Amino acid dipepetide frequency for Candidatus Kryptonium thompsoni

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.442AlaAla: 2.442 ± 0.08
0.573AlaCys: 0.573 ± 0.031
2.897AlaAsp: 2.897 ± 0.065
4.282AlaGlu: 4.282 ± 0.089
3.08AlaPhe: 3.08 ± 0.07
4.921AlaGly: 4.921 ± 0.083
0.897AlaHis: 0.897 ± 0.036
5.675AlaIle: 5.675 ± 0.102
4.705AlaLys: 4.705 ± 0.09
5.946AlaLeu: 5.946 ± 0.096
1.461AlaMet: 1.461 ± 0.048
2.556AlaAsn: 2.556 ± 0.06
1.858AlaPro: 1.858 ± 0.049
2.141AlaGln: 2.141 ± 0.058
3.013AlaArg: 3.013 ± 0.069
3.528AlaSer: 3.528 ± 0.067
2.882AlaThr: 2.882 ± 0.068
4.631AlaVal: 4.631 ± 0.08
0.639AlaTrp: 0.639 ± 0.026
2.345AlaTyr: 2.345 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.52CysAla: 0.52 ± 0.027
0.068CysCys: 0.068 ± 0.008
0.45CysAsp: 0.45 ± 0.024
0.504CysGlu: 0.504 ± 0.03
0.359CysPhe: 0.359 ± 0.022
0.768CysGly: 0.768 ± 0.034
0.36CysHis: 0.36 ± 0.061
0.442CysIle: 0.442 ± 0.022
0.452CysLys: 0.452 ± 0.02
0.488CysLeu: 0.488 ± 0.022
0.112CysMet: 0.112 ± 0.011
0.264CysAsn: 0.264 ± 0.019
0.413CysPro: 0.413 ± 0.026
0.176CysGln: 0.176 ± 0.015
0.284CysArg: 0.284 ± 0.019
0.424CysSer: 0.424 ± 0.025
0.289CysThr: 0.289 ± 0.019
0.5CysVal: 0.5 ± 0.024
0.081CysTrp: 0.081 ± 0.011
0.278CysTyr: 0.278 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.018AspAla: 3.018 ± 0.058
0.328AspCys: 0.328 ± 0.021
2.607AspAsp: 2.607 ± 0.058
4.762AspGlu: 4.762 ± 0.1
3.099AspPhe: 3.099 ± 0.065
3.979AspGly: 3.979 ± 0.105
0.54AspHis: 0.54 ± 0.026
4.505AspIle: 4.505 ± 0.08
4.026AspLys: 4.026 ± 0.079
4.536AspLeu: 4.536 ± 0.064
0.938AspMet: 0.938 ± 0.033
1.786AspAsn: 1.786 ± 0.048
2.226AspPro: 2.226 ± 0.053
0.847AspGln: 0.847 ± 0.033
2.081AspArg: 2.081 ± 0.059
2.916AspSer: 2.916 ± 0.066
2.19AspThr: 2.19 ± 0.065
4.296AspVal: 4.296 ± 0.083
0.621AspTrp: 0.621 ± 0.031
2.253AspTyr: 2.253 ± 0.069
0.0AspXaa: 0.0 ± 0.0
Glu
4.245GluAla: 4.245 ± 0.102
0.42GluCys: 0.42 ± 0.023
3.04GluAsp: 3.04 ± 0.07
5.302GluGlu: 5.302 ± 0.124
4.003GluPhe: 4.003 ± 0.074
3.751GluGly: 3.751 ± 0.07
1.069GluHis: 1.069 ± 0.041
8.289GluIle: 8.289 ± 0.129
7.268GluLys: 7.268 ± 0.131
6.987GluLeu: 6.987 ± 0.125
1.601GluMet: 1.601 ± 0.053
3.884GluAsn: 3.884 ± 0.063
2.141GluPro: 2.141 ± 0.059
1.92GluGln: 1.92 ± 0.058
3.855GluArg: 3.855 ± 0.081
3.286GluSer: 3.286 ± 0.071
3.138GluThr: 3.138 ± 0.071
5.373GluVal: 5.373 ± 0.089
0.677GluTrp: 0.677 ± 0.027
2.524GluTyr: 2.524 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
3.504PheAla: 3.504 ± 0.07
0.376PheCys: 0.376 ± 0.022
3.381PheAsp: 3.381 ± 0.079
4.191PheGlu: 4.191 ± 0.059
2.776PhePhe: 2.776 ± 0.078
4.038PheGly: 4.038 ± 0.081
0.697PheHis: 0.697 ± 0.03
4.671PheIle: 4.671 ± 0.087
4.279PheLys: 4.279 ± 0.073
5.126PheLeu: 5.126 ± 0.109
0.986PheMet: 0.986 ± 0.036
2.625PheAsn: 2.625 ± 0.068
2.024PhePro: 2.024 ± 0.052
1.235PheGln: 1.235 ± 0.04
2.039PheArg: 2.039 ± 0.054
3.739PheSer: 3.739 ± 0.079
2.693PheThr: 2.693 ± 0.066
4.062PheVal: 4.062 ± 0.075
0.573PheTrp: 0.573 ± 0.029
2.414PheTyr: 2.414 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
4.061GlyAla: 4.061 ± 0.077
0.611GlyCys: 0.611 ± 0.033
3.489GlyAsp: 3.489 ± 0.091
4.622GlyGlu: 4.622 ± 0.082
4.08GlyPhe: 4.08 ± 0.085
5.066GlyGly: 5.066 ± 0.115
1.1GlyHis: 1.1 ± 0.037
6.377GlyIle: 6.377 ± 0.087
5.859GlyLys: 5.859 ± 0.095
6.074GlyLeu: 6.074 ± 0.099
1.451GlyMet: 1.451 ± 0.046
3.033GlyAsn: 3.033 ± 0.074
1.592GlyPro: 1.592 ± 0.054
1.533GlyGln: 1.533 ± 0.043
3.186GlyArg: 3.186 ± 0.067
3.713GlySer: 3.713 ± 0.071
3.541GlyThr: 3.541 ± 0.072
5.634GlyVal: 5.634 ± 0.107
0.782GlyTrp: 0.782 ± 0.035
3.061GlyTyr: 3.061 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
0.818HisAla: 0.818 ± 0.035
0.132HisCys: 0.132 ± 0.012
0.627HisAsp: 0.627 ± 0.026
0.834HisGlu: 0.834 ± 0.035
0.834HisPhe: 0.834 ± 0.034
1.109HisGly: 1.109 ± 0.044
0.313HisHis: 0.313 ± 0.022
1.261HisIle: 1.261 ± 0.036
0.871HisLys: 0.871 ± 0.035
1.433HisLeu: 1.433 ± 0.04
0.211HisMet: 0.211 ± 0.017
0.656HisAsn: 0.656 ± 0.03
0.96HisPro: 0.96 ± 0.036
0.429HisGln: 0.429 ± 0.023
0.747HisArg: 0.747 ± 0.034
0.908HisSer: 0.908 ± 0.037
0.691HisThr: 0.691 ± 0.029
0.822HisVal: 0.822 ± 0.031
0.192HisTrp: 0.192 ± 0.015
0.592HisTyr: 0.592 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
6.36IleAla: 6.36 ± 0.099
0.671IleCys: 0.671 ± 0.031
5.12IleAsp: 5.12 ± 0.089
6.96IleGlu: 6.96 ± 0.129
5.093IlePhe: 5.093 ± 0.091
5.69IleGly: 5.69 ± 0.089
1.217IleHis: 1.217 ± 0.042
6.677IleIle: 6.677 ± 0.11
6.694IleLys: 6.694 ± 0.126
8.589IleLeu: 8.589 ± 0.151
1.447IleMet: 1.447 ± 0.044
3.814IleAsn: 3.814 ± 0.074
3.929IlePro: 3.929 ± 0.065
2.352IleGln: 2.352 ± 0.06
3.35IleArg: 3.35 ± 0.064
6.168IleSer: 6.168 ± 0.101
4.231IleThr: 4.231 ± 0.073
6.337IleVal: 6.337 ± 0.102
0.827IleTrp: 0.827 ± 0.034
3.737IleTyr: 3.737 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
4.475LysAla: 4.475 ± 0.091
0.471LysCys: 0.471 ± 0.027
3.793LysAsp: 3.793 ± 0.071
5.603LysGlu: 5.603 ± 0.114
5.006LysPhe: 5.006 ± 0.093
4.128LysGly: 4.128 ± 0.069
1.127LysHis: 1.127 ± 0.043
8.868LysIle: 8.868 ± 0.132
6.404LysLys: 6.404 ± 0.13
7.551LysLeu: 7.551 ± 0.131
1.928LysMet: 1.928 ± 0.047
4.308LysAsn: 4.308 ± 0.076
3.232LysPro: 3.232 ± 0.065
1.976LysGln: 1.976 ± 0.048
3.712LysArg: 3.712 ± 0.083
4.054LysSer: 4.054 ± 0.081
3.667LysThr: 3.667 ± 0.067
6.301LysVal: 6.301 ± 0.098
0.767LysTrp: 0.767 ± 0.047
3.064LysTyr: 3.064 ± 0.062
0.0LysXaa: 0.0 ± 0.0
Leu
5.972LeuAla: 5.972 ± 0.109
0.63LeuCys: 0.63 ± 0.029
4.251LeuAsp: 4.251 ± 0.084
5.873LeuGlu: 5.873 ± 0.104
4.504LeuPhe: 4.504 ± 0.097
6.576LeuGly: 6.576 ± 0.089
1.19LeuHis: 1.19 ± 0.041
8.556LeuIle: 8.556 ± 0.128
8.834LeuLys: 8.834 ± 0.135
8.173LeuLeu: 8.173 ± 0.125
1.84LeuMet: 1.84 ± 0.053
5.067LeuAsn: 5.067 ± 0.093
3.946LeuPro: 3.946 ± 0.083
2.168LeuGln: 2.168 ± 0.06
4.601LeuArg: 4.601 ± 0.076
6.512LeuSer: 6.512 ± 0.09
4.96LeuThr: 4.96 ± 0.084
5.959LeuVal: 5.959 ± 0.089
0.859LeuTrp: 0.859 ± 0.033
3.012LeuTyr: 3.012 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
1.309MetAla: 1.309 ± 0.046
0.124MetCys: 0.124 ± 0.013
0.834MetAsp: 0.834 ± 0.033
1.241MetGlu: 1.241 ± 0.041
0.895MetPhe: 0.895 ± 0.041
1.271MetGly: 1.271 ± 0.042
0.296MetHis: 0.296 ± 0.019
1.552MetIle: 1.552 ± 0.045
2.052MetLys: 2.052 ± 0.043
1.996MetLeu: 1.996 ± 0.061
0.506MetMet: 0.506 ± 0.026
0.907MetAsn: 0.907 ± 0.035
0.842MetPro: 0.842 ± 0.037
0.547MetGln: 0.547 ± 0.03
1.266MetArg: 1.266 ± 0.04
1.099MetSer: 1.099 ± 0.035
0.896MetThr: 0.896 ± 0.037
1.289MetVal: 1.289 ± 0.041
0.189MetTrp: 0.189 ± 0.017
0.485MetTyr: 0.485 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
2.721AsnAla: 2.721 ± 0.06
0.396AsnCys: 0.396 ± 0.029
2.041AsnAsp: 2.041 ± 0.052
3.179AsnGlu: 3.179 ± 0.074
3.365AsnPhe: 3.365 ± 0.089
2.996AsnGly: 2.996 ± 0.083
0.586AsnHis: 0.586 ± 0.026
3.789AsnIle: 3.789 ± 0.066
2.86AsnLys: 2.86 ± 0.06
5.512AsnLeu: 5.512 ± 0.09
0.783AsnMet: 0.783 ± 0.03
1.756AsnAsn: 1.756 ± 0.059
2.886AsnPro: 2.886 ± 0.063
1.222AsnGln: 1.222 ± 0.044
1.88AsnArg: 1.88 ± 0.051
2.877AsnSer: 2.877 ± 0.075
1.728AsnThr: 1.728 ± 0.046
3.229AsnVal: 3.229 ± 0.062
0.642AsnTrp: 0.642 ± 0.041
2.4AsnTyr: 2.4 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
2.146ProAla: 2.146 ± 0.059
0.249ProCys: 0.249 ± 0.018
2.78ProAsp: 2.78 ± 0.067
3.822ProGlu: 3.822 ± 0.076
2.088ProPhe: 2.088 ± 0.061
2.644ProGly: 2.644 ± 0.07
0.6ProHis: 0.6 ± 0.027
2.984ProIle: 2.984 ± 0.061
2.62ProLys: 2.62 ± 0.059
3.102ProLeu: 3.102 ± 0.068
0.656ProMet: 0.656 ± 0.031
1.95ProAsn: 1.95 ± 0.049
1.51ProPro: 1.51 ± 0.047
0.997ProGln: 0.997 ± 0.033
1.564ProArg: 1.564 ± 0.044
2.344ProSer: 2.344 ± 0.062
1.87ProThr: 1.87 ± 0.055
3.026ProVal: 3.026 ± 0.061
0.399ProTrp: 0.399 ± 0.025
1.583ProTyr: 1.583 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
1.615GlnAla: 1.615 ± 0.047
0.128GlnCys: 0.128 ± 0.015
1.093GlnAsp: 1.093 ± 0.039
1.604GlnGlu: 1.604 ± 0.045
1.251GlnPhe: 1.251 ± 0.04
1.524GlnGly: 1.524 ± 0.052
0.353GlnHis: 0.353 ± 0.021
2.687GlnIle: 2.687 ± 0.061
2.269GlnLys: 2.269 ± 0.056
2.233GlnLeu: 2.233 ± 0.058
0.638GlnMet: 0.638 ± 0.029
1.52GlnAsn: 1.52 ± 0.051
1.003GlnPro: 1.003 ± 0.036
0.712GlnGln: 0.712 ± 0.035
1.445GlnArg: 1.445 ± 0.047
1.324GlnSer: 1.324 ± 0.042
1.319GlnThr: 1.319 ± 0.041
1.823GlnVal: 1.823 ± 0.047
0.262GlnTrp: 0.262 ± 0.02
0.821GlnTyr: 0.821 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
2.76ArgAla: 2.76 ± 0.059
0.288ArgCys: 0.288 ± 0.02
2.464ArgAsp: 2.464 ± 0.062
3.763ArgGlu: 3.763 ± 0.089
2.566ArgPhe: 2.566 ± 0.062
2.978ArgGly: 2.978 ± 0.064
0.649ArgHis: 0.649 ± 0.028
3.936ArgIle: 3.936 ± 0.067
3.949ArgLys: 3.949 ± 0.081
4.024ArgLeu: 4.024 ± 0.069
1.05ArgMet: 1.05 ± 0.038
2.292ArgAsn: 2.292 ± 0.06
1.313ArgPro: 1.313 ± 0.043
1.145ArgGln: 1.145 ± 0.036
2.392ArgArg: 2.392 ± 0.067
2.136ArgSer: 2.136 ± 0.055
2.029ArgThr: 2.029 ± 0.05
3.316ArgVal: 3.316 ± 0.07
0.585ArgTrp: 0.585 ± 0.03
1.992ArgTyr: 1.992 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
3.837SerAla: 3.837 ± 0.072
0.456SerCys: 0.456 ± 0.031
3.163SerAsp: 3.163 ± 0.065
4.285SerGlu: 4.285 ± 0.076
3.36SerPhe: 3.36 ± 0.089
4.739SerGly: 4.739 ± 0.094
0.855SerHis: 0.855 ± 0.036
4.816SerIle: 4.816 ± 0.089
4.325SerLys: 4.325 ± 0.072
5.711SerLeu: 5.711 ± 0.104
0.988SerMet: 0.988 ± 0.033
2.602SerAsn: 2.602 ± 0.069
2.313SerPro: 2.313 ± 0.055
1.686SerGln: 1.686 ± 0.052
2.408SerArg: 2.408 ± 0.058
3.739SerSer: 3.739 ± 0.096
2.733SerThr: 2.733 ± 0.063
4.179SerVal: 4.179 ± 0.093
0.629SerTrp: 0.629 ± 0.031
2.242SerTyr: 2.242 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
3.088ThrAla: 3.088 ± 0.065
0.349ThrCys: 0.349 ± 0.023
2.282ThrAsp: 2.282 ± 0.059
2.668ThrGlu: 2.668 ± 0.061
2.464ThrPhe: 2.464 ± 0.064
4.065ThrGly: 4.065 ± 0.08
0.753ThrHis: 0.753 ± 0.026
4.078ThrIle: 4.078 ± 0.07
2.937ThrLys: 2.937 ± 0.053
4.679ThrLeu: 4.679 ± 0.082
0.853ThrMet: 0.853 ± 0.034
1.872ThrAsn: 1.872 ± 0.054
2.229ThrPro: 2.229 ± 0.054
1.283ThrGln: 1.283 ± 0.043
1.944ThrArg: 1.944 ± 0.042
2.814ThrSer: 2.814 ± 0.062
2.537ThrThr: 2.537 ± 0.067
3.381ThrVal: 3.381 ± 0.068
0.473ThrTrp: 0.473 ± 0.025
1.796ThrTyr: 1.796 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
4.593ValAla: 4.593 ± 0.087
0.59ValCys: 0.59 ± 0.031
4.29ValAsp: 4.29 ± 0.079
5.795ValGlu: 5.795 ± 0.099
3.645ValPhe: 3.645 ± 0.077
4.95ValGly: 4.95 ± 0.089
0.957ValHis: 0.957 ± 0.032
6.09ValIle: 6.09 ± 0.093
6.635ValLys: 6.635 ± 0.108
6.477ValLeu: 6.477 ± 0.106
1.34ValMet: 1.34 ± 0.042
3.457ValAsn: 3.457 ± 0.068
2.528ValPro: 2.528 ± 0.059
1.772ValGln: 1.772 ± 0.048
3.326ValArg: 3.326 ± 0.059
4.448ValSer: 4.448 ± 0.086
2.877ValThr: 2.877 ± 0.058
5.65ValVal: 5.65 ± 0.102
0.756ValTrp: 0.756 ± 0.038
3.139ValTyr: 3.139 ± 0.079
0.0ValXaa: 0.0 ± 0.0
Trp
0.661TrpAla: 0.661 ± 0.029
0.084TrpCys: 0.084 ± 0.011
0.655TrpAsp: 0.655 ± 0.032
0.677TrpGlu: 0.677 ± 0.031
0.559TrpPhe: 0.559 ± 0.029
0.785TrpGly: 0.785 ± 0.033
0.189TrpHis: 0.189 ± 0.015
0.892TrpIle: 0.892 ± 0.043
0.744TrpLys: 0.744 ± 0.032
0.991TrpLeu: 0.991 ± 0.04
0.232TrpMet: 0.232 ± 0.017
0.591TrpAsn: 0.591 ± 0.031
0.24TrpPro: 0.24 ± 0.021
0.285TrpGln: 0.285 ± 0.02
0.606TrpArg: 0.606 ± 0.032
0.519TrpSer: 0.519 ± 0.028
0.49TrpThr: 0.49 ± 0.033
0.78TrpVal: 0.78 ± 0.034
0.182TrpTrp: 0.182 ± 0.019
0.429TrpTyr: 0.429 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.328TyrAla: 2.328 ± 0.052
0.289TyrCys: 0.289 ± 0.019
2.297TyrAsp: 2.297 ± 0.055
2.806TyrGlu: 2.806 ± 0.061
2.4TyrPhe: 2.4 ± 0.062
2.883TyrGly: 2.883 ± 0.064
0.693TyrHis: 0.693 ± 0.029
3.115TyrIle: 3.115 ± 0.058
2.652TyrLys: 2.652 ± 0.062
3.859TyrLeu: 3.859 ± 0.082
0.575TyrMet: 0.575 ± 0.028
1.907TyrAsn: 1.907 ± 0.053
1.751TyrPro: 1.751 ± 0.047
1.196TyrGln: 1.196 ± 0.043
1.927TyrArg: 1.927 ± 0.055
2.518TyrSer: 2.518 ± 0.06
1.786TyrThr: 1.786 ± 0.056
2.727TyrVal: 2.727 ± 0.067
0.457TyrTrp: 0.457 ± 0.025
1.748TyrTyr: 1.748 ± 0.06
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2301 proteins (813688 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski