Amino acid dipepetide frequency for Oceanicaulis sp. HTCC2633

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.48AlaAla: 16.48 ± 0.214	1.239AlaCys: 1.239 ± 0.041	7.703AlaAsp: 7.703 ± 0.103	8.725AlaGlu: 8.725 ± 0.107	4.715AlaPhe: 4.715 ± 0.079	10.789AlaGly: 10.789 ± 0.131	2.398AlaHis: 2.398 ± 0.054	5.626AlaIle: 5.626 ± 0.081	3.395AlaLys: 3.395 ± 0.08	15.403AlaLeu: 15.403 ± 0.175	3.324AlaMet: 3.324 ± 0.068	2.955AlaAsn: 2.955 ± 0.064	6.698AlaPro: 6.698 ± 0.103	4.949AlaGln: 4.949 ± 0.075	9.648AlaArg: 9.648 ± 0.132	7.142AlaSer: 7.142 ± 0.105	4.765AlaThr: 4.765 ± 0.088	8.429AlaVal: 8.429 ± 0.109	1.475AlaTrp: 1.475 ± 0.041	2.831AlaTyr: 2.831 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	1.063CysAla: 1.063 ± 0.031	0.075CysCys: 0.075 ± 0.009	0.499CysAsp: 0.499 ± 0.029	0.499CysGlu: 0.499 ± 0.024	0.264CysPhe: 0.264 ± 0.019	0.77CysGly: 0.77 ± 0.03	0.176CysHis: 0.176 ± 0.013	0.277CysIle: 0.277 ± 0.017	0.174CysLys: 0.174 ± 0.015	0.679CysLeu: 0.679 ± 0.029	0.12CysMet: 0.12 ± 0.011	0.149CysAsn: 0.149 ± 0.015	0.416CysPro: 0.416 ± 0.023	0.224CysGln: 0.224 ± 0.014	0.451CysArg: 0.451 ± 0.023	0.415CysSer: 0.415 ± 0.021	0.356CysThr: 0.356 ± 0.021	0.612CysVal: 0.612 ± 0.03	0.099CysTrp: 0.099 ± 0.01	0.142CysTyr: 0.142 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.736AspAla: 8.736 ± 0.111	0.416AspCys: 0.416 ± 0.02	3.616AspAsp: 3.616 ± 0.082	4.279AspGlu: 4.279 ± 0.064	2.385AspPhe: 2.385 ± 0.049	5.762AspGly: 5.762 ± 0.099	1.333AspHis: 1.333 ± 0.043	2.764AspIle: 2.764 ± 0.065	1.542AspLys: 1.542 ± 0.052	6.516AspLeu: 6.516 ± 0.091	1.536AspMet: 1.536 ± 0.04	1.362AspAsn: 1.362 ± 0.041	3.965AspPro: 3.965 ± 0.077	2.429AspGln: 2.429 ± 0.053	4.602AspArg: 4.602 ± 0.062	2.608AspSer: 2.608 ± 0.055	2.699AspThr: 2.699 ± 0.058	4.459AspVal: 4.459 ± 0.074	1.215AspTrp: 1.215 ± 0.035	1.576AspTyr: 1.576 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	9.774GluAla: 9.774 ± 0.119	0.337GluCys: 0.337 ± 0.018	4.269GluAsp: 4.269 ± 0.071	3.869GluGlu: 3.869 ± 0.079	1.867GluPhe: 1.867 ± 0.05	5.37GluGly: 5.37 ± 0.077	1.272GluHis: 1.272 ± 0.035	3.492GluIle: 3.492 ± 0.064	1.854GluLys: 1.854 ± 0.052	5.909GluLeu: 5.909 ± 0.086	1.609GluMet: 1.609 ± 0.037	1.757GluAsn: 1.757 ± 0.045	3.178GluPro: 3.178 ± 0.074	2.371GluGln: 2.371 ± 0.052	5.625GluArg: 5.625 ± 0.091	2.814GluSer: 2.814 ± 0.057	4.658GluThr: 4.658 ± 0.064	4.007GluVal: 4.007 ± 0.072	0.635GluTrp: 0.635 ± 0.026	1.144GluTyr: 1.144 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	4.499PheAla: 4.499 ± 0.079	0.276PheCys: 0.276 ± 0.017	2.912PheAsp: 2.912 ± 0.053	2.818PheGlu: 2.818 ± 0.055	1.394PhePhe: 1.394 ± 0.048	3.413PheGly: 3.413 ± 0.069	0.683PheHis: 0.683 ± 0.028	1.686PheIle: 1.686 ± 0.048	1.079PheLys: 1.079 ± 0.032	3.178PheLeu: 3.178 ± 0.068	0.859PheMet: 0.859 ± 0.029	1.147PheAsn: 1.147 ± 0.043	1.41PhePro: 1.41 ± 0.036	0.973PheGln: 0.973 ± 0.031	1.984PheArg: 1.984 ± 0.043	2.256PheSer: 2.256 ± 0.051	2.227PheThr: 2.227 ± 0.05	2.567PheVal: 2.567 ± 0.058	0.519PheTrp: 0.519 ± 0.025	0.822PheTyr: 0.822 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.904GlyAla: 10.904 ± 0.122	0.714GlyCys: 0.714 ± 0.031	5.063GlyAsp: 5.063 ± 0.101	6.088GlyGlu: 6.088 ± 0.076	3.8GlyPhe: 3.8 ± 0.065	7.473GlyGly: 7.473 ± 0.124	1.619GlyHis: 1.619 ± 0.05	2.912GlyIle: 2.912 ± 0.076	2.418GlyLys: 2.418 ± 0.058	9.462GlyLeu: 9.462 ± 0.114	2.063GlyMet: 2.063 ± 0.052	1.563GlyAsn: 1.563 ± 0.054	3.641GlyPro: 3.641 ± 0.064	3.124GlyGln: 3.124 ± 0.058	5.824GlyArg: 5.824 ± 0.086	4.057GlySer: 4.057 ± 0.064	2.986GlyThr: 2.986 ± 0.074	7.536GlyVal: 7.536 ± 0.099	1.51GlyTrp: 1.51 ± 0.044	2.288GlyTyr: 2.288 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	2.439HisAla: 2.439 ± 0.052	0.179HisCys: 0.179 ± 0.016	1.192HisAsp: 1.192 ± 0.036	1.153HisGlu: 1.153 ± 0.035	0.749HisPhe: 0.749 ± 0.028	1.718HisGly: 1.718 ± 0.046	0.513HisHis: 0.513 ± 0.025	0.801HisIle: 0.801 ± 0.028	0.477HisLys: 0.477 ± 0.024	1.826HisLeu: 1.826 ± 0.042	0.452HisMet: 0.452 ± 0.021	0.386HisAsn: 0.386 ± 0.018	1.188HisPro: 1.188 ± 0.038	0.569HisGln: 0.569 ± 0.022	1.232HisArg: 1.232 ± 0.035	0.816HisSer: 0.816 ± 0.034	0.813HisThr: 0.813 ± 0.029	1.448HisVal: 1.448 ± 0.04	0.302HisTrp: 0.302 ± 0.018	0.472HisTyr: 0.472 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.561IleAla: 6.561 ± 0.089	0.425IleCys: 0.425 ± 0.024	3.195IleAsp: 3.195 ± 0.063	3.785IleGlu: 3.785 ± 0.065	1.45IlePhe: 1.45 ± 0.042	4.081IleGly: 4.081 ± 0.08	0.858IleHis: 0.858 ± 0.03	2.145IleIle: 2.145 ± 0.052	1.354IleLys: 1.354 ± 0.036	4.192IleLeu: 4.192 ± 0.077	0.929IleMet: 0.929 ± 0.032	1.445IleAsn: 1.445 ± 0.045	1.833IlePro: 1.833 ± 0.045	1.279IleGln: 1.279 ± 0.04	2.954IleArg: 2.954 ± 0.054	2.918IleSer: 2.918 ± 0.068	2.636IleThr: 2.636 ± 0.059	3.365IleVal: 3.365 ± 0.07	0.633IleTrp: 0.633 ± 0.028	1.016IleTyr: 1.016 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.195LysAla: 4.195 ± 0.081	0.1LysCys: 0.1 ± 0.009	1.626LysAsp: 1.626 ± 0.05	1.39LysGlu: 1.39 ± 0.046	0.732LysPhe: 0.732 ± 0.032	2.251LysGly: 2.251 ± 0.053	0.511LysHis: 0.511 ± 0.027	1.262LysIle: 1.262 ± 0.041	1.156LysLys: 1.156 ± 0.042	2.721LysLeu: 2.721 ± 0.063	0.583LysMet: 0.583 ± 0.024	0.627LysAsn: 0.627 ± 0.029	1.852LysPro: 1.852 ± 0.045	0.838LysGln: 0.838 ± 0.032	2.25LysArg: 2.25 ± 0.058	1.79LysSer: 1.79 ± 0.052	1.883LysThr: 1.883 ± 0.042	1.822LysVal: 1.822 ± 0.046	0.273LysTrp: 0.273 ± 0.018	0.455LysTyr: 0.455 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	12.94LeuAla: 12.94 ± 0.145	0.776LeuCys: 0.776 ± 0.026	6.895LeuAsp: 6.895 ± 0.087	6.585LeuGlu: 6.585 ± 0.089	3.669LeuPhe: 3.669 ± 0.071	8.403LeuGly: 8.403 ± 0.114	1.768LeuHis: 1.768 ± 0.052	5.489LeuIle: 5.489 ± 0.09	3.643LeuLys: 3.643 ± 0.074	8.279LeuLeu: 8.279 ± 0.123	2.536LeuMet: 2.536 ± 0.049	3.109LeuAsn: 3.109 ± 0.061	4.789LeuPro: 4.789 ± 0.069	2.82LeuGln: 2.82 ± 0.059	6.224LeuArg: 6.224 ± 0.102	7.408LeuSer: 7.408 ± 0.103	5.994LeuThr: 5.994 ± 0.086	7.038LeuVal: 7.038 ± 0.091	1.101LeuTrp: 1.101 ± 0.038	2.146LeuTyr: 2.146 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.085MetAla: 3.085 ± 0.053	0.138MetCys: 0.138 ± 0.012	1.288MetAsp: 1.288 ± 0.036	1.214MetGlu: 1.214 ± 0.036	0.629MetPhe: 0.629 ± 0.029	1.964MetGly: 1.964 ± 0.046	0.415MetHis: 0.415 ± 0.017	1.343MetIle: 1.343 ± 0.041	0.921MetLys: 0.921 ± 0.036	2.162MetLeu: 2.162 ± 0.052	0.699MetMet: 0.699 ± 0.028	0.738MetAsn: 0.738 ± 0.032	1.164MetPro: 1.164 ± 0.038	0.795MetGln: 0.795 ± 0.032	1.81MetArg: 1.81 ± 0.05	1.742MetSer: 1.742 ± 0.044	1.986MetThr: 1.986 ± 0.042	1.545MetVal: 1.545 ± 0.041	0.196MetTrp: 0.196 ± 0.013	0.284MetTyr: 0.284 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.714AsnAla: 3.714 ± 0.07	0.177AsnCys: 0.177 ± 0.016	1.448AsnAsp: 1.448 ± 0.041	1.3AsnGlu: 1.3 ± 0.04	0.871AsnPhe: 0.871 ± 0.029	2.364AsnGly: 2.364 ± 0.066	0.458AsnHis: 0.458 ± 0.02	1.087AsnIle: 1.087 ± 0.038	0.592AsnLys: 0.592 ± 0.026	2.589AsnLeu: 2.589 ± 0.054	0.57AsnMet: 0.57 ± 0.024	0.669AsnAsn: 0.669 ± 0.033	1.811AsnPro: 1.811 ± 0.048	0.838AsnGln: 0.838 ± 0.031	1.694AsnArg: 1.694 ± 0.046	1.218AsnSer: 1.218 ± 0.044	1.326AsnThr: 1.326 ± 0.044	1.757AsnVal: 1.757 ± 0.049	0.408AsnTrp: 0.408 ± 0.02	0.621AsnTyr: 0.621 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.731ProAla: 5.731 ± 0.083	0.279ProCys: 0.279 ± 0.018	4.306ProAsp: 4.306 ± 0.075	4.231ProGlu: 4.231 ± 0.088	1.872ProPhe: 1.872 ± 0.045	4.507ProGly: 4.507 ± 0.079	0.958ProHis: 0.958 ± 0.034	2.125ProIle: 2.125 ± 0.044	1.393ProLys: 1.393 ± 0.043	4.326ProLeu: 4.326 ± 0.072	1.096ProMet: 1.096 ± 0.034	1.301ProAsn: 1.301 ± 0.039	2.186ProPro: 2.186 ± 0.06	1.606ProGln: 1.606 ± 0.041	2.741ProArg: 2.741 ± 0.051	2.783ProSer: 2.783 ± 0.064	2.039ProThr: 2.039 ± 0.044	4.336ProVal: 4.336 ± 0.068	0.596ProTrp: 0.596 ± 0.024	1.17ProTyr: 1.17 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.883GlnAla: 4.883 ± 0.084	0.189GlnCys: 0.189 ± 0.017	1.843GlnAsp: 1.843 ± 0.046	1.627GlnGlu: 1.627 ± 0.042	1.118GlnPhe: 1.118 ± 0.036	2.659GlnGly: 2.659 ± 0.056	0.544GlnHis: 0.544 ± 0.026	1.866GlnIle: 1.866 ± 0.05	0.766GlnLys: 0.766 ± 0.033	3.097GlnLeu: 3.097 ± 0.052	0.889GlnMet: 0.889 ± 0.032	0.843GlnAsn: 0.843 ± 0.035	1.65GlnPro: 1.65 ± 0.041	1.05GlnGln: 1.05 ± 0.038	2.487GlnArg: 2.487 ± 0.048	2.238GlnSer: 2.238 ± 0.052	2.241GlnThr: 2.241 ± 0.049	2.267GlnVal: 2.267 ± 0.048	0.381GlnTrp: 0.381 ± 0.021	0.593GlnTyr: 0.593 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	8.495ArgAla: 8.495 ± 0.116	0.452ArgCys: 0.452 ± 0.021	4.257ArgAsp: 4.257 ± 0.072	4.482ArgGlu: 4.482 ± 0.067	3.096ArgPhe: 3.096 ± 0.056	4.574ArgGly: 4.574 ± 0.079	1.378ArgHis: 1.378 ± 0.044	3.666ArgIle: 3.666 ± 0.067	2.081ArgLys: 2.081 ± 0.052	8.332ArgLeu: 8.332 ± 0.123	1.813ArgMet: 1.813 ± 0.048	1.807ArgAsn: 1.807 ± 0.044	3.355ArgPro: 3.355 ± 0.07	2.571ArgGln: 2.571 ± 0.054	5.184ArgArg: 5.184 ± 0.108	3.573ArgSer: 3.573 ± 0.06	3.512ArgThr: 3.512 ± 0.06	4.695ArgVal: 4.695 ± 0.075	0.967ArgTrp: 0.967 ± 0.029	1.75ArgTyr: 1.75 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	7.144SerAla: 7.144 ± 0.105	0.361SerCys: 0.361 ± 0.022	3.919SerAsp: 3.919 ± 0.071	3.765SerGlu: 3.765 ± 0.071	2.061SerPhe: 2.061 ± 0.05	5.638SerGly: 5.638 ± 0.102	0.987SerHis: 0.987 ± 0.034	2.419SerIle: 2.419 ± 0.056	1.432SerLys: 1.432 ± 0.044	5.634SerLeu: 5.634 ± 0.09	1.357SerMet: 1.357 ± 0.04	1.474SerAsn: 1.474 ± 0.046	2.793SerPro: 2.793 ± 0.049	1.854SerGln: 1.854 ± 0.048	3.689SerArg: 3.689 ± 0.071	2.983SerSer: 2.983 ± 0.075	2.569SerThr: 2.569 ± 0.056	4.244SerVal: 4.244 ± 0.076	0.793SerTrp: 0.793 ± 0.029	1.319SerTyr: 1.319 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.425ThrAla: 6.425 ± 0.104	0.371ThrCys: 0.371 ± 0.019	3.102ThrAsp: 3.102 ± 0.064	2.937ThrGlu: 2.937 ± 0.064	1.682ThrPhe: 1.682 ± 0.051	5.161ThrGly: 5.161 ± 0.084	0.944ThrHis: 0.944 ± 0.036	2.267ThrIle: 2.267 ± 0.063	1.077ThrLys: 1.077 ± 0.035	6.124ThrLeu: 6.124 ± 0.084	0.87ThrMet: 0.87 ± 0.026	1.245ThrAsn: 1.245 ± 0.041	3.507ThrPro: 3.507 ± 0.061	1.632ThrGln: 1.632 ± 0.046	3.413ThrArg: 3.413 ± 0.06	2.586ThrSer: 2.586 ± 0.061	2.338ThrThr: 2.338 ± 0.066	3.879ThrVal: 3.879 ± 0.077	0.493ThrTrp: 0.493 ± 0.023	1.087ThrTyr: 1.087 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	7.332ValAla: 7.332 ± 0.089	0.633ValCys: 0.633 ± 0.027	4.279ValAsp: 4.279 ± 0.059	4.98ValGlu: 4.98 ± 0.076	3.013ValPhe: 3.013 ± 0.054	5.092ValGly: 5.092 ± 0.078	1.28ValHis: 1.28 ± 0.04	4.339ValIle: 4.339 ± 0.071	2.112ValLys: 2.112 ± 0.058	7.544ValLeu: 7.544 ± 0.103	1.995ValMet: 1.995 ± 0.055	2.043ValAsn: 2.043 ± 0.046	2.526ValPro: 2.526 ± 0.055	2.17ValGln: 2.17 ± 0.047	5.273ValArg: 5.273 ± 0.075	4.937ValSer: 4.937 ± 0.089	4.215ValThr: 4.215 ± 0.079	4.988ValVal: 4.988 ± 0.091	1.044ValTrp: 1.044 ± 0.036	1.608ValTyr: 1.608 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.385TrpAla: 1.385 ± 0.045	0.114TrpCys: 0.114 ± 0.011	0.68TrpAsp: 0.68 ± 0.024	0.565TrpGlu: 0.565 ± 0.023	0.522TrpPhe: 0.522 ± 0.022	0.882TrpGly: 0.882 ± 0.029	0.226TrpHis: 0.226 ± 0.015	0.684TrpIle: 0.684 ± 0.025	0.325TrpLys: 0.325 ± 0.018	1.521TrpLeu: 1.521 ± 0.038	0.375TrpMet: 0.375 ± 0.021	0.361TrpAsn: 0.361 ± 0.019	0.648TrpPro: 0.648 ± 0.025	0.332TrpGln: 0.332 ± 0.017	1.44TrpArg: 1.44 ± 0.041	1.021TrpSer: 1.021 ± 0.034	0.836TrpThr: 0.836 ± 0.032	0.836TrpVal: 0.836 ± 0.025	0.185TrpTrp: 0.185 ± 0.015	0.243TrpTyr: 0.243 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.904TyrAla: 2.904 ± 0.053	0.21TyrCys: 0.21 ± 0.015	1.708TyrAsp: 1.708 ± 0.044	1.518TyrGlu: 1.518 ± 0.04	0.812TyrPhe: 0.812 ± 0.029	2.176TyrGly: 2.176 ± 0.053	0.406TyrHis: 0.406 ± 0.021	0.801TyrIle: 0.801 ± 0.029	0.524TyrLys: 0.524 ± 0.025	2.118TyrLeu: 2.118 ± 0.054	0.44TyrMet: 0.44 ± 0.018	0.534TyrAsn: 0.534 ± 0.024	0.972TyrPro: 0.972 ± 0.034	0.806TyrGln: 0.806 ± 0.032	1.518TyrArg: 1.518 ± 0.043	1.129TyrSer: 1.129 ± 0.041	1.06TyrThr: 1.06 ± 0.046	1.573TyrVal: 1.573 ± 0.039	0.359TyrTrp: 0.359 ± 0.019	0.58TyrTyr: 0.58 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3028 proteins (953775 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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