Amino acid dipepetide frequency for Laribacter hongkongensis (strain HLHK9)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.892AlaAla: 15.892 ± 0.199	1.568AlaCys: 1.568 ± 0.043	6.85AlaAsp: 6.85 ± 0.102	6.685AlaGlu: 6.685 ± 0.107	3.774AlaPhe: 3.774 ± 0.065	12.168AlaGly: 12.168 ± 0.141	2.194AlaHis: 2.194 ± 0.053	5.388AlaIle: 5.388 ± 0.091	2.834AlaLys: 2.834 ± 0.061	13.291AlaLeu: 13.291 ± 0.159	3.466AlaMet: 3.466 ± 0.07	2.671AlaAsn: 2.671 ± 0.055	5.064AlaPro: 5.064 ± 0.081	4.044AlaGln: 4.044 ± 0.076	9.633AlaArg: 9.633 ± 0.132	6.431AlaSer: 6.431 ± 0.097	5.711AlaThr: 5.711 ± 0.088	8.53AlaVal: 8.53 ± 0.113	1.675AlaTrp: 1.675 ± 0.047	2.3AlaTyr: 2.3 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.106CysAla: 1.106 ± 0.035	0.174CysCys: 0.174 ± 0.013	0.588CysAsp: 0.588 ± 0.024	0.562CysGlu: 0.562 ± 0.026	0.352CysPhe: 0.352 ± 0.019	1.103CysGly: 1.103 ± 0.04	0.389CysHis: 0.389 ± 0.02	0.477CysIle: 0.477 ± 0.026	0.273CysLys: 0.273 ± 0.018	1.166CysLeu: 1.166 ± 0.036	0.238CysMet: 0.238 ± 0.017	0.303CysAsn: 0.303 ± 0.016	0.709CysPro: 0.709 ± 0.031	0.435CysGln: 0.435 ± 0.025	0.982CysArg: 0.982 ± 0.041	0.551CysSer: 0.551 ± 0.026	0.488CysThr: 0.488 ± 0.022	0.719CysVal: 0.719 ± 0.03	0.165CysTrp: 0.165 ± 0.015	0.266CysTyr: 0.266 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.389AspAla: 6.389 ± 0.095	0.641AspCys: 0.641 ± 0.024	2.935AspAsp: 2.935 ± 0.063	3.295AspGlu: 3.295 ± 0.07	2.01AspPhe: 2.01 ± 0.048	4.594AspGly: 4.594 ± 0.082	1.021AspHis: 1.021 ± 0.037	2.874AspIle: 2.874 ± 0.06	1.872AspLys: 1.872 ± 0.055	5.348AspLeu: 5.348 ± 0.081	1.449AspMet: 1.449 ± 0.037	1.515AspAsn: 1.515 ± 0.046	2.823AspPro: 2.823 ± 0.057	1.643AspGln: 1.643 ± 0.043	3.52AspArg: 3.52 ± 0.064	2.697AspSer: 2.697 ± 0.066	2.908AspThr: 2.908 ± 0.068	3.887AspVal: 3.887 ± 0.072	1.179AspTrp: 1.179 ± 0.041	1.594AspTyr: 1.594 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.914GluAla: 6.914 ± 0.109	0.463GluCys: 0.463 ± 0.02	2.121GluAsp: 2.121 ± 0.048	2.498GluGlu: 2.498 ± 0.06	1.713GluPhe: 1.713 ± 0.047	3.517GluGly: 3.517 ± 0.073	1.309GluHis: 1.309 ± 0.04	2.802GluIle: 2.802 ± 0.062	1.909GluLys: 1.909 ± 0.053	6.329GluLeu: 6.329 ± 0.094	1.28GluMet: 1.28 ± 0.04	1.396GluAsn: 1.396 ± 0.04	2.508GluPro: 2.508 ± 0.068	2.82GluGln: 2.82 ± 0.062	4.383GluArg: 4.383 ± 0.067	2.72GluSer: 2.72 ± 0.065	2.713GluThr: 2.713 ± 0.066	3.838GluVal: 3.838 ± 0.073	0.767GluTrp: 0.767 ± 0.029	1.09GluTyr: 1.09 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	4.311PheAla: 4.311 ± 0.071	0.449PheCys: 0.449 ± 0.025	2.413PheAsp: 2.413 ± 0.061	1.82PheGlu: 1.82 ± 0.045	1.428PhePhe: 1.428 ± 0.049	3.311PheGly: 3.311 ± 0.072	0.733PheHis: 0.733 ± 0.027	1.597PheIle: 1.597 ± 0.051	1.032PheLys: 1.032 ± 0.033	3.188PheLeu: 3.188 ± 0.08	0.894PheMet: 0.894 ± 0.031	1.141PheAsn: 1.141 ± 0.03	1.415PhePro: 1.415 ± 0.041	0.959PheGln: 0.959 ± 0.031	2.092PheArg: 2.092 ± 0.047	2.264PheSer: 2.264 ± 0.054	1.736PheThr: 1.736 ± 0.049	2.899PheVal: 2.899 ± 0.058	0.56PheTrp: 0.56 ± 0.028	0.97PheTyr: 0.97 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.369GlyAla: 7.369 ± 0.117	1.142GlyCys: 1.142 ± 0.037	3.875GlyAsp: 3.875 ± 0.075	4.622GlyGlu: 4.622 ± 0.077	3.443GlyPhe: 3.443 ± 0.057	6.396GlyGly: 6.396 ± 0.154	2.05GlyHis: 2.05 ± 0.058	4.438GlyIle: 4.438 ± 0.08	3.331GlyLys: 3.331 ± 0.068	9.225GlyLeu: 9.225 ± 0.115	2.606GlyMet: 2.606 ± 0.055	2.497GlyAsn: 2.497 ± 0.085	2.57GlyPro: 2.57 ± 0.057	3.758GlyGln: 3.758 ± 0.079	5.882GlyArg: 5.882 ± 0.096	4.603GlySer: 4.603 ± 0.099	4.035GlyThr: 4.035 ± 0.081	6.01GlyVal: 6.01 ± 0.082	1.636GlyTrp: 1.636 ± 0.054	2.21GlyTyr: 2.21 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.775HisAla: 2.775 ± 0.06	0.318HisCys: 0.318 ± 0.02	1.355HisAsp: 1.355 ± 0.041	1.213HisGlu: 1.213 ± 0.038	0.867HisPhe: 0.867 ± 0.033	2.128HisGly: 2.128 ± 0.053	0.672HisHis: 0.672 ± 0.03	0.918HisIle: 0.918 ± 0.034	0.559HisLys: 0.559 ± 0.027	2.185HisLeu: 2.185 ± 0.054	0.473HisMet: 0.473 ± 0.021	0.568HisAsn: 0.568 ± 0.027	1.609HisPro: 1.609 ± 0.042	0.738HisGln: 0.738 ± 0.032	1.485HisArg: 1.485 ± 0.046	1.064HisSer: 1.064 ± 0.037	0.986HisThr: 0.986 ± 0.034	1.533HisVal: 1.533 ± 0.043	0.418HisTrp: 0.418 ± 0.022	0.688HisTyr: 0.688 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.58IleAla: 5.58 ± 0.087	0.481IleCys: 0.481 ± 0.021	3.353IleAsp: 3.353 ± 0.066	2.993IleGlu: 2.993 ± 0.065	1.308IlePhe: 1.308 ± 0.043	4.317IleGly: 4.317 ± 0.074	0.966IleHis: 0.966 ± 0.032	1.966IleIle: 1.966 ± 0.061	1.649IleLys: 1.649 ± 0.052	4.029IleLeu: 4.029 ± 0.086	0.902IleMet: 0.902 ± 0.036	1.561IleAsn: 1.561 ± 0.04	2.193IlePro: 2.193 ± 0.054	1.373IleGln: 1.373 ± 0.04	3.28IleArg: 3.28 ± 0.068	2.653IleSer: 2.653 ± 0.06	2.501IleThr: 2.501 ± 0.057	3.542IleVal: 3.542 ± 0.065	0.445IleTrp: 0.445 ± 0.023	0.934IleTyr: 0.934 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.483LysAla: 3.483 ± 0.073	0.203LysCys: 0.203 ± 0.016	1.482LysAsp: 1.482 ± 0.043	1.463LysGlu: 1.463 ± 0.041	0.882LysPhe: 0.882 ± 0.034	2.354LysGly: 2.354 ± 0.066	0.596LysHis: 0.596 ± 0.028	1.577LysIle: 1.577 ± 0.045	1.56LysLys: 1.56 ± 0.052	3.445LysLeu: 3.445 ± 0.072	0.785LysMet: 0.785 ± 0.027	1.129LysAsn: 1.129 ± 0.036	1.976LysPro: 1.976 ± 0.051	1.316LysGln: 1.316 ± 0.037	2.025LysArg: 2.025 ± 0.052	1.798LysSer: 1.798 ± 0.043	2.041LysThr: 2.041 ± 0.049	2.198LysVal: 2.198 ± 0.061	0.369LysTrp: 0.369 ± 0.019	0.685LysTyr: 0.685 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	16.55LeuAla: 16.55 ± 0.215	1.078LeuCys: 1.078 ± 0.038	6.494LeuAsp: 6.494 ± 0.096	5.567LeuGlu: 5.567 ± 0.091	3.8LeuPhe: 3.8 ± 0.087	8.177LeuGly: 8.177 ± 0.105	2.292LeuHis: 2.292 ± 0.058	4.595LeuIle: 4.595 ± 0.091	3.684LeuLys: 3.684 ± 0.071	12.155LeuLeu: 12.155 ± 0.185	2.73LeuMet: 2.73 ± 0.062	2.84LeuAsn: 2.84 ± 0.064	6.958LeuPro: 6.958 ± 0.093	3.557LeuGln: 3.557 ± 0.072	6.718LeuArg: 6.718 ± 0.112	6.582LeuSer: 6.582 ± 0.107	6.555LeuThr: 6.555 ± 0.082	8.233LeuVal: 8.233 ± 0.118	1.388LeuTrp: 1.388 ± 0.05	2.272LeuTyr: 2.272 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.096MetAla: 3.096 ± 0.064	0.185MetCys: 0.185 ± 0.015	1.159MetAsp: 1.159 ± 0.035	1.051MetGlu: 1.051 ± 0.035	0.691MetPhe: 0.691 ± 0.034	1.768MetGly: 1.768 ± 0.05	0.558MetHis: 0.558 ± 0.028	1.123MetIle: 1.123 ± 0.041	1.076MetLys: 1.076 ± 0.037	3.032MetLeu: 3.032 ± 0.067	0.631MetMet: 0.631 ± 0.032	0.919MetAsn: 0.919 ± 0.035	1.532MetPro: 1.532 ± 0.044	1.346MetGln: 1.346 ± 0.042	1.549MetArg: 1.549 ± 0.044	1.606MetSer: 1.606 ± 0.046	1.698MetThr: 1.698 ± 0.038	1.719MetVal: 1.719 ± 0.052	0.229MetTrp: 0.229 ± 0.017	0.392MetTyr: 0.392 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.007AsnAla: 3.007 ± 0.061	0.257AsnCys: 0.257 ± 0.017	1.46AsnAsp: 1.46 ± 0.048	1.232AsnGlu: 1.232 ± 0.036	0.835AsnPhe: 0.835 ± 0.035	2.411AsnGly: 2.411 ± 0.079	0.587AsnHis: 0.587 ± 0.028	1.337AsnIle: 1.337 ± 0.043	0.866AsnLys: 0.866 ± 0.035	2.946AsnLeu: 2.946 ± 0.057	0.621AsnMet: 0.621 ± 0.028	0.758AsnAsn: 0.758 ± 0.033	1.925AsnPro: 1.925 ± 0.042	1.158AsnGln: 1.158 ± 0.04	1.982AsnArg: 1.982 ± 0.051	1.315AsnSer: 1.315 ± 0.042	1.432AsnThr: 1.432 ± 0.047	1.879AsnVal: 1.879 ± 0.052	0.43AsnTrp: 0.43 ± 0.023	0.666AsnTyr: 0.666 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.835ProAla: 7.835 ± 0.154	0.514ProCys: 0.514 ± 0.024	3.721ProAsp: 3.721 ± 0.066	3.405ProGlu: 3.405 ± 0.078	1.905ProPhe: 1.905 ± 0.052	4.186ProGly: 4.186 ± 0.072	1.086ProHis: 1.086 ± 0.037	1.543ProIle: 1.543 ± 0.041	1.276ProLys: 1.276 ± 0.038	5.532ProLeu: 5.532 ± 0.09	1.095ProMet: 1.095 ± 0.038	1.067ProAsn: 1.067 ± 0.033	2.551ProPro: 2.551 ± 0.07	2.039ProGln: 2.039 ± 0.048	2.792ProArg: 2.792 ± 0.059	2.317ProSer: 2.317 ± 0.053	1.932ProThr: 1.932 ± 0.048	5.141ProVal: 5.141 ± 0.08	0.684ProTrp: 0.684 ± 0.03	1.148ProTyr: 1.148 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	5.221GlnAla: 5.221 ± 0.092	0.34GlnCys: 0.34 ± 0.021	1.748GlnAsp: 1.748 ± 0.043	1.752GlnGlu: 1.752 ± 0.037	1.265GlnPhe: 1.265 ± 0.041	2.847GlnGly: 2.847 ± 0.057	1.052GlnHis: 1.052 ± 0.039	1.948GlnIle: 1.948 ± 0.048	1.32GlnLys: 1.32 ± 0.037	4.558GlnLeu: 4.558 ± 0.081	0.996GlnMet: 0.996 ± 0.032	1.017GlnAsn: 1.017 ± 0.039	2.43GlnPro: 2.43 ± 0.055	2.34GlnGln: 2.34 ± 0.069	2.915GlnArg: 2.915 ± 0.065	2.131GlnSer: 2.131 ± 0.052	2.088GlnThr: 2.088 ± 0.055	2.943GlnVal: 2.943 ± 0.052	0.548GlnTrp: 0.548 ± 0.024	0.904GlnTyr: 0.904 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.739ArgAla: 6.739 ± 0.093	0.674ArgCys: 0.674 ± 0.03	3.763ArgAsp: 3.763 ± 0.067	4.375ArgGlu: 4.375 ± 0.076	2.98ArgPhe: 2.98 ± 0.063	4.089ArgGly: 4.089 ± 0.08	2.23ArgHis: 2.23 ± 0.057	3.611ArgIle: 3.611 ± 0.068	2.096ArgLys: 2.096 ± 0.052	9.148ArgLeu: 9.148 ± 0.129	1.848ArgMet: 1.848 ± 0.049	1.788ArgAsn: 1.788 ± 0.048	3.561ArgPro: 3.561 ± 0.058	4.315ArgGln: 4.315 ± 0.073	5.254ArgArg: 5.254 ± 0.097	3.105ArgSer: 3.105 ± 0.062	3.168ArgThr: 3.168 ± 0.062	4.808ArgVal: 4.808 ± 0.091	1.138ArgTrp: 1.138 ± 0.043	1.992ArgTyr: 1.992 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.811SerAla: 5.811 ± 0.09	0.642SerCys: 0.642 ± 0.025	2.474SerAsp: 2.474 ± 0.056	2.523SerGlu: 2.523 ± 0.059	1.864SerPhe: 1.864 ± 0.052	5.333SerGly: 5.333 ± 0.127	1.242SerHis: 1.242 ± 0.04	2.542SerIle: 2.542 ± 0.063	1.549SerLys: 1.549 ± 0.046	6.318SerLeu: 6.318 ± 0.109	1.499SerMet: 1.499 ± 0.047	1.5SerAsn: 1.5 ± 0.049	2.808SerPro: 2.808 ± 0.065	2.048SerGln: 2.048 ± 0.055	4.076SerArg: 4.076 ± 0.081	3.122SerSer: 3.122 ± 0.085	2.567SerThr: 2.567 ± 0.066	4.112SerVal: 4.112 ± 0.071	0.787SerTrp: 0.787 ± 0.032	1.157SerTyr: 1.157 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.77ThrAla: 5.77 ± 0.09	0.523ThrCys: 0.523 ± 0.026	2.694ThrAsp: 2.694 ± 0.06	2.407ThrGlu: 2.407 ± 0.065	1.753ThrPhe: 1.753 ± 0.047	5.234ThrGly: 5.234 ± 0.095	1.108ThrHis: 1.108 ± 0.031	2.131ThrIle: 2.131 ± 0.049	1.028ThrLys: 1.028 ± 0.039	6.831ThrLeu: 6.831 ± 0.087	1.004ThrMet: 1.004 ± 0.036	1.16ThrAsn: 1.16 ± 0.045	3.399ThrPro: 3.399 ± 0.066	1.679ThrGln: 1.679 ± 0.046	3.538ThrArg: 3.538 ± 0.064	2.469ThrSer: 2.469 ± 0.059	2.509ThrThr: 2.509 ± 0.06	4.246ThrVal: 4.246 ± 0.085	0.541ThrTrp: 0.541 ± 0.024	0.996ThrTyr: 0.996 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	8.683ValAla: 8.683 ± 0.102	0.934ValCys: 0.934 ± 0.04	3.888ValAsp: 3.888 ± 0.07	4.165ValGlu: 4.165 ± 0.073	2.773ValPhe: 2.773 ± 0.059	4.987ValGly: 4.987 ± 0.089	1.492ValHis: 1.492 ± 0.037	3.711ValIle: 3.711 ± 0.071	2.376ValLys: 2.376 ± 0.067	8.289ValLeu: 8.289 ± 0.114	1.982ValMet: 1.982 ± 0.052	2.293ValAsn: 2.293 ± 0.055	3.74ValPro: 3.74 ± 0.073	2.546ValGln: 2.546 ± 0.066	5.331ValArg: 5.331 ± 0.079	4.662ValSer: 4.662 ± 0.083	4.189ValThr: 4.189 ± 0.101	5.989ValVal: 5.989 ± 0.095	1.135ValTrp: 1.135 ± 0.035	1.536ValTyr: 1.536 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.142TrpAla: 1.142 ± 0.039	0.182TrpCys: 0.182 ± 0.013	0.555TrpAsp: 0.555 ± 0.027	0.484TrpGlu: 0.484 ± 0.024	0.58TrpPhe: 0.58 ± 0.028	0.84TrpGly: 0.84 ± 0.032	0.447TrpHis: 0.447 ± 0.022	0.624TrpIle: 0.624 ± 0.031	0.442TrpLys: 0.442 ± 0.023	2.559TrpLeu: 2.559 ± 0.068	0.41TrpMet: 0.41 ± 0.02	0.364TrpAsn: 0.364 ± 0.021	0.781TrpPro: 0.781 ± 0.032	1.202TrpGln: 1.202 ± 0.044	1.308TrpArg: 1.308 ± 0.045	0.736TrpSer: 0.736 ± 0.028	0.585TrpThr: 0.585 ± 0.025	0.949TrpVal: 0.949 ± 0.03	0.285TrpTrp: 0.285 ± 0.019	0.29TrpTyr: 0.29 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.493TyrAla: 2.493 ± 0.051	0.282TyrCys: 0.282 ± 0.017	1.268TyrAsp: 1.268 ± 0.038	0.977TyrGlu: 0.977 ± 0.034	0.989TyrPhe: 0.989 ± 0.037	1.938TyrGly: 1.938 ± 0.047	0.527TyrHis: 0.527 ± 0.023	0.823TyrIle: 0.823 ± 0.029	0.638TyrLys: 0.638 ± 0.031	2.649TyrLeu: 2.649 ± 0.052	0.452TyrMet: 0.452 ± 0.025	0.617TyrAsn: 0.617 ± 0.028	1.219TyrPro: 1.219 ± 0.039	1.045TyrGln: 1.045 ± 0.04	1.937TyrArg: 1.937 ± 0.046	1.148TyrSer: 1.148 ± 0.043	1.176TyrThr: 1.176 ± 0.034	1.526TyrVal: 1.526 ± 0.04	0.387TyrTrp: 0.387 ± 0.021	0.588TyrTyr: 0.588 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3208 proteins (919481 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---