Amino acid dipepetide frequency for Mucilaginibacter frigoritolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.184AlaAla: 6.184 ± 0.071	0.687AlaCys: 0.687 ± 0.023	4.575AlaAsp: 4.575 ± 0.057	4.041AlaGlu: 4.041 ± 0.065	3.556AlaPhe: 3.556 ± 0.047	5.532AlaGly: 5.532 ± 0.069	1.273AlaHis: 1.273 ± 0.026	5.921AlaIle: 5.921 ± 0.074	4.616AlaLys: 4.616 ± 0.059	6.789AlaLeu: 6.789 ± 0.071	1.647AlaMet: 1.647 ± 0.04	3.903AlaAsn: 3.903 ± 0.058	2.45AlaPro: 2.45 ± 0.047	2.932AlaGln: 2.932 ± 0.046	2.279AlaArg: 2.279 ± 0.04	4.649AlaSer: 4.649 ± 0.055	4.199AlaThr: 4.199 ± 0.07	4.736AlaVal: 4.736 ± 0.057	0.781AlaTrp: 0.781 ± 0.025	2.89AlaTyr: 2.89 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.541CysAla: 0.541 ± 0.02	0.15CysCys: 0.15 ± 0.01	0.397CysAsp: 0.397 ± 0.018	0.378CysGlu: 0.378 ± 0.017	0.469CysPhe: 0.469 ± 0.017	0.623CysGly: 0.623 ± 0.021	0.2CysHis: 0.2 ± 0.012	0.668CysIle: 0.668 ± 0.02	0.475CysLys: 0.475 ± 0.018	0.818CysLeu: 0.818 ± 0.023	0.187CysMet: 0.187 ± 0.012	0.442CysAsn: 0.442 ± 0.018	0.35CysPro: 0.35 ± 0.017	0.219CysGln: 0.219 ± 0.011	0.285CysArg: 0.285 ± 0.012	0.58CysSer: 0.58 ± 0.022	0.456CysThr: 0.456 ± 0.017	0.437CysVal: 0.437 ± 0.016	0.087CysTrp: 0.087 ± 0.009	0.32CysTyr: 0.32 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	4.036AspAla: 4.036 ± 0.054	0.388AspCys: 0.388 ± 0.015	2.887AspAsp: 2.887 ± 0.049	3.388AspGlu: 3.388 ± 0.053	3.069AspPhe: 3.069 ± 0.042	3.672AspGly: 3.672 ± 0.057	1.065AspHis: 1.065 ± 0.027	4.101AspIle: 4.101 ± 0.055	3.946AspLys: 3.946 ± 0.056	4.812AspLeu: 4.812 ± 0.06	1.171AspMet: 1.171 ± 0.026	2.956AspAsn: 2.956 ± 0.044	2.152AspPro: 2.152 ± 0.039	1.839AspGln: 1.839 ± 0.034	1.837AspArg: 1.837 ± 0.033	3.054AspSer: 3.054 ± 0.054	2.783AspThr: 2.783 ± 0.046	3.419AspVal: 3.419 ± 0.051	0.736AspTrp: 0.736 ± 0.021	2.653AspTyr: 2.653 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	3.887GluAla: 3.887 ± 0.055	0.306GluCys: 0.306 ± 0.013	2.532GluAsp: 2.532 ± 0.042	3.126GluGlu: 3.126 ± 0.058	2.304GluPhe: 2.304 ± 0.044	2.961GluGly: 2.961 ± 0.045	1.121GluHis: 1.121 ± 0.025	4.111GluIle: 4.111 ± 0.063	4.319GluLys: 4.319 ± 0.061	5.376GluLeu: 5.376 ± 0.074	1.315GluMet: 1.315 ± 0.03	3.093GluAsn: 3.093 ± 0.044	1.6GluPro: 1.6 ± 0.033	2.27GluGln: 2.27 ± 0.047	2.14GluArg: 2.14 ± 0.035	2.66GluSer: 2.66 ± 0.044	2.828GluThr: 2.828 ± 0.045	3.432GluVal: 3.432 ± 0.049	0.629GluTrp: 0.629 ± 0.02	2.064GluTyr: 2.064 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.408PheAla: 3.408 ± 0.055	0.496PheCys: 0.496 ± 0.018	2.866PheAsp: 2.866 ± 0.046	2.606PheGlu: 2.606 ± 0.042	2.604PhePhe: 2.604 ± 0.053	3.357PheGly: 3.357 ± 0.051	0.843PheHis: 0.843 ± 0.023	3.904PheIle: 3.904 ± 0.059	3.485PheLys: 3.485 ± 0.053	4.388PheLeu: 4.388 ± 0.061	1.113PheMet: 1.113 ± 0.027	3.345PheAsn: 3.345 ± 0.052	1.704PhePro: 1.704 ± 0.033	1.302PheGln: 1.302 ± 0.028	1.639PheArg: 1.639 ± 0.03	3.641PheSer: 3.641 ± 0.048	3.3PheThr: 3.3 ± 0.044	2.828PheVal: 2.828 ± 0.047	0.633PheTrp: 0.633 ± 0.022	2.261PheTyr: 2.261 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	4.574GlyAla: 4.574 ± 0.058	0.597GlyCys: 0.597 ± 0.022	3.39GlyAsp: 3.39 ± 0.049	3.083GlyGlu: 3.083 ± 0.042	3.648GlyPhe: 3.648 ± 0.057	4.839GlyGly: 4.839 ± 0.078	1.264GlyHis: 1.264 ± 0.031	5.505GlyIle: 5.505 ± 0.074	5.06GlyLys: 5.06 ± 0.055	6.156GlyLeu: 6.156 ± 0.065	1.535GlyMet: 1.535 ± 0.034	3.9GlyAsn: 3.9 ± 0.057	1.758GlyPro: 1.758 ± 0.038	2.239GlyGln: 2.239 ± 0.041	2.25GlyArg: 2.25 ± 0.04	4.557GlySer: 4.557 ± 0.072	4.378GlyThr: 4.378 ± 0.087	4.402GlyVal: 4.402 ± 0.057	0.94GlyTrp: 0.94 ± 0.026	3.246GlyTyr: 3.246 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.111HisAla: 1.111 ± 0.024	0.191HisCys: 0.191 ± 0.011	1.005HisAsp: 1.005 ± 0.026	1.004HisGlu: 1.004 ± 0.028	1.165HisPhe: 1.165 ± 0.028	1.191HisGly: 1.191 ± 0.028	0.582HisHis: 0.582 ± 0.024	1.515HisIle: 1.515 ± 0.035	1.11HisLys: 1.11 ± 0.025	1.987HisLeu: 1.987 ± 0.037	0.391HisMet: 0.391 ± 0.017	1.043HisAsn: 1.043 ± 0.024	1.047HisPro: 1.047 ± 0.025	0.838HisGln: 0.838 ± 0.023	0.71HisArg: 0.71 ± 0.022	1.123HisSer: 1.123 ± 0.024	1.076HisThr: 1.076 ± 0.023	1.056HisVal: 1.056 ± 0.027	0.254HisTrp: 0.254 ± 0.013	0.98HisTyr: 0.98 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.266IleAla: 6.266 ± 0.074	0.76IleCys: 0.76 ± 0.022	4.506IleAsp: 4.506 ± 0.057	4.079IleGlu: 4.079 ± 0.054	3.384IlePhe: 3.384 ± 0.049	4.999IleGly: 4.999 ± 0.069	1.374IleHis: 1.374 ± 0.029	5.989IleIle: 5.989 ± 0.078	5.458IleLys: 5.458 ± 0.064	6.621IleLeu: 6.621 ± 0.077	1.425IleMet: 1.425 ± 0.031	4.893IleAsn: 4.893 ± 0.056	3.228IlePro: 3.228 ± 0.047	2.298IleGln: 2.298 ± 0.035	2.776IleArg: 2.776 ± 0.044	5.445IleSer: 5.445 ± 0.065	5.269IleThr: 5.269 ± 0.065	4.475IleVal: 4.475 ± 0.057	0.787IleTrp: 0.787 ± 0.024	2.89IleTyr: 2.89 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	5.163LysAla: 5.163 ± 0.068	0.334LysCys: 0.334 ± 0.013	3.941LysAsp: 3.941 ± 0.056	4.231LysGlu: 4.231 ± 0.059	2.651LysPhe: 2.651 ± 0.045	4.352LysGly: 4.352 ± 0.055	1.393LysHis: 1.393 ± 0.03	5.226LysIle: 5.226 ± 0.058	5.597LysLys: 5.597 ± 0.064	6.376LysLeu: 6.376 ± 0.076	1.807LysMet: 1.807 ± 0.032	4.245LysAsn: 4.245 ± 0.049	2.777LysPro: 2.777 ± 0.044	2.953LysGln: 2.953 ± 0.044	2.563LysArg: 2.563 ± 0.044	4.03LysSer: 4.03 ± 0.051	4.275LysThr: 4.275 ± 0.054	4.361LysVal: 4.361 ± 0.05	0.827LysTrp: 0.827 ± 0.024	2.955LysTyr: 2.955 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	6.666LeuAla: 6.666 ± 0.082	0.824LeuCys: 0.824 ± 0.027	4.549LeuAsp: 4.549 ± 0.066	4.275LeuGlu: 4.275 ± 0.061	4.78LeuPhe: 4.78 ± 0.069	5.564LeuGly: 5.564 ± 0.066	1.78LeuHis: 1.78 ± 0.035	7.154LeuIle: 7.154 ± 0.08	7.434LeuLys: 7.434 ± 0.07	9.595LeuLeu: 9.595 ± 0.112	2.173LeuMet: 2.173 ± 0.039	5.931LeuAsn: 5.931 ± 0.068	4.21LeuPro: 4.21 ± 0.053	3.582LeuGln: 3.582 ± 0.052	3.341LeuArg: 3.341 ± 0.057	6.898LeuSer: 6.898 ± 0.065	5.625LeuThr: 5.625 ± 0.072	5.523LeuVal: 5.523 ± 0.07	0.957LeuTrp: 0.957 ± 0.024	3.456LeuTyr: 3.456 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	1.864MetAla: 1.864 ± 0.032	0.141MetCys: 0.141 ± 0.009	1.191MetAsp: 1.191 ± 0.027	1.258MetGlu: 1.258 ± 0.027	0.871MetPhe: 0.871 ± 0.026	1.475MetGly: 1.475 ± 0.031	0.457MetHis: 0.457 ± 0.016	1.556MetIle: 1.556 ± 0.032	1.809MetLys: 1.809 ± 0.033	2.075MetLeu: 2.075 ± 0.042	0.561MetMet: 0.561 ± 0.018	1.231MetAsn: 1.231 ± 0.027	1.014MetPro: 1.014 ± 0.024	0.906MetGln: 0.906 ± 0.026	0.873MetArg: 0.873 ± 0.025	1.316MetSer: 1.316 ± 0.027	1.061MetThr: 1.061 ± 0.03	1.431MetVal: 1.431 ± 0.028	0.173MetTrp: 0.173 ± 0.009	0.626MetTyr: 0.626 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	4.202AsnAla: 4.202 ± 0.059	0.464AsnCys: 0.464 ± 0.018	3.033AsnAsp: 3.033 ± 0.049	3.0AsnGlu: 3.0 ± 0.042	2.737AsnPhe: 2.737 ± 0.043	4.339AsnGly: 4.339 ± 0.068	1.159AsnHis: 1.159 ± 0.024	4.585AsnIle: 4.585 ± 0.055	3.955AsnLys: 3.955 ± 0.048	5.168AsnLeu: 5.168 ± 0.06	1.228AsnMet: 1.228 ± 0.03	3.947AsnAsn: 3.947 ± 0.058	2.835AsnPro: 2.835 ± 0.044	2.202AsnGln: 2.202 ± 0.038	2.059AsnArg: 2.059 ± 0.035	3.604AsnSer: 3.604 ± 0.052	3.616AsnThr: 3.616 ± 0.069	3.346AsnVal: 3.346 ± 0.058	0.841AsnTrp: 0.841 ± 0.026	2.937AsnTyr: 2.937 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	3.276ProAla: 3.276 ± 0.053	0.227ProCys: 0.227 ± 0.013	2.642ProAsp: 2.642 ± 0.046	2.562ProGlu: 2.562 ± 0.044	1.979ProPhe: 1.979 ± 0.031	2.967ProGly: 2.967 ± 0.053	0.729ProHis: 0.729 ± 0.022	2.577ProIle: 2.577 ± 0.041	2.143ProLys: 2.143 ± 0.043	3.406ProLeu: 3.406 ± 0.047	0.692ProMet: 0.692 ± 0.022	2.092ProAsn: 2.092 ± 0.04	1.192ProPro: 1.192 ± 0.031	1.511ProGln: 1.511 ± 0.032	0.995ProArg: 0.995 ± 0.028	2.338ProSer: 2.338 ± 0.042	2.088ProThr: 2.088 ± 0.042	3.347ProVal: 3.347 ± 0.048	0.446ProTrp: 0.446 ± 0.018	1.701ProTyr: 1.701 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	2.517GlnAla: 2.517 ± 0.051	0.212GlnCys: 0.212 ± 0.013	1.532GlnAsp: 1.532 ± 0.031	1.695GlnGlu: 1.695 ± 0.035	1.821GlnPhe: 1.821 ± 0.036	1.961GlnGly: 1.961 ± 0.033	0.815GlnHis: 0.815 ± 0.024	2.626GlnIle: 2.626 ± 0.039	2.679GlnLys: 2.679 ± 0.046	3.951GlnLeu: 3.951 ± 0.054	0.921GlnMet: 0.921 ± 0.026	2.239GlnAsn: 2.239 ± 0.048	1.555GlnPro: 1.555 ± 0.034	2.146GlnGln: 2.146 ± 0.08	1.347GlnArg: 1.347 ± 0.03	2.309GlnSer: 2.309 ± 0.037	2.303GlnThr: 2.303 ± 0.039	2.322GlnVal: 2.322 ± 0.039	0.469GlnTrp: 0.469 ± 0.018	1.69GlnTyr: 1.69 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.198ArgAla: 2.198 ± 0.039	0.233ArgCys: 0.233 ± 0.015	1.779ArgAsp: 1.779 ± 0.034	1.925ArgGlu: 1.925 ± 0.039	1.884ArgPhe: 1.884 ± 0.033	1.994ArgGly: 1.994 ± 0.034	0.652ArgHis: 0.652 ± 0.019	2.815ArgIle: 2.815 ± 0.042	2.581ArgLys: 2.581 ± 0.044	3.551ArgLeu: 3.551 ± 0.05	0.923ArgMet: 0.923 ± 0.023	1.955ArgAsn: 1.955 ± 0.038	1.243ArgPro: 1.243 ± 0.031	1.326ArgGln: 1.326 ± 0.035	1.403ArgArg: 1.403 ± 0.034	2.021ArgSer: 2.021 ± 0.038	1.868ArgThr: 1.868 ± 0.033	2.204ArgVal: 2.204 ± 0.038	0.458ArgTrp: 0.458 ± 0.018	1.607ArgTyr: 1.607 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	4.803SerAla: 4.803 ± 0.06	0.541SerCys: 0.541 ± 0.016	3.145SerAsp: 3.145 ± 0.041	2.845SerGlu: 2.845 ± 0.046	3.694SerPhe: 3.694 ± 0.051	5.09SerGly: 5.09 ± 0.072	1.195SerHis: 1.195 ± 0.027	5.116SerIle: 5.116 ± 0.055	4.015SerLys: 4.015 ± 0.058	6.269SerLeu: 6.269 ± 0.069	1.276SerMet: 1.276 ± 0.032	3.429SerAsn: 3.429 ± 0.054	2.504SerPro: 2.504 ± 0.045	2.063SerGln: 2.063 ± 0.041	2.136SerArg: 2.136 ± 0.04	4.32SerSer: 4.32 ± 0.072	3.979SerThr: 3.979 ± 0.064	4.29SerVal: 4.29 ± 0.056	0.763SerTrp: 0.763 ± 0.022	2.889SerTyr: 2.889 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	4.796ThrAla: 4.796 ± 0.066	0.411ThrCys: 0.411 ± 0.017	3.604ThrAsp: 3.604 ± 0.049	2.961ThrGlu: 2.961 ± 0.046	2.905ThrPhe: 2.905 ± 0.047	5.04ThrGly: 5.04 ± 0.074	1.105ThrHis: 1.105 ± 0.024	4.762ThrIle: 4.762 ± 0.066	3.171ThrLys: 3.171 ± 0.047	5.545ThrLeu: 5.545 ± 0.066	1.034ThrMet: 1.034 ± 0.024	3.159ThrAsn: 3.159 ± 0.052	2.722ThrPro: 2.722 ± 0.049	2.097ThrGln: 2.097 ± 0.039	1.826ThrArg: 1.826 ± 0.034	3.873ThrSer: 3.873 ± 0.066	4.013ThrThr: 4.013 ± 0.096	4.19ThrVal: 4.19 ± 0.063	0.68ThrTrp: 0.68 ± 0.024	2.633ThrTyr: 2.633 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	4.533ValAla: 4.533 ± 0.056	0.62ValCys: 0.62 ± 0.028	3.414ValAsp: 3.414 ± 0.047	3.111ValGlu: 3.111 ± 0.048	3.22ValPhe: 3.22 ± 0.046	3.655ValGly: 3.655 ± 0.054	1.086ValHis: 1.086 ± 0.027	5.118ValIle: 5.118 ± 0.055	4.62ValLys: 4.62 ± 0.061	6.026ValLeu: 6.026 ± 0.071	1.393ValMet: 1.393 ± 0.029	3.986ValAsn: 3.986 ± 0.059	2.399ValPro: 2.399 ± 0.041	2.006ValGln: 2.006 ± 0.034	1.985ValArg: 1.985 ± 0.033	4.459ValSer: 4.459 ± 0.053	4.001ValThr: 4.001 ± 0.07	4.113ValVal: 4.113 ± 0.054	0.697ValTrp: 0.697 ± 0.022	2.569ValTyr: 2.569 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.787TrpAla: 0.787 ± 0.023	0.108TrpCys: 0.108 ± 0.008	0.659TrpAsp: 0.659 ± 0.019	0.597TrpGlu: 0.597 ± 0.021	0.618TrpPhe: 0.618 ± 0.022	0.829TrpGly: 0.829 ± 0.025	0.309TrpHis: 0.309 ± 0.012	0.838TrpIle: 0.838 ± 0.026	0.798TrpLys: 0.798 ± 0.024	1.226TrpLeu: 1.226 ± 0.031	0.334TrpMet: 0.334 ± 0.015	0.684TrpAsn: 0.684 ± 0.024	0.361TrpPro: 0.361 ± 0.016	0.566TrpGln: 0.566 ± 0.018	0.475TrpArg: 0.475 ± 0.018	0.638TrpSer: 0.638 ± 0.019	0.662TrpThr: 0.662 ± 0.027	0.75TrpVal: 0.75 ± 0.022	0.224TrpTrp: 0.224 ± 0.012	0.455TrpTyr: 0.455 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.83TyrAla: 2.83 ± 0.046	0.393TyrCys: 0.393 ± 0.015	2.316TyrAsp: 2.316 ± 0.037	1.907TyrGlu: 1.907 ± 0.037	2.363TyrPhe: 2.363 ± 0.041	2.881TyrGly: 2.881 ± 0.046	0.975TyrHis: 0.975 ± 0.024	2.836TyrIle: 2.836 ± 0.038	2.791TyrLys: 2.791 ± 0.043	4.184TyrLeu: 4.184 ± 0.056	0.76TyrMet: 0.76 ± 0.024	2.783TyrAsn: 2.783 ± 0.052	1.806TyrPro: 1.806 ± 0.036	1.815TyrGln: 1.815 ± 0.036	1.704TyrArg: 1.704 ± 0.034	2.848TyrSer: 2.848 ± 0.046	2.747TyrThr: 2.747 ± 0.049	2.35TyrVal: 2.35 ± 0.039	0.534TyrTrp: 0.534 ± 0.019	2.098TyrTyr: 2.098 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4865 proteins (1664168 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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