.284LysGln: 3.284 ± 0.731
5.337LysArg: 5.337 ± 1.981
2.463LysSer: 2.463 ± 1.321
2.463LysThr: 2.463 ± 0.724
3.695LysVal: 3.695 ± 1.391
0.821LysTrp: 0.821 ± 0.473
2.053LysTyr: 2.053 ± 0.764
0.0LysXaa: 0.0 ± 0.0
Leu
4.516LeuAla: 4.516 ± 1.219
2.463LeuCys: 2.463 ± 1.593
2.463LeuAsp: 2.463 ± 1.251
9.031LeuGlu: 9.031 ± 2.036
4.926LeuPhe: 4.926 ± 1.83
5.337LeuGly: 5.337 ± 1.974
2.053LeuHis: 2.053 ± 0.812
3.284LeuIle: 3.284 ± 0.81
4.516LeuLys: 4.516 ± 0.948
10.263LeuLeu: 10.263 ± 3.076
2.874LeuMet: 2.874 ± 1.159
5.337LeuAsn: 5.337 ± 1.92
4.926LeuPro: 4.926 ± 1.671
4.516LeuGln: 4.516 ± 1.702
4.105LeuArg: 4.105 ± 1.602
7.389LeuSer: 7.389 ± 1.337
5.337LeuThr: 5.337 ± 1.179
5.337LeuVal: 5.337 ± 0.812
0.411LeuTrp: 0.411 ± 0.375
4.105LeuTyr: 4.105 ± 1.147
0.0LeuXaa: 0.0 ± 0.0
Met
1.642MetAla: 1.642 ± 0.636
0.821MetCys: 0.821 ± 0.386
1.232MetAsp: 1.232 ± 0.645
0.821MetGlu: 0.821 ± 0.619
1.232MetPhe: 1.232 ± 0.559
0.0MetGly: 0.0 ± 0.0
1.232MetHis: 1.232 ± 0.751
0.0MetIle: 0.0 ± 0.0
0.411MetLys: 0.411 ± 0.544
1.232MetLeu: 1.232 ± 0.897
0.411MetMet: 0.411 ± 0.375
1.232MetAsn: 1.232 ± 0.346
0.821MetPro: 0.821 ± 0.398
1.232MetGln: 1.232 ± 0.818
1.232MetArg: 1.232 ± 0.67
1.232MetSer: 1.232 ± 0.665
2.053MetThr: 2.053 ± 0.663
1.232MetVal: 1.232 ± 1.029
0.0MetTrp: 0.0 ± 0.0
0.411MetTyr: 0.411 ± 0.343
0.0MetXaa: 0.0 ± 0.0
Asn
2.053AsnAla: 2.053 ± 0.686
0.821AsnCys: 0.821 ± 0.604
3.284AsnAsp: 3.284 ± 0.518
3.284AsnGlu: 3.284 ± 1.008
1.642AsnPhe: 1.642 ± 0.978
1.642AsnGly: 1.642 ± 0.652
0.0AsnHis: 0.0 ± 0.0
2.053AsnIle: 2.053 ± 1.03
2.874AsnLys: 2.874 ± 1.179
4.105AsnLeu: 4.105 ± 1.293
0.821AsnMet: 0.821 ± 0.398
2.053AsnAsn: 2.053 ± 0.823
3.284AsnPro: 3.284 ± 1.12
2.463AsnGln: 2.463 ± 0.894
3.695AsnArg: 3.695 ± 0.602
5.747AsnSer: 5.747 ± 1.349
3.695AsnThr: 3.695 ± 0.902
3.695AsnVal: 3.695 ± 1.188
0.411AsnTrp: 0.411 ± 0.342
2.463AsnTyr: 2.463 ± 0.697
0.0AsnXaa: 0.0 ± 0.0
Pro
3.284ProAla: 3.284 ± 1.274
0.411ProCys: 0.411 ± 0.544
4.105ProAsp: 4.105 ± 1.19
6.158ProGlu: 6.158 ± 1.047
0.411ProPhe: 0.411 ± 0.342
1.642ProGly: 1.642 ± 0.953
0.821ProHis: 0.821 ± 0.494
1.232ProIle: 1.232 ± 0.65
4.105ProLys: 4.105 ± 1.052
5.337ProLeu: 5.337 ± 1.799
0.0ProMet: 0.0 ± 0.0
2.463ProAsn: 2.463 ± 0.894
5.337ProPro: 5.337 ± 2.09
2.463ProGln: 2.463 ± 0.505
2.463ProArg: 2.463 ± 1.246
4.105ProSer: 4.105 ± 0.973
6.158ProThr: 6.158 ± 2.259
2.874ProVal: 2.874 ± 0.844
0.411ProTrp: 0.411 ± 0.456
1.642ProTyr: 1.642 ± 0.864
0.0ProXaa: 0.0 ± 0.0
Gln
1.232GlnAla: 1.232 ± 0.421
1.232GlnCys: 1.232 ± 1.172
1.642GlnAsp: 1.642 ± 0.584
4.516GlnGlu: 4.516 ± 1.702
0.821GlnPhe: 0.821 ± 0.398
2.463GlnGly: 2.463 ± 1.188
1.232GlnHis: 1.232 ± 0.648
2.053GlnIle: 2.053 ± 0.687
1.232GlnLys: 1.232 ± 0.782
6.158GlnLeu: 6.158 ± 2.262
0.411GlnMet: 0.411 ± 0.342
0.821GlnAsn: 0.821 ± 0.473
1.232GlnPro: 1.232 ± 0.65
1.232GlnGln: 1.232 ± 0.666
1.232GlnArg: 1.232 ± 0.782
1.642GlnSer: 1.642 ± 0.842
4.926GlnThr: 4.926 ± 1.903
3.284GlnVal: 3.284 ± 0.972
0.821GlnTrp: 0.821 ± 0.421
1.232GlnTyr: 1.232 ± 0.559
0.0GlnXaa: 0.0 ± 0.0
Arg
3.284ArgAla: 3.284 ± 0.805
1.642ArgCys: 1.642 ± 0.533
1.642ArgAsp: 1.642 ± 1.123
3.284ArgGlu: 3.284 ± 0.909
2.053ArgPhe: 2.053 ± 0.836
4.516ArgGly: 4.516 ± 2.091
1.232ArgHis: 1.232 ± 0.735
1.642ArgIle: 1.642 ± 0.864
4.105ArgLys: 4.105 ± 1.631
7.389ArgLeu: 7.389 ± 2.037
1.642ArgMet: 1.642 ± 0.715
2.053ArgAsn: 2.053 ± 0.836
4.105ArgPro: 4.105 ± 1.274
2.874ArgGln: 2.874 ± 1.249
10.263ArgArg: 10.263 ± 3.259
2.463ArgSer: 2.463 ± 0.795
1.642ArgThr: 1.642 ± 0.595
3.695ArgVal: 3.695 ± 1.565
0.411ArgTrp: 0.411 ± 0.456
2.463ArgTyr: 2.463 ± 0.714
0.0ArgXaa: 0.0 ± 0.0
Ser
2.874SerAla: 2.874 ± 1.286
0.411SerCys: 0.411 ± 0.333
4.926SerAsp: 4.926 ± 1.518
3.284SerGlu: 3.284 ± 0.928
3.284SerPhe: 3.284 ± 1.959
5.747SerGly: 5.747 ± 0.873
2.053SerHis: 2.053 ± 0.785
5.747SerIle: 5.747 ± 1.032
3.695SerLys: 3.695 ± 1.817
8.21SerLeu: 8.21 ± 1.569
1.232SerMet: 1.232 ± 0.644
4.516SerAsn: 4.516 ± 1.226
3.284SerPro: 3.284 ± 1.169
0.821SerGln: 0.821 ± 0.473
6.568SerArg: 6.568 ± 1.349
9.031SerSer: 9.031 ± 2.45
8.21SerThr: 8.21 ± 2.512
4.926SerVal: 4.926 ± 1.728
0.821SerTrp: 0.821 ± 0.421
3.284SerTyr: 3.284 ± 1.434
0.0SerXaa: 0.0 ± 0.0
Thr
4.926ThrAla: 4.926 ± 1.302
1.232ThrCys: 1.232 ± 0.74
3.695ThrAsp: 3.695 ± 0.766
4.516ThrGlu: 4.516 ± 0.649
3.284ThrPhe: 3.284 ± 1.161
3.284ThrGly: 3.284 ± 1.019
0.411ThrHis: 0.411 ± 0.342
4.516ThrIle: 4.516 ± 0.727
2.053ThrLys: 2.053 ± 0.66
5.337ThrLeu: 5.337 ± 1.168
0.411ThrMet: 0.411 ± 0.333
3.284ThrAsn: 3.284 ± 0.999
5.337ThrPro: 5.337 ± 1.857
2.874ThrGln: 2.874 ± 0.8
4.926ThrArg: 4.926 ± 1.471
6.568ThrSer: 6.568 ± 2.082
5.337ThrThr: 5.337 ± 1.347
6.568ThrVal: 6.568 ± 0.781
0.411ThrTrp: 0.411 ± 0.343
1.232ThrTyr: 1.232 ± 0.637
0.0ThrXaa: 0.0 ± 0.0
Val
3.695ValAla: 3.695 ± 0.809
1.232ValCys: 1.232 ± 0.74
4.926ValAsp: 4.926 ± 1.041
2.463ValGlu: 2.463 ± 1.114
2.463ValPhe: 2.463 ± 0.456
2.874ValGly: 2.874 ± 1.304
1.232ValHis: 1.232 ± 0.65
2.874ValIle: 2.874 ± 0.972
2.053ValLys: 2.053 ± 0.71
5.747ValLeu: 5.747 ± 1.191
0.411ValMet: 0.411 ± 0.333
2.463ValAsn: 2.463 ± 0.695
4.926ValPro: 4.926 ± 1.062
3.284ValGln: 3.284 ± 0.518
2.463ValArg: 2.463 ± 1.2
6.158ValSer: 6.158 ± 1.579
6.568ValThr: 6.568 ± 1.782
5.747ValVal: 5.747 ± 1.599
0.821ValTrp: 0.821 ± 0.473
4.105ValTyr: 4.105 ± 0.904
0.0ValXaa: 0.0 ± 0.0
Trp
0.821TrpAla: 0.821 ± 0.686
0.0TrpCys: 0.0 ± 0.0
0.821TrpAsp: 0.821 ± 0.685
0.0TrpGlu: 0.0 ± 0.0
0.411TrpPhe: 0.411 ± 0.343
0.411TrpGly: 0.411 ± 0.456
0.411TrpHis: 0.411 ± 0.375
0.411TrpIle: 0.411 ± 0.343
1.642TrpLys: 1.642 ± 0.693
2.053TrpLeu: 2.053 ± 0.925
0.411TrpMet: 0.411 ± 0.342
1.232TrpAsn: 1.232 ± 0.735
0.411TrpPro: 0.411 ± 0.342
0.411TrpGln: 0.411 ± 0.343
0.411TrpArg: 0.411 ± 0.544
0.0TrpSer: 0.0 ± 0.0
0.821TrpThr: 0.821 ± 0.751
0.821TrpVal: 0.821 ± 0.421
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.232TyrAla: 1.232 ± 0.417
0.411TyrCys: 0.411 ± 0.525
1.642TyrAsp: 1.642 ± 0.239
1.232TyrGlu: 1.232 ± 0.609
2.874TyrPhe: 2.874 ± 1.162
1.232TyrGly: 1.232 ± 0.664
0.821TyrHis: 0.821 ± 0.421
1.642TyrIle: 1.642 ± 0.636
0.821TyrLys: 0.821 ± 0.494
2.463TyrLeu: 2.463 ± 1.29
0.821TyrMet: 0.821 ± 0.398
2.463TyrAsn: 2.463 ± 0.842
1.232TyrPro: 1.232 ± 1.126
2.053TyrGln: 2.053 ± 0.732
2.053TyrArg: 2.053 ± 0.834
2.874TyrSer: 2.874 ± 1.061
0.821TyrThr: 0.821 ± 0.751
2.874TyrVal: 2.874 ± 0.514
0.821TyrTrp: 0.821 ± 0.473
3.695TyrTyr: 3.695 ± 2.044
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2437 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski