Amino acid dipepetide frequency for Pelagovum pacificum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.888AlaAla: 15.888 ± 0.179	1.102AlaCys: 1.102 ± 0.035	7.129AlaAsp: 7.129 ± 0.081	8.747AlaGlu: 8.747 ± 0.117	4.127AlaPhe: 4.127 ± 0.054	10.346AlaGly: 10.346 ± 0.109	2.045AlaHis: 2.045 ± 0.048	5.906AlaIle: 5.906 ± 0.071	3.056AlaLys: 3.056 ± 0.052	13.174AlaLeu: 13.174 ± 0.125	3.65AlaMet: 3.65 ± 0.044	2.506AlaAsn: 2.506 ± 0.051	5.672AlaPro: 5.672 ± 0.087	3.618AlaGln: 3.618 ± 0.06	8.401AlaArg: 8.401 ± 0.105	5.786AlaSer: 5.786 ± 0.071	6.329AlaThr: 6.329 ± 0.077	8.315AlaVal: 8.315 ± 0.088	1.472AlaTrp: 1.472 ± 0.039	2.414AlaTyr: 2.414 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.937CysAla: 0.937 ± 0.029	0.117CysCys: 0.117 ± 0.01	0.589CysAsp: 0.589 ± 0.022	0.461CysGlu: 0.461 ± 0.019	0.315CysPhe: 0.315 ± 0.017	0.979CysGly: 0.979 ± 0.03	0.268CysHis: 0.268 ± 0.014	0.405CysIle: 0.405 ± 0.017	0.156CysLys: 0.156 ± 0.012	0.811CysLeu: 0.811 ± 0.026	0.16CysMet: 0.16 ± 0.012	0.207CysAsn: 0.207 ± 0.014	0.473CysPro: 0.473 ± 0.021	0.2CysGln: 0.2 ± 0.013	0.596CysArg: 0.596 ± 0.024	0.419CysSer: 0.419 ± 0.019	0.396CysThr: 0.396 ± 0.02	0.543CysVal: 0.543 ± 0.018	0.126CysTrp: 0.126 ± 0.008	0.219CysTyr: 0.219 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.305AspAla: 7.305 ± 0.092	0.558AspCys: 0.558 ± 0.023	3.808AspAsp: 3.808 ± 0.077	4.166AspGlu: 4.166 ± 0.073	2.339AspPhe: 2.339 ± 0.044	6.492AspGly: 6.492 ± 0.081	1.39AspHis: 1.39 ± 0.032	3.049AspIle: 3.049 ± 0.05	1.435AspLys: 1.435 ± 0.041	6.394AspLeu: 6.394 ± 0.078	1.675AspMet: 1.675 ± 0.034	1.34AspAsn: 1.34 ± 0.033	3.95AspPro: 3.95 ± 0.067	1.755AspGln: 1.755 ± 0.032	5.012AspArg: 5.012 ± 0.067	2.502AspSer: 2.502 ± 0.05	3.04AspThr: 3.04 ± 0.066	4.452AspVal: 4.452 ± 0.061	1.303AspTrp: 1.303 ± 0.036	1.627AspTyr: 1.627 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	8.747GluAla: 8.747 ± 0.108	0.322GluCys: 0.322 ± 0.015	3.729GluAsp: 3.729 ± 0.064	4.301GluGlu: 4.301 ± 0.07	1.822GluPhe: 1.822 ± 0.036	5.353GluGly: 5.353 ± 0.074	1.159GluHis: 1.159 ± 0.032	3.561GluIle: 3.561 ± 0.059	1.847GluLys: 1.847 ± 0.054	5.631GluLeu: 5.631 ± 0.076	1.964GluMet: 1.964 ± 0.038	1.657GluAsn: 1.657 ± 0.034	3.054GluPro: 3.054 ± 0.064	2.032GluGln: 2.032 ± 0.04	4.733GluArg: 4.733 ± 0.061	2.777GluSer: 2.777 ± 0.044	4.148GluThr: 4.148 ± 0.059	4.99GluVal: 4.99 ± 0.066	0.809GluTrp: 0.809 ± 0.024	1.057GluTyr: 1.057 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.377PheAla: 4.377 ± 0.06	0.372PheCys: 0.372 ± 0.018	2.959PheAsp: 2.959 ± 0.048	2.32PheGlu: 2.32 ± 0.043	1.371PhePhe: 1.371 ± 0.042	3.677PheGly: 3.677 ± 0.056	0.725PheHis: 0.725 ± 0.025	1.643PheIle: 1.643 ± 0.042	0.681PheLys: 0.681 ± 0.024	3.314PheLeu: 3.314 ± 0.058	0.792PheMet: 0.792 ± 0.026	0.962PheAsn: 0.962 ± 0.026	1.541PhePro: 1.541 ± 0.032	0.965PheGln: 0.965 ± 0.031	2.398PheArg: 2.398 ± 0.045	2.1PheSer: 2.1 ± 0.042	2.053PheThr: 2.053 ± 0.041	2.669PheVal: 2.669 ± 0.057	0.612PheTrp: 0.612 ± 0.023	0.963PheTyr: 0.963 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.685GlyAla: 9.685 ± 0.096	0.85GlyCys: 0.85 ± 0.027	5.152GlyAsp: 5.152 ± 0.097	5.415GlyGlu: 5.415 ± 0.068	3.569GlyPhe: 3.569 ± 0.055	7.513GlyGly: 7.513 ± 0.117	1.942GlyHis: 1.942 ± 0.045	4.593GlyIle: 4.593 ± 0.059	2.747GlyLys: 2.747 ± 0.054	9.289GlyLeu: 9.289 ± 0.087	2.532GlyMet: 2.532 ± 0.048	2.197GlyAsn: 2.197 ± 0.067	4.069GlyPro: 4.069 ± 0.061	2.971GlyGln: 2.971 ± 0.052	6.195GlyArg: 6.195 ± 0.072	4.451GlySer: 4.451 ± 0.068	5.116GlyThr: 5.116 ± 0.081	6.242GlyVal: 6.242 ± 0.076	1.614GlyTrp: 1.614 ± 0.039	2.255GlyTyr: 2.255 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.154HisAla: 2.154 ± 0.04	0.222HisCys: 0.222 ± 0.015	1.305HisAsp: 1.305 ± 0.035	1.155HisGlu: 1.155 ± 0.033	0.825HisPhe: 0.825 ± 0.027	1.877HisGly: 1.877 ± 0.046	0.542HisHis: 0.542 ± 0.027	0.839HisIle: 0.839 ± 0.026	0.461HisLys: 0.461 ± 0.02	2.026HisLeu: 2.026 ± 0.042	0.506HisMet: 0.506 ± 0.021	0.396HisAsn: 0.396 ± 0.021	1.333HisPro: 1.333 ± 0.036	0.555HisGln: 0.555 ± 0.025	1.43HisArg: 1.43 ± 0.034	0.834HisSer: 0.834 ± 0.026	0.781HisThr: 0.781 ± 0.027	1.558HisVal: 1.558 ± 0.034	0.366HisTrp: 0.366 ± 0.017	0.569HisTyr: 0.569 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.849IleAla: 6.849 ± 0.072	0.545IleCys: 0.545 ± 0.018	3.699IleAsp: 3.699 ± 0.06	3.621IleGlu: 3.621 ± 0.062	1.763IlePhe: 1.763 ± 0.039	4.979IleGly: 4.979 ± 0.072	0.893IleHis: 0.893 ± 0.03	2.017IleIle: 2.017 ± 0.042	1.017IleLys: 1.017 ± 0.034	4.657IleLeu: 4.657 ± 0.072	1.003IleMet: 1.003 ± 0.03	1.182IleAsn: 1.182 ± 0.031	2.311IlePro: 2.311 ± 0.045	1.024IleGln: 1.024 ± 0.029	3.301IleArg: 3.301 ± 0.054	2.727IleSer: 2.727 ± 0.052	2.792IleThr: 2.792 ± 0.049	4.011IleVal: 4.011 ± 0.053	0.659IleTrp: 0.659 ± 0.023	1.157IleTyr: 1.157 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.21LysAla: 3.21 ± 0.066	0.164LysCys: 0.164 ± 0.011	1.525LysAsp: 1.525 ± 0.044	1.444LysGlu: 1.444 ± 0.041	0.792LysPhe: 0.792 ± 0.024	2.276LysGly: 2.276 ± 0.048	0.502LysHis: 0.502 ± 0.024	1.284LysIle: 1.284 ± 0.035	0.956LysLys: 0.956 ± 0.037	2.489LysLeu: 2.489 ± 0.056	0.7LysMet: 0.7 ± 0.026	0.63LysAsn: 0.63 ± 0.022	1.423LysPro: 1.423 ± 0.04	0.72LysGln: 0.72 ± 0.023	1.936LysArg: 1.936 ± 0.05	1.632LysSer: 1.632 ± 0.037	1.539LysThr: 1.539 ± 0.036	2.143LysVal: 2.143 ± 0.045	0.315LysTrp: 0.315 ± 0.015	0.519LysTyr: 0.519 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	12.673LeuAla: 12.673 ± 0.12	0.868LeuCys: 0.868 ± 0.032	6.413LeuAsp: 6.413 ± 0.075	5.457LeuGlu: 5.457 ± 0.067	3.576LeuPhe: 3.576 ± 0.06	8.344LeuGly: 8.344 ± 0.097	1.838LeuHis: 1.838 ± 0.048	5.126LeuIle: 5.126 ± 0.068	2.815LeuLys: 2.815 ± 0.054	9.327LeuLeu: 9.327 ± 0.111	2.552LeuMet: 2.552 ± 0.048	2.454LeuAsn: 2.454 ± 0.047	5.599LeuPro: 5.599 ± 0.08	2.531LeuGln: 2.531 ± 0.044	6.948LeuArg: 6.948 ± 0.082	6.914LeuSer: 6.914 ± 0.084	6.181LeuThr: 6.181 ± 0.07	7.398LeuVal: 7.398 ± 0.088	1.335LeuTrp: 1.335 ± 0.034	1.998LeuTyr: 1.998 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.254MetAla: 3.254 ± 0.049	0.149MetCys: 0.149 ± 0.01	1.356MetAsp: 1.356 ± 0.03	1.457MetGlu: 1.457 ± 0.037	0.837MetPhe: 0.837 ± 0.029	1.973MetGly: 1.973 ± 0.044	0.433MetHis: 0.433 ± 0.02	1.527MetIle: 1.527 ± 0.039	0.952MetLys: 0.952 ± 0.026	2.568MetLeu: 2.568 ± 0.052	0.71MetMet: 0.71 ± 0.025	0.829MetAsn: 0.829 ± 0.029	1.554MetPro: 1.554 ± 0.039	0.844MetGln: 0.844 ± 0.026	1.904MetArg: 1.904 ± 0.042	1.957MetSer: 1.957 ± 0.036	2.163MetThr: 2.163 ± 0.043	1.884MetVal: 1.884 ± 0.04	0.26MetTrp: 0.26 ± 0.017	0.367MetTyr: 0.367 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.829AsnAla: 2.829 ± 0.054	0.223AsnCys: 0.223 ± 0.014	1.496AsnAsp: 1.496 ± 0.049	1.282AsnGlu: 1.282 ± 0.035	0.916AsnPhe: 0.916 ± 0.03	2.302AsnGly: 2.302 ± 0.051	0.496AsnHis: 0.496 ± 0.021	1.215AsnIle: 1.215 ± 0.03	0.54AsnLys: 0.54 ± 0.023	2.453AsnLeu: 2.453 ± 0.044	0.607AsnMet: 0.607 ± 0.022	0.638AsnAsn: 0.638 ± 0.027	1.726AsnPro: 1.726 ± 0.042	0.624AsnGln: 0.624 ± 0.024	1.771AsnArg: 1.771 ± 0.043	1.202AsnSer: 1.202 ± 0.038	1.123AsnThr: 1.123 ± 0.034	1.787AsnVal: 1.787 ± 0.038	0.405AsnTrp: 0.405 ± 0.018	0.708AsnTyr: 0.708 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.819ProAla: 5.819 ± 0.084	0.334ProCys: 0.334 ± 0.019	4.358ProAsp: 4.358 ± 0.064	4.401ProGlu: 4.401 ± 0.072	1.939ProPhe: 1.939 ± 0.039	4.756ProGly: 4.756 ± 0.062	1.053ProHis: 1.053 ± 0.028	2.162ProIle: 2.162 ± 0.042	1.425ProLys: 1.425 ± 0.042	4.818ProLeu: 4.818 ± 0.059	1.314ProMet: 1.314 ± 0.031	1.288ProAsn: 1.288 ± 0.036	2.618ProPro: 2.618 ± 0.051	1.402ProGln: 1.402 ± 0.031	2.924ProArg: 2.924 ± 0.051	2.594ProSer: 2.594 ± 0.043	2.674ProThr: 2.674 ± 0.047	4.473ProVal: 4.473 ± 0.064	0.729ProTrp: 0.729 ± 0.024	1.202ProTyr: 1.202 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.306GlnAla: 3.306 ± 0.053	0.178GlnCys: 0.178 ± 0.014	1.582GlnAsp: 1.582 ± 0.038	1.517GlnGlu: 1.517 ± 0.04	0.987GlnPhe: 0.987 ± 0.031	2.294GlnGly: 2.294 ± 0.042	0.505GlnHis: 0.505 ± 0.022	1.649GlnIle: 1.649 ± 0.035	0.844GlnLys: 0.844 ± 0.025	2.814GlnLeu: 2.814 ± 0.048	0.911GlnMet: 0.911 ± 0.022	0.762GlnAsn: 0.762 ± 0.022	1.509GlnPro: 1.509 ± 0.032	1.02GlnGln: 1.02 ± 0.036	2.15GlnArg: 2.15 ± 0.047	1.703GlnSer: 1.703 ± 0.037	1.631GlnThr: 1.631 ± 0.033	2.332GlnVal: 2.332 ± 0.048	0.37GlnTrp: 0.37 ± 0.017	0.569GlnTyr: 0.569 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.919ArgAla: 7.919 ± 0.104	0.482ArgCys: 0.482 ± 0.023	4.507ArgAsp: 4.507 ± 0.052	4.204ArgGlu: 4.204 ± 0.062	2.74ArgPhe: 2.74 ± 0.048	4.746ArgGly: 4.746 ± 0.066	1.686ArgHis: 1.686 ± 0.036	3.998ArgIle: 3.998 ± 0.057	2.0ArgLys: 2.0 ± 0.044	7.858ArgLeu: 7.858 ± 0.096	2.083ArgMet: 2.083 ± 0.037	1.813ArgAsn: 1.813 ± 0.039	3.658ArgPro: 3.658 ± 0.062	2.458ArgGln: 2.458 ± 0.05	5.594ArgArg: 5.594 ± 0.085	3.469ArgSer: 3.469 ± 0.054	3.625ArgThr: 3.625 ± 0.052	4.644ArgVal: 4.644 ± 0.061	1.039ArgTrp: 1.039 ± 0.029	1.572ArgTyr: 1.572 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.902SerAla: 5.902 ± 0.081	0.408SerCys: 0.408 ± 0.019	3.61SerAsp: 3.61 ± 0.059	3.198SerGlu: 3.198 ± 0.055	2.2SerPhe: 2.2 ± 0.048	5.769SerGly: 5.769 ± 0.086	1.057SerHis: 1.057 ± 0.029	2.595SerIle: 2.595 ± 0.05	1.269SerLys: 1.269 ± 0.036	5.212SerLeu: 5.212 ± 0.062	1.442SerMet: 1.442 ± 0.031	1.276SerAsn: 1.276 ± 0.035	2.665SerPro: 2.665 ± 0.049	1.441SerGln: 1.441 ± 0.037	3.681SerArg: 3.681 ± 0.054	2.805SerSer: 2.805 ± 0.049	2.765SerThr: 2.765 ± 0.048	4.064SerVal: 4.064 ± 0.066	0.775SerTrp: 0.775 ± 0.026	1.265SerTyr: 1.265 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.252ThrAla: 6.252 ± 0.084	0.48ThrCys: 0.48 ± 0.022	3.583ThrAsp: 3.583 ± 0.067	3.412ThrGlu: 3.412 ± 0.054	2.223ThrPhe: 2.223 ± 0.038	5.625ThrGly: 5.625 ± 0.082	1.046ThrHis: 1.046 ± 0.028	2.923ThrIle: 2.923 ± 0.05	1.197ThrLys: 1.197 ± 0.033	6.229ThrLeu: 6.229 ± 0.075	1.369ThrMet: 1.369 ± 0.033	1.259ThrAsn: 1.259 ± 0.032	3.312ThrPro: 3.312 ± 0.054	1.33ThrGln: 1.33 ± 0.036	3.598ThrArg: 3.598 ± 0.056	2.969ThrSer: 2.969 ± 0.049	3.013ThrThr: 3.013 ± 0.056	4.577ThrVal: 4.577 ± 0.058	0.795ThrTrp: 0.795 ± 0.023	1.326ThrTyr: 1.326 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.913ValAla: 8.913 ± 0.103	0.618ValCys: 0.618 ± 0.024	4.304ValAsp: 4.304 ± 0.059	5.004ValGlu: 5.004 ± 0.065	2.711ValPhe: 2.711 ± 0.043	5.852ValGly: 5.852 ± 0.074	1.286ValHis: 1.286 ± 0.035	4.022ValIle: 4.022 ± 0.067	1.89ValLys: 1.89 ± 0.048	7.403ValLeu: 7.403 ± 0.088	2.096ValMet: 2.096 ± 0.037	1.905ValAsn: 1.905 ± 0.042	3.875ValPro: 3.875 ± 0.065	1.931ValGln: 1.931 ± 0.039	4.751ValArg: 4.751 ± 0.062	4.452ValSer: 4.452 ± 0.057	5.16ValThr: 5.16 ± 0.059	5.686ValVal: 5.686 ± 0.072	0.968ValTrp: 0.968 ± 0.028	1.476ValTyr: 1.476 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.288TrpAla: 1.288 ± 0.034	0.143TrpCys: 0.143 ± 0.012	0.828TrpAsp: 0.828 ± 0.027	0.713TrpGlu: 0.713 ± 0.023	0.547TrpPhe: 0.547 ± 0.021	1.064TrpGly: 1.064 ± 0.031	0.35TrpHis: 0.35 ± 0.019	0.787TrpIle: 0.787 ± 0.026	0.434TrpLys: 0.434 ± 0.018	1.698TrpLeu: 1.698 ± 0.043	0.426TrpMet: 0.426 ± 0.02	0.442TrpAsn: 0.442 ± 0.02	0.771TrpPro: 0.771 ± 0.023	0.587TrpGln: 0.587 ± 0.025	1.148TrpArg: 1.148 ± 0.03	0.926TrpSer: 0.926 ± 0.029	0.923TrpThr: 0.923 ± 0.024	0.97TrpVal: 0.97 ± 0.028	0.255TrpTrp: 0.255 ± 0.012	0.292TrpTyr: 0.292 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.372TyrAla: 2.372 ± 0.047	0.243TyrCys: 0.243 ± 0.014	1.663TyrAsp: 1.663 ± 0.038	1.419TyrGlu: 1.419 ± 0.041	0.896TyrPhe: 0.896 ± 0.026	2.18TyrGly: 2.18 ± 0.06	0.517TyrHis: 0.517 ± 0.021	0.904TyrIle: 0.904 ± 0.027	0.476TyrLys: 0.476 ± 0.02	2.183TyrLeu: 2.183 ± 0.045	0.484TyrMet: 0.484 ± 0.019	0.6TyrAsn: 0.6 ± 0.023	1.172TyrPro: 1.172 ± 0.032	0.622TyrGln: 0.622 ± 0.025	1.627TyrArg: 1.627 ± 0.032	1.182TyrSer: 1.182 ± 0.033	1.066TyrThr: 1.066 ± 0.035	1.566TyrVal: 1.566 ± 0.035	0.383TyrTrp: 0.383 ± 0.019	0.576TyrTyr: 0.576 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3956 proteins (1240708 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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