Amino acid dipepetide frequency for Pepper vein yellows virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.961AlaAla: 3.961 ± 1.194
0.88AlaCys: 0.88 ± 0.553
3.081AlaAsp: 3.081 ± 0.868
4.842AlaGlu: 4.842 ± 0.738
0.88AlaPhe: 0.88 ± 0.706
6.162AlaGly: 6.162 ± 1.011
2.641AlaHis: 2.641 ± 1.849
0.88AlaIle: 0.88 ± 0.699
2.641AlaLys: 2.641 ± 0.863
7.482AlaLeu: 7.482 ± 2.569
2.201AlaMet: 2.201 ± 1.287
1.32AlaAsn: 1.32 ± 0.838
5.722AlaPro: 5.722 ± 1.57
3.081AlaGln: 3.081 ± 0.95
1.32AlaArg: 1.32 ± 0.694
7.923AlaSer: 7.923 ± 2.397
3.081AlaThr: 3.081 ± 0.884
1.32AlaVal: 1.32 ± 0.789
0.88AlaTrp: 0.88 ± 0.495
3.521AlaTyr: 3.521 ± 1.159
0.0AlaXaa: 0.0 ± 0.0
Cys
1.761CysAla: 1.761 ± 0.651
0.0CysCys: 0.0 ± 0.0
0.88CysAsp: 0.88 ± 0.503
0.88CysGlu: 0.88 ± 0.492
0.0CysPhe: 0.0 ± 0.0
0.88CysGly: 0.88 ± 0.679
0.44CysHis: 0.44 ± 0.353
0.44CysIle: 0.44 ± 0.519
2.201CysLys: 2.201 ± 0.918
2.201CysLeu: 2.201 ± 1.039
0.44CysMet: 0.44 ± 0.349
0.88CysAsn: 0.88 ± 0.553
0.44CysPro: 0.44 ± 0.435
0.44CysGln: 0.44 ± 0.353
0.0CysArg: 0.0 ± 0.0
1.32CysSer: 1.32 ± 1.128
0.0CysThr: 0.0 ± 0.0
0.88CysVal: 0.88 ± 0.553
0.44CysTrp: 0.44 ± 0.435
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.201AspAla: 2.201 ± 0.623
0.44AspCys: 0.44 ± 0.519
2.201AspAsp: 2.201 ± 1.188
3.961AspGlu: 3.961 ± 1.33
1.32AspPhe: 1.32 ± 0.621
2.201AspGly: 2.201 ± 0.578
1.32AspHis: 1.32 ± 0.876
0.88AspIle: 0.88 ± 0.492
2.201AspLys: 2.201 ± 1.746
3.961AspLeu: 3.961 ± 1.251
0.88AspMet: 0.88 ± 1.038
0.88AspAsn: 0.88 ± 0.359
3.081AspPro: 3.081 ± 1.331
1.32AspGln: 1.32 ± 0.578
2.201AspArg: 2.201 ± 1.081
6.162AspSer: 6.162 ± 2.111
1.761AspThr: 1.761 ± 0.636
1.761AspVal: 1.761 ± 1.039
1.32AspTrp: 1.32 ± 0.961
1.761AspTyr: 1.761 ± 0.6
0.0AspXaa: 0.0 ± 0.0
Glu
3.521GluAla: 3.521 ± 1.412
0.44GluCys: 0.44 ± 0.349
5.282GluAsp: 5.282 ± 1.427
3.081GluGlu: 3.081 ± 0.892
2.201GluPhe: 2.201 ± 1.188
6.602GluGly: 6.602 ± 2.19
0.0GluHis: 0.0 ± 0.0
2.201GluIle: 2.201 ± 1.327
7.923GluLys: 7.923 ± 3.48
5.722GluLeu: 5.722 ± 1.669
0.88GluMet: 0.88 ± 0.728
2.201GluAsn: 2.201 ± 0.885
3.081GluPro: 3.081 ± 0.868
1.32GluGln: 1.32 ± 0.655
2.201GluArg: 2.201 ± 1.055
4.401GluSer: 4.401 ± 1.043
2.641GluThr: 2.641 ± 0.872
4.401GluVal: 4.401 ± 2.876
2.201GluTrp: 2.201 ± 0.485
0.88GluTyr: 0.88 ± 0.526
0.0GluXaa: 0.0 ± 0.0
Phe
1.761PheAla: 1.761 ± 0.713
0.44PheCys: 0.44 ± 0.519
0.88PheAsp: 0.88 ± 0.503
1.761PheGlu: 1.761 ± 0.607
2.201PhePhe: 2.201 ± 0.906
2.641PheGly: 2.641 ± 1.043
0.44PheHis: 0.44 ± 0.349
1.761PheIle: 1.761 ± 0.625
1.761PheLys: 1.761 ± 0.532
3.081PheLeu: 3.081 ± 2.041
0.88PheMet: 0.88 ± 0.706
1.761PheAsn: 1.761 ± 0.625
1.32PhePro: 1.32 ± 0.632
3.521PheGln: 3.521 ± 0.932
2.641PheArg: 2.641 ± 0.777
1.32PheSer: 1.32 ± 0.796
3.961PheThr: 3.961 ± 2.243
4.401PheVal: 4.401 ± 1.167
0.44PheTrp: 0.44 ± 0.349
0.88PheTyr: 0.88 ± 0.706
0.0PheXaa: 0.0 ± 0.0
Gly
3.961GlyAla: 3.961 ± 1.143
0.88GlyCys: 0.88 ± 0.359
2.641GlyAsp: 2.641 ± 0.744
3.081GlyGlu: 3.081 ± 0.757
2.641GlyPhe: 2.641 ± 1.317
8.363GlyGly: 8.363 ± 2.526
1.32GlyHis: 1.32 ± 0.425
1.761GlyIle: 1.761 ± 0.607
6.162GlyLys: 6.162 ± 1.475
3.081GlyLeu: 3.081 ± 0.955
0.44GlyMet: 0.44 ± 0.65
6.602GlyAsn: 6.602 ± 2.201
2.641GlyPro: 2.641 ± 0.889
1.761GlyGln: 1.761 ± 0.422
5.722GlyArg: 5.722 ± 1.606
8.363GlySer: 8.363 ± 1.535
6.162GlyThr: 6.162 ± 1.541
5.722GlyVal: 5.722 ± 1.609
0.88GlyTrp: 0.88 ± 0.359
2.641GlyTyr: 2.641 ± 0.744
0.0GlyXaa: 0.0 ± 0.0
His
1.32HisAla: 1.32 ± 0.876
2.201HisCys: 2.201 ± 0.981
2.201HisAsp: 2.201 ± 1.212
1.761HisGlu: 1.761 ± 0.625
0.88HisPhe: 0.88 ± 0.495
1.32HisGly: 1.32 ± 0.796
0.88HisHis: 0.88 ± 0.495
1.32HisIle: 1.32 ± 0.613
0.44HisLys: 0.44 ± 0.519
1.761HisLeu: 1.761 ± 1.739
0.0HisMet: 0.0 ± 0.0
1.761HisAsn: 1.761 ± 0.802
0.88HisPro: 0.88 ± 0.721
0.44HisGln: 0.44 ± 0.519
0.88HisArg: 0.88 ± 0.495
0.44HisSer: 0.44 ± 0.353
0.88HisThr: 0.88 ± 0.495
1.761HisVal: 1.761 ± 0.933
0.44HisTrp: 0.44 ± 0.353
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
4.401IleAla: 4.401 ± 1.503
0.88IleCys: 0.88 ± 0.679
1.761IleAsp: 1.761 ± 0.933
2.201IleGlu: 2.201 ± 1.31
3.081IlePhe: 3.081 ± 0.973
0.44IleGly: 0.44 ± 0.349
0.44IleHis: 0.44 ± 0.353
0.44IleIle: 0.44 ± 0.353
2.201IleLys: 2.201 ± 1.019
1.761IleLeu: 1.761 ± 0.6
0.44IleMet: 0.44 ± 0.519
1.32IleAsn: 1.32 ± 0.632
3.081IlePro: 3.081 ± 1.297
1.761IleGln: 1.761 ± 1.271
3.081IleArg: 3.081 ± 1.25
2.641IleSer: 2.641 ± 0.796
2.201IleThr: 2.201 ± 0.752
2.641IleVal: 2.641 ± 1.373
0.44IleTrp: 0.44 ± 0.353
1.761IleTyr: 1.761 ± 1.05
0.0IleXaa: 0.0 ± 0.0
Lys
4.401LysAla: 4.401 ± 1.734
0.44LysCys: 0.44 ± 0.519
4.401LysAsp: 4.401 ± 2.284
2.641LysGlu: 2.641 ± 0.858
2.641LysPhe: 2.641 ± 0.889
7.482LysGly: 7.482 ± 2.059
0.88LysHis: 0.88 ± 0.699
3.521LysIle: 3.521 ± 1.198
1.32LysLys: 1.32 ± 1.059
6.162LysLeu: 6.162 ± 1.807
1.761LysMet: 1.761 ± 0.385
1.761LysAsn: 1.761 ± 0.944
4.401LysPro: 4.401 ± 0.914
0.88LysGln: 0.88 ± 0.553
3.521LysArg: 3.521 ± 1.501
6.602LysSer: 6.602 ± 2.336
1.761LysThr: 1.761 ± 0.719
3.521LysVal: 3.521 ± 0.981
0.88LysTrp: 0.88 ± 0.699
1.32LysTyr: 1.32 ± 0.415
0.44LysXaa: 0.44 ± 0.349
Leu
5.722LeuAla: 5.722 ± 1.73
2.201LeuCys: 2.201 ± 1.287
3.521LeuAsp: 3.521 ± 0.831
6.162LeuGlu: 6.162 ± 2.442
2.201LeuPhe: 2.201 ± 1.055
3.961LeuGly: 3.961 ± 1.066
3.081LeuHis: 3.081 ± 1.21
3.521LeuIle: 3.521 ± 1.124
3.961LeuLys: 3.961 ± 0.719
7.923LeuLeu: 7.923 ± 1.633
1.32LeuMet: 1.32 ± 0.876
2.641LeuAsn: 2.641 ± 0.846
3.081LeuPro: 3.081 ± 1.207
3.521LeuGln: 3.521 ± 1.264
5.722LeuArg: 5.722 ± 0.569
9.243LeuSer: 9.243 ± 2.332
6.162LeuThr: 6.162 ± 1.4
4.842LeuVal: 4.842 ± 2.339
2.641LeuTrp: 2.641 ± 1.104
3.081LeuTyr: 3.081 ± 0.72
0.0LeuXaa: 0.0 ± 0.0
Met
2.201MetAla: 2.201 ± 1.132
0.0MetCys: 0.0 ± 0.0
0.44MetAsp: 0.44 ± 0.435
0.88MetGlu: 0.88 ± 0.721
0.44MetPhe: 0.44 ± 0.353
0.88MetGly: 0.88 ± 0.896
0.0MetHis: 0.0 ± 0.0
0.44MetIle: 0.44 ± 0.349
0.88MetLys: 0.88 ± 0.706
1.761MetLeu: 1.761 ± 1.512
0.44MetMet: 0.44 ± 0.353
2.201MetAsn: 2.201 ± 1.063
0.44MetPro: 0.44 ± 0.349
0.0MetGln: 0.0 ± 0.0
0.88MetArg: 0.88 ± 0.706
2.201MetSer: 2.201 ± 1.235
0.44MetThr: 0.44 ± 0.353
2.201MetVal: 2.201 ± 0.768
0.0MetTrp: 0.0 ± 0.0
0.44MetTyr: 0.44 ± 0.349
0.0MetXaa: 0.0 ± 0.0
Asn
0.44AsnAla: 0.44 ± 0.353
0.0AsnCys: 0.0 ± 0.0
1.32AsnAsp: 1.32 ± 0.615
3.081AsnGlu: 3.081 ± 1.042
1.761AsnPhe: 1.761 ± 0.6
6.602AsnGly: 6.602 ± 1.964
0.44AsnHis: 0.44 ± 0.435
2.641AsnIle: 2.641 ± 1.222
3.521AsnLys: 3.521 ± 1.084
3.081AsnLeu: 3.081 ± 1.304
0.44AsnMet: 0.44 ± 0.478
2.641AsnAsn: 2.641 ± 0.777
4.842AsnPro: 4.842 ± 1.675
0.44AsnGln: 0.44 ± 0.519
3.081AsnArg: 3.081 ± 1.427
3.521AsnSer: 3.521 ± 1.204
3.521AsnThr: 3.521 ± 0.831
0.88AsnVal: 0.88 ± 0.706
1.32AsnTrp: 1.32 ± 0.621
3.081AsnTyr: 3.081 ± 1.442
0.0AsnXaa: 0.0 ± 0.0
Pro
4.842ProAla: 4.842 ± 1.536
1.32ProCys: 1.32 ± 0.789
1.761ProAsp: 1.761 ± 1.007
2.201ProGlu: 2.201 ± 0.578
2.201ProPhe: 2.201 ± 0.915
4.842ProGly: 4.842 ± 1.09
2.201ProHis: 2.201 ± 0.485
1.761ProIle: 1.761 ± 0.584
2.641ProLys: 2.641 ± 0.802
4.842ProLeu: 4.842 ± 1.381
0.0ProMet: 0.0 ± 0.0
1.32ProAsn: 1.32 ± 0.621
10.563ProPro: 10.563 ± 3.951
5.282ProGln: 5.282 ± 1.234
5.282ProArg: 5.282 ± 1.611
4.842ProSer: 4.842 ± 1.816
3.081ProThr: 3.081 ± 1.46
4.842ProVal: 4.842 ± 1.284
0.44ProTrp: 0.44 ± 0.349
0.44ProTyr: 0.44 ± 0.353
0.0ProXaa: 0.0 ± 0.0
Gln
2.201GlnAla: 2.201 ± 0.983
0.44GlnCys: 0.44 ± 0.435
0.88GlnAsp: 0.88 ± 0.359
1.761GlnGlu: 1.761 ± 0.896
0.88GlnPhe: 0.88 ± 0.526
2.201GlnGly: 2.201 ± 1.381
0.44GlnHis: 0.44 ± 0.353
2.201GlnIle: 2.201 ± 1.078
3.521GlnLys: 3.521 ± 0.803
2.641GlnLeu: 2.641 ± 0.832
0.88GlnMet: 0.88 ± 0.457
2.641GlnAsn: 2.641 ± 1.308
1.32GlnPro: 1.32 ± 0.615
0.88GlnGln: 0.88 ± 0.359
3.081GlnArg: 3.081 ± 1.238
3.521GlnSer: 3.521 ± 0.654
2.641GlnThr: 2.641 ± 0.85
3.081GlnVal: 3.081 ± 0.978
1.761GlnTrp: 1.761 ± 0.651
0.88GlnTyr: 0.88 ± 0.492
0.0GlnXaa: 0.0 ± 0.0
Arg
4.401ArgAla: 4.401 ± 1.58
0.44ArgCys: 0.44 ± 0.349
2.201ArgAsp: 2.201 ± 0.951
2.201ArgGlu: 2.201 ± 1.246
4.401ArgPhe: 4.401 ± 1.745
4.401ArgGly: 4.401 ± 1.888
0.44ArgHis: 0.44 ± 0.519
2.641ArgIle: 2.641 ± 0.937
3.081ArgLys: 3.081 ± 0.687
4.842ArgLeu: 4.842 ± 1.206
0.88ArgMet: 0.88 ± 0.492
4.842ArgAsn: 4.842 ± 1.578
3.961ArgPro: 3.961 ± 1.114
2.201ArgGln: 2.201 ± 0.918
12.764ArgArg: 12.764 ± 4.125
4.842ArgSer: 4.842 ± 1.159
2.641ArgThr: 2.641 ± 0.739
4.842ArgVal: 4.842 ± 1.146
0.44ArgTrp: 0.44 ± 0.353
1.32ArgTyr: 1.32 ± 0.769
0.0ArgXaa: 0.0 ± 0.0
Ser
4.401SerAla: 4.401 ± 1.377
1.32SerCys: 1.32 ± 0.621
2.201SerAsp: 2.201 ± 1.161
7.042SerGlu: 7.042 ± 2.214
3.081SerPhe: 3.081 ± 1.148
8.363SerGly: 8.363 ± 1.236
2.641SerHis: 2.641 ± 0.651
4.401SerIle: 4.401 ± 2.062
7.042SerLys: 7.042 ± 2.753
8.803SerLeu: 8.803 ± 1.72
0.88SerMet: 0.88 ± 0.99
3.961SerAsn: 3.961 ± 0.991
3.521SerPro: 3.521 ± 1.987
4.401SerGln: 4.401 ± 1.188
6.602SerArg: 6.602 ± 1.237
13.644SerSer: 13.644 ± 2.538
5.722SerThr: 5.722 ± 1.025
5.282SerVal: 5.282 ± 3.239
2.641SerTrp: 2.641 ± 0.55
2.201SerTyr: 2.201 ± 0.518
0.0SerXaa: 0.0 ± 0.0
Thr
4.401ThrAla: 4.401 ± 1.392
0.88ThrCys: 0.88 ± 0.706
1.761ThrAsp: 1.761 ± 1.074
2.641ThrGlu: 2.641 ± 0.708
4.842ThrPhe: 4.842 ± 1.205
2.201ThrGly: 2.201 ± 1.283
0.44ThrHis: 0.44 ± 0.435
3.081ThrIle: 3.081 ± 1.558
2.641ThrLys: 2.641 ± 1.11
5.282ThrLeu: 5.282 ± 1.087
1.32ThrMet: 1.32 ± 0.913
2.641ThrAsn: 2.641 ± 0.501
6.162ThrPro: 6.162 ± 1.532
1.32ThrGln: 1.32 ± 0.624
3.961ThrArg: 3.961 ± 1.679
6.162ThrSer: 6.162 ± 1.251
6.162ThrThr: 6.162 ± 2.133
3.961ThrVal: 3.961 ± 1.273
0.0ThrTrp: 0.0 ± 0.0
0.44ThrTyr: 0.44 ± 0.349
0.0ThrXaa: 0.0 ± 0.0
Val
5.282ValAla: 5.282 ± 1.073
0.44ValCys: 0.44 ± 0.353
2.641ValAsp: 2.641 ± 1.44
7.042ValGlu: 7.042 ± 1.02
1.32ValPhe: 1.32 ± 0.742
3.081ValGly: 3.081 ± 0.993
0.44ValHis: 0.44 ± 0.353
1.761ValIle: 1.761 ± 1.106
2.201ValLys: 2.201 ± 0.578
3.961ValLeu: 3.961 ± 2.278
0.88ValMet: 0.88 ± 0.553
3.081ValAsn: 3.081 ± 0.772
4.401ValPro: 4.401 ± 1.739
3.081ValGln: 3.081 ± 1.285
3.081ValArg: 3.081 ± 0.923
8.363ValSer: 8.363 ± 1.139
4.401ValThr: 4.401 ± 1.144
7.042ValVal: 7.042 ± 1.256
0.88ValTrp: 0.88 ± 0.679
1.32ValTyr: 1.32 ± 0.613
0.0ValXaa: 0.0 ± 0.0
Trp
0.88TrpAla: 0.88 ± 0.553
0.0TrpCys: 0.0 ± 0.0
0.88TrpAsp: 0.88 ± 0.699
1.761TrpGlu: 1.761 ± 0.584
0.88TrpPhe: 0.88 ± 0.359
0.88TrpGly: 0.88 ± 0.699
1.32TrpHis: 1.32 ± 0.632
0.0TrpIle: 0.0 ± 0.0
0.44TrpLys: 0.44 ± 0.349
2.641TrpLeu: 2.641 ± 1.019
1.761TrpMet: 1.761 ± 0.584
0.88TrpAsn: 0.88 ± 0.492
0.44TrpPro: 0.44 ± 0.353
0.44TrpGln: 0.44 ± 0.353
0.44TrpArg: 0.44 ± 0.519
1.32TrpSer: 1.32 ± 0.838
2.201TrpThr: 2.201 ± 0.689
0.44TrpVal: 0.44 ± 0.353
0.0TrpTrp: 0.0 ± 0.0
0.44TrpTyr: 0.44 ± 0.353
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.761TyrAla: 1.761 ± 0.713
0.88TyrCys: 0.88 ± 0.492
0.88TyrAsp: 0.88 ± 0.359
2.201TyrGlu: 2.201 ± 0.918
0.0TyrPhe: 0.0 ± 0.0
1.32TyrGly: 1.32 ± 0.425
1.761TyrHis: 1.761 ± 0.678
1.32TyrIle: 1.32 ± 0.613
3.961TyrLys: 3.961 ± 1.167
3.521TyrLeu: 3.521 ± 0.803
0.0TyrMet: 0.0 ± 0.0
1.32TyrAsn: 1.32 ± 0.961
1.32TyrPro: 1.32 ± 0.621
1.761TyrGln: 1.761 ± 0.713
1.32TyrArg: 1.32 ± 1.016
1.761TyrSer: 1.761 ± 0.933
0.88TyrThr: 0.88 ± 0.699
0.44TyrVal: 0.44 ± 0.353
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.44XaaVal: 0.44 ± 0.349
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (2273 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski