Amino acid dipepetide frequency for Knoellia subterranea KCTC 19937

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.826AlaAla: 18.826 ± 0.2	0.8AlaCys: 0.8 ± 0.03	7.989AlaAsp: 7.989 ± 0.106	7.517AlaGlu: 7.517 ± 0.098	3.57AlaPhe: 3.57 ± 0.062	11.853AlaGly: 11.853 ± 0.129	2.738AlaHis: 2.738 ± 0.05	5.023AlaIle: 5.023 ± 0.076	3.064AlaLys: 3.064 ± 0.071	13.559AlaLeu: 13.559 ± 0.156	2.875AlaMet: 2.875 ± 0.058	2.299AlaAsn: 2.299 ± 0.047	6.198AlaPro: 6.198 ± 0.111	3.622AlaGln: 3.622 ± 0.061	9.059AlaArg: 9.059 ± 0.116	6.811AlaSer: 6.811 ± 0.086	8.216AlaThr: 8.216 ± 0.097	11.27AlaVal: 11.27 ± 0.133	1.958AlaTrp: 1.958 ± 0.052	2.656AlaTyr: 2.656 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.765CysAla: 0.765 ± 0.027	0.082CysCys: 0.082 ± 0.009	0.44CysAsp: 0.44 ± 0.02	0.294CysGlu: 0.294 ± 0.018	0.211CysPhe: 0.211 ± 0.016	0.74CysGly: 0.74 ± 0.026	0.165CysHis: 0.165 ± 0.012	0.219CysIle: 0.219 ± 0.016	0.108CysLys: 0.108 ± 0.01	0.589CysLeu: 0.589 ± 0.023	0.103CysMet: 0.103 ± 0.009	0.114CysAsn: 0.114 ± 0.011	0.383CysPro: 0.383 ± 0.021	0.146CysGln: 0.146 ± 0.012	0.458CysArg: 0.458 ± 0.02	0.39CysSer: 0.39 ± 0.019	0.437CysThr: 0.437 ± 0.022	0.553CysVal: 0.553 ± 0.023	0.083CysTrp: 0.083 ± 0.009	0.112CysTyr: 0.112 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.094AspAla: 8.094 ± 0.096	0.35AspCys: 0.35 ± 0.019	4.342AspAsp: 4.342 ± 0.086	4.614AspGlu: 4.614 ± 0.08	1.649AspPhe: 1.649 ± 0.043	6.228AspGly: 6.228 ± 0.089	1.548AspHis: 1.548 ± 0.042	2.282AspIle: 2.282 ± 0.045	1.3AspLys: 1.3 ± 0.041	7.079AspLeu: 7.079 ± 0.089	0.916AspMet: 0.916 ± 0.03	1.14AspAsn: 1.14 ± 0.04	4.189AspPro: 4.189 ± 0.076	1.545AspGln: 1.545 ± 0.039	4.596AspArg: 4.596 ± 0.075	2.847AspSer: 2.847 ± 0.055	3.115AspThr: 3.115 ± 0.061	6.192AspVal: 6.192 ± 0.095	0.911AspTrp: 0.911 ± 0.03	1.142AspTyr: 1.142 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.377GluAla: 7.377 ± 0.102	0.331GluCys: 0.331 ± 0.016	3.157GluAsp: 3.157 ± 0.058	3.192GluGlu: 3.192 ± 0.068	1.716GluPhe: 1.716 ± 0.044	4.542GluGly: 4.542 ± 0.069	1.555GluHis: 1.555 ± 0.045	2.495GluIle: 2.495 ± 0.05	1.428GluLys: 1.428 ± 0.042	6.089GluLeu: 6.089 ± 0.078	0.999GluMet: 0.999 ± 0.032	1.04GluAsn: 1.04 ± 0.034	2.971GluPro: 2.971 ± 0.06	2.045GluGln: 2.045 ± 0.045	5.257GluArg: 5.257 ± 0.083	3.204GluSer: 3.204 ± 0.054	3.062GluThr: 3.062 ± 0.053	5.369GluVal: 5.369 ± 0.077	0.922GluTrp: 0.922 ± 0.034	0.874GluTyr: 0.874 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.727PheAla: 3.727 ± 0.061	0.227PheCys: 0.227 ± 0.014	2.138PheAsp: 2.138 ± 0.053	1.53PheGlu: 1.53 ± 0.039	0.927PhePhe: 0.927 ± 0.032	3.217PheGly: 3.217 ± 0.055	0.608PheHis: 0.608 ± 0.023	1.006PheIle: 1.006 ± 0.034	0.51PheLys: 0.51 ± 0.024	2.467PheLeu: 2.467 ± 0.051	0.466PheMet: 0.466 ± 0.022	0.63PheAsn: 0.63 ± 0.028	1.337PhePro: 1.337 ± 0.04	0.565PheGln: 0.565 ± 0.025	1.684PheArg: 1.684 ± 0.043	1.421PheSer: 1.421 ± 0.038	1.908PheThr: 1.908 ± 0.048	2.845PheVal: 2.845 ± 0.054	0.469PheTrp: 0.469 ± 0.026	0.589PheTyr: 0.589 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	10.58GlyAla: 10.58 ± 0.13	0.683GlyCys: 0.683 ± 0.027	5.516GlyAsp: 5.516 ± 0.08	5.288GlyGlu: 5.288 ± 0.064	3.003GlyPhe: 3.003 ± 0.059	8.089GlyGly: 8.089 ± 0.123	2.227GlyHis: 2.227 ± 0.043	4.035GlyIle: 4.035 ± 0.069	2.379GlyLys: 2.379 ± 0.056	9.515GlyLeu: 9.515 ± 0.108	2.015GlyMet: 2.015 ± 0.046	1.725GlyAsn: 1.725 ± 0.049	4.294GlyPro: 4.294 ± 0.066	2.762GlyGln: 2.762 ± 0.06	6.892GlyArg: 6.892 ± 0.096	5.806GlySer: 5.806 ± 0.086	5.763GlyThr: 5.763 ± 0.082	8.083GlyVal: 8.083 ± 0.106	1.772GlyTrp: 1.772 ± 0.046	2.021GlyTyr: 2.021 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.519HisAla: 2.519 ± 0.048	0.18HisCys: 0.18 ± 0.013	1.655HisAsp: 1.655 ± 0.043	1.393HisGlu: 1.393 ± 0.037	0.581HisPhe: 0.581 ± 0.023	2.231HisGly: 2.231 ± 0.044	0.663HisHis: 0.663 ± 0.028	0.635HisIle: 0.635 ± 0.023	0.358HisLys: 0.358 ± 0.018	2.375HisLeu: 2.375 ± 0.06	0.324HisMet: 0.324 ± 0.019	0.394HisAsn: 0.394 ± 0.018	1.517HisPro: 1.517 ± 0.034	0.54HisGln: 0.54 ± 0.023	1.756HisArg: 1.756 ± 0.045	1.009HisSer: 1.009 ± 0.03	1.166HisThr: 1.166 ± 0.03	2.092HisVal: 2.092 ± 0.038	0.341HisTrp: 0.341 ± 0.019	0.387HisTyr: 0.387 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.688IleAla: 5.688 ± 0.095	0.277IleCys: 0.277 ± 0.017	2.961IleAsp: 2.961 ± 0.056	2.595IleGlu: 2.595 ± 0.052	0.989IlePhe: 0.989 ± 0.033	4.062IleGly: 4.062 ± 0.072	0.782IleHis: 0.782 ± 0.029	1.337IleIle: 1.337 ± 0.041	0.9IleLys: 0.9 ± 0.031	3.149IleLeu: 3.149 ± 0.061	0.523IleMet: 0.523 ± 0.023	0.893IleAsn: 0.893 ± 0.034	2.071IlePro: 2.071 ± 0.049	0.901IleGln: 0.901 ± 0.032	2.396IleArg: 2.396 ± 0.048	2.008IleSer: 2.008 ± 0.049	2.538IleThr: 2.538 ± 0.05	3.819IleVal: 3.819 ± 0.069	0.457IleTrp: 0.457 ± 0.019	0.612IleTyr: 0.612 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.085LysAla: 3.085 ± 0.071	0.112LysCys: 0.112 ± 0.01	1.422LysAsp: 1.422 ± 0.041	1.149LysGlu: 1.149 ± 0.038	0.543LysPhe: 0.543 ± 0.022	1.971LysGly: 1.971 ± 0.048	0.463LysHis: 0.463 ± 0.022	0.83LysIle: 0.83 ± 0.033	0.854LysLys: 0.854 ± 0.041	1.753LysLeu: 1.753 ± 0.046	0.392LysMet: 0.392 ± 0.017	0.546LysAsn: 0.546 ± 0.025	1.299LysPro: 1.299 ± 0.04	0.689LysGln: 0.689 ± 0.026	1.501LysArg: 1.501 ± 0.041	1.308LysSer: 1.308 ± 0.038	1.26LysThr: 1.26 ± 0.041	2.233LysVal: 2.233 ± 0.053	0.28LysTrp: 0.28 ± 0.019	0.437LysTyr: 0.437 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.18LeuAla: 14.18 ± 0.165	0.61LeuCys: 0.61 ± 0.023	7.09LeuAsp: 7.09 ± 0.076	5.283LeuGlu: 5.283 ± 0.093	2.395LeuPhe: 2.395 ± 0.051	9.661LeuGly: 9.661 ± 0.12	1.864LeuHis: 1.864 ± 0.045	3.512LeuIle: 3.512 ± 0.067	1.911LeuLys: 1.911 ± 0.053	9.915LeuLeu: 9.915 ± 0.135	1.704LeuMet: 1.704 ± 0.041	1.598LeuAsn: 1.598 ± 0.04	5.389LeuPro: 5.389 ± 0.067	2.213LeuGln: 2.213 ± 0.049	7.476LeuArg: 7.476 ± 0.094	5.541LeuSer: 5.541 ± 0.077	6.793LeuThr: 6.793 ± 0.088	9.787LeuVal: 9.787 ± 0.127	1.217LeuTrp: 1.217 ± 0.034	1.353LeuTyr: 1.353 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.443MetAla: 2.443 ± 0.049	0.133MetCys: 0.133 ± 0.01	0.922MetAsp: 0.922 ± 0.029	0.788MetGlu: 0.788 ± 0.025	0.539MetPhe: 0.539 ± 0.024	1.629MetGly: 1.629 ± 0.043	0.333MetHis: 0.333 ± 0.019	0.681MetIle: 0.681 ± 0.025	0.457MetLys: 0.457 ± 0.02	1.818MetLeu: 1.818 ± 0.042	0.304MetMet: 0.304 ± 0.017	0.456MetAsn: 0.456 ± 0.021	1.284MetPro: 1.284 ± 0.032	0.483MetGln: 0.483 ± 0.022	1.473MetArg: 1.473 ± 0.04	1.557MetSer: 1.557 ± 0.038	1.766MetThr: 1.766 ± 0.04	1.474MetVal: 1.474 ± 0.037	0.25MetTrp: 0.25 ± 0.016	0.297MetTyr: 0.297 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.407AsnAla: 2.407 ± 0.054	0.146AsnCys: 0.146 ± 0.011	1.09AsnAsp: 1.09 ± 0.032	0.882AsnGlu: 0.882 ± 0.031	0.563AsnPhe: 0.563 ± 0.023	1.863AsnGly: 1.863 ± 0.05	0.425AsnHis: 0.425 ± 0.019	0.728AsnIle: 0.728 ± 0.025	0.423AsnLys: 0.423 ± 0.021	1.903AsnLeu: 1.903 ± 0.047	0.272AsnMet: 0.272 ± 0.016	0.445AsnAsn: 0.445 ± 0.02	1.612AsnPro: 1.612 ± 0.042	0.515AsnGln: 0.515 ± 0.025	1.274AsnArg: 1.274 ± 0.037	0.978AsnSer: 0.978 ± 0.032	1.083AsnThr: 1.083 ± 0.036	1.59AsnVal: 1.59 ± 0.043	0.298AsnTrp: 0.298 ± 0.019	0.451AsnTyr: 0.451 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.712ProAla: 6.712 ± 0.094	0.267ProCys: 0.267 ± 0.017	4.088ProAsp: 4.088 ± 0.069	3.988ProGlu: 3.988 ± 0.066	1.548ProPhe: 1.548 ± 0.039	5.33ProGly: 5.33 ± 0.076	1.178ProHis: 1.178 ± 0.032	1.826ProIle: 1.826 ± 0.046	1.218ProLys: 1.218 ± 0.032	4.626ProLeu: 4.626 ± 0.064	1.127ProMet: 1.127 ± 0.034	1.05ProAsn: 1.05 ± 0.034	2.416ProPro: 2.416 ± 0.065	1.521ProGln: 1.521 ± 0.038	3.436ProArg: 3.436 ± 0.062	3.451ProSer: 3.451 ± 0.072	3.893ProThr: 3.893 ± 0.07	4.902ProVal: 4.902 ± 0.072	0.96ProTrp: 0.96 ± 0.032	0.926ProTyr: 0.926 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.331GlnAla: 3.331 ± 0.055	0.151GlnCys: 0.151 ± 0.013	1.26GlnAsp: 1.26 ± 0.033	1.247GlnGlu: 1.247 ± 0.04	0.775GlnPhe: 0.775 ± 0.029	2.256GlnGly: 2.256 ± 0.041	0.658GlnHis: 0.658 ± 0.025	1.182GlnIle: 1.182 ± 0.037	0.619GlnLys: 0.619 ± 0.023	2.771GlnLeu: 2.771 ± 0.057	0.539GlnMet: 0.539 ± 0.025	0.518GlnAsn: 0.518 ± 0.025	1.589GlnPro: 1.589 ± 0.039	1.084GlnGln: 1.084 ± 0.045	2.417GlnArg: 2.417 ± 0.053	1.456GlnSer: 1.456 ± 0.038	1.46GlnThr: 1.46 ± 0.043	2.49GlnVal: 2.49 ± 0.049	0.499GlnTrp: 0.499 ± 0.023	0.452GlnTyr: 0.452 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.575ArgAla: 8.575 ± 0.099	0.407ArgCys: 0.407 ± 0.021	4.643ArgAsp: 4.643 ± 0.075	4.629ArgGlu: 4.629 ± 0.077	2.141ArgPhe: 2.141 ± 0.042	5.803ArgGly: 5.803 ± 0.085	1.842ArgHis: 1.842 ± 0.045	3.336ArgIle: 3.336 ± 0.057	1.481ArgLys: 1.481 ± 0.037	7.567ArgLeu: 7.567 ± 0.099	1.7ArgMet: 1.7 ± 0.039	1.321ArgAsn: 1.321 ± 0.036	3.971ArgPro: 3.971 ± 0.067	1.977ArgGln: 1.977 ± 0.046	6.591ArgArg: 6.591 ± 0.105	4.2ArgSer: 4.2 ± 0.078	4.563ArgThr: 4.563 ± 0.067	5.976ArgVal: 5.976 ± 0.088	1.337ArgTrp: 1.337 ± 0.039	1.421ArgTyr: 1.421 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	7.151SerAla: 7.151 ± 0.096	0.318SerCys: 0.318 ± 0.018	3.284SerAsp: 3.284 ± 0.057	2.777SerGlu: 2.777 ± 0.049	1.619SerPhe: 1.619 ± 0.039	6.076SerGly: 6.076 ± 0.095	1.121SerHis: 1.121 ± 0.035	2.177SerIle: 2.177 ± 0.048	1.147SerLys: 1.147 ± 0.036	5.243SerLeu: 5.243 ± 0.063	1.425SerMet: 1.425 ± 0.038	1.097SerAsn: 1.097 ± 0.031	3.177SerPro: 3.177 ± 0.066	1.481SerGln: 1.481 ± 0.032	4.101SerArg: 4.101 ± 0.07	3.362SerSer: 3.362 ± 0.064	3.904SerThr: 3.904 ± 0.081	4.795SerVal: 4.795 ± 0.065	0.936SerTrp: 0.936 ± 0.034	1.005SerTyr: 1.005 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	7.86ThrAla: 7.86 ± 0.1	0.421ThrCys: 0.421 ± 0.021	3.849ThrAsp: 3.849 ± 0.066	3.246ThrGlu: 3.246 ± 0.06	1.991ThrPhe: 1.991 ± 0.046	5.954ThrGly: 5.954 ± 0.079	1.356ThrHis: 1.356 ± 0.035	2.589ThrIle: 2.589 ± 0.054	1.463ThrLys: 1.463 ± 0.046	5.822ThrLeu: 5.822 ± 0.085	1.204ThrMet: 1.204 ± 0.032	1.254ThrAsn: 1.254 ± 0.036	4.251ThrPro: 4.251 ± 0.07	1.587ThrGln: 1.587 ± 0.043	3.988ThrArg: 3.988 ± 0.064	3.944ThrSer: 3.944 ± 0.071	4.684ThrThr: 4.684 ± 0.087	5.937ThrVal: 5.937 ± 0.086	1.04ThrTrp: 1.04 ± 0.033	1.337ThrTyr: 1.337 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	12.21ValAla: 12.21 ± 0.13	0.631ValCys: 0.631 ± 0.024	6.089ValAsp: 6.089 ± 0.084	5.487ValGlu: 5.487 ± 0.088	2.313ValPhe: 2.313 ± 0.057	8.032ValGly: 8.032 ± 0.113	1.951ValHis: 1.951 ± 0.041	3.872ValIle: 3.872 ± 0.066	1.825ValLys: 1.825 ± 0.042	9.54ValLeu: 9.54 ± 0.115	1.64ValMet: 1.64 ± 0.035	1.684ValAsn: 1.684 ± 0.042	4.777ValPro: 4.777 ± 0.068	2.117ValGln: 2.117 ± 0.054	6.541ValArg: 6.541 ± 0.082	4.983ValSer: 4.983 ± 0.075	6.215ValThr: 6.215 ± 0.081	9.981ValVal: 9.981 ± 0.12	1.197ValTrp: 1.197 ± 0.034	1.209ValTyr: 1.209 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.695TrpAla: 1.695 ± 0.04	0.134TrpCys: 0.134 ± 0.013	0.841TrpAsp: 0.841 ± 0.036	0.685TrpGlu: 0.685 ± 0.027	0.611TrpPhe: 0.611 ± 0.024	1.194TrpGly: 1.194 ± 0.037	0.345TrpHis: 0.345 ± 0.017	0.649TrpIle: 0.649 ± 0.022	0.335TrpLys: 0.335 ± 0.021	1.837TrpLeu: 1.837 ± 0.05	0.331TrpMet: 0.331 ± 0.017	0.388TrpAsn: 0.388 ± 0.021	0.813TrpPro: 0.813 ± 0.026	0.499TrpGln: 0.499 ± 0.02	1.206TrpArg: 1.206 ± 0.038	1.032TrpSer: 1.032 ± 0.03	1.0TrpThr: 1.0 ± 0.034	1.308TrpVal: 1.308 ± 0.035	0.423TrpTrp: 0.423 ± 0.023	0.291TrpTyr: 0.291 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.681TyrAla: 2.681 ± 0.05	0.135TyrCys: 0.135 ± 0.011	1.305TyrAsp: 1.305 ± 0.038	1.04TyrGlu: 1.04 ± 0.034	0.585TyrPhe: 0.585 ± 0.024	1.717TyrGly: 1.717 ± 0.04	0.296TyrHis: 0.296 ± 0.017	0.543TyrIle: 0.543 ± 0.024	0.346TyrLys: 0.346 ± 0.016	1.872TyrLeu: 1.872 ± 0.042	0.228TyrMet: 0.228 ± 0.015	0.358TyrAsn: 0.358 ± 0.019	0.927TyrPro: 0.927 ± 0.032	0.459TyrGln: 0.459 ± 0.021	1.381TyrArg: 1.381 ± 0.04	0.886TyrSer: 0.886 ± 0.029	0.951TyrThr: 0.951 ± 0.036	1.595TyrVal: 1.595 ± 0.044	0.266TyrTrp: 0.266 ± 0.015	0.402TyrTyr: 0.402 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3418 proteins (1069712 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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