Amino acid dipepetide frequency for Streptomyces formicae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.661AlaAla: 21.661 ± 0.143	1.101AlaCys: 1.101 ± 0.019	8.705AlaAsp: 8.705 ± 0.082	8.939AlaGlu: 8.939 ± 0.077	3.577AlaPhe: 3.577 ± 0.044	12.663AlaGly: 12.663 ± 0.086	3.032AlaHis: 3.032 ± 0.038	3.404AlaIle: 3.404 ± 0.046	3.126AlaLys: 3.126 ± 0.049	15.016AlaLeu: 15.016 ± 0.106	2.437AlaMet: 2.437 ± 0.033	1.834AlaAsn: 1.834 ± 0.028	7.347AlaPro: 7.347 ± 0.07	3.606AlaGln: 3.606 ± 0.045	10.525AlaArg: 10.525 ± 0.079	6.111AlaSer: 6.111 ± 0.053	7.094AlaThr: 7.094 ± 0.05	12.161AlaVal: 12.161 ± 0.082	1.875AlaTrp: 1.875 ± 0.029	2.916AlaTyr: 2.916 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.176CysAla: 1.176 ± 0.021	0.088CysCys: 0.088 ± 0.007	0.474CysAsp: 0.474 ± 0.013	0.409CysGlu: 0.409 ± 0.012	0.226CysPhe: 0.226 ± 0.009	0.964CysGly: 0.964 ± 0.022	0.185CysHis: 0.185 ± 0.008	0.14CysIle: 0.14 ± 0.008	0.112CysLys: 0.112 ± 0.007	0.74CysLeu: 0.74 ± 0.017	0.134CysMet: 0.134 ± 0.007	0.125CysAsn: 0.125 ± 0.007	0.477CysPro: 0.477 ± 0.013	0.157CysGln: 0.157 ± 0.009	0.583CysArg: 0.583 ± 0.012	0.426CysSer: 0.426 ± 0.011	0.484CysThr: 0.484 ± 0.013	0.695CysVal: 0.695 ± 0.017	0.126CysTrp: 0.126 ± 0.007	0.15CysTyr: 0.15 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	8.314AspAla: 8.314 ± 0.068	0.408AspCys: 0.408 ± 0.014	3.838AspAsp: 3.838 ± 0.057	4.102AspGlu: 4.102 ± 0.036	1.644AspPhe: 1.644 ± 0.026	6.411AspGly: 6.411 ± 0.054	1.424AspHis: 1.424 ± 0.022	1.895AspIle: 1.895 ± 0.026	1.431AspLys: 1.431 ± 0.035	6.257AspLeu: 6.257 ± 0.055	0.815AspMet: 0.815 ± 0.017	0.87AspAsn: 0.87 ± 0.021	4.457AspPro: 4.457 ± 0.043	1.469AspGln: 1.469 ± 0.024	4.821AspArg: 4.821 ± 0.052	2.579AspSer: 2.579 ± 0.032	3.193AspThr: 3.193 ± 0.041	4.939AspVal: 4.939 ± 0.05	1.029AspTrp: 1.029 ± 0.021	1.07AspTyr: 1.07 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	7.195GluAla: 7.195 ± 0.071	0.377GluCys: 0.377 ± 0.012	2.691GluAsp: 2.691 ± 0.037	3.434GluGlu: 3.434 ± 0.046	1.518GluPhe: 1.518 ± 0.022	4.756GluGly: 4.756 ± 0.045	1.565GluHis: 1.565 ± 0.027	2.138GluIle: 2.138 ± 0.03	1.566GluLys: 1.566 ± 0.033	7.138GluLeu: 7.138 ± 0.059	0.861GluMet: 0.861 ± 0.018	0.991GluAsn: 0.991 ± 0.017	3.39GluPro: 3.39 ± 0.04	2.23GluGln: 2.23 ± 0.034	5.884GluArg: 5.884 ± 0.053	2.724GluSer: 2.724 ± 0.037	2.802GluThr: 2.802 ± 0.032	4.394GluVal: 4.394 ± 0.045	0.734GluTrp: 0.734 ± 0.016	1.089GluTyr: 1.089 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.76PheAla: 3.76 ± 0.04	0.26PheCys: 0.26 ± 0.009	2.039PheAsp: 2.039 ± 0.033	1.435PheGlu: 1.435 ± 0.026	0.903PhePhe: 0.903 ± 0.02	3.081PheGly: 3.081 ± 0.036	0.631PheHis: 0.631 ± 0.015	0.708PheIle: 0.708 ± 0.017	0.522PheLys: 0.522 ± 0.015	2.638PheLeu: 2.638 ± 0.029	0.428PheMet: 0.428 ± 0.014	0.543PheAsn: 0.543 ± 0.015	1.384PhePro: 1.384 ± 0.02	0.681PheGln: 0.681 ± 0.016	1.81PheArg: 1.81 ± 0.029	1.436PheSer: 1.436 ± 0.023	1.992PheThr: 1.992 ± 0.029	2.297PheVal: 2.297 ± 0.033	0.44PheTrp: 0.44 ± 0.014	0.552PheTyr: 0.552 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	11.902GlyAla: 11.902 ± 0.08	0.834GlyCys: 0.834 ± 0.02	5.45GlyAsp: 5.45 ± 0.05	5.338GlyGlu: 5.338 ± 0.048	2.913GlyPhe: 2.913 ± 0.036	9.111GlyGly: 9.111 ± 0.081	2.314GlyHis: 2.314 ± 0.029	3.463GlyIle: 3.463 ± 0.032	2.753GlyLys: 2.753 ± 0.045	9.504GlyLeu: 9.504 ± 0.066	1.964GlyMet: 1.964 ± 0.028	1.663GlyAsn: 1.663 ± 0.026	5.137GlyPro: 5.137 ± 0.054	2.633GlyGln: 2.633 ± 0.04	7.546GlyArg: 7.546 ± 0.058	5.397GlySer: 5.397 ± 0.048	6.334GlyThr: 6.334 ± 0.057	7.66GlyVal: 7.66 ± 0.065	1.682GlyTrp: 1.682 ± 0.028	2.241GlyTyr: 2.241 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	2.798HisAla: 2.798 ± 0.034	0.215HisCys: 0.215 ± 0.009	1.371HisAsp: 1.371 ± 0.022	1.294HisGlu: 1.294 ± 0.024	0.637HisPhe: 0.637 ± 0.017	2.409HisGly: 2.409 ± 0.029	0.71HisHis: 0.71 ± 0.02	0.668HisIle: 0.668 ± 0.014	0.397HisLys: 0.397 ± 0.014	2.389HisLeu: 2.389 ± 0.034	0.332HisMet: 0.332 ± 0.01	0.34HisAsn: 0.34 ± 0.012	1.815HisPro: 1.815 ± 0.034	0.664HisGln: 0.664 ± 0.017	2.098HisArg: 2.098 ± 0.029	1.029HisSer: 1.029 ± 0.02	1.326HisThr: 1.326 ± 0.024	1.762HisVal: 1.762 ± 0.029	0.389HisTrp: 0.389 ± 0.012	0.485HisTyr: 0.485 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.782IleAla: 4.782 ± 0.044	0.282IleCys: 0.282 ± 0.011	2.172IleAsp: 2.172 ± 0.028	1.961IleGlu: 1.961 ± 0.028	0.676IlePhe: 0.676 ± 0.017	3.71IleGly: 3.71 ± 0.038	0.603IleHis: 0.603 ± 0.016	0.807IleIle: 0.807 ± 0.02	0.781IleLys: 0.781 ± 0.021	2.267IleLeu: 2.267 ± 0.034	0.424IleMet: 0.424 ± 0.013	0.648IleAsn: 0.648 ± 0.017	1.655IlePro: 1.655 ± 0.024	0.667IleGln: 0.667 ± 0.017	2.066IleArg: 2.066 ± 0.026	1.65IleSer: 1.65 ± 0.026	2.115IleThr: 2.115 ± 0.032	2.583IleVal: 2.583 ± 0.036	0.346IleTrp: 0.346 ± 0.012	0.504IleTyr: 0.504 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	3.076LysAla: 3.076 ± 0.049	0.125LysCys: 0.125 ± 0.007	1.558LysAsp: 1.558 ± 0.037	1.382LysGlu: 1.382 ± 0.025	0.496LysPhe: 0.496 ± 0.013	2.15LysGly: 2.15 ± 0.041	0.465LysHis: 0.465 ± 0.015	0.882LysIle: 0.882 ± 0.022	1.136LysLys: 1.136 ± 0.034	2.123LysLeu: 2.123 ± 0.038	0.418LysMet: 0.418 ± 0.014	0.575LysAsn: 0.575 ± 0.018	1.476LysPro: 1.476 ± 0.035	0.718LysGln: 0.718 ± 0.019	1.511LysArg: 1.511 ± 0.026	1.315LysSer: 1.315 ± 0.028	1.342LysThr: 1.342 ± 0.025	2.007LysVal: 2.007 ± 0.035	0.297LysTrp: 0.297 ± 0.01	0.456LysTyr: 0.456 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.436LeuAla: 15.436 ± 0.104	0.916LeuCys: 0.916 ± 0.018	6.752LeuAsp: 6.752 ± 0.05	4.376LeuGlu: 4.376 ± 0.046	2.761LeuPhe: 2.761 ± 0.034	9.429LeuGly: 9.429 ± 0.067	2.351LeuHis: 2.351 ± 0.036	3.282LeuIle: 3.282 ± 0.04	2.125LeuLys: 2.125 ± 0.036	11.379LeuLeu: 11.379 ± 0.093	1.655LeuMet: 1.655 ± 0.027	1.691LeuAsn: 1.691 ± 0.025	6.608LeuPro: 6.608 ± 0.055	2.0LeuGln: 2.0 ± 0.026	8.737LeuArg: 8.737 ± 0.072	5.435LeuSer: 5.435 ± 0.053	7.004LeuThr: 7.004 ± 0.057	8.892LeuVal: 8.892 ± 0.067	1.333LeuTrp: 1.333 ± 0.024	1.783LeuTyr: 1.783 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.196MetAla: 2.196 ± 0.034	0.138MetCys: 0.138 ± 0.007	0.891MetAsp: 0.891 ± 0.019	0.738MetGlu: 0.738 ± 0.019	0.455MetPhe: 0.455 ± 0.012	1.322MetGly: 1.322 ± 0.023	0.346MetHis: 0.346 ± 0.012	0.638MetIle: 0.638 ± 0.018	0.454MetLys: 0.454 ± 0.014	1.633MetLeu: 1.633 ± 0.026	0.298MetMet: 0.298 ± 0.011	0.422MetAsn: 0.422 ± 0.012	1.087MetPro: 1.087 ± 0.019	0.396MetGln: 0.396 ± 0.012	1.425MetArg: 1.425 ± 0.026	1.319MetSer: 1.319 ± 0.024	1.491MetThr: 1.491 ± 0.025	1.276MetVal: 1.276 ± 0.025	0.217MetTrp: 0.217 ± 0.009	0.34MetTyr: 0.34 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.082AsnAla: 2.082 ± 0.026	0.165AsnCys: 0.165 ± 0.008	0.927AsnAsp: 0.927 ± 0.02	0.783AsnGlu: 0.783 ± 0.018	0.455AsnPhe: 0.455 ± 0.015	1.825AsnGly: 1.825 ± 0.028	0.371AsnHis: 0.371 ± 0.011	0.602AsnIle: 0.602 ± 0.015	0.427AsnLys: 0.427 ± 0.014	1.542AsnLeu: 1.542 ± 0.023	0.28AsnMet: 0.28 ± 0.009	0.398AsnAsn: 0.398 ± 0.015	1.262AsnPro: 1.262 ± 0.023	0.48AsnGln: 0.48 ± 0.014	1.209AsnArg: 1.209 ± 0.023	0.903AsnSer: 0.903 ± 0.021	1.066AsnThr: 1.066 ± 0.024	1.317AsnVal: 1.317 ± 0.023	0.276AsnTrp: 0.276 ± 0.009	0.38AsnTyr: 0.38 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	8.094ProAla: 8.094 ± 0.07	0.336ProCys: 0.336 ± 0.013	4.533ProAsp: 4.533 ± 0.043	4.39ProGlu: 4.39 ± 0.042	1.541ProPhe: 1.541 ± 0.023	6.549ProGly: 6.549 ± 0.06	1.448ProHis: 1.448 ± 0.024	1.275ProIle: 1.275 ± 0.027	1.332ProLys: 1.332 ± 0.027	5.557ProLeu: 5.557 ± 0.052	0.965ProMet: 0.965 ± 0.018	0.862ProAsn: 0.862 ± 0.018	3.408ProPro: 3.408 ± 0.057	1.661ProGln: 1.661 ± 0.031	4.051ProArg: 4.051 ± 0.04	3.215ProSer: 3.215 ± 0.043	3.262ProThr: 3.262 ± 0.044	5.419ProVal: 5.419 ± 0.049	0.898ProTrp: 0.898 ± 0.019	1.367ProTyr: 1.367 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.413GlnAla: 3.413 ± 0.046	0.169GlnCys: 0.169 ± 0.009	1.448GlnAsp: 1.448 ± 0.024	1.485GlnGlu: 1.485 ± 0.026	0.643GlnPhe: 0.643 ± 0.016	2.394GlnGly: 2.394 ± 0.032	0.649GlnHis: 0.649 ± 0.016	0.978GlnIle: 0.978 ± 0.022	0.609GlnLys: 0.609 ± 0.018	2.985GlnLeu: 2.985 ± 0.034	0.44GlnMet: 0.44 ± 0.013	0.463GlnAsn: 0.463 ± 0.013	1.531GlnPro: 1.531 ± 0.033	1.162GlnGln: 1.162 ± 0.031	2.321GlnArg: 2.321 ± 0.031	1.239GlnSer: 1.239 ± 0.02	1.193GlnThr: 1.193 ± 0.022	2.196GlnVal: 2.196 ± 0.03	0.465GlnTrp: 0.465 ± 0.014	0.592GlnTyr: 0.592 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.289ArgAla: 10.289 ± 0.081	0.573ArgCys: 0.573 ± 0.015	4.365ArgAsp: 4.365 ± 0.044	4.808ArgGlu: 4.808 ± 0.044	2.307ArgPhe: 2.307 ± 0.026	6.129ArgGly: 6.129 ± 0.049	2.176ArgHis: 2.176 ± 0.032	3.057ArgIle: 3.057 ± 0.04	1.7ArgLys: 1.7 ± 0.029	8.538ArgLeu: 8.538 ± 0.067	1.708ArgMet: 1.708 ± 0.023	1.244ArgAsn: 1.244 ± 0.022	4.782ArgPro: 4.782 ± 0.052	2.21ArgGln: 2.21 ± 0.031	7.362ArgArg: 7.362 ± 0.072	3.948ArgSer: 3.948 ± 0.036	5.476ArgThr: 5.476 ± 0.049	6.055ArgVal: 6.055 ± 0.043	1.348ArgTrp: 1.348 ± 0.024	1.731ArgTyr: 1.731 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	6.846SerAla: 6.846 ± 0.048	0.433SerCys: 0.433 ± 0.014	2.732SerAsp: 2.732 ± 0.042	2.405SerGlu: 2.405 ± 0.034	1.538SerPhe: 1.538 ± 0.024	6.084SerGly: 6.084 ± 0.063	1.014SerHis: 1.014 ± 0.019	1.372SerIle: 1.372 ± 0.025	1.117SerLys: 1.117 ± 0.026	5.046SerLeu: 5.046 ± 0.046	1.079SerMet: 1.079 ± 0.02	0.822SerAsn: 0.822 ± 0.018	3.169SerPro: 3.169 ± 0.038	1.225SerGln: 1.225 ± 0.021	3.621SerArg: 3.621 ± 0.037	2.811SerSer: 2.811 ± 0.04	3.037SerThr: 3.037 ± 0.034	4.397SerVal: 4.397 ± 0.04	0.883SerTrp: 0.883 ± 0.022	1.263SerTyr: 1.263 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	8.657ThrAla: 8.657 ± 0.057	0.416ThrCys: 0.416 ± 0.012	3.684ThrAsp: 3.684 ± 0.037	3.353ThrGlu: 3.353 ± 0.039	1.652ThrPhe: 1.652 ± 0.025	6.771ThrGly: 6.771 ± 0.051	1.243ThrHis: 1.243 ± 0.021	1.596ThrIle: 1.596 ± 0.029	1.3ThrLys: 1.3 ± 0.027	5.779ThrLeu: 5.779 ± 0.048	0.908ThrMet: 0.908 ± 0.018	0.916ThrAsn: 0.916 ± 0.021	4.09ThrPro: 4.09 ± 0.046	1.271ThrGln: 1.271 ± 0.021	3.848ThrArg: 3.848 ± 0.037	3.175ThrSer: 3.175 ± 0.038	3.704ThrThr: 3.704 ± 0.045	5.875ThrVal: 5.875 ± 0.048	0.873ThrTrp: 0.873 ± 0.019	1.464ThrTyr: 1.464 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	10.955ValAla: 10.955 ± 0.074	0.722ValCys: 0.722 ± 0.017	5.031ValAsp: 5.031 ± 0.046	4.749ValGlu: 4.749 ± 0.052	2.438ValPhe: 2.438 ± 0.031	6.723ValGly: 6.723 ± 0.056	1.86ValHis: 1.86 ± 0.029	2.821ValIle: 2.821 ± 0.037	1.821ValLys: 1.821 ± 0.035	9.597ValLeu: 9.597 ± 0.077	1.405ValMet: 1.405 ± 0.025	1.564ValAsn: 1.564 ± 0.022	5.277ValPro: 5.277 ± 0.049	1.953ValGln: 1.953 ± 0.028	7.255ValArg: 7.255 ± 0.062	4.328ValSer: 4.328 ± 0.044	5.563ValThr: 5.563 ± 0.053	7.945ValVal: 7.945 ± 0.065	1.095ValTrp: 1.095 ± 0.018	1.488ValTyr: 1.488 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.601TrpAla: 1.601 ± 0.025	0.15TrpCys: 0.15 ± 0.008	0.82TrpAsp: 0.82 ± 0.018	0.727TrpGlu: 0.727 ± 0.018	0.512TrpPhe: 0.512 ± 0.013	1.092TrpGly: 1.092 ± 0.023	0.374TrpHis: 0.374 ± 0.011	0.537TrpIle: 0.537 ± 0.014	0.374TrpLys: 0.374 ± 0.014	1.824TrpLeu: 1.824 ± 0.029	0.276TrpMet: 0.276 ± 0.011	0.404TrpAsn: 0.404 ± 0.013	0.77TrpPro: 0.77 ± 0.017	0.644TrpGln: 0.644 ± 0.017	1.357TrpArg: 1.357 ± 0.022	0.955TrpSer: 0.955 ± 0.018	0.977TrpThr: 0.977 ± 0.019	0.963TrpVal: 0.963 ± 0.02	0.335TrpTrp: 0.335 ± 0.012	0.331TrpTyr: 0.331 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.897TyrAla: 2.897 ± 0.034	0.165TyrCys: 0.165 ± 0.008	1.486TyrAsp: 1.486 ± 0.025	1.369TyrGlu: 1.369 ± 0.025	0.652TyrPhe: 0.652 ± 0.015	2.267TyrGly: 2.267 ± 0.03	0.368TyrHis: 0.368 ± 0.013	0.436TyrIle: 0.436 ± 0.012	0.425TyrLys: 0.425 ± 0.014	1.994TyrLeu: 1.994 ± 0.027	0.253TyrMet: 0.253 ± 0.011	0.374TyrAsn: 0.374 ± 0.011	1.044TyrPro: 1.044 ± 0.018	0.546TyrGln: 0.546 ± 0.016	1.772TyrArg: 1.772 ± 0.024	0.897TyrSer: 0.897 ± 0.02	1.12TyrThr: 1.12 ± 0.021	1.758TyrVal: 1.758 ± 0.03	0.377TyrTrp: 0.377 ± 0.013	0.425TyrTyr: 0.425 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8132 proteins (2853658 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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