Amino acid dipepetide frequency for Streptomyces peucetius subsp. caesius ATCC 27952

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.425AlaAla: 21.425 ± 0.16	1.073AlaCys: 1.073 ± 0.025	8.272AlaAsp: 8.272 ± 0.068	8.91AlaGlu: 8.91 ± 0.093	3.507AlaPhe: 3.507 ± 0.044	13.063AlaGly: 13.063 ± 0.101	2.832AlaHis: 2.832 ± 0.039	3.432AlaIle: 3.432 ± 0.051	2.916AlaLys: 2.916 ± 0.048	14.152AlaLeu: 14.152 ± 0.095	2.622AlaMet: 2.622 ± 0.036	1.851AlaAsn: 1.851 ± 0.035	7.017AlaPro: 7.017 ± 0.087	3.904AlaGln: 3.904 ± 0.053	10.055AlaArg: 10.055 ± 0.085	5.875AlaSer: 5.875 ± 0.058	6.723AlaThr: 6.723 ± 0.06	12.522AlaVal: 12.522 ± 0.097	1.859AlaTrp: 1.859 ± 0.029	2.697AlaTyr: 2.697 ± 0.042	0.0AlaXaa: 0.0 ± 0.001
Cys	1.101CysAla: 1.101 ± 0.02	0.096CysCys: 0.096 ± 0.007	0.516CysAsp: 0.516 ± 0.016	0.459CysGlu: 0.459 ± 0.014	0.216CysPhe: 0.216 ± 0.01	1.01CysGly: 1.01 ± 0.021	0.2CysHis: 0.2 ± 0.01	0.201CysIle: 0.201 ± 0.009	0.117CysLys: 0.117 ± 0.007	0.755CysLeu: 0.755 ± 0.018	0.127CysMet: 0.127 ± 0.008	0.134CysAsn: 0.134 ± 0.006	0.534CysPro: 0.534 ± 0.017	0.154CysGln: 0.154 ± 0.008	0.67CysArg: 0.67 ± 0.02	0.455CysSer: 0.455 ± 0.016	0.55CysThr: 0.55 ± 0.017	0.671CysVal: 0.671 ± 0.019	0.128CysTrp: 0.128 ± 0.009	0.147CysTyr: 0.147 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.751AspAla: 7.751 ± 0.078	0.457AspCys: 0.457 ± 0.018	3.703AspAsp: 3.703 ± 0.055	4.048AspGlu: 4.048 ± 0.051	1.703AspPhe: 1.703 ± 0.031	6.182AspGly: 6.182 ± 0.063	1.423AspHis: 1.423 ± 0.027	1.957AspIle: 1.957 ± 0.037	1.274AspLys: 1.274 ± 0.032	6.076AspLeu: 6.076 ± 0.067	0.878AspMet: 0.878 ± 0.021	0.968AspAsn: 0.968 ± 0.024	4.419AspPro: 4.419 ± 0.053	1.548AspGln: 1.548 ± 0.025	4.933AspArg: 4.933 ± 0.052	2.573AspSer: 2.573 ± 0.037	3.153AspThr: 3.153 ± 0.04	4.721AspVal: 4.721 ± 0.053	1.017AspTrp: 1.017 ± 0.024	1.066AspTyr: 1.066 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	7.477GluAla: 7.477 ± 0.07	0.388GluCys: 0.388 ± 0.013	2.902GluAsp: 2.902 ± 0.039	3.723GluGlu: 3.723 ± 0.053	1.482GluPhe: 1.482 ± 0.031	4.524GluGly: 4.524 ± 0.047	1.577GluHis: 1.577 ± 0.029	2.366GluIle: 2.366 ± 0.036	1.545GluLys: 1.545 ± 0.033	7.043GluLeu: 7.043 ± 0.081	0.954GluMet: 0.954 ± 0.022	1.085GluAsn: 1.085 ± 0.022	3.577GluPro: 3.577 ± 0.053	2.493GluGln: 2.493 ± 0.041	5.65GluArg: 5.65 ± 0.062	2.744GluSer: 2.744 ± 0.039	2.924GluThr: 2.924 ± 0.036	4.579GluVal: 4.579 ± 0.053	0.819GluTrp: 0.819 ± 0.02	1.117GluTyr: 1.117 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.67PheAla: 3.67 ± 0.046	0.297PheCys: 0.297 ± 0.012	1.968PheAsp: 1.968 ± 0.033	1.503PheGlu: 1.503 ± 0.027	0.833PhePhe: 0.833 ± 0.026	2.95PheGly: 2.95 ± 0.038	0.613PheHis: 0.613 ± 0.018	0.758PheIle: 0.758 ± 0.018	0.523PheLys: 0.523 ± 0.017	2.595PheLeu: 2.595 ± 0.041	0.433PheMet: 0.433 ± 0.016	0.583PheAsn: 0.583 ± 0.017	1.367PhePro: 1.367 ± 0.03	0.674PheGln: 0.674 ± 0.019	1.835PheArg: 1.835 ± 0.03	1.475PheSer: 1.475 ± 0.024	1.989PheThr: 1.989 ± 0.03	2.226PheVal: 2.226 ± 0.037	0.41PheTrp: 0.41 ± 0.016	0.569PheTyr: 0.569 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	10.928GlyAla: 10.928 ± 0.09	0.887GlyCys: 0.887 ± 0.023	5.277GlyAsp: 5.277 ± 0.055	5.331GlyGlu: 5.331 ± 0.053	2.844GlyPhe: 2.844 ± 0.035	8.749GlyGly: 8.749 ± 0.097	2.341GlyHis: 2.341 ± 0.038	3.519GlyIle: 3.519 ± 0.046	2.416GlyLys: 2.416 ± 0.035	9.291GlyLeu: 9.291 ± 0.079	2.059GlyMet: 2.059 ± 0.033	1.728GlyAsn: 1.728 ± 0.032	5.344GlyPro: 5.344 ± 0.067	2.684GlyGln: 2.684 ± 0.04	8.085GlyArg: 8.085 ± 0.077	5.373GlySer: 5.373 ± 0.058	6.095GlyThr: 6.095 ± 0.057	7.44GlyVal: 7.44 ± 0.066	1.621GlyTrp: 1.621 ± 0.03	2.12GlyTyr: 2.12 ± 0.034	0.0GlyXaa: 0.0 ± 0.001
His	2.68HisAla: 2.68 ± 0.038	0.232HisCys: 0.232 ± 0.012	1.352HisAsp: 1.352 ± 0.024	1.253HisGlu: 1.253 ± 0.024	0.637HisPhe: 0.637 ± 0.019	2.451HisGly: 2.451 ± 0.032	0.689HisHis: 0.689 ± 0.02	0.713HisIle: 0.713 ± 0.02	0.377HisLys: 0.377 ± 0.016	2.456HisLeu: 2.456 ± 0.041	0.375HisMet: 0.375 ± 0.013	0.375HisAsn: 0.375 ± 0.014	1.775HisPro: 1.775 ± 0.027	0.634HisGln: 0.634 ± 0.017	2.146HisArg: 2.146 ± 0.035	1.061HisSer: 1.061 ± 0.024	1.286HisThr: 1.286 ± 0.026	1.746HisVal: 1.746 ± 0.032	0.373HisTrp: 0.373 ± 0.013	0.43HisTyr: 0.43 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.828IleAla: 4.828 ± 0.048	0.315IleCys: 0.315 ± 0.013	2.327IleAsp: 2.327 ± 0.035	2.079IleGlu: 2.079 ± 0.035	0.766IlePhe: 0.766 ± 0.019	3.681IleGly: 3.681 ± 0.05	0.643IleHis: 0.643 ± 0.019	0.895IleIle: 0.895 ± 0.023	0.757IleLys: 0.757 ± 0.02	2.406IleLeu: 2.406 ± 0.038	0.438IleMet: 0.438 ± 0.015	0.743IleAsn: 0.743 ± 0.019	1.668IlePro: 1.668 ± 0.029	0.712IleGln: 0.712 ± 0.018	2.267IleArg: 2.267 ± 0.032	1.711IleSer: 1.711 ± 0.03	2.227IleThr: 2.227 ± 0.04	2.808IleVal: 2.808 ± 0.045	0.367IleTrp: 0.367 ± 0.014	0.536IleTyr: 0.536 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	3.001LysAla: 3.001 ± 0.043	0.123LysCys: 0.123 ± 0.008	1.412LysAsp: 1.412 ± 0.032	1.305LysGlu: 1.305 ± 0.03	0.454LysPhe: 0.454 ± 0.015	1.896LysGly: 1.896 ± 0.034	0.459LysHis: 0.459 ± 0.012	0.902LysIle: 0.902 ± 0.023	0.877LysLys: 0.877 ± 0.029	2.053LysLeu: 2.053 ± 0.032	0.379LysMet: 0.379 ± 0.013	0.53LysAsn: 0.53 ± 0.02	1.385LysPro: 1.385 ± 0.034	0.73LysGln: 0.73 ± 0.019	1.502LysArg: 1.502 ± 0.03	1.149LysSer: 1.149 ± 0.025	1.263LysThr: 1.263 ± 0.03	1.972LysVal: 1.972 ± 0.037	0.269LysTrp: 0.269 ± 0.012	0.455LysTyr: 0.455 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	14.822LeuAla: 14.822 ± 0.096	0.852LeuCys: 0.852 ± 0.02	6.593LeuAsp: 6.593 ± 0.061	5.2LeuGlu: 5.2 ± 0.062	2.612LeuPhe: 2.612 ± 0.047	9.156LeuGly: 9.156 ± 0.068	2.293LeuHis: 2.293 ± 0.033	3.267LeuIle: 3.267 ± 0.048	2.053LeuLys: 2.053 ± 0.037	11.286LeuLeu: 11.286 ± 0.101	1.739LeuMet: 1.739 ± 0.03	1.641LeuAsn: 1.641 ± 0.031	6.527LeuPro: 6.527 ± 0.063	2.281LeuGln: 2.281 ± 0.034	8.619LeuArg: 8.619 ± 0.071	5.268LeuSer: 5.268 ± 0.052	6.565LeuThr: 6.565 ± 0.058	8.897LeuVal: 8.897 ± 0.077	1.269LeuTrp: 1.269 ± 0.026	1.785LeuTyr: 1.785 ± 0.036	0.001LeuXaa: 0.001 ± 0.001
Met	2.317MetAla: 2.317 ± 0.036	0.149MetCys: 0.149 ± 0.008	0.955MetAsp: 0.955 ± 0.02	0.873MetGlu: 0.873 ± 0.02	0.47MetPhe: 0.47 ± 0.017	1.385MetGly: 1.385 ± 0.026	0.383MetHis: 0.383 ± 0.015	0.661MetIle: 0.661 ± 0.018	0.447MetLys: 0.447 ± 0.016	1.786MetLeu: 1.786 ± 0.034	0.314MetMet: 0.314 ± 0.013	0.444MetAsn: 0.444 ± 0.018	1.196MetPro: 1.196 ± 0.023	0.483MetGln: 0.483 ± 0.015	1.491MetArg: 1.491 ± 0.025	1.379MetSer: 1.379 ± 0.024	1.545MetThr: 1.545 ± 0.028	1.341MetVal: 1.341 ± 0.034	0.218MetTrp: 0.218 ± 0.011	0.344MetTyr: 0.344 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.216AsnAla: 2.216 ± 0.038	0.176AsnCys: 0.176 ± 0.01	0.994AsnAsp: 0.994 ± 0.025	0.864AsnGlu: 0.864 ± 0.021	0.49AsnPhe: 0.49 ± 0.017	1.838AsnGly: 1.838 ± 0.034	0.392AsnHis: 0.392 ± 0.014	0.653AsnIle: 0.653 ± 0.02	0.451AsnLys: 0.451 ± 0.015	1.65AsnLeu: 1.65 ± 0.034	0.308AsnMet: 0.308 ± 0.012	0.428AsnAsn: 0.428 ± 0.015	1.291AsnPro: 1.291 ± 0.029	0.496AsnGln: 0.496 ± 0.018	1.272AsnArg: 1.272 ± 0.028	0.934AsnSer: 0.934 ± 0.023	1.077AsnThr: 1.077 ± 0.027	1.39AsnVal: 1.39 ± 0.033	0.281AsnTrp: 0.281 ± 0.012	0.396AsnTyr: 0.396 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.561ProAla: 8.561 ± 0.097	0.352ProCys: 0.352 ± 0.014	4.347ProAsp: 4.347 ± 0.052	4.42ProGlu: 4.42 ± 0.058	1.524ProPhe: 1.524 ± 0.031	6.651ProGly: 6.651 ± 0.075	1.348ProHis: 1.348 ± 0.027	1.26ProIle: 1.26 ± 0.023	1.25ProLys: 1.25 ± 0.026	5.373ProLeu: 5.373 ± 0.05	1.037ProMet: 1.037 ± 0.023	0.896ProAsn: 0.896 ± 0.021	3.579ProPro: 3.579 ± 0.065	1.956ProGln: 1.956 ± 0.036	3.976ProArg: 3.976 ± 0.049	3.295ProSer: 3.295 ± 0.046	3.075ProThr: 3.075 ± 0.042	5.605ProVal: 5.605 ± 0.06	0.921ProTrp: 0.921 ± 0.023	1.357ProTyr: 1.357 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.864GlnAla: 3.864 ± 0.056	0.181GlnCys: 0.181 ± 0.01	1.463GlnAsp: 1.463 ± 0.026	1.58GlnGlu: 1.58 ± 0.032	0.688GlnPhe: 0.688 ± 0.018	2.377GlnGly: 2.377 ± 0.044	0.687GlnHis: 0.687 ± 0.02	1.107GlnIle: 1.107 ± 0.024	0.615GlnLys: 0.615 ± 0.019	3.205GlnLeu: 3.205 ± 0.043	0.551GlnMet: 0.551 ± 0.019	0.51GlnAsn: 0.51 ± 0.019	1.78GlnPro: 1.78 ± 0.037	1.348GlnGln: 1.348 ± 0.034	2.46GlnArg: 2.46 ± 0.035	1.311GlnSer: 1.311 ± 0.029	1.353GlnThr: 1.353 ± 0.027	2.421GlnVal: 2.421 ± 0.041	0.447GlnTrp: 0.447 ± 0.013	0.586GlnTyr: 0.586 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.724ArgAla: 9.724 ± 0.094	0.647ArgCys: 0.647 ± 0.019	4.294ArgAsp: 4.294 ± 0.045	4.757ArgGlu: 4.757 ± 0.055	2.364ArgPhe: 2.364 ± 0.032	5.884ArgGly: 5.884 ± 0.057	2.13ArgHis: 2.13 ± 0.034	3.367ArgIle: 3.367 ± 0.042	1.742ArgLys: 1.742 ± 0.03	8.9ArgLeu: 8.9 ± 0.089	1.797ArgMet: 1.797 ± 0.034	1.431ArgAsn: 1.431 ± 0.027	5.03ArgPro: 5.03 ± 0.061	2.404ArgGln: 2.404 ± 0.033	7.945ArgArg: 7.945 ± 0.08	4.304ArgSer: 4.304 ± 0.044	5.416ArgThr: 5.416 ± 0.059	5.625ArgVal: 5.625 ± 0.053	1.345ArgTrp: 1.345 ± 0.024	1.788ArgTyr: 1.788 ± 0.036	0.0ArgXaa: 0.0 ± 0.001
Ser	6.701SerAla: 6.701 ± 0.068	0.451SerCys: 0.451 ± 0.015	2.754SerAsp: 2.754 ± 0.037	2.522SerGlu: 2.522 ± 0.039	1.565SerPhe: 1.565 ± 0.027	5.858SerGly: 5.858 ± 0.056	1.067SerHis: 1.067 ± 0.023	1.477SerIle: 1.477 ± 0.029	1.078SerLys: 1.078 ± 0.027	4.907SerLeu: 4.907 ± 0.056	1.121SerMet: 1.121 ± 0.025	0.88SerAsn: 0.88 ± 0.021	3.208SerPro: 3.208 ± 0.043	1.322SerGln: 1.322 ± 0.028	3.839SerArg: 3.839 ± 0.04	2.93SerSer: 2.93 ± 0.041	2.984SerThr: 2.984 ± 0.042	4.361SerVal: 4.361 ± 0.044	0.9SerTrp: 0.9 ± 0.021	1.196SerTyr: 1.196 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	8.723ThrAla: 8.723 ± 0.066	0.427ThrCys: 0.427 ± 0.014	3.529ThrAsp: 3.529 ± 0.043	3.239ThrGlu: 3.239 ± 0.04	1.578ThrPhe: 1.578 ± 0.03	6.645ThrGly: 6.645 ± 0.064	1.168ThrHis: 1.168 ± 0.021	1.715ThrIle: 1.715 ± 0.037	1.13ThrLys: 1.13 ± 0.026	5.503ThrLeu: 5.503 ± 0.052	0.962ThrMet: 0.962 ± 0.024	0.954ThrAsn: 0.954 ± 0.023	3.884ThrPro: 3.884 ± 0.052	1.357ThrGln: 1.357 ± 0.026	3.874ThrArg: 3.874 ± 0.044	3.033ThrSer: 3.033 ± 0.046	3.704ThrThr: 3.704 ± 0.048	5.996ThrVal: 5.996 ± 0.054	0.864ThrTrp: 0.864 ± 0.022	1.3ThrTyr: 1.3 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	10.655ValAla: 10.655 ± 0.082	0.784ValCys: 0.784 ± 0.02	4.897ValAsp: 4.897 ± 0.053	4.826ValGlu: 4.826 ± 0.055	2.4ValPhe: 2.4 ± 0.038	6.538ValGly: 6.538 ± 0.067	2.072ValHis: 2.072 ± 0.034	2.868ValIle: 2.868 ± 0.038	1.802ValLys: 1.802 ± 0.037	9.621ValLeu: 9.621 ± 0.076	1.55ValMet: 1.55 ± 0.029	1.631ValAsn: 1.631 ± 0.033	5.354ValPro: 5.354 ± 0.057	2.142ValGln: 2.142 ± 0.031	7.186ValArg: 7.186 ± 0.067	4.42ValSer: 4.42 ± 0.06	5.532ValThr: 5.532 ± 0.052	8.124ValVal: 8.124 ± 0.082	1.085ValTrp: 1.085 ± 0.027	1.541ValTyr: 1.541 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.612TrpAla: 1.612 ± 0.027	0.162TrpCys: 0.162 ± 0.009	0.835TrpAsp: 0.835 ± 0.023	0.756TrpGlu: 0.756 ± 0.02	0.502TrpPhe: 0.502 ± 0.016	1.021TrpGly: 1.021 ± 0.022	0.36TrpHis: 0.36 ± 0.012	0.545TrpIle: 0.545 ± 0.019	0.368TrpLys: 0.368 ± 0.014	1.681TrpLeu: 1.681 ± 0.033	0.292TrpMet: 0.292 ± 0.013	0.383TrpAsn: 0.383 ± 0.013	0.815TrpPro: 0.815 ± 0.021	0.641TrpGln: 0.641 ± 0.018	1.31TrpArg: 1.31 ± 0.026	0.933TrpSer: 0.933 ± 0.023	0.99TrpThr: 0.99 ± 0.022	0.967TrpVal: 0.967 ± 0.024	0.338TrpTrp: 0.338 ± 0.013	0.342TrpTyr: 0.342 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.65TyrAla: 2.65 ± 0.036	0.192TyrCys: 0.192 ± 0.01	1.458TyrAsp: 1.458 ± 0.035	1.321TyrGlu: 1.321 ± 0.027	0.636TyrPhe: 0.636 ± 0.019	2.271TyrGly: 2.271 ± 0.031	0.362TyrHis: 0.362 ± 0.015	0.51TyrIle: 0.51 ± 0.017	0.378TyrLys: 0.378 ± 0.015	1.989TyrLeu: 1.989 ± 0.034	0.246TyrMet: 0.246 ± 0.011	0.402TyrAsn: 0.402 ± 0.014	1.034TyrPro: 1.034 ± 0.025	0.573TyrGln: 0.573 ± 0.02	1.781TyrArg: 1.781 ± 0.035	0.894TyrSer: 0.894 ± 0.023	1.135TyrThr: 1.135 ± 0.025	1.616TyrVal: 1.616 ± 0.026	0.323TyrTrp: 0.323 ± 0.013	0.422TyrTyr: 0.422 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 6389 proteins (2050681 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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