Amino acid dipepetide frequency for Phialophora attinorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.046AlaAla: 10.046 ± 0.074	1.048AlaCys: 1.048 ± 0.014	4.737AlaAsp: 4.737 ± 0.033	5.449AlaGlu: 5.449 ± 0.035	3.317AlaPhe: 3.317 ± 0.028	6.292AlaGly: 6.292 ± 0.044	1.844AlaHis: 1.844 ± 0.02	4.445AlaIle: 4.445 ± 0.03	4.289AlaLys: 4.289 ± 0.033	8.004AlaLeu: 8.004 ± 0.045	2.134AlaMet: 2.134 ± 0.022	3.068AlaAsn: 3.068 ± 0.025	4.872AlaPro: 4.872 ± 0.036	3.679AlaGln: 3.679 ± 0.03	5.238AlaArg: 5.238 ± 0.037	7.586AlaSer: 7.586 ± 0.046	5.874AlaThr: 5.874 ± 0.04	5.769AlaVal: 5.769 ± 0.038	1.25AlaTrp: 1.25 ± 0.016	2.305AlaTyr: 2.305 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.924CysAla: 0.924 ± 0.013	0.218CysCys: 0.218 ± 0.007	0.615CysAsp: 0.615 ± 0.011	0.525CysGlu: 0.525 ± 0.009	0.524CysPhe: 0.524 ± 0.011	0.887CysGly: 0.887 ± 0.015	0.3CysHis: 0.3 ± 0.007	0.676CysIle: 0.676 ± 0.011	0.483CysLys: 0.483 ± 0.009	1.161CysLeu: 1.161 ± 0.013	0.26CysMet: 0.26 ± 0.007	0.397CysAsn: 0.397 ± 0.008	0.589CysPro: 0.589 ± 0.01	0.389CysGln: 0.389 ± 0.009	0.662CysArg: 0.662 ± 0.013	0.787CysSer: 0.787 ± 0.012	0.673CysThr: 0.673 ± 0.011	0.764CysVal: 0.764 ± 0.011	0.209CysTrp: 0.209 ± 0.007	0.353CysTyr: 0.353 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.182AspAla: 5.182 ± 0.031	0.605AspCys: 0.605 ± 0.01	4.497AspAsp: 4.497 ± 0.037	4.458AspGlu: 4.458 ± 0.036	2.281AspPhe: 2.281 ± 0.02	4.223AspGly: 4.223 ± 0.029	1.353AspHis: 1.353 ± 0.015	2.859AspIle: 2.859 ± 0.02	2.403AspLys: 2.403 ± 0.022	5.228AspLeu: 5.228 ± 0.035	1.261AspMet: 1.261 ± 0.016	1.875AspAsn: 1.875 ± 0.019	3.344AspPro: 3.344 ± 0.025	2.018AspGln: 2.018 ± 0.017	3.201AspArg: 3.201 ± 0.029	4.166AspSer: 4.166 ± 0.03	3.125AspThr: 3.125 ± 0.025	3.941AspVal: 3.941 ± 0.03	0.921AspTrp: 0.921 ± 0.014	1.598AspTyr: 1.598 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.661GluAla: 5.661 ± 0.039	0.569GluCys: 0.569 ± 0.011	4.201GluAsp: 4.201 ± 0.031	4.951GluGlu: 4.951 ± 0.041	1.735GluPhe: 1.735 ± 0.017	3.74GluGly: 3.74 ± 0.029	1.49GluHis: 1.49 ± 0.015	2.841GluIle: 2.841 ± 0.024	3.482GluLys: 3.482 ± 0.031	5.081GluLeu: 5.081 ± 0.04	1.42GluMet: 1.42 ± 0.015	1.964GluAsn: 1.964 ± 0.018	2.683GluPro: 2.683 ± 0.027	2.631GluGln: 2.631 ± 0.022	3.838GluArg: 3.838 ± 0.033	3.982GluSer: 3.982 ± 0.032	3.205GluThr: 3.205 ± 0.026	3.797GluVal: 3.797 ± 0.035	0.888GluTrp: 0.888 ± 0.014	1.594GluTyr: 1.594 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	3.22PheAla: 3.22 ± 0.025	0.522PheCys: 0.522 ± 0.01	2.343PheAsp: 2.343 ± 0.019	2.102PheGlu: 2.102 ± 0.021	1.574PhePhe: 1.574 ± 0.02	2.925PheGly: 2.925 ± 0.031	0.827PheHis: 0.827 ± 0.012	1.671PheIle: 1.671 ± 0.021	1.41PheLys: 1.41 ± 0.017	3.241PheLeu: 3.241 ± 0.029	0.786PheMet: 0.786 ± 0.012	1.375PheAsn: 1.375 ± 0.016	1.823PhePro: 1.823 ± 0.019	1.297PheGln: 1.297 ± 0.016	1.916PheArg: 1.916 ± 0.019	2.804PheSer: 2.804 ± 0.026	2.095PheThr: 2.095 ± 0.023	2.404PheVal: 2.404 ± 0.025	0.65PheTrp: 0.65 ± 0.011	1.055PheTyr: 1.055 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	5.537GlyAla: 5.537 ± 0.035	0.816GlyCys: 0.816 ± 0.013	3.683GlyAsp: 3.683 ± 0.029	3.563GlyGlu: 3.563 ± 0.026	2.786GlyPhe: 2.786 ± 0.025	6.122GlyGly: 6.122 ± 0.059	1.686GlyHis: 1.686 ± 0.02	3.473GlyIle: 3.473 ± 0.03	3.47GlyLys: 3.47 ± 0.028	6.225GlyLeu: 6.225 ± 0.041	1.756GlyMet: 1.756 ± 0.022	2.468GlyAsn: 2.468 ± 0.021	3.395GlyPro: 3.395 ± 0.028	2.688GlyGln: 2.688 ± 0.024	4.252GlyArg: 4.252 ± 0.032	5.705GlySer: 5.705 ± 0.038	4.129GlyThr: 4.129 ± 0.032	4.529GlyVal: 4.529 ± 0.033	1.246GlyTrp: 1.246 ± 0.015	2.128GlyTyr: 2.128 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.99HisAla: 1.99 ± 0.022	0.308HisCys: 0.308 ± 0.009	1.444HisAsp: 1.444 ± 0.017	1.353HisGlu: 1.353 ± 0.016	0.925HisPhe: 0.925 ± 0.013	1.703HisGly: 1.703 ± 0.019	0.865HisHis: 0.865 ± 0.017	1.181HisIle: 1.181 ± 0.015	0.987HisLys: 0.987 ± 0.014	2.187HisLeu: 2.187 ± 0.02	0.487HisMet: 0.487 ± 0.009	0.862HisAsn: 0.862 ± 0.013	1.589HisPro: 1.589 ± 0.019	0.981HisGln: 0.981 ± 0.015	1.509HisArg: 1.509 ± 0.018	1.804HisSer: 1.804 ± 0.02	1.32HisThr: 1.32 ± 0.015	1.492HisVal: 1.492 ± 0.016	0.358HisTrp: 0.358 ± 0.008	0.697HisTyr: 0.697 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.467IleAla: 4.467 ± 0.03	0.721IleCys: 0.721 ± 0.012	2.959IleAsp: 2.959 ± 0.025	2.84IleGlu: 2.84 ± 0.023	1.883IlePhe: 1.883 ± 0.022	3.249IleGly: 3.249 ± 0.031	1.098IleHis: 1.098 ± 0.014	2.365IleIle: 2.365 ± 0.024	2.049IleLys: 2.049 ± 0.021	4.247IleLeu: 4.247 ± 0.031	1.008IleMet: 1.008 ± 0.016	1.784IleAsn: 1.784 ± 0.019	2.835IlePro: 2.835 ± 0.022	1.699IleGln: 1.699 ± 0.018	2.672IleArg: 2.672 ± 0.025	3.623IleSer: 3.623 ± 0.026	2.826IleThr: 2.826 ± 0.023	3.148IleVal: 3.148 ± 0.025	0.72IleTrp: 0.72 ± 0.013	1.356IleTyr: 1.356 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.487LysAla: 4.487 ± 0.033	0.448LysCys: 0.448 ± 0.01	2.853LysAsp: 2.853 ± 0.024	3.179LysGlu: 3.179 ± 0.035	1.399LysPhe: 1.399 ± 0.015	2.956LysGly: 2.956 ± 0.023	1.229LysHis: 1.229 ± 0.016	2.146LysIle: 2.146 ± 0.021	3.095LysLys: 3.095 ± 0.04	3.946LysLeu: 3.946 ± 0.03	0.98LysMet: 0.98 ± 0.015	1.552LysAsn: 1.552 ± 0.015	2.717LysPro: 2.717 ± 0.027	1.984LysGln: 1.984 ± 0.019	3.411LysArg: 3.411 ± 0.033	3.463LysSer: 3.463 ± 0.028	2.732LysThr: 2.732 ± 0.025	2.871LysVal: 2.871 ± 0.023	0.71LysTrp: 0.71 ± 0.012	1.341LysTyr: 1.341 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	8.076LeuAla: 8.076 ± 0.046	1.165LeuCys: 1.165 ± 0.018	5.155LeuAsp: 5.155 ± 0.032	5.219LeuGlu: 5.219 ± 0.034	3.172LeuPhe: 3.172 ± 0.028	5.871LeuGly: 5.871 ± 0.04	2.15LeuHis: 2.15 ± 0.022	3.879LeuIle: 3.879 ± 0.03	4.081LeuLys: 4.081 ± 0.029	8.268LeuLeu: 8.268 ± 0.056	1.818LeuMet: 1.818 ± 0.019	3.112LeuAsn: 3.112 ± 0.024	5.52LeuPro: 5.52 ± 0.032	3.833LeuGln: 3.833 ± 0.025	5.676LeuArg: 5.676 ± 0.038	6.939LeuSer: 6.939 ± 0.043	4.988LeuThr: 4.988 ± 0.029	5.275LeuVal: 5.275 ± 0.045	1.224LeuTrp: 1.224 ± 0.016	2.285LeuTyr: 2.285 ± 0.019	0.0LeuXaa: 0.0 ± 0.0
Met	2.355MetAla: 2.355 ± 0.019	0.252MetCys: 0.252 ± 0.007	1.203MetAsp: 1.203 ± 0.018	1.11MetGlu: 1.11 ± 0.014	0.77MetPhe: 0.77 ± 0.013	1.508MetGly: 1.508 ± 0.02	0.506MetHis: 0.506 ± 0.009	0.947MetIle: 0.947 ± 0.014	0.975MetLys: 0.975 ± 0.013	1.973MetLeu: 1.973 ± 0.019	0.564MetMet: 0.564 ± 0.011	0.767MetAsn: 0.767 ± 0.013	1.421MetPro: 1.421 ± 0.017	0.92MetGln: 0.92 ± 0.016	1.281MetArg: 1.281 ± 0.016	1.946MetSer: 1.946 ± 0.017	1.378MetThr: 1.378 ± 0.016	1.296MetVal: 1.296 ± 0.018	0.268MetTrp: 0.268 ± 0.007	0.563MetTyr: 0.563 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.381AsnAla: 3.381 ± 0.026	0.389AsnCys: 0.389 ± 0.008	2.106AsnAsp: 2.106 ± 0.021	1.945AsnGlu: 1.945 ± 0.02	1.337AsnPhe: 1.337 ± 0.015	3.16AsnGly: 3.16 ± 0.031	0.818AsnHis: 0.818 ± 0.012	1.918AsnIle: 1.918 ± 0.018	1.505AsnLys: 1.505 ± 0.017	3.036AsnLeu: 3.036 ± 0.027	0.788AsnMet: 0.788 ± 0.013	1.487AsnAsn: 1.487 ± 0.022	2.233AsnPro: 2.233 ± 0.022	1.231AsnGln: 1.231 ± 0.017	1.806AsnArg: 1.806 ± 0.02	2.55AsnSer: 2.55 ± 0.023	2.207AsnThr: 2.207 ± 0.021	2.382AsnVal: 2.382 ± 0.021	0.52AsnTrp: 0.52 ± 0.009	1.027AsnTyr: 1.027 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.492ProAla: 5.492 ± 0.049	0.452ProCys: 0.452 ± 0.01	3.274ProAsp: 3.274 ± 0.024	3.702ProGlu: 3.702 ± 0.03	1.983ProPhe: 1.983 ± 0.019	3.855ProGly: 3.855 ± 0.03	1.305ProHis: 1.305 ± 0.016	2.488ProIle: 2.488 ± 0.021	2.633ProLys: 2.633 ± 0.023	4.542ProLeu: 4.542 ± 0.028	1.105ProMet: 1.105 ± 0.014	2.201ProAsn: 2.201 ± 0.021	5.212ProPro: 5.212 ± 0.057	2.554ProGln: 2.554 ± 0.027	3.294ProArg: 3.294 ± 0.032	5.749ProSer: 5.749 ± 0.043	4.218ProThr: 4.218 ± 0.031	3.526ProVal: 3.526 ± 0.028	0.748ProTrp: 0.748 ± 0.012	1.518ProTyr: 1.518 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.635GlnAla: 3.635 ± 0.03	0.422GlnCys: 0.422 ± 0.01	2.101GlnAsp: 2.101 ± 0.02	2.333GlnGlu: 2.333 ± 0.022	1.219GlnPhe: 1.219 ± 0.016	2.42GlnGly: 2.42 ± 0.02	1.214GlnHis: 1.214 ± 0.017	1.936GlnIle: 1.936 ± 0.018	1.951GlnLys: 1.951 ± 0.019	3.486GlnLeu: 3.486 ± 0.02	0.896GlnMet: 0.896 ± 0.014	1.557GlnAsn: 1.557 ± 0.017	2.669GlnPro: 2.669 ± 0.026	2.736GlnGln: 2.736 ± 0.04	2.806GlnArg: 2.806 ± 0.026	3.231GlnSer: 3.231 ± 0.026	2.388GlnThr: 2.388 ± 0.023	2.149GlnVal: 2.149 ± 0.02	0.588GlnTrp: 0.588 ± 0.011	1.216GlnTyr: 1.216 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.89ArgAla: 4.89 ± 0.032	0.632ArgCys: 0.632 ± 0.011	3.388ArgAsp: 3.388 ± 0.036	3.716ArgGlu: 3.716 ± 0.037	1.997ArgPhe: 1.997 ± 0.018	3.735ArgGly: 3.735 ± 0.028	1.592ArgHis: 1.592 ± 0.018	2.75ArgIle: 2.75 ± 0.02	3.547ArgLys: 3.547 ± 0.032	5.383ArgLeu: 5.383 ± 0.034	1.386ArgMet: 1.386 ± 0.015	2.208ArgAsn: 2.208 ± 0.021	3.598ArgPro: 3.598 ± 0.03	2.734ArgGln: 2.734 ± 0.024	5.108ArgArg: 5.108 ± 0.042	4.87ArgSer: 4.87 ± 0.036	3.408ArgThr: 3.408 ± 0.025	3.276ArgVal: 3.276 ± 0.026	0.958ArgTrp: 0.958 ± 0.014	1.705ArgTyr: 1.705 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	7.044SerAla: 7.044 ± 0.047	0.759SerCys: 0.759 ± 0.013	4.465SerAsp: 4.465 ± 0.033	4.028SerGlu: 4.028 ± 0.031	2.78SerPhe: 2.78 ± 0.025	5.511SerGly: 5.511 ± 0.037	1.882SerHis: 1.882 ± 0.018	3.891SerIle: 3.891 ± 0.029	3.673SerLys: 3.673 ± 0.031	6.742SerLeu: 6.742 ± 0.041	1.764SerMet: 1.764 ± 0.017	2.99SerAsn: 2.99 ± 0.026	5.349SerPro: 5.349 ± 0.044	3.231SerGln: 3.231 ± 0.028	4.86SerArg: 4.86 ± 0.037	8.342SerSer: 8.342 ± 0.063	5.95SerThr: 5.95 ± 0.05	4.502SerVal: 4.502 ± 0.029	1.119SerTrp: 1.119 ± 0.015	2.001SerTyr: 2.001 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.798ThrAla: 5.798 ± 0.039	0.682ThrCys: 0.682 ± 0.01	3.079ThrAsp: 3.079 ± 0.026	3.108ThrGlu: 3.108 ± 0.025	2.231ThrPhe: 2.231 ± 0.02	4.214ThrGly: 4.214 ± 0.032	1.307ThrHis: 1.307 ± 0.017	3.166ThrIle: 3.166 ± 0.027	2.733ThrLys: 2.733 ± 0.025	5.196ThrLeu: 5.196 ± 0.037	1.253ThrMet: 1.253 ± 0.015	2.265ThrAsn: 2.265 ± 0.023	4.334ThrPro: 4.334 ± 0.031	2.21ThrGln: 2.21 ± 0.019	3.135ThrArg: 3.135 ± 0.022	5.733ThrSer: 5.733 ± 0.046	5.035ThrThr: 5.035 ± 0.061	3.75ThrVal: 3.75 ± 0.032	0.885ThrTrp: 0.885 ± 0.016	1.642ThrTyr: 1.642 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.607ValAla: 5.607 ± 0.036	0.798ValCys: 0.798 ± 0.012	3.839ValAsp: 3.839 ± 0.03	3.85ValGlu: 3.85 ± 0.038	2.398ValPhe: 2.398 ± 0.024	4.215ValGly: 4.215 ± 0.032	1.416ValHis: 1.416 ± 0.017	2.819ValIle: 2.819 ± 0.024	2.897ValLys: 2.897 ± 0.026	5.713ValLeu: 5.713 ± 0.046	1.351ValMet: 1.351 ± 0.018	2.19ValAsn: 2.19 ± 0.021	3.609ValPro: 3.609 ± 0.027	2.386ValGln: 2.386 ± 0.022	3.564ValArg: 3.564 ± 0.028	4.502ValSer: 4.502 ± 0.031	3.551ValThr: 3.551 ± 0.027	4.635ValVal: 4.635 ± 0.067	0.95ValTrp: 0.95 ± 0.012	1.703ValTyr: 1.703 ± 0.016	0.0ValXaa: 0.0 ± 0.0
Trp	1.155TrpAla: 1.155 ± 0.017	0.199TrpCys: 0.199 ± 0.006	0.845TrpAsp: 0.845 ± 0.012	0.829TrpGlu: 0.829 ± 0.012	0.554TrpPhe: 0.554 ± 0.011	0.923TrpGly: 0.923 ± 0.015	0.398TrpHis: 0.398 ± 0.008	0.792TrpIle: 0.792 ± 0.014	0.778TrpLys: 0.778 ± 0.011	1.466TrpLeu: 1.466 ± 0.017	0.384TrpMet: 0.384 ± 0.008	0.59TrpAsn: 0.59 ± 0.011	0.654TrpPro: 0.654 ± 0.012	0.649TrpGln: 0.649 ± 0.011	1.031TrpArg: 1.031 ± 0.014	1.113TrpSer: 1.113 ± 0.013	1.001TrpThr: 1.001 ± 0.014	0.851TrpVal: 0.851 ± 0.012	0.306TrpTrp: 0.306 ± 0.007	0.449TrpTyr: 0.449 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.301TyrAla: 2.301 ± 0.02	0.393TyrCys: 0.393 ± 0.009	1.749TyrAsp: 1.749 ± 0.02	1.495TyrGlu: 1.495 ± 0.016	1.175TyrPhe: 1.175 ± 0.016	2.15TyrGly: 2.15 ± 0.023	0.761TyrHis: 0.761 ± 0.011	1.305TyrIle: 1.305 ± 0.014	1.062TyrLys: 1.062 ± 0.015	2.582TyrLeu: 2.582 ± 0.022	0.6TyrMet: 0.6 ± 0.011	1.113TyrAsn: 1.113 ± 0.014	1.404TyrPro: 1.404 ± 0.017	1.101TyrGln: 1.101 ± 0.011	1.621TyrArg: 1.621 ± 0.019	1.986TyrSer: 1.986 ± 0.019	1.653TyrThr: 1.653 ± 0.019	1.635TyrVal: 1.635 ± 0.016	0.45TyrTrp: 0.45 ± 0.009	0.923TyrTyr: 0.923 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11848 proteins (5661895 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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