Amino acid dipepetide frequency for Leucobacter sp. wl10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.67AlaAla: 20.67 ± 0.194
0.789AlaCys: 0.789 ± 0.03
7.44AlaAsp: 7.44 ± 0.095
9.588AlaGlu: 9.588 ± 0.122
3.865AlaPhe: 3.865 ± 0.062
12.562AlaGly: 12.562 ± 0.135
2.43AlaHis: 2.43 ± 0.048
5.865AlaIle: 5.865 ± 0.08
2.632AlaLys: 2.632 ± 0.055
14.634AlaLeu: 14.634 ± 0.14
2.72AlaMet: 2.72 ± 0.049
2.244AlaAsn: 2.244 ± 0.045
6.555AlaPro: 6.555 ± 0.094
3.962AlaGln: 3.962 ± 0.068
10.371AlaArg: 10.371 ± 0.115
7.077AlaSer: 7.077 ± 0.085
6.207AlaThr: 6.207 ± 0.079
11.44AlaVal: 11.44 ± 0.113
1.736AlaTrp: 1.736 ± 0.048
2.401AlaTyr: 2.401 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.717CysAla: 0.717 ± 0.028
0.071CysCys: 0.071 ± 0.009
0.374CysAsp: 0.374 ± 0.018
0.364CysGlu: 0.364 ± 0.018
0.188CysPhe: 0.188 ± 0.012
0.69CysGly: 0.69 ± 0.029
0.12CysHis: 0.12 ± 0.012
0.22CysIle: 0.22 ± 0.014
0.055CysLys: 0.055 ± 0.008
0.487CysLeu: 0.487 ± 0.023
0.086CysMet: 0.086 ± 0.007
0.101CysAsn: 0.101 ± 0.01
0.294CysPro: 0.294 ± 0.018
0.118CysGln: 0.118 ± 0.01
0.409CysArg: 0.409 ± 0.018
0.364CysSer: 0.364 ± 0.019
0.358CysThr: 0.358 ± 0.02
0.446CysVal: 0.446 ± 0.019
0.072CysTrp: 0.072 ± 0.008
0.124CysTyr: 0.124 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.826AspAla: 7.826 ± 0.089
0.278AspCys: 0.278 ± 0.018
3.357AspAsp: 3.357 ± 0.068
4.288AspGlu: 4.288 ± 0.066
1.687AspPhe: 1.687 ± 0.033
5.446AspGly: 5.446 ± 0.08
1.036AspHis: 1.036 ± 0.029
2.047AspIle: 2.047 ± 0.042
0.753AspLys: 0.753 ± 0.029
5.616AspLeu: 5.616 ± 0.081
0.78AspMet: 0.78 ± 0.025
0.756AspAsn: 0.756 ± 0.026
4.719AspPro: 4.719 ± 0.084
1.392AspGln: 1.392 ± 0.04
5.16AspArg: 5.16 ± 0.078
2.321AspSer: 2.321 ± 0.049
2.595AspThr: 2.595 ± 0.055
4.356AspVal: 4.356 ± 0.063
0.836AspTrp: 0.836 ± 0.025
1.199AspTyr: 1.199 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
8.467GluAla: 8.467 ± 0.109
0.298GluCys: 0.298 ± 0.019
2.806GluAsp: 2.806 ± 0.051
3.625GluGlu: 3.625 ± 0.067
1.908GluPhe: 1.908 ± 0.035
4.533GluGly: 4.533 ± 0.062
1.703GluHis: 1.703 ± 0.05
2.993GluIle: 2.993 ± 0.051
1.23GluLys: 1.23 ± 0.04
7.439GluLeu: 7.439 ± 0.102
1.158GluMet: 1.158 ± 0.032
1.325GluAsn: 1.325 ± 0.035
3.186GluPro: 3.186 ± 0.064
2.679GluGln: 2.679 ± 0.062
6.664GluArg: 6.664 ± 0.094
3.012GluSer: 3.012 ± 0.05
3.303GluThr: 3.303 ± 0.053
4.972GluVal: 4.972 ± 0.076
0.942GluTrp: 0.942 ± 0.029
1.227GluTyr: 1.227 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
4.359PheAla: 4.359 ± 0.073
0.189PheCys: 0.189 ± 0.012
2.254PheAsp: 2.254 ± 0.046
2.017PheGlu: 2.017 ± 0.048
1.061PhePhe: 1.061 ± 0.032
3.545PheGly: 3.545 ± 0.058
0.495PheHis: 0.495 ± 0.019
1.219PheIle: 1.219 ± 0.038
0.47PheLys: 0.47 ± 0.025
2.689PheLeu: 2.689 ± 0.054
0.489PheMet: 0.489 ± 0.022
0.615PheAsn: 0.615 ± 0.026
1.456PhePro: 1.456 ± 0.034
0.744PheGln: 0.744 ± 0.025
1.851PheArg: 1.851 ± 0.036
1.904PheSer: 1.904 ± 0.04
1.975PheThr: 1.975 ± 0.045
2.707PheVal: 2.707 ± 0.051
0.46PheTrp: 0.46 ± 0.024
0.587PheTyr: 0.587 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
11.807GlyAla: 11.807 ± 0.125
0.629GlyCys: 0.629 ± 0.023
4.977GlyAsp: 4.977 ± 0.068
5.876GlyGlu: 5.876 ± 0.073
3.392GlyPhe: 3.392 ± 0.052
8.458GlyGly: 8.458 ± 0.115
1.644GlyHis: 1.644 ± 0.041
4.865GlyIle: 4.865 ± 0.077
2.055GlyLys: 2.055 ± 0.044
9.222GlyLeu: 9.222 ± 0.103
1.965GlyMet: 1.965 ± 0.039
1.627GlyAsn: 1.627 ± 0.041
4.078GlyPro: 4.078 ± 0.064
2.383GlyGln: 2.383 ± 0.049
7.228GlyArg: 7.228 ± 0.079
5.858GlySer: 5.858 ± 0.078
4.986GlyThr: 4.986 ± 0.069
8.029GlyVal: 8.029 ± 0.095
1.573GlyTrp: 1.573 ± 0.038
2.242GlyTyr: 2.242 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.324HisAla: 2.324 ± 0.044
0.143HisCys: 0.143 ± 0.01
1.181HisAsp: 1.181 ± 0.033
1.211HisGlu: 1.211 ± 0.037
0.511HisPhe: 0.511 ± 0.022
1.914HisGly: 1.914 ± 0.044
0.509HisHis: 0.509 ± 0.025
0.655HisIle: 0.655 ± 0.023
0.253HisLys: 0.253 ± 0.017
2.103HisLeu: 2.103 ± 0.044
0.278HisMet: 0.278 ± 0.015
0.3HisAsn: 0.3 ± 0.016
1.424HisPro: 1.424 ± 0.036
0.498HisGln: 0.498 ± 0.021
1.874HisArg: 1.874 ± 0.045
0.908HisSer: 0.908 ± 0.031
0.892HisThr: 0.892 ± 0.033
1.395HisVal: 1.395 ± 0.04
0.26HisTrp: 0.26 ± 0.016
0.395HisTyr: 0.395 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
7.341IleAla: 7.341 ± 0.075
0.278IleCys: 0.278 ± 0.017
3.237IleAsp: 3.237 ± 0.061
3.172IleGlu: 3.172 ± 0.054
1.112IlePhe: 1.112 ± 0.037
4.826IleGly: 4.826 ± 0.076
0.64IleHis: 0.64 ± 0.026
1.758IleIle: 1.758 ± 0.045
0.673IleLys: 0.673 ± 0.027
3.859IleLeu: 3.859 ± 0.063
0.669IleMet: 0.669 ± 0.024
0.816IleAsn: 0.816 ± 0.029
2.49IlePro: 2.49 ± 0.046
0.906IleGln: 0.906 ± 0.026
2.883IleArg: 2.883 ± 0.051
2.385IleSer: 2.385 ± 0.039
2.671IleThr: 2.671 ± 0.053
4.311IleVal: 4.311 ± 0.07
0.477IleTrp: 0.477 ± 0.022
0.68IleTyr: 0.68 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
1.944LysAla: 1.944 ± 0.054
0.069LysCys: 0.069 ± 0.009
0.893LysAsp: 0.893 ± 0.031
0.882LysGlu: 0.882 ± 0.033
0.449LysPhe: 0.449 ± 0.019
1.355LysGly: 1.355 ± 0.041
0.419LysHis: 0.419 ± 0.02
0.914LysIle: 0.914 ± 0.028
0.673LysLys: 0.673 ± 0.031
1.829LysLeu: 1.829 ± 0.04
0.363LysMet: 0.363 ± 0.018
0.551LysAsn: 0.551 ± 0.023
1.127LysPro: 1.127 ± 0.035
0.76LysGln: 0.76 ± 0.03
1.727LysArg: 1.727 ± 0.041
1.079LysSer: 1.079 ± 0.034
1.219LysThr: 1.219 ± 0.037
1.322LysVal: 1.322 ± 0.033
0.231LysTrp: 0.231 ± 0.014
0.392LysTyr: 0.392 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
15.012LeuAla: 15.012 ± 0.145
0.573LeuCys: 0.573 ± 0.023
6.536LeuAsp: 6.536 ± 0.083
5.845LeuGlu: 5.845 ± 0.083
2.898LeuPhe: 2.898 ± 0.053
9.842LeuGly: 9.842 ± 0.117
1.809LeuHis: 1.809 ± 0.045
4.657LeuIle: 4.657 ± 0.07
1.717LeuLys: 1.717 ± 0.046
11.157LeuLeu: 11.157 ± 0.128
1.798LeuMet: 1.798 ± 0.044
1.791LeuAsn: 1.791 ± 0.042
5.593LeuPro: 5.593 ± 0.077
2.591LeuGln: 2.591 ± 0.053
8.346LeuArg: 8.346 ± 0.101
6.036LeuSer: 6.036 ± 0.062
5.808LeuThr: 5.808 ± 0.074
9.095LeuVal: 9.095 ± 0.11
1.265LeuTrp: 1.265 ± 0.033
1.609LeuTyr: 1.609 ± 0.032
0.0LeuXaa: 0.0 ± 0.0
Met
1.983MetAla: 1.983 ± 0.037
0.102MetCys: 0.102 ± 0.01
0.783MetAsp: 0.783 ± 0.027
0.737MetGlu: 0.737 ± 0.027
0.527MetPhe: 0.527 ± 0.021
1.412MetGly: 1.412 ± 0.036
0.353MetHis: 0.353 ± 0.019
0.968MetIle: 0.968 ± 0.032
0.399MetLys: 0.399 ± 0.018
2.164MetLeu: 2.164 ± 0.053
0.346MetMet: 0.346 ± 0.02
0.555MetAsn: 0.555 ± 0.021
1.031MetPro: 1.031 ± 0.028
0.579MetGln: 0.579 ± 0.022
1.67MetArg: 1.67 ± 0.042
1.516MetSer: 1.516 ± 0.035
1.532MetThr: 1.532 ± 0.037
1.339MetVal: 1.339 ± 0.038
0.175MetTrp: 0.175 ± 0.014
0.299MetTyr: 0.299 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.433AsnAla: 2.433 ± 0.052
0.091AsnCys: 0.091 ± 0.009
0.994AsnAsp: 0.994 ± 0.032
1.052AsnGlu: 1.052 ± 0.033
0.592AsnPhe: 0.592 ± 0.025
1.889AsnGly: 1.889 ± 0.043
0.332AsnHis: 0.332 ± 0.016
0.797AsnIle: 0.797 ± 0.027
0.304AsnLys: 0.304 ± 0.016
1.798AsnLeu: 1.798 ± 0.038
0.295AsnMet: 0.295 ± 0.018
0.373AsnAsn: 0.373 ± 0.021
1.5AsnPro: 1.5 ± 0.037
0.51AsnGln: 0.51 ± 0.018
1.44AsnArg: 1.44 ± 0.036
0.985AsnSer: 0.985 ± 0.031
1.052AsnThr: 1.052 ± 0.03
1.531AsnVal: 1.531 ± 0.038
0.301AsnTrp: 0.301 ± 0.016
0.44AsnTyr: 0.44 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
7.007ProAla: 7.007 ± 0.095
0.211ProCys: 0.211 ± 0.015
3.578ProAsp: 3.578 ± 0.059
4.603ProGlu: 4.603 ± 0.072
1.628ProPhe: 1.628 ± 0.036
5.699ProGly: 5.699 ± 0.091
1.069ProHis: 1.069 ± 0.029
2.067ProIle: 2.067 ± 0.042
1.009ProLys: 1.009 ± 0.031
4.986ProLeu: 4.986 ± 0.068
0.958ProMet: 0.958 ± 0.028
1.045ProAsn: 1.045 ± 0.029
2.404ProPro: 2.404 ± 0.057
1.559ProGln: 1.559 ± 0.042
3.814ProArg: 3.814 ± 0.067
3.06ProSer: 3.06 ± 0.049
2.645ProThr: 2.645 ± 0.052
4.894ProVal: 4.894 ± 0.078
0.767ProTrp: 0.767 ± 0.028
1.039ProTyr: 1.039 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.517GlnAla: 3.517 ± 0.066
0.128GlnCys: 0.128 ± 0.01
1.161GlnAsp: 1.161 ± 0.034
1.397GlnGlu: 1.397 ± 0.034
0.801GlnPhe: 0.801 ± 0.03
2.139GlnGly: 2.139 ± 0.046
0.7GlnHis: 0.7 ± 0.023
1.462GlnIle: 1.462 ± 0.043
0.573GlnLys: 0.573 ± 0.024
3.358GlnLeu: 3.358 ± 0.062
0.528GlnMet: 0.528 ± 0.024
0.665GlnAsn: 0.665 ± 0.024
1.5GlnPro: 1.5 ± 0.046
1.365GlnGln: 1.365 ± 0.046
2.818GlnArg: 2.818 ± 0.048
1.46GlnSer: 1.46 ± 0.039
1.404GlnThr: 1.404 ± 0.039
2.085GlnVal: 2.085 ± 0.048
0.408GlnTrp: 0.408 ± 0.02
0.619GlnTyr: 0.619 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
10.472ArgAla: 10.472 ± 0.113
0.38ArgCys: 0.38 ± 0.021
4.477ArgAsp: 4.477 ± 0.07
5.491ArgGlu: 5.491 ± 0.082
2.748ArgPhe: 2.748 ± 0.049
6.608ArgGly: 6.608 ± 0.086
1.609ArgHis: 1.609 ± 0.038
4.212ArgIle: 4.212 ± 0.058
1.46ArgLys: 1.46 ± 0.038
8.363ArgLeu: 8.363 ± 0.104
1.717ArgMet: 1.717 ± 0.037
1.358ArgAsn: 1.358 ± 0.036
4.119ArgPro: 4.119 ± 0.062
2.08ArgGln: 2.08 ± 0.048
7.47ArgArg: 7.47 ± 0.11
4.705ArgSer: 4.705 ± 0.07
4.282ArgThr: 4.282 ± 0.064
6.863ArgVal: 6.863 ± 0.09
1.207ArgTrp: 1.207 ± 0.035
1.717ArgTyr: 1.717 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
7.129SerAla: 7.129 ± 0.088
0.341SerCys: 0.341 ± 0.018
2.889SerAsp: 2.889 ± 0.053
3.343SerGlu: 3.343 ± 0.052
1.951SerPhe: 1.951 ± 0.037
6.349SerGly: 6.349 ± 0.09
0.944SerHis: 0.944 ± 0.032
2.563SerIle: 2.563 ± 0.051
1.037SerLys: 1.037 ± 0.034
5.61SerLeu: 5.61 ± 0.064
1.231SerMet: 1.231 ± 0.037
1.083SerAsn: 1.083 ± 0.035
3.024SerPro: 3.024 ± 0.054
1.428SerGln: 1.428 ± 0.042
4.256SerArg: 4.256 ± 0.057
3.282SerSer: 3.282 ± 0.069
3.209SerThr: 3.209 ± 0.061
4.393SerVal: 4.393 ± 0.067
0.859SerTrp: 0.859 ± 0.027
1.123SerTyr: 1.123 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
7.147ThrAla: 7.147 ± 0.081
0.28ThrCys: 0.28 ± 0.017
2.79ThrAsp: 2.79 ± 0.055
2.972ThrGlu: 2.972 ± 0.054
1.597ThrPhe: 1.597 ± 0.04
5.842ThrGly: 5.842 ± 0.082
1.034ThrHis: 1.034 ± 0.032
2.532ThrIle: 2.532 ± 0.046
0.876ThrLys: 0.876 ± 0.031
5.544ThrLeu: 5.544 ± 0.064
0.981ThrMet: 0.981 ± 0.034
1.021ThrAsn: 1.021 ± 0.033
3.385ThrPro: 3.385 ± 0.056
1.275ThrGln: 1.275 ± 0.032
3.894ThrArg: 3.894 ± 0.067
3.014ThrSer: 3.014 ± 0.053
3.065ThrThr: 3.065 ± 0.061
5.284ThrVal: 5.284 ± 0.073
0.654ThrTrp: 0.654 ± 0.026
0.914ThrTyr: 0.914 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
11.1ValAla: 11.1 ± 0.108
0.566ValCys: 0.566 ± 0.023
4.864ValAsp: 4.864 ± 0.069
5.184ValGlu: 5.184 ± 0.068
2.969ValPhe: 2.969 ± 0.051
6.789ValGly: 6.789 ± 0.088
1.575ValHis: 1.575 ± 0.04
4.083ValIle: 4.083 ± 0.063
1.466ValLys: 1.466 ± 0.038
9.338ValLeu: 9.338 ± 0.1
1.548ValMet: 1.548 ± 0.041
1.693ValAsn: 1.693 ± 0.043
4.468ValPro: 4.468 ± 0.074
2.22ValGln: 2.22 ± 0.042
6.369ValArg: 6.369 ± 0.075
5.153ValSer: 5.153 ± 0.072
5.107ValThr: 5.107 ± 0.072
7.891ValVal: 7.891 ± 0.098
1.058ValTrp: 1.058 ± 0.031
1.511ValTyr: 1.511 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.547TrpAla: 1.547 ± 0.036
0.103TrpCys: 0.103 ± 0.009
0.638TrpAsp: 0.638 ± 0.025
0.717TrpGlu: 0.717 ± 0.023
0.539TrpPhe: 0.539 ± 0.022
1.053TrpGly: 1.053 ± 0.032
0.294TrpHis: 0.294 ± 0.017
0.721TrpIle: 0.721 ± 0.026
0.294TrpLys: 0.294 ± 0.017
1.576TrpLeu: 1.576 ± 0.04
0.291TrpMet: 0.291 ± 0.017
0.384TrpAsn: 0.384 ± 0.018
0.65TrpPro: 0.65 ± 0.027
0.482TrpGln: 0.482 ± 0.02
1.28TrpArg: 1.28 ± 0.037
0.869TrpSer: 0.869 ± 0.028
0.733TrpThr: 0.733 ± 0.029
1.108TrpVal: 1.108 ± 0.034
0.317TrpTrp: 0.317 ± 0.019
0.285TrpTyr: 0.285 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.386TyrAla: 2.386 ± 0.045
0.141TyrCys: 0.141 ± 0.011
1.22TyrAsp: 1.22 ± 0.036
1.106TyrGlu: 1.106 ± 0.033
0.662TyrPhe: 0.662 ± 0.025
1.942TyrGly: 1.942 ± 0.042
0.311TyrHis: 0.311 ± 0.016
0.585TyrIle: 0.585 ± 0.022
0.271TyrLys: 0.271 ± 0.015
2.205TyrLeu: 2.205 ± 0.048
0.268TyrMet: 0.268 ± 0.019
0.406TyrAsn: 0.406 ± 0.017
1.037TyrPro: 1.037 ± 0.035
0.559TyrGln: 0.559 ± 0.021
1.814TyrArg: 1.814 ± 0.041
1.056TyrSer: 1.056 ± 0.029
1.056TyrThr: 1.056 ± 0.031
1.495TyrVal: 1.495 ± 0.04
0.284TyrTrp: 0.284 ± 0.018
0.429TyrTyr: 0.429 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3409 proteins (1124320 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski