Amino acid dipepetide frequency for Kingella oralis ATCC 51147

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.837AlaAla: 16.837 ± 0.223
1.343AlaCys: 1.343 ± 0.044
6.064AlaAsp: 6.064 ± 0.099
6.719AlaGlu: 6.719 ± 0.111
4.208AlaPhe: 4.208 ± 0.082
7.891AlaGly: 7.891 ± 0.158
2.748AlaHis: 2.748 ± 0.08
5.398AlaIle: 5.398 ± 0.093
5.375AlaLys: 5.375 ± 0.101
11.92AlaLeu: 11.92 ± 0.173
3.104AlaMet: 3.104 ± 0.069
4.099AlaAsn: 4.099 ± 0.091
4.649AlaPro: 4.649 ± 0.099
7.412AlaGln: 7.412 ± 0.153
5.692AlaArg: 5.692 ± 0.114
5.294AlaSer: 5.294 ± 0.093
4.977AlaThr: 4.977 ± 0.096
7.411AlaVal: 7.411 ± 0.126
1.623AlaTrp: 1.623 ± 0.065
2.917AlaTyr: 2.917 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
1.253CysAla: 1.253 ± 0.04
0.234CysCys: 0.234 ± 0.022
0.521CysAsp: 0.521 ± 0.03
0.547CysGlu: 0.547 ± 0.029
0.537CysPhe: 0.537 ± 0.027
1.132CysGly: 1.132 ± 0.042
0.349CysHis: 0.349 ± 0.024
0.51CysIle: 0.51 ± 0.033
0.431CysLys: 0.431 ± 0.027
1.45CysLeu: 1.45 ± 0.047
0.214CysMet: 0.214 ± 0.018
0.342CysAsn: 0.342 ± 0.022
0.667CysPro: 0.667 ± 0.03
0.5CysGln: 0.5 ± 0.027
0.738CysArg: 0.738 ± 0.037
0.559CysSer: 0.559 ± 0.027
0.524CysThr: 0.524 ± 0.027
0.702CysVal: 0.702 ± 0.033
0.131CysTrp: 0.131 ± 0.014
0.317CysTyr: 0.317 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
5.112AspAla: 5.112 ± 0.087
0.551AspCys: 0.551 ± 0.029
2.634AspAsp: 2.634 ± 0.071
3.165AspGlu: 3.165 ± 0.076
2.442AspPhe: 2.442 ± 0.058
3.736AspGly: 3.736 ± 0.091
0.795AspHis: 0.795 ± 0.036
3.033AspIle: 3.033 ± 0.068
2.66AspLys: 2.66 ± 0.079
4.671AspLeu: 4.671 ± 0.079
1.196AspMet: 1.196 ± 0.036
2.243AspAsn: 2.243 ± 0.065
1.677AspPro: 1.677 ± 0.052
1.191AspGln: 1.191 ± 0.047
1.773AspArg: 1.773 ± 0.055
2.386AspSer: 2.386 ± 0.064
2.567AspThr: 2.567 ± 0.059
3.138AspVal: 3.138 ± 0.071
0.957AspTrp: 0.957 ± 0.037
2.011AspTyr: 2.011 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
5.713GluAla: 5.713 ± 0.102
0.502GluCys: 0.502 ± 0.027
1.974GluAsp: 1.974 ± 0.053
2.332GluGlu: 2.332 ± 0.074
1.832GluPhe: 1.832 ± 0.048
2.558GluGly: 2.558 ± 0.082
1.649GluHis: 1.649 ± 0.048
3.551GluIle: 3.551 ± 0.071
3.128GluLys: 3.128 ± 0.086
5.294GluLeu: 5.294 ± 0.099
1.582GluMet: 1.582 ± 0.051
3.207GluAsn: 3.207 ± 0.075
2.036GluPro: 2.036 ± 0.074
3.364GluGln: 3.364 ± 0.084
3.586GluArg: 3.586 ± 0.079
2.274GluSer: 2.274 ± 0.052
3.448GluThr: 3.448 ± 0.068
2.872GluVal: 2.872 ± 0.075
0.744GluTrp: 0.744 ± 0.035
1.46GluTyr: 1.46 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
5.094PheAla: 5.094 ± 0.087
0.614PheCys: 0.614 ± 0.026
2.312PheAsp: 2.312 ± 0.054
1.873PheGlu: 1.873 ± 0.051
1.714PhePhe: 1.714 ± 0.051
3.292PheGly: 3.292 ± 0.081
0.836PheHis: 0.836 ± 0.038
2.262PheIle: 2.262 ± 0.067
1.64PheLys: 1.64 ± 0.051
3.279PheLeu: 3.279 ± 0.086
0.965PheMet: 0.965 ± 0.039
1.84PheAsn: 1.84 ± 0.047
1.523PhePro: 1.523 ± 0.053
2.029PheGln: 2.029 ± 0.061
2.336PheArg: 2.336 ± 0.056
2.704PheSer: 2.704 ± 0.073
2.139PheThr: 2.139 ± 0.058
2.72PheVal: 2.72 ± 0.068
0.593PheTrp: 0.593 ± 0.031
1.296PheTyr: 1.296 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
6.692GlyAla: 6.692 ± 0.129
1.485GlyCys: 1.485 ± 0.054
3.389GlyAsp: 3.389 ± 0.085
4.156GlyGlu: 4.156 ± 0.089
3.334GlyPhe: 3.334 ± 0.084
5.601GlyGly: 5.601 ± 0.142
1.333GlyHis: 1.333 ± 0.045
4.523GlyIle: 4.523 ± 0.09
5.029GlyLys: 5.029 ± 0.092
6.434GlyLeu: 6.434 ± 0.107
2.032GlyMet: 2.032 ± 0.052
3.064GlyAsn: 3.064 ± 0.093
0.703GlyPro: 0.703 ± 0.04
2.538GlyGln: 2.538 ± 0.062
3.269GlyArg: 3.269 ± 0.072
4.984GlySer: 4.984 ± 0.105
3.42GlyThr: 3.42 ± 0.1
4.98GlyVal: 4.98 ± 0.107
1.158GlyTrp: 1.158 ± 0.044
2.318GlyTyr: 2.318 ± 0.068
0.0GlyXaa: 0.0 ± 0.0
His
2.765HisAla: 2.765 ± 0.07
0.302HisCys: 0.302 ± 0.024
1.15HisAsp: 1.15 ± 0.043
1.229HisGlu: 1.229 ± 0.043
1.125HisPhe: 1.125 ± 0.043
2.001HisGly: 2.001 ± 0.061
0.838HisHis: 0.838 ± 0.032
1.742HisIle: 1.742 ± 0.054
0.977HisLys: 0.977 ± 0.037
2.146HisLeu: 2.146 ± 0.056
0.417HisMet: 0.417 ± 0.028
1.068HisAsn: 1.068 ± 0.036
1.646HisPro: 1.646 ± 0.054
1.156HisGln: 1.156 ± 0.037
1.377HisArg: 1.377 ± 0.051
1.37HisSer: 1.37 ± 0.048
1.525HisThr: 1.525 ± 0.049
1.108HisVal: 1.108 ± 0.041
0.31HisTrp: 0.31 ± 0.023
0.946HisTyr: 0.946 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
7.612IleAla: 7.612 ± 0.106
0.597IleCys: 0.597 ± 0.029
2.937IleAsp: 2.937 ± 0.067
3.02IleGlu: 3.02 ± 0.076
1.933IlePhe: 1.933 ± 0.06
4.692IleGly: 4.692 ± 0.107
1.333IleHis: 1.333 ± 0.042
3.388IleIle: 3.388 ± 0.078
2.546IleLys: 2.546 ± 0.069
4.8IleLeu: 4.8 ± 0.098
1.215IleMet: 1.215 ± 0.049
2.496IleAsn: 2.496 ± 0.064
2.498IlePro: 2.498 ± 0.056
2.376IleGln: 2.376 ± 0.072
3.296IleArg: 3.296 ± 0.073
3.166IleSer: 3.166 ± 0.072
3.281IleThr: 3.281 ± 0.064
3.761IleVal: 3.761 ± 0.088
0.655IleTrp: 0.655 ± 0.032
1.354IleTyr: 1.354 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
4.824LysAla: 4.824 ± 0.089
0.292LysCys: 0.292 ± 0.021
2.11LysAsp: 2.11 ± 0.061
2.301LysGlu: 2.301 ± 0.074
1.358LysPhe: 1.358 ± 0.046
3.134LysGly: 3.134 ± 0.071
1.194LysHis: 1.194 ± 0.042
3.31LysIle: 3.31 ± 0.081
2.742LysLys: 2.742 ± 0.071
4.773LysLeu: 4.773 ± 0.099
1.599LysMet: 1.599 ± 0.046
2.349LysAsn: 2.349 ± 0.066
2.66LysPro: 2.66 ± 0.07
2.911LysGln: 2.911 ± 0.075
2.944LysArg: 2.944 ± 0.077
2.365LysSer: 2.365 ± 0.053
3.665LysThr: 3.665 ± 0.073
2.577LysVal: 2.577 ± 0.079
0.633LysTrp: 0.633 ± 0.031
1.226LysTyr: 1.226 ± 0.046
0.0LysXaa: 0.0 ± 0.0
Leu
12.265LeuAla: 12.265 ± 0.161
1.164LeuCys: 1.164 ± 0.049
5.053LeuAsp: 5.053 ± 0.078
4.108LeuGlu: 4.108 ± 0.081
4.305LeuPhe: 4.305 ± 0.097
6.906LeuGly: 6.906 ± 0.108
2.503LeuHis: 2.503 ± 0.066
5.19LeuIle: 5.19 ± 0.088
5.348LeuLys: 5.348 ± 0.084
10.226LeuLeu: 10.226 ± 0.196
2.405LeuMet: 2.405 ± 0.065
4.399LeuAsn: 4.399 ± 0.085
6.336LeuPro: 6.336 ± 0.114
4.204LeuGln: 4.204 ± 0.089
5.527LeuArg: 5.527 ± 0.102
5.869LeuSer: 5.869 ± 0.095
5.227LeuThr: 5.227 ± 0.095
5.713LeuVal: 5.713 ± 0.113
1.171LeuTrp: 1.171 ± 0.043
2.548LeuTyr: 2.548 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
2.434MetAla: 2.434 ± 0.06
0.224MetCys: 0.224 ± 0.02
1.039MetAsp: 1.039 ± 0.042
1.034MetGlu: 1.034 ± 0.038
0.896MetPhe: 0.896 ± 0.039
1.776MetGly: 1.776 ± 0.053
0.497MetHis: 0.497 ± 0.022
1.165MetIle: 1.165 ± 0.048
1.399MetLys: 1.399 ± 0.049
2.768MetLeu: 2.768 ± 0.066
0.775MetMet: 0.775 ± 0.04
1.082MetAsn: 1.082 ± 0.039
1.499MetPro: 1.499 ± 0.051
1.402MetGln: 1.402 ± 0.041
1.498MetArg: 1.498 ± 0.049
1.34MetSer: 1.34 ± 0.044
1.313MetThr: 1.313 ± 0.043
1.567MetVal: 1.567 ± 0.045
0.256MetTrp: 0.256 ± 0.018
0.493MetTyr: 0.493 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
4.477AsnAla: 4.477 ± 0.09
0.361AsnCys: 0.361 ± 0.025
1.897AsnAsp: 1.897 ± 0.058
2.26AsnGlu: 2.26 ± 0.062
1.271AsnPhe: 1.271 ± 0.042
3.743AsnGly: 3.743 ± 0.086
1.218AsnHis: 1.218 ± 0.044
2.682AsnIle: 2.682 ± 0.066
2.042AsnLys: 2.042 ± 0.06
3.678AsnLeu: 3.678 ± 0.071
0.838AsnMet: 0.838 ± 0.035
1.725AsnAsn: 1.725 ± 0.074
2.573AsnPro: 2.573 ± 0.068
2.074AsnGln: 2.074 ± 0.065
2.524AsnArg: 2.524 ± 0.063
2.066AsnSer: 2.066 ± 0.078
2.304AsnThr: 2.304 ± 0.066
2.529AsnVal: 2.529 ± 0.076
0.548AsnTrp: 0.548 ± 0.03
1.082AsnTyr: 1.082 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
5.256ProAla: 5.256 ± 0.107
0.517ProCys: 0.517 ± 0.027
2.56ProAsp: 2.56 ± 0.061
4.619ProGlu: 4.619 ± 0.088
2.157ProPhe: 2.157 ± 0.06
1.103ProGly: 1.103 ± 0.046
1.413ProHis: 1.413 ± 0.056
2.508ProIle: 2.508 ± 0.06
2.339ProLys: 2.339 ± 0.061
4.273ProLeu: 4.273 ± 0.097
1.058ProMet: 1.058 ± 0.039
2.181ProAsn: 2.181 ± 0.065
2.071ProPro: 2.071 ± 0.06
2.658ProGln: 2.658 ± 0.074
2.09ProArg: 2.09 ± 0.058
2.59ProSer: 2.59 ± 0.07
2.443ProThr: 2.443 ± 0.068
2.882ProVal: 2.882 ± 0.073
0.397ProTrp: 0.397 ± 0.024
1.264ProTyr: 1.264 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
6.895GlnAla: 6.895 ± 0.124
0.414GlnCys: 0.414 ± 0.024
2.009GlnAsp: 2.009 ± 0.058
2.084GlnGlu: 2.084 ± 0.075
1.871GlnPhe: 1.871 ± 0.053
3.028GlnGly: 3.028 ± 0.076
1.659GlnHis: 1.659 ± 0.058
3.269GlnIle: 3.269 ± 0.081
2.297GlnLys: 2.297 ± 0.062
4.299GlnLeu: 4.299 ± 0.101
1.247GlnMet: 1.247 ± 0.045
2.319GlnAsn: 2.319 ± 0.066
3.62GlnPro: 3.62 ± 0.086
3.275GlnGln: 3.275 ± 0.088
3.128GlnArg: 3.128 ± 0.075
2.825GlnSer: 2.825 ± 0.077
3.275GlnThr: 3.275 ± 0.074
2.29GlnVal: 2.29 ± 0.056
0.689GlnTrp: 0.689 ± 0.032
1.404GlnTyr: 1.404 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
5.472ArgAla: 5.472 ± 0.095
0.565ArgCys: 0.565 ± 0.026
2.739ArgAsp: 2.739 ± 0.07
3.24ArgGlu: 3.24 ± 0.082
2.82ArgPhe: 2.82 ± 0.06
3.369ArgGly: 3.369 ± 0.079
1.55ArgHis: 1.55 ± 0.049
3.254ArgIle: 3.254 ± 0.068
2.407ArgLys: 2.407 ± 0.07
6.223ArgLeu: 6.223 ± 0.113
1.298ArgMet: 1.298 ± 0.047
2.032ArgAsn: 2.032 ± 0.053
2.148ArgPro: 2.148 ± 0.051
3.824ArgGln: 3.824 ± 0.081
3.416ArgArg: 3.416 ± 0.088
2.627ArgSer: 2.627 ± 0.066
2.225ArgThr: 2.225 ± 0.059
3.533ArgVal: 3.533 ± 0.073
0.623ArgTrp: 0.623 ± 0.028
1.912ArgTyr: 1.912 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
5.211SerAla: 5.211 ± 0.092
0.592SerCys: 0.592 ± 0.033
2.479SerAsp: 2.479 ± 0.063
2.954SerGlu: 2.954 ± 0.072
2.101SerPhe: 2.101 ± 0.055
5.238SerGly: 5.238 ± 0.112
1.389SerHis: 1.389 ± 0.046
2.87SerIle: 2.87 ± 0.065
2.463SerLys: 2.463 ± 0.063
6.216SerLeu: 6.216 ± 0.101
1.122SerMet: 1.122 ± 0.04
2.021SerAsn: 2.021 ± 0.057
2.607SerPro: 2.607 ± 0.058
2.441SerGln: 2.441 ± 0.061
2.971SerArg: 2.971 ± 0.057
2.777SerSer: 2.777 ± 0.078
2.372SerThr: 2.372 ± 0.067
3.5SerVal: 3.5 ± 0.083
0.574SerTrp: 0.574 ± 0.031
1.475SerTyr: 1.475 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
6.382ThrAla: 6.382 ± 0.122
0.458ThrCys: 0.458 ± 0.025
2.317ThrAsp: 2.317 ± 0.077
2.501ThrGlu: 2.501 ± 0.061
1.967ThrPhe: 1.967 ± 0.057
3.803ThrGly: 3.803 ± 0.099
1.354ThrHis: 1.354 ± 0.046
2.913ThrIle: 2.913 ± 0.061
1.767ThrLys: 1.767 ± 0.053
6.286ThrLeu: 6.286 ± 0.093
1.024ThrMet: 1.024 ± 0.037
1.618ThrAsn: 1.618 ± 0.062
3.506ThrPro: 3.506 ± 0.083
2.769ThrGln: 2.769 ± 0.072
2.803ThrArg: 2.803 ± 0.065
2.401ThrSer: 2.401 ± 0.059
2.708ThrThr: 2.708 ± 0.071
3.719ThrVal: 3.719 ± 0.087
0.628ThrTrp: 0.628 ± 0.029
1.191ThrTyr: 1.191 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
6.989ValAla: 6.989 ± 0.131
0.875ValCys: 0.875 ± 0.033
2.71ValAsp: 2.71 ± 0.068
3.185ValGlu: 3.185 ± 0.088
3.087ValPhe: 3.087 ± 0.078
4.485ValGly: 4.485 ± 0.092
1.32ValHis: 1.32 ± 0.043
3.272ValIle: 3.272 ± 0.081
2.872ValLys: 2.872 ± 0.081
6.727ValLeu: 6.727 ± 0.128
1.588ValMet: 1.588 ± 0.055
2.355ValAsn: 2.355 ± 0.069
2.389ValPro: 2.389 ± 0.07
2.765ValGln: 2.765 ± 0.067
3.378ValArg: 3.378 ± 0.071
3.919ValSer: 3.919 ± 0.074
2.467ValThr: 2.467 ± 0.077
4.339ValVal: 4.339 ± 0.098
0.905ValTrp: 0.905 ± 0.042
1.914ValTyr: 1.914 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
1.333TrpAla: 1.333 ± 0.05
0.178TrpCys: 0.178 ± 0.015
0.59TrpAsp: 0.59 ± 0.026
0.469TrpGlu: 0.469 ± 0.027
0.662TrpPhe: 0.662 ± 0.028
0.826TrpGly: 0.826 ± 0.038
0.482TrpHis: 0.482 ± 0.031
0.619TrpIle: 0.619 ± 0.032
0.457TrpLys: 0.457 ± 0.024
2.129TrpLeu: 2.129 ± 0.068
0.29TrpMet: 0.29 ± 0.022
0.376TrpAsn: 0.376 ± 0.021
0.124TrpPro: 0.124 ± 0.014
1.419TrpGln: 1.419 ± 0.054
0.96TrpArg: 0.96 ± 0.037
0.435TrpSer: 0.435 ± 0.028
0.516TrpThr: 0.516 ± 0.03
0.807TrpVal: 0.807 ± 0.041
0.189TrpTrp: 0.189 ± 0.016
0.358TrpTyr: 0.358 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.066TyrAla: 3.066 ± 0.075
0.392TyrCys: 0.392 ± 0.03
1.454TyrAsp: 1.454 ± 0.045
1.312TyrGlu: 1.312 ± 0.046
1.442TyrPhe: 1.442 ± 0.049
2.129TyrGly: 2.129 ± 0.059
0.734TyrHis: 0.734 ± 0.034
1.498TyrIle: 1.498 ± 0.051
1.047TyrLys: 1.047 ± 0.04
2.873TyrLeu: 2.873 ± 0.065
0.485TyrMet: 0.485 ± 0.022
1.074TyrAsn: 1.074 ± 0.044
1.45TyrPro: 1.45 ± 0.046
1.592TyrGln: 1.592 ± 0.058
1.971TyrArg: 1.971 ± 0.055
1.419TyrSer: 1.419 ± 0.048
1.719TyrThr: 1.719 ± 0.055
1.394TyrVal: 1.394 ± 0.045
0.434TyrTrp: 0.434 ± 0.029
0.884TyrTyr: 0.884 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3160 proteins (709645 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski