Amino acid dipepetide frequency for Burkholderia phage vB_BceS_AH2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.954AlaAla: 14.954 ± 1.988
1.293AlaCys: 1.293 ± 0.276
6.296AlaAsp: 6.296 ± 0.828
7.083AlaGlu: 7.083 ± 0.651
3.71AlaPhe: 3.71 ± 0.454
8.545AlaGly: 8.545 ± 1.034
1.518AlaHis: 1.518 ± 0.311
6.577AlaIle: 6.577 ± 0.724
5.509AlaLys: 5.509 ± 0.799
9.782AlaLeu: 9.782 ± 0.95
3.542AlaMet: 3.542 ± 0.47
3.935AlaAsn: 3.935 ± 0.546
3.654AlaPro: 3.654 ± 0.479
4.104AlaGln: 4.104 ± 0.908
7.477AlaArg: 7.477 ± 0.868
6.409AlaSer: 6.409 ± 0.8
5.284AlaThr: 5.284 ± 0.74
7.027AlaVal: 7.027 ± 0.798
1.911AlaTrp: 1.911 ± 0.374
2.811AlaTyr: 2.811 ± 0.469
0.0AlaXaa: 0.0 ± 0.0
Cys
1.181CysAla: 1.181 ± 0.253
0.056CysCys: 0.056 ± 0.058
1.293CysAsp: 1.293 ± 0.295
0.394CysGlu: 0.394 ± 0.137
0.281CysPhe: 0.281 ± 0.137
0.956CysGly: 0.956 ± 0.244
0.056CysHis: 0.056 ± 0.065
0.337CysIle: 0.337 ± 0.169
0.337CysLys: 0.337 ± 0.15
0.506CysLeu: 0.506 ± 0.188
0.281CysMet: 0.281 ± 0.128
0.169CysAsn: 0.169 ± 0.1
0.618CysPro: 0.618 ± 0.233
0.394CysGln: 0.394 ± 0.151
0.618CysArg: 0.618 ± 0.215
0.506CysSer: 0.506 ± 0.153
0.45CysThr: 0.45 ± 0.151
0.618CysVal: 0.618 ± 0.205
0.112CysTrp: 0.112 ± 0.077
0.337CysTyr: 0.337 ± 0.143
0.0CysXaa: 0.0 ± 0.0
Asp
7.702AspAla: 7.702 ± 0.772
0.562AspCys: 0.562 ± 0.193
5.509AspAsp: 5.509 ± 0.858
4.779AspGlu: 4.779 ± 0.749
2.08AspPhe: 2.08 ± 0.389
5.734AspGly: 5.734 ± 0.708
1.068AspHis: 1.068 ± 0.259
2.698AspIle: 2.698 ± 0.348
3.373AspLys: 3.373 ± 0.393
6.072AspLeu: 6.072 ± 0.709
1.405AspMet: 1.405 ± 0.289
2.305AspAsn: 2.305 ± 0.377
3.598AspPro: 3.598 ± 0.499
2.08AspGln: 2.08 ± 0.323
4.16AspArg: 4.16 ± 0.591
2.755AspSer: 2.755 ± 0.412
2.698AspThr: 2.698 ± 0.475
4.666AspVal: 4.666 ± 0.478
1.181AspTrp: 1.181 ± 0.271
2.024AspTyr: 2.024 ± 0.358
0.0AspXaa: 0.0 ± 0.0
Glu
6.915GluAla: 6.915 ± 0.927
0.899GluCys: 0.899 ± 0.21
3.373GluAsp: 3.373 ± 0.495
3.823GluGlu: 3.823 ± 0.569
2.417GluPhe: 2.417 ± 0.338
3.654GluGly: 3.654 ± 0.407
1.124GluHis: 1.124 ± 0.292
4.554GluIle: 4.554 ± 0.63
2.811GluLys: 2.811 ± 0.402
4.61GluLeu: 4.61 ± 0.573
1.63GluMet: 1.63 ± 0.257
1.799GluAsn: 1.799 ± 0.415
2.192GluPro: 2.192 ± 0.428
2.755GluGln: 2.755 ± 0.405
4.947GluArg: 4.947 ± 0.557
2.642GluSer: 2.642 ± 0.431
2.249GluThr: 2.249 ± 0.357
3.092GluVal: 3.092 ± 0.508
1.293GluTrp: 1.293 ± 0.348
1.743GluTyr: 1.743 ± 0.414
0.0GluXaa: 0.0 ± 0.0
Phe
4.385PheAla: 4.385 ± 0.592
0.225PheCys: 0.225 ± 0.108
2.417PheAsp: 2.417 ± 0.391
2.361PheGlu: 2.361 ± 0.356
0.956PhePhe: 0.956 ± 0.252
3.092PheGly: 3.092 ± 0.467
0.394PheHis: 0.394 ± 0.16
1.855PheIle: 1.855 ± 0.28
1.63PheLys: 1.63 ± 0.277
2.923PheLeu: 2.923 ± 0.409
0.506PheMet: 0.506 ± 0.141
1.63PheAsn: 1.63 ± 0.328
1.63PhePro: 1.63 ± 0.42
1.237PheGln: 1.237 ± 0.252
1.799PheArg: 1.799 ± 0.367
2.417PheSer: 2.417 ± 0.347
1.743PheThr: 1.743 ± 0.406
3.036PheVal: 3.036 ± 0.372
0.618PheTrp: 0.618 ± 0.193
1.012PheTyr: 1.012 ± 0.19
0.0PheXaa: 0.0 ± 0.0
Gly
7.589GlyAla: 7.589 ± 1.074
1.012GlyCys: 1.012 ± 0.278
4.441GlyAsp: 4.441 ± 0.588
4.891GlyGlu: 4.891 ± 0.577
2.53GlyPhe: 2.53 ± 0.422
7.027GlyGly: 7.027 ± 1.13
1.518GlyHis: 1.518 ± 0.302
3.485GlyIle: 3.485 ± 0.481
3.71GlyLys: 3.71 ± 0.459
5.397GlyLeu: 5.397 ± 0.598
2.192GlyMet: 2.192 ± 0.38
3.261GlyAsn: 3.261 ± 0.468
2.53GlyPro: 2.53 ± 0.425
3.317GlyGln: 3.317 ± 0.406
5.116GlyArg: 5.116 ± 0.661
4.16GlySer: 4.16 ± 0.539
5.228GlyThr: 5.228 ± 0.72
5.116GlyVal: 5.116 ± 0.481
2.08GlyTrp: 2.08 ± 0.372
2.867GlyTyr: 2.867 ± 0.525
0.0GlyXaa: 0.0 ± 0.0
His
1.237HisAla: 1.237 ± 0.299
0.281HisCys: 0.281 ± 0.153
1.349HisAsp: 1.349 ± 0.343
1.012HisGlu: 1.012 ± 0.239
1.124HisPhe: 1.124 ± 0.351
2.08HisGly: 2.08 ± 0.463
0.562HisHis: 0.562 ± 0.201
0.956HisIle: 0.956 ± 0.224
0.787HisLys: 0.787 ± 0.202
1.518HisLeu: 1.518 ± 0.337
0.45HisMet: 0.45 ± 0.154
0.618HisAsn: 0.618 ± 0.205
1.068HisPro: 1.068 ± 0.237
0.169HisGln: 0.169 ± 0.139
1.181HisArg: 1.181 ± 0.25
0.843HisSer: 0.843 ± 0.236
0.899HisThr: 0.899 ± 0.23
1.012HisVal: 1.012 ± 0.235
0.281HisTrp: 0.281 ± 0.149
0.731HisTyr: 0.731 ± 0.19
0.0HisXaa: 0.0 ± 0.0
Ile
5.566IleAla: 5.566 ± 0.563
0.394IleCys: 0.394 ± 0.138
5.003IleAsp: 5.003 ± 0.639
4.441IleGlu: 4.441 ± 0.535
1.068IlePhe: 1.068 ± 0.335
4.722IleGly: 4.722 ± 0.505
0.956IleHis: 0.956 ± 0.275
2.867IleIle: 2.867 ± 0.386
2.811IleLys: 2.811 ± 0.422
2.867IleLeu: 2.867 ± 0.355
0.731IleMet: 0.731 ± 0.221
2.305IleAsn: 2.305 ± 0.382
3.317IlePro: 3.317 ± 0.407
1.181IleGln: 1.181 ± 0.262
3.654IleArg: 3.654 ± 0.483
2.98IleSer: 2.98 ± 0.34
2.98IleThr: 2.98 ± 0.392
3.373IleVal: 3.373 ± 0.432
0.787IleTrp: 0.787 ± 0.199
0.899IleTyr: 0.899 ± 0.234
0.0IleXaa: 0.0 ± 0.0
Lys
5.003LysAla: 5.003 ± 0.858
0.45LysCys: 0.45 ± 0.151
2.586LysAsp: 2.586 ± 0.419
2.305LysGlu: 2.305 ± 0.358
1.63LysPhe: 1.63 ± 0.316
3.261LysGly: 3.261 ± 0.402
1.181LysHis: 1.181 ± 0.281
1.687LysIle: 1.687 ± 0.266
3.204LysLys: 3.204 ± 0.434
5.678LysLeu: 5.678 ± 0.528
1.518LysMet: 1.518 ± 0.301
2.136LysAsn: 2.136 ± 0.34
2.811LysPro: 2.811 ± 0.46
2.305LysGln: 2.305 ± 0.661
3.71LysArg: 3.71 ± 0.623
2.08LysSer: 2.08 ± 0.323
3.654LysThr: 3.654 ± 0.406
3.317LysVal: 3.317 ± 0.451
0.675LysTrp: 0.675 ± 0.181
0.899LysTyr: 0.899 ± 0.242
0.0LysXaa: 0.0 ± 0.0
Leu
7.927LeuAla: 7.927 ± 0.736
0.675LeuCys: 0.675 ± 0.189
5.284LeuAsp: 5.284 ± 0.478
2.811LeuGlu: 2.811 ± 0.432
3.036LeuPhe: 3.036 ± 0.422
5.228LeuGly: 5.228 ± 0.476
1.743LeuHis: 1.743 ± 0.28
4.61LeuIle: 4.61 ± 0.529
5.172LeuLys: 5.172 ± 0.661
5.284LeuLeu: 5.284 ± 0.708
2.361LeuMet: 2.361 ± 0.401
3.317LeuAsn: 3.317 ± 0.41
4.273LeuPro: 4.273 ± 0.459
3.204LeuGln: 3.204 ± 0.655
6.015LeuArg: 6.015 ± 0.627
5.003LeuSer: 5.003 ± 0.607
5.903LeuThr: 5.903 ± 0.569
5.06LeuVal: 5.06 ± 0.484
0.731LeuTrp: 0.731 ± 0.213
2.642LeuTyr: 2.642 ± 0.444
0.0LeuXaa: 0.0 ± 0.0
Met
3.654MetAla: 3.654 ± 0.432
0.169MetCys: 0.169 ± 0.093
1.012MetAsp: 1.012 ± 0.194
1.293MetGlu: 1.293 ± 0.316
0.843MetPhe: 0.843 ± 0.248
1.743MetGly: 1.743 ± 0.302
0.506MetHis: 0.506 ± 0.167
0.899MetIle: 0.899 ± 0.283
1.462MetLys: 1.462 ± 0.303
1.799MetLeu: 1.799 ± 0.351
0.618MetMet: 0.618 ± 0.244
1.293MetAsn: 1.293 ± 0.29
1.237MetPro: 1.237 ± 0.326
1.405MetGln: 1.405 ± 0.296
1.855MetArg: 1.855 ± 0.319
1.687MetSer: 1.687 ± 0.271
1.349MetThr: 1.349 ± 0.275
1.968MetVal: 1.968 ± 0.393
0.394MetTrp: 0.394 ± 0.135
0.337MetTyr: 0.337 ± 0.134
0.0MetXaa: 0.0 ± 0.0
Asn
4.497AsnAla: 4.497 ± 0.706
0.337AsnCys: 0.337 ± 0.128
2.53AsnAsp: 2.53 ± 0.357
1.743AsnGlu: 1.743 ± 0.399
0.899AsnPhe: 0.899 ± 0.203
3.71AsnGly: 3.71 ± 0.462
0.675AsnHis: 0.675 ± 0.225
1.799AsnIle: 1.799 ± 0.33
0.843AsnLys: 0.843 ± 0.186
2.867AsnLeu: 2.867 ± 0.48
0.956AsnMet: 0.956 ± 0.263
1.124AsnAsn: 1.124 ± 0.326
2.474AsnPro: 2.474 ± 0.356
1.518AsnGln: 1.518 ± 0.326
2.698AsnArg: 2.698 ± 0.329
2.417AsnSer: 2.417 ± 0.496
2.361AsnThr: 2.361 ± 0.4
3.036AsnVal: 3.036 ± 0.49
0.843AsnTrp: 0.843 ± 0.241
1.293AsnTyr: 1.293 ± 0.308
0.0AsnXaa: 0.0 ± 0.0
Pro
5.453ProAla: 5.453 ± 0.619
0.787ProCys: 0.787 ± 0.203
3.823ProAsp: 3.823 ± 0.563
2.811ProGlu: 2.811 ± 0.442
1.799ProPhe: 1.799 ± 0.352
3.71ProGly: 3.71 ± 0.422
0.899ProHis: 0.899 ± 0.203
2.024ProIle: 2.024 ± 0.419
3.767ProLys: 3.767 ± 0.547
3.036ProLeu: 3.036 ± 0.386
0.899ProMet: 0.899 ± 0.298
1.799ProAsn: 1.799 ± 0.403
2.08ProPro: 2.08 ± 0.397
1.574ProGln: 1.574 ± 0.296
2.53ProArg: 2.53 ± 0.428
2.98ProSer: 2.98 ± 0.45
2.698ProThr: 2.698 ± 0.448
2.698ProVal: 2.698 ± 0.518
0.843ProTrp: 0.843 ± 0.258
1.349ProTyr: 1.349 ± 0.306
0.0ProXaa: 0.0 ± 0.0
Gln
5.06GlnAla: 5.06 ± 1.156
0.112GlnCys: 0.112 ± 0.077
2.08GlnAsp: 2.08 ± 0.408
2.474GlnGlu: 2.474 ± 0.456
1.349GlnPhe: 1.349 ± 0.255
2.305GlnGly: 2.305 ± 0.416
0.675GlnHis: 0.675 ± 0.216
2.867GlnIle: 2.867 ± 0.417
1.405GlnLys: 1.405 ± 0.401
2.249GlnLeu: 2.249 ± 0.482
0.956GlnMet: 0.956 ± 0.249
1.743GlnAsn: 1.743 ± 0.352
1.968GlnPro: 1.968 ± 0.329
2.586GlnGln: 2.586 ± 0.546
2.361GlnArg: 2.361 ± 0.373
2.08GlnSer: 2.08 ± 0.404
1.799GlnThr: 1.799 ± 0.293
2.811GlnVal: 2.811 ± 0.394
0.675GlnTrp: 0.675 ± 0.155
0.787GlnTyr: 0.787 ± 0.268
0.0GlnXaa: 0.0 ± 0.0
Arg
6.409ArgAla: 6.409 ± 0.648
0.394ArgCys: 0.394 ± 0.146
4.329ArgAsp: 4.329 ± 0.469
4.666ArgGlu: 4.666 ± 0.516
3.373ArgPhe: 3.373 ± 0.439
5.003ArgGly: 5.003 ± 0.579
1.237ArgHis: 1.237 ± 0.284
3.542ArgIle: 3.542 ± 0.532
3.204ArgLys: 3.204 ± 0.486
6.802ArgLeu: 6.802 ± 0.638
2.361ArgMet: 2.361 ± 0.337
2.698ArgAsn: 2.698 ± 0.338
3.092ArgPro: 3.092 ± 0.488
2.361ArgGln: 2.361 ± 0.471
4.947ArgArg: 4.947 ± 0.685
2.923ArgSer: 2.923 ± 0.389
3.148ArgThr: 3.148 ± 0.432
5.172ArgVal: 5.172 ± 0.579
1.012ArgTrp: 1.012 ± 0.271
1.63ArgTyr: 1.63 ± 0.359
0.0ArgXaa: 0.0 ± 0.0
Ser
5.903SerAla: 5.903 ± 0.645
0.056SerCys: 0.056 ± 0.055
4.497SerAsp: 4.497 ± 0.455
2.361SerGlu: 2.361 ± 0.335
1.63SerPhe: 1.63 ± 0.31
5.172SerGly: 5.172 ± 0.695
0.562SerHis: 0.562 ± 0.19
2.698SerIle: 2.698 ± 0.397
2.192SerLys: 2.192 ± 0.385
4.554SerLeu: 4.554 ± 0.58
1.518SerMet: 1.518 ± 0.387
1.743SerAsn: 1.743 ± 0.287
2.192SerPro: 2.192 ± 0.421
1.799SerGln: 1.799 ± 0.277
4.273SerArg: 4.273 ± 0.608
3.598SerSer: 3.598 ± 0.511
2.53SerThr: 2.53 ± 0.429
2.867SerVal: 2.867 ± 0.438
1.012SerTrp: 1.012 ± 0.277
2.024SerTyr: 2.024 ± 0.323
0.0SerXaa: 0.0 ± 0.0
Thr
5.903ThrAla: 5.903 ± 0.612
0.281ThrCys: 0.281 ± 0.134
3.373ThrAsp: 3.373 ± 0.457
2.698ThrGlu: 2.698 ± 0.501
2.024ThrPhe: 2.024 ± 0.346
4.273ThrGly: 4.273 ± 0.652
0.675ThrHis: 0.675 ± 0.229
3.317ThrIle: 3.317 ± 0.509
3.092ThrLys: 3.092 ± 0.363
4.61ThrLeu: 4.61 ± 0.414
1.068ThrMet: 1.068 ± 0.229
2.192ThrAsn: 2.192 ± 0.411
3.092ThrPro: 3.092 ± 0.496
2.417ThrGln: 2.417 ± 0.396
3.654ThrArg: 3.654 ± 0.503
2.417ThrSer: 2.417 ± 0.336
3.429ThrThr: 3.429 ± 0.536
4.554ThrVal: 4.554 ± 0.572
0.843ThrTrp: 0.843 ± 0.223
1.349ThrTyr: 1.349 ± 0.297
0.0ThrXaa: 0.0 ± 0.0
Val
8.208ValAla: 8.208 ± 0.495
0.731ValCys: 0.731 ± 0.213
3.598ValAsp: 3.598 ± 0.528
4.722ValGlu: 4.722 ± 0.692
3.148ValPhe: 3.148 ± 0.393
4.273ValGly: 4.273 ± 0.551
1.574ValHis: 1.574 ± 0.397
3.935ValIle: 3.935 ± 0.492
3.092ValLys: 3.092 ± 0.458
4.891ValLeu: 4.891 ± 0.486
1.462ValMet: 1.462 ± 0.316
2.698ValAsn: 2.698 ± 0.517
3.429ValPro: 3.429 ± 0.421
2.361ValGln: 2.361 ± 0.494
3.991ValArg: 3.991 ± 0.444
2.586ValSer: 2.586 ± 0.384
4.104ValThr: 4.104 ± 0.467
4.385ValVal: 4.385 ± 0.642
1.63ValTrp: 1.63 ± 0.31
1.574ValTyr: 1.574 ± 0.316
0.0ValXaa: 0.0 ± 0.0
Trp
1.462TrpAla: 1.462 ± 0.293
0.281TrpCys: 0.281 ± 0.126
1.181TrpAsp: 1.181 ± 0.397
0.843TrpGlu: 0.843 ± 0.25
0.843TrpPhe: 0.843 ± 0.234
1.012TrpGly: 1.012 ± 0.24
0.675TrpHis: 0.675 ± 0.278
0.899TrpIle: 0.899 ± 0.193
0.787TrpLys: 0.787 ± 0.232
2.192TrpLeu: 2.192 ± 0.428
0.337TrpMet: 0.337 ± 0.14
0.731TrpAsn: 0.731 ± 0.229
0.787TrpPro: 0.787 ± 0.209
0.731TrpGln: 0.731 ± 0.202
1.349TrpArg: 1.349 ± 0.349
1.349TrpSer: 1.349 ± 0.335
0.731TrpThr: 0.731 ± 0.188
1.068TrpVal: 1.068 ± 0.21
0.562TrpTrp: 0.562 ± 0.237
0.506TrpTyr: 0.506 ± 0.15
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.417TyrAla: 2.417 ± 0.355
0.506TyrCys: 0.506 ± 0.156
2.53TyrAsp: 2.53 ± 0.426
1.012TyrGlu: 1.012 ± 0.258
1.124TyrPhe: 1.124 ± 0.352
1.968TyrGly: 1.968 ± 0.404
0.562TyrHis: 0.562 ± 0.161
1.293TyrIle: 1.293 ± 0.345
0.899TyrLys: 0.899 ± 0.223
2.642TyrLeu: 2.642 ± 0.337
0.675TyrMet: 0.675 ± 0.208
1.124TyrAsn: 1.124 ± 0.252
1.518TyrPro: 1.518 ± 0.293
0.843TyrGln: 0.843 ± 0.188
1.968TyrArg: 1.968 ± 0.345
1.349TyrSer: 1.349 ± 0.294
2.024TyrThr: 2.024 ± 0.319
1.518TyrVal: 1.518 ± 0.331
0.843TyrTrp: 0.843 ± 0.253
1.012TyrTyr: 1.012 ± 0.254
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 78 proteins (17789 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski