Amino acid dipepetide frequency for Denitrovibrio acetiphilus (strain DSM 12809 / NBRC 114555 / N2460)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.273AlaAla: 6.273 ± 0.118	0.999AlaCys: 0.999 ± 0.04	4.975AlaAsp: 4.975 ± 0.085	5.837AlaGlu: 5.837 ± 0.082	3.31AlaPhe: 3.31 ± 0.068	6.322AlaGly: 6.322 ± 0.096	1.27AlaHis: 1.27 ± 0.038	4.544AlaIle: 4.544 ± 0.072	4.978AlaLys: 4.978 ± 0.081	6.704AlaLeu: 6.704 ± 0.085	2.281AlaMet: 2.281 ± 0.045	2.525AlaAsn: 2.525 ± 0.053	1.999AlaPro: 1.999 ± 0.052	1.841AlaGln: 1.841 ± 0.053	2.6AlaArg: 2.6 ± 0.057	4.442AlaSer: 4.442 ± 0.076	3.106AlaThr: 3.106 ± 0.075	6.456AlaVal: 6.456 ± 0.093	0.431AlaTrp: 0.431 ± 0.025	2.555AlaTyr: 2.555 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.896CysAla: 0.896 ± 0.034	0.169CysCys: 0.169 ± 0.014	0.664CysAsp: 0.664 ± 0.027	0.738CysGlu: 0.738 ± 0.03	0.48CysPhe: 0.48 ± 0.023	1.223CysGly: 1.223 ± 0.037	0.507CysHis: 0.507 ± 0.046	0.796CysIle: 0.796 ± 0.032	0.673CysLys: 0.673 ± 0.028	0.85CysLeu: 0.85 ± 0.032	0.333CysMet: 0.333 ± 0.018	0.479CysAsn: 0.479 ± 0.021	0.606CysPro: 0.606 ± 0.034	0.275CysGln: 0.275 ± 0.017	0.575CysArg: 0.575 ± 0.023	0.898CysSer: 0.898 ± 0.034	0.646CysThr: 0.646 ± 0.028	0.823CysVal: 0.823 ± 0.029	0.075CysTrp: 0.075 ± 0.008	0.374CysTyr: 0.374 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.138AspAla: 4.138 ± 0.078	0.687AspCys: 0.687 ± 0.028	3.465AspAsp: 3.465 ± 0.083	4.426AspGlu: 4.426 ± 0.084	3.023AspPhe: 3.023 ± 0.052	4.038AspGly: 4.038 ± 0.11	0.941AspHis: 0.941 ± 0.035	5.9AspIle: 5.9 ± 0.081	4.465AspLys: 4.465 ± 0.068	4.548AspLeu: 4.548 ± 0.077	2.012AspMet: 2.012 ± 0.044	2.864AspAsn: 2.864 ± 0.066	1.892AspPro: 1.892 ± 0.049	1.176AspGln: 1.176 ± 0.041	2.544AspArg: 2.544 ± 0.061	3.679AspSer: 3.679 ± 0.078	3.116AspThr: 3.116 ± 0.068	4.294AspVal: 4.294 ± 0.07	0.488AspTrp: 0.488 ± 0.023	2.541AspTyr: 2.541 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	4.725GluAla: 4.725 ± 0.075	0.666GluCys: 0.666 ± 0.026	3.798GluAsp: 3.798 ± 0.083	4.812GluGlu: 4.812 ± 0.088	2.809GluPhe: 2.809 ± 0.054	3.95GluGly: 3.95 ± 0.064	1.38GluHis: 1.38 ± 0.041	5.604GluIle: 5.604 ± 0.082	6.323GluLys: 6.323 ± 0.085	6.876GluLeu: 6.876 ± 0.103	2.241GluMet: 2.241 ± 0.049	3.804GluAsn: 3.804 ± 0.067	1.936GluPro: 1.936 ± 0.046	2.233GluGln: 2.233 ± 0.047	3.104GluArg: 3.104 ± 0.062	3.896GluSer: 3.896 ± 0.071	3.799GluThr: 3.799 ± 0.068	4.345GluVal: 4.345 ± 0.081	0.519GluTrp: 0.519 ± 0.027	2.686GluTyr: 2.686 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	3.484PheAla: 3.484 ± 0.068	0.644PheCys: 0.644 ± 0.024	2.962PheAsp: 2.962 ± 0.058	2.878PheGlu: 2.878 ± 0.061	2.344PhePhe: 2.344 ± 0.065	3.226PheGly: 3.226 ± 0.059	0.789PheHis: 0.789 ± 0.03	3.723PheIle: 3.723 ± 0.072	2.72PheLys: 2.72 ± 0.057	3.937PheLeu: 3.937 ± 0.078	1.573PheMet: 1.573 ± 0.045	2.094PheAsn: 2.094 ± 0.047	1.473PhePro: 1.473 ± 0.038	1.116PheGln: 1.116 ± 0.034	1.993PheArg: 1.993 ± 0.054	3.52PheSer: 3.52 ± 0.067	2.686PheThr: 2.686 ± 0.065	2.988PheVal: 2.988 ± 0.067	0.38PheTrp: 0.38 ± 0.022	1.896PheTyr: 1.896 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	5.025GlyAla: 5.025 ± 0.082	1.037GlyCys: 1.037 ± 0.038	3.829GlyAsp: 3.829 ± 0.086	4.474GlyGlu: 4.474 ± 0.082	3.579GlyPhe: 3.579 ± 0.066	4.941GlyGly: 4.941 ± 0.085	1.32GlyHis: 1.32 ± 0.041	5.489GlyIle: 5.489 ± 0.092	5.028GlyLys: 5.028 ± 0.069	6.2GlyLeu: 6.2 ± 0.092	2.286GlyMet: 2.286 ± 0.054	2.657GlyAsn: 2.657 ± 0.057	1.252GlyPro: 1.252 ± 0.04	1.662GlyGln: 1.662 ± 0.045	3.226GlyArg: 3.226 ± 0.067	4.159GlySer: 4.159 ± 0.073	3.86GlyThr: 3.86 ± 0.092	5.245GlyVal: 5.245 ± 0.085	0.661GlyTrp: 0.661 ± 0.032	3.006GlyTyr: 3.006 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.117HisAla: 1.117 ± 0.036	0.245HisCys: 0.245 ± 0.017	0.985HisAsp: 0.985 ± 0.036	1.202HisGlu: 1.202 ± 0.037	0.864HisPhe: 0.864 ± 0.033	1.324HisGly: 1.324 ± 0.039	0.425HisHis: 0.425 ± 0.023	1.591HisIle: 1.591 ± 0.042	1.262HisLys: 1.262 ± 0.045	1.54HisLeu: 1.54 ± 0.05	0.602HisMet: 0.602 ± 0.023	0.829HisAsn: 0.829 ± 0.036	0.871HisPro: 0.871 ± 0.031	0.469HisGln: 0.469 ± 0.023	0.813HisArg: 0.813 ± 0.025	1.239HisSer: 1.239 ± 0.038	1.034HisThr: 1.034 ± 0.04	1.09HisVal: 1.09 ± 0.037	0.155HisTrp: 0.155 ± 0.013	0.686HisTyr: 0.686 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.711IleAla: 5.711 ± 0.093	0.983IleCys: 0.983 ± 0.036	4.619IleAsp: 4.619 ± 0.072	5.213IleGlu: 5.213 ± 0.08	3.418IlePhe: 3.418 ± 0.075	4.806IleGly: 4.806 ± 0.077	1.221IleHis: 1.221 ± 0.04	5.862IleIle: 5.862 ± 0.091	5.396IleLys: 5.396 ± 0.082	6.654IleLeu: 6.654 ± 0.097	2.004IleMet: 2.004 ± 0.049	3.948IleAsn: 3.948 ± 0.069	2.98IlePro: 2.98 ± 0.063	1.859IleGln: 1.859 ± 0.048	3.199IleArg: 3.199 ± 0.059	5.784IleSer: 5.784 ± 0.099	4.399IleThr: 4.399 ± 0.073	4.853IleVal: 4.853 ± 0.071	0.442IleTrp: 0.442 ± 0.023	2.722IleTyr: 2.722 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	5.068LysAla: 5.068 ± 0.081	0.77LysCys: 0.77 ± 0.031	4.544LysAsp: 4.544 ± 0.072	5.479LysGlu: 5.479 ± 0.09	2.589LysPhe: 2.589 ± 0.055	4.7LysGly: 4.7 ± 0.076	1.384LysHis: 1.384 ± 0.039	5.262LysIle: 5.262 ± 0.084	5.797LysLys: 5.797 ± 0.104	6.519LysLeu: 6.519 ± 0.085	2.261LysMet: 2.261 ± 0.046	3.897LysAsn: 3.897 ± 0.064	2.469LysPro: 2.469 ± 0.06	2.078LysGln: 2.078 ± 0.05	3.022LysArg: 3.022 ± 0.06	4.304LysSer: 4.304 ± 0.068	3.99LysThr: 3.99 ± 0.069	4.466LysVal: 4.466 ± 0.089	0.52LysTrp: 0.52 ± 0.022	2.913LysTyr: 2.913 ± 0.061	0.0LysXaa: 0.0 ± 0.0
Leu	6.75LeuAla: 6.75 ± 0.102	1.039LeuCys: 1.039 ± 0.035	5.169LeuAsp: 5.169 ± 0.083	5.901LeuGlu: 5.901 ± 0.095	3.967LeuPhe: 3.967 ± 0.083	5.785LeuGly: 5.785 ± 0.089	1.6LeuHis: 1.6 ± 0.043	6.427LeuIle: 6.427 ± 0.109	6.951LeuLys: 6.951 ± 0.093	8.024LeuLeu: 8.024 ± 0.122	2.515LeuMet: 2.515 ± 0.054	4.407LeuAsn: 4.407 ± 0.076	3.278LeuPro: 3.278 ± 0.063	2.399LeuGln: 2.399 ± 0.053	3.918LeuArg: 3.918 ± 0.068	6.771LeuSer: 6.771 ± 0.098	5.198LeuThr: 5.198 ± 0.077	5.534LeuVal: 5.534 ± 0.082	0.594LeuTrp: 0.594 ± 0.027	3.08LeuTyr: 3.08 ± 0.071	0.0LeuXaa: 0.0 ± 0.0
Met	2.219MetAla: 2.219 ± 0.052	0.298MetCys: 0.298 ± 0.019	1.687MetAsp: 1.687 ± 0.04	1.854MetGlu: 1.854 ± 0.041	1.308MetPhe: 1.308 ± 0.033	2.006MetGly: 2.006 ± 0.047	0.624MetHis: 0.624 ± 0.029	1.994MetIle: 1.994 ± 0.052	2.522MetLys: 2.522 ± 0.047	3.112MetLeu: 3.112 ± 0.06	0.877MetMet: 0.877 ± 0.033	1.493MetAsn: 1.493 ± 0.04	1.222MetPro: 1.222 ± 0.03	0.983MetGln: 0.983 ± 0.034	1.316MetArg: 1.316 ± 0.039	2.163MetSer: 2.163 ± 0.05	1.684MetThr: 1.684 ± 0.043	1.839MetVal: 1.839 ± 0.042	0.21MetTrp: 0.21 ± 0.014	0.867MetTyr: 0.867 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.03AsnAla: 3.03 ± 0.056	0.566AsnCys: 0.566 ± 0.026	2.47AsnAsp: 2.47 ± 0.068	2.794AsnGlu: 2.794 ± 0.062	2.035AsnPhe: 2.035 ± 0.048	3.082AsnGly: 3.082 ± 0.07	0.727AsnHis: 0.727 ± 0.032	4.466AsnIle: 4.466 ± 0.07	2.988AsnLys: 2.988 ± 0.059	4.036AsnLeu: 4.036 ± 0.077	1.478AsnMet: 1.478 ± 0.038	2.224AsnAsn: 2.224 ± 0.052	2.063AsnPro: 2.063 ± 0.053	1.012AsnGln: 1.012 ± 0.034	2.08AsnArg: 2.08 ± 0.056	3.005AsnSer: 3.005 ± 0.061	2.526AsnThr: 2.526 ± 0.056	3.132AsnVal: 3.132 ± 0.061	0.35AsnTrp: 0.35 ± 0.021	1.613AsnTyr: 1.613 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	2.696ProAla: 2.696 ± 0.065	0.339ProCys: 0.339 ± 0.02	2.668ProAsp: 2.668 ± 0.056	3.297ProGlu: 3.297 ± 0.07	1.682ProPhe: 1.682 ± 0.045	2.023ProGly: 2.023 ± 0.049	0.644ProHis: 0.644 ± 0.029	1.843ProIle: 1.843 ± 0.048	1.958ProLys: 1.958 ± 0.045	2.825ProLeu: 2.825 ± 0.055	0.887ProMet: 0.887 ± 0.036	1.162ProAsn: 1.162 ± 0.033	0.931ProPro: 0.931 ± 0.034	0.919ProGln: 0.919 ± 0.037	0.936ProArg: 0.936 ± 0.035	2.037ProSer: 2.037 ± 0.049	1.487ProThr: 1.487 ± 0.04	3.448ProVal: 3.448 ± 0.069	0.274ProTrp: 0.274 ± 0.017	1.365ProTyr: 1.365 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	1.966GlnAla: 1.966 ± 0.05	0.284GlnCys: 0.284 ± 0.018	1.317GlnAsp: 1.317 ± 0.038	1.825GlnGlu: 1.825 ± 0.048	1.122GlnPhe: 1.122 ± 0.03	1.626GlnGly: 1.626 ± 0.043	0.469GlnHis: 0.469 ± 0.022	2.025GlnIle: 2.025 ± 0.051	2.217GlnLys: 2.217 ± 0.052	2.303GlnLeu: 2.303 ± 0.056	0.904GlnMet: 0.904 ± 0.03	1.364GlnAsn: 1.364 ± 0.04	0.828GlnPro: 0.828 ± 0.033	0.949GlnGln: 0.949 ± 0.038	1.098GlnArg: 1.098 ± 0.035	1.679GlnSer: 1.679 ± 0.046	1.553GlnThr: 1.553 ± 0.044	1.698GlnVal: 1.698 ± 0.048	0.226GlnTrp: 0.226 ± 0.014	1.035GlnTyr: 1.035 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.632ArgAla: 2.632 ± 0.059	0.468ArgCys: 0.468 ± 0.022	2.354ArgAsp: 2.354 ± 0.056	3.014ArgGlu: 3.014 ± 0.068	2.12ArgPhe: 2.12 ± 0.05	2.467ArgGly: 2.467 ± 0.052	0.854ArgHis: 0.854 ± 0.032	3.29ArgIle: 3.29 ± 0.057	3.432ArgLys: 3.432 ± 0.059	4.066ArgLeu: 4.066 ± 0.079	1.327ArgMet: 1.327 ± 0.04	2.109ArgAsn: 2.109 ± 0.043	1.308ArgPro: 1.308 ± 0.045	1.393ArgGln: 1.393 ± 0.041	1.931ArgArg: 1.931 ± 0.05	2.42ArgSer: 2.42 ± 0.051	2.067ArgThr: 2.067 ± 0.053	2.774ArgVal: 2.774 ± 0.053	0.377ArgTrp: 0.377 ± 0.019	1.78ArgTyr: 1.78 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	4.922SerAla: 4.922 ± 0.075	0.838SerCys: 0.838 ± 0.039	4.197SerAsp: 4.197 ± 0.094	4.616SerGlu: 4.616 ± 0.08	3.49SerPhe: 3.49 ± 0.067	5.521SerGly: 5.521 ± 0.087	1.155SerHis: 1.155 ± 0.036	4.854SerIle: 4.854 ± 0.084	4.181SerLys: 4.181 ± 0.07	5.756SerLeu: 5.756 ± 0.082	1.927SerMet: 1.927 ± 0.043	2.405SerAsn: 2.405 ± 0.052	1.96SerPro: 1.96 ± 0.047	1.559SerGln: 1.559 ± 0.045	2.755SerArg: 2.755 ± 0.056	4.431SerSer: 4.431 ± 0.08	3.079SerThr: 3.079 ± 0.06	5.208SerVal: 5.208 ± 0.082	0.564SerTrp: 0.564 ± 0.026	2.567SerTyr: 2.567 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	4.548ThrAla: 4.548 ± 0.076	0.629ThrCys: 0.629 ± 0.029	3.515ThrAsp: 3.515 ± 0.071	3.691ThrGlu: 3.691 ± 0.061	2.455ThrPhe: 2.455 ± 0.055	4.725ThrGly: 4.725 ± 0.082	0.904ThrHis: 0.904 ± 0.028	3.752ThrIle: 3.752 ± 0.063	3.175ThrLys: 3.175 ± 0.061	4.716ThrLeu: 4.716 ± 0.087	1.281ThrMet: 1.281 ± 0.044	1.982ThrAsn: 1.982 ± 0.048	2.376ThrPro: 2.376 ± 0.056	1.348ThrGln: 1.348 ± 0.037	1.855ThrArg: 1.855 ± 0.044	3.342ThrSer: 3.342 ± 0.067	2.73ThrThr: 2.73 ± 0.068	4.356ThrVal: 4.356 ± 0.141	0.295ThrTrp: 0.295 ± 0.017	1.943ThrTyr: 1.943 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	5.1ValAla: 5.1 ± 0.092	0.901ValCys: 0.901 ± 0.034	4.093ValAsp: 4.093 ± 0.079	4.514ValGlu: 4.514 ± 0.078	3.587ValPhe: 3.587 ± 0.067	4.029ValGly: 4.029 ± 0.069	1.223ValHis: 1.223 ± 0.034	5.349ValIle: 5.349 ± 0.071	4.934ValLys: 4.934 ± 0.083	6.368ValLeu: 6.368 ± 0.083	2.171ValMet: 2.171 ± 0.043	3.257ValAsn: 3.257 ± 0.092	2.417ValPro: 2.417 ± 0.054	1.923ValGln: 1.923 ± 0.044	3.164ValArg: 3.164 ± 0.051	5.073ValSer: 5.073 ± 0.084	4.217ValThr: 4.217 ± 0.088	5.172ValVal: 5.172 ± 0.091	0.522ValTrp: 0.522 ± 0.021	2.477ValTyr: 2.477 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.541TrpAla: 0.541 ± 0.024	0.079TrpCys: 0.079 ± 0.01	0.457TrpAsp: 0.457 ± 0.025	0.476TrpGlu: 0.476 ± 0.025	0.357TrpPhe: 0.357 ± 0.02	0.537TrpGly: 0.537 ± 0.025	0.213TrpHis: 0.213 ± 0.015	0.5TrpIle: 0.5 ± 0.022	0.491TrpLys: 0.491 ± 0.023	0.789TrpLeu: 0.789 ± 0.028	0.229TrpMet: 0.229 ± 0.015	0.337TrpAsn: 0.337 ± 0.02	0.172TrpPro: 0.172 ± 0.013	0.285TrpGln: 0.285 ± 0.019	0.357TrpArg: 0.357 ± 0.022	0.415TrpSer: 0.415 ± 0.021	0.32TrpThr: 0.32 ± 0.017	0.494TrpVal: 0.494 ± 0.022	0.087TrpTrp: 0.087 ± 0.01	0.325TrpTyr: 0.325 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.608TyrAla: 2.608 ± 0.054	0.438TyrCys: 0.438 ± 0.023	2.468TyrAsp: 2.468 ± 0.057	2.461TyrGlu: 2.461 ± 0.054	1.888TyrPhe: 1.888 ± 0.05	2.606TyrGly: 2.606 ± 0.056	0.693TyrHis: 0.693 ± 0.028	2.801TyrIle: 2.801 ± 0.063	2.538TyrLys: 2.538 ± 0.05	3.486TyrLeu: 3.486 ± 0.071	1.09TyrMet: 1.09 ± 0.035	1.843TyrAsn: 1.843 ± 0.049	1.389TyrPro: 1.389 ± 0.041	1.01TyrGln: 1.01 ± 0.031	1.697TyrArg: 1.697 ± 0.041	2.728TyrSer: 2.728 ± 0.054	2.119TyrThr: 2.119 ± 0.06	2.274TyrVal: 2.274 ± 0.041	0.295TyrTrp: 0.295 ± 0.019	1.576TyrTyr: 1.576 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2901 proteins (946645 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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