Amino acid dipepetide frequency for Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic green alga)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.55AlaAla: 20.55 ± 0.195	1.81AlaCys: 1.81 ± 0.027	6.584AlaAsp: 6.584 ± 0.05	8.384AlaGlu: 8.384 ± 0.108	3.64AlaPhe: 3.64 ± 0.039	9.593AlaGly: 9.593 ± 0.062	2.311AlaHis: 2.311 ± 0.027	3.646AlaIle: 3.646 ± 0.03	5.834AlaLys: 5.834 ± 0.066	10.377AlaLeu: 10.377 ± 0.078	3.057AlaMet: 3.057 ± 0.029	3.178AlaAsn: 3.178 ± 0.029	6.731AlaPro: 6.731 ± 0.066	3.047AlaGln: 3.047 ± 0.033	9.876AlaArg: 9.876 ± 0.089	8.85AlaSer: 8.85 ± 0.068	6.454AlaThr: 6.454 ± 0.05	8.619AlaVal: 8.619 ± 0.057	1.52AlaTrp: 1.52 ± 0.019	2.116AlaTyr: 2.116 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.981CysAla: 1.981 ± 0.028	0.313CysCys: 0.313 ± 0.011	1.049CysAsp: 1.049 ± 0.017	1.142CysGlu: 1.142 ± 0.025	0.511CysPhe: 0.511 ± 0.011	1.552CysGly: 1.552 ± 0.029	0.323CysHis: 0.323 ± 0.009	0.488CysIle: 0.488 ± 0.011	0.74CysLys: 0.74 ± 0.025	1.192CysLeu: 1.192 ± 0.018	0.292CysMet: 0.292 ± 0.008	0.376CysAsn: 0.376 ± 0.01	0.784CysPro: 0.784 ± 0.019	0.376CysGln: 0.376 ± 0.01	0.926CysArg: 0.926 ± 0.016	0.853CysSer: 0.853 ± 0.02	0.765CysThr: 0.765 ± 0.017	1.559CysVal: 1.559 ± 0.022	0.201CysTrp: 0.201 ± 0.008	0.313CysTyr: 0.313 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	9.422AspAla: 9.422 ± 0.075	0.724AspCys: 0.724 ± 0.015	6.916AspAsp: 6.916 ± 0.071	5.647AspGlu: 5.647 ± 0.042	1.926AspPhe: 1.926 ± 0.024	6.645AspGly: 6.645 ± 0.053	1.001AspHis: 1.001 ± 0.016	1.906AspIle: 1.906 ± 0.022	2.207AspLys: 2.207 ± 0.028	4.434AspLeu: 4.434 ± 0.033	1.139AspMet: 1.139 ± 0.017	1.275AspAsn: 1.275 ± 0.017	3.796AspPro: 3.796 ± 0.036	1.187AspGln: 1.187 ± 0.017	3.523AspArg: 3.523 ± 0.037	3.205AspSer: 3.205 ± 0.035	2.362AspThr: 2.362 ± 0.021	5.359AspVal: 5.359 ± 0.038	0.821AspTrp: 0.821 ± 0.014	1.158AspTyr: 1.158 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	7.907GluAla: 7.907 ± 0.086	1.145GluCys: 1.145 ± 0.024	4.558GluAsp: 4.558 ± 0.036	6.384GluGlu: 6.384 ± 0.069	1.848GluPhe: 1.848 ± 0.023	4.845GluGly: 4.845 ± 0.04	1.453GluHis: 1.453 ± 0.023	2.4GluIle: 2.4 ± 0.027	3.414GluLys: 3.414 ± 0.043	5.813GluLeu: 5.813 ± 0.046	1.585GluMet: 1.585 ± 0.02	1.779GluAsn: 1.779 ± 0.021	3.016GluPro: 3.016 ± 0.036	1.78GluGln: 1.78 ± 0.021	5.967GluArg: 5.967 ± 0.063	3.739GluSer: 3.739 ± 0.033	3.363GluThr: 3.363 ± 0.03	4.169GluVal: 4.169 ± 0.03	0.938GluTrp: 0.938 ± 0.013	1.371GluTyr: 1.371 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.579PheAla: 3.579 ± 0.032	0.538PheCys: 0.538 ± 0.011	2.363PheAsp: 2.363 ± 0.026	1.997PheGlu: 1.997 ± 0.023	1.236PhePhe: 1.236 ± 0.018	3.03PheGly: 3.03 ± 0.038	0.7PheHis: 0.7 ± 0.011	1.103PheIle: 1.103 ± 0.018	1.286PheLys: 1.286 ± 0.019	2.515PheLeu: 2.515 ± 0.029	0.665PheMet: 0.665 ± 0.011	1.035PheAsn: 1.035 ± 0.021	1.449PhePro: 1.449 ± 0.019	0.867PheGln: 0.867 ± 0.014	1.887PheArg: 1.887 ± 0.022	1.956PheSer: 1.956 ± 0.025	1.658PheThr: 1.658 ± 0.024	2.466PheVal: 2.466 ± 0.025	0.406PheTrp: 0.406 ± 0.01	0.738PheTyr: 0.738 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	10.389GlyAla: 10.389 ± 0.083	1.284GlyCys: 1.284 ± 0.021	6.365GlyAsp: 6.365 ± 0.051	5.384GlyGlu: 5.384 ± 0.043	2.836GlyPhe: 2.836 ± 0.03	12.381GlyGly: 12.381 ± 0.131	1.611GlyHis: 1.611 ± 0.026	2.626GlyIle: 2.626 ± 0.03	3.883GlyLys: 3.883 ± 0.041	5.726GlyLeu: 5.726 ± 0.045	1.807GlyMet: 1.807 ± 0.026	2.2GlyAsn: 2.2 ± 0.029	3.493GlyPro: 3.493 ± 0.033	1.855GlyGln: 1.855 ± 0.027	5.886GlyArg: 5.886 ± 0.052	6.28GlySer: 6.28 ± 0.052	4.423GlyThr: 4.423 ± 0.042	6.577GlyVal: 6.577 ± 0.045	1.291GlyTrp: 1.291 ± 0.021	1.89GlyTyr: 1.89 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	2.514HisAla: 2.514 ± 0.027	0.341HisCys: 0.341 ± 0.009	1.193HisAsp: 1.193 ± 0.017	1.197HisGlu: 1.197 ± 0.017	0.686HisPhe: 0.686 ± 0.013	1.979HisGly: 1.979 ± 0.029	0.656HisHis: 0.656 ± 0.015	0.605HisIle: 0.605 ± 0.014	0.698HisLys: 0.698 ± 0.015	1.784HisLeu: 1.784 ± 0.021	0.398HisMet: 0.398 ± 0.01	0.493HisAsn: 0.493 ± 0.013	1.392HisPro: 1.392 ± 0.019	0.577HisGln: 0.577 ± 0.011	1.654HisArg: 1.654 ± 0.022	1.161HisSer: 1.161 ± 0.019	0.852HisThr: 0.852 ± 0.014	1.688HisVal: 1.688 ± 0.019	0.279HisTrp: 0.279 ± 0.007	0.454HisTyr: 0.454 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	4.036IleAla: 4.036 ± 0.033	0.642IleCys: 0.642 ± 0.021	2.261IleAsp: 2.261 ± 0.024	2.142IleGlu: 2.142 ± 0.027	1.09IlePhe: 1.09 ± 0.018	2.573IleGly: 2.573 ± 0.031	0.674IleHis: 0.674 ± 0.014	1.155IleIle: 1.155 ± 0.022	1.434IleLys: 1.434 ± 0.022	2.546IleLeu: 2.546 ± 0.025	0.653IleMet: 0.653 ± 0.013	0.942IleAsn: 0.942 ± 0.016	1.657IlePro: 1.657 ± 0.02	0.892IleGln: 0.892 ± 0.017	2.1IleArg: 2.1 ± 0.019	1.982IleSer: 1.982 ± 0.032	1.591IleThr: 1.591 ± 0.026	2.555IleVal: 2.555 ± 0.023	0.343IleTrp: 0.343 ± 0.009	0.649IleTyr: 0.649 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	4.91LysAla: 4.91 ± 0.068	0.622LysCys: 0.622 ± 0.015	2.485LysAsp: 2.485 ± 0.027	3.424LysGlu: 3.424 ± 0.046	1.307LysPhe: 1.307 ± 0.017	3.208LysGly: 3.208 ± 0.034	0.874LysHis: 0.874 ± 0.014	1.68LysIle: 1.68 ± 0.024	3.301LysLys: 3.301 ± 0.049	3.625LysLeu: 3.625 ± 0.037	1.108LysMet: 1.108 ± 0.017	1.314LysAsn: 1.314 ± 0.019	2.396LysPro: 2.396 ± 0.032	1.278LysGln: 1.278 ± 0.02	3.413LysArg: 3.413 ± 0.032	2.663LysSer: 2.663 ± 0.03	2.422LysThr: 2.422 ± 0.03	2.853LysVal: 2.853 ± 0.028	0.506LysTrp: 0.506 ± 0.011	1.021LysTyr: 1.021 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	10.212LeuAla: 10.212 ± 0.076	1.382LeuCys: 1.382 ± 0.018	5.016LeuAsp: 5.016 ± 0.033	5.407LeuGlu: 5.407 ± 0.046	2.464LeuPhe: 2.464 ± 0.031	6.414LeuGly: 6.414 ± 0.038	1.735LeuHis: 1.735 ± 0.022	2.416LeuIle: 2.416 ± 0.027	3.483LeuLys: 3.483 ± 0.045	6.685LeuLeu: 6.685 ± 0.054	1.736LeuMet: 1.736 ± 0.021	2.269LeuAsn: 2.269 ± 0.026	4.157LeuPro: 4.157 ± 0.035	2.314LeuGln: 2.314 ± 0.028	6.761LeuArg: 6.761 ± 0.05	4.881LeuSer: 4.881 ± 0.038	4.35LeuThr: 4.35 ± 0.048	5.664LeuVal: 5.664 ± 0.048	0.918LeuTrp: 0.918 ± 0.016	1.598LeuTyr: 1.598 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.421MetAla: 2.421 ± 0.026	0.387MetCys: 0.387 ± 0.009	1.348MetAsp: 1.348 ± 0.018	1.41MetGlu: 1.41 ± 0.019	0.773MetPhe: 0.773 ± 0.019	1.714MetGly: 1.714 ± 0.023	0.466MetHis: 0.466 ± 0.01	0.723MetIle: 0.723 ± 0.014	0.957MetLys: 0.957 ± 0.016	1.835MetLeu: 1.835 ± 0.021	0.627MetMet: 0.627 ± 0.015	0.701MetAsn: 0.701 ± 0.014	1.155MetPro: 1.155 ± 0.018	0.693MetGln: 0.693 ± 0.014	1.778MetArg: 1.778 ± 0.02	1.688MetSer: 1.688 ± 0.02	1.274MetThr: 1.274 ± 0.014	1.254MetVal: 1.254 ± 0.021	0.254MetTrp: 0.254 ± 0.007	0.51MetTyr: 0.51 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.41AsnAla: 3.41 ± 0.028	0.376AsnCys: 0.376 ± 0.01	1.706AsnAsp: 1.706 ± 0.02	1.655AsnGlu: 1.655 ± 0.02	0.948AsnPhe: 0.948 ± 0.017	2.425AsnGly: 2.425 ± 0.031	0.536AsnHis: 0.536 ± 0.012	0.974AsnIle: 0.974 ± 0.019	1.175AsnLys: 1.175 ± 0.016	2.302AsnLeu: 2.302 ± 0.026	0.609AsnMet: 0.609 ± 0.013	0.85AsnAsn: 0.85 ± 0.022	1.829AsnPro: 1.829 ± 0.022	0.808AsnGln: 0.808 ± 0.017	1.638AsnArg: 1.638 ± 0.022	1.526AsnSer: 1.526 ± 0.022	1.265AsnThr: 1.265 ± 0.017	2.132AsnVal: 2.132 ± 0.021	0.335AsnTrp: 0.335 ± 0.01	0.604AsnTyr: 0.604 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	6.695ProAla: 6.695 ± 0.068	0.638ProCys: 0.638 ± 0.014	3.208ProAsp: 3.208 ± 0.033	3.605ProGlu: 3.605 ± 0.037	1.614ProPhe: 1.614 ± 0.02	5.155ProGly: 5.155 ± 0.046	1.056ProHis: 1.056 ± 0.015	1.544ProIle: 1.544 ± 0.022	2.335ProLys: 2.335 ± 0.029	3.661ProLeu: 3.661 ± 0.036	1.023ProMet: 1.023 ± 0.016	1.607ProAsn: 1.607 ± 0.02	5.769ProPro: 5.769 ± 0.086	1.144ProGln: 1.144 ± 0.017	3.98ProArg: 3.98 ± 0.045	4.231ProSer: 4.231 ± 0.046	3.19ProThr: 3.19 ± 0.033	3.541ProVal: 3.541 ± 0.035	0.662ProTrp: 0.662 ± 0.015	0.946ProTyr: 0.946 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	2.6GlnAla: 2.6 ± 0.028	0.47GlnCys: 0.47 ± 0.013	1.072GlnAsp: 1.072 ± 0.016	1.439GlnGlu: 1.439 ± 0.02	0.808GlnPhe: 0.808 ± 0.016	1.683GlnGly: 1.683 ± 0.023	0.623GlnHis: 0.623 ± 0.013	1.041GlnIle: 1.041 ± 0.017	1.25GlnLys: 1.25 ± 0.019	2.681GlnLeu: 2.681 ± 0.041	0.762GlnMet: 0.762 ± 0.016	0.772GlnAsn: 0.772 ± 0.014	1.368GlnPro: 1.368 ± 0.022	1.267GlnGln: 1.267 ± 0.049	2.327GlnArg: 2.327 ± 0.026	1.569GlnSer: 1.569 ± 0.022	1.425GlnThr: 1.425 ± 0.019	1.643GlnVal: 1.643 ± 0.021	0.389GlnTrp: 0.389 ± 0.009	0.604GlnTyr: 0.604 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	9.75ArgAla: 9.75 ± 0.095	1.346ArgCys: 1.346 ± 0.021	4.641ArgAsp: 4.641 ± 0.043	5.36ArgGlu: 5.36 ± 0.046	2.155ArgPhe: 2.155 ± 0.023	6.449ArgGly: 6.449 ± 0.057	1.643ArgHis: 1.643 ± 0.019	2.271ArgIle: 2.271 ± 0.025	3.08ArgLys: 3.08 ± 0.028	6.257ArgLeu: 6.257 ± 0.05	1.671ArgMet: 1.671 ± 0.019	1.78ArgAsn: 1.78 ± 0.021	3.339ArgPro: 3.339 ± 0.034	1.919ArgGln: 1.919 ± 0.023	8.339ArgArg: 8.339 ± 0.097	4.745ArgSer: 4.745 ± 0.044	3.468ArgThr: 3.468 ± 0.033	5.623ArgVal: 5.623 ± 0.046	1.265ArgTrp: 1.265 ± 0.02	1.461ArgTyr: 1.461 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	7.517SerAla: 7.517 ± 0.055	0.922SerCys: 0.922 ± 0.019	3.83SerAsp: 3.83 ± 0.038	3.423SerGlu: 3.423 ± 0.031	2.249SerPhe: 2.249 ± 0.023	5.882SerGly: 5.882 ± 0.057	1.363SerHis: 1.363 ± 0.02	2.21SerIle: 2.21 ± 0.03	2.725SerLys: 2.725 ± 0.028	5.471SerLeu: 5.471 ± 0.05	1.382SerMet: 1.382 ± 0.019	1.766SerAsn: 1.766 ± 0.022	4.274SerPro: 4.274 ± 0.05	1.685SerGln: 1.685 ± 0.02	4.787SerArg: 4.787 ± 0.05	6.122SerSer: 6.122 ± 0.076	3.58SerThr: 3.58 ± 0.034	4.489SerVal: 4.489 ± 0.039	0.817SerTrp: 0.817 ± 0.014	1.214SerTyr: 1.214 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	5.827ThrAla: 5.827 ± 0.049	0.936ThrCys: 0.936 ± 0.019	2.646ThrAsp: 2.646 ± 0.025	2.749ThrGlu: 2.749 ± 0.029	1.756ThrPhe: 1.756 ± 0.018	4.199ThrGly: 4.199 ± 0.039	1.182ThrHis: 1.182 ± 0.016	1.75ThrIle: 1.75 ± 0.023	2.141ThrLys: 2.141 ± 0.023	4.435ThrLeu: 4.435 ± 0.034	1.113ThrMet: 1.113 ± 0.016	1.469ThrAsn: 1.469 ± 0.019	3.534ThrPro: 3.534 ± 0.035	1.363ThrGln: 1.363 ± 0.019	3.911ThrArg: 3.911 ± 0.036	3.775ThrSer: 3.775 ± 0.043	2.985ThrThr: 2.985 ± 0.031	3.694ThrVal: 3.694 ± 0.033	0.709ThrTrp: 0.709 ± 0.013	1.128ThrTyr: 1.128 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	9.13ValAla: 9.13 ± 0.059	1.227ValCys: 1.227 ± 0.018	5.033ValAsp: 5.033 ± 0.032	4.628ValGlu: 4.628 ± 0.033	2.427ValPhe: 2.427 ± 0.027	5.704ValGly: 5.704 ± 0.041	1.588ValHis: 1.588 ± 0.02	2.255ValIle: 2.255 ± 0.021	3.11ValLys: 3.11 ± 0.029	5.62ValLeu: 5.62 ± 0.044	1.546ValMet: 1.546 ± 0.019	2.148ValAsn: 2.148 ± 0.024	3.996ValPro: 3.996 ± 0.037	1.783ValGln: 1.783 ± 0.021	5.158ValArg: 5.158 ± 0.04	4.441ValSer: 4.441 ± 0.039	4.133ValThr: 4.133 ± 0.038	5.917ValVal: 5.917 ± 0.052	0.867ValTrp: 0.867 ± 0.015	1.513ValTyr: 1.513 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.176TrpAla: 1.176 ± 0.017	0.275TrpCys: 0.275 ± 0.007	0.885TrpAsp: 0.885 ± 0.018	0.799TrpGlu: 0.799 ± 0.014	0.442TrpPhe: 0.442 ± 0.01	0.973TrpGly: 0.973 ± 0.016	0.327TrpHis: 0.327 ± 0.01	0.506TrpIle: 0.506 ± 0.011	0.55TrpLys: 0.55 ± 0.012	1.131TrpLeu: 1.131 ± 0.018	0.344TrpMet: 0.344 ± 0.009	0.479TrpAsn: 0.479 ± 0.011	0.503TrpPro: 0.503 ± 0.011	0.381TrpGln: 0.381 ± 0.009	1.299TrpArg: 1.299 ± 0.024	0.884TrpSer: 0.884 ± 0.014	0.789TrpThr: 0.789 ± 0.013	0.754TrpVal: 0.754 ± 0.013	0.233TrpTrp: 0.233 ± 0.006	0.305TrpTyr: 0.305 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.152TyrAla: 2.152 ± 0.024	0.359TyrCys: 0.359 ± 0.01	1.492TyrAsp: 1.492 ± 0.024	1.296TyrGlu: 1.296 ± 0.019	0.756TyrPhe: 0.756 ± 0.014	1.785TyrGly: 1.785 ± 0.023	0.48TyrHis: 0.48 ± 0.01	0.618TyrIle: 0.618 ± 0.015	0.81TyrLys: 0.81 ± 0.015	1.772TyrLeu: 1.772 ± 0.022	0.448TyrMet: 0.448 ± 0.01	0.667TyrAsn: 0.667 ± 0.015	0.966TyrPro: 0.966 ± 0.014	0.577TyrGln: 0.577 ± 0.012	1.356TyrArg: 1.356 ± 0.018	1.156TyrSer: 1.156 ± 0.016	0.951TyrThr: 0.951 ± 0.016	1.67TyrVal: 1.67 ± 0.022	0.28TyrTrp: 0.28 ± 0.009	0.621TyrTyr: 0.621 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10115 proteins (4889369 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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