Amino acid dipepetide frequency for Leucobacter sp. G161

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.686AlaAla: 20.686 ± 0.204
0.689AlaCys: 0.689 ± 0.026
7.487AlaAsp: 7.487 ± 0.085
9.143AlaGlu: 9.143 ± 0.109
3.976AlaPhe: 3.976 ± 0.067
12.344AlaGly: 12.344 ± 0.123
2.58AlaHis: 2.58 ± 0.058
6.276AlaIle: 6.276 ± 0.084
3.138AlaLys: 3.138 ± 0.071
14.265AlaLeu: 14.265 ± 0.156
2.729AlaMet: 2.729 ± 0.053
2.58AlaAsn: 2.58 ± 0.048
6.188AlaPro: 6.188 ± 0.097
4.105AlaGln: 4.105 ± 0.069
8.319AlaArg: 8.319 ± 0.122
7.056AlaSer: 7.056 ± 0.082
7.449AlaThr: 7.449 ± 0.09
10.825AlaVal: 10.825 ± 0.122
1.671AlaTrp: 1.671 ± 0.043
2.225AlaTyr: 2.225 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.72CysAla: 0.72 ± 0.03
0.052CysCys: 0.052 ± 0.007
0.328CysAsp: 0.328 ± 0.019
0.302CysGlu: 0.302 ± 0.017
0.174CysPhe: 0.174 ± 0.014
0.596CysGly: 0.596 ± 0.025
0.099CysHis: 0.099 ± 0.009
0.197CysIle: 0.197 ± 0.013
0.069CysLys: 0.069 ± 0.009
0.425CysLeu: 0.425 ± 0.019
0.1CysMet: 0.1 ± 0.011
0.113CysAsn: 0.113 ± 0.011
0.228CysPro: 0.228 ± 0.015
0.124CysGln: 0.124 ± 0.01
0.302CysArg: 0.302 ± 0.018
0.356CysSer: 0.356 ± 0.019
0.324CysThr: 0.324 ± 0.018
0.432CysVal: 0.432 ± 0.018
0.06CysTrp: 0.06 ± 0.009
0.109CysTyr: 0.109 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.676AspAla: 7.676 ± 0.097
0.239AspCys: 0.239 ± 0.015
3.19AspAsp: 3.19 ± 0.07
4.038AspGlu: 4.038 ± 0.067
1.817AspPhe: 1.817 ± 0.042
5.343AspGly: 5.343 ± 0.087
1.133AspHis: 1.133 ± 0.042
2.339AspIle: 2.339 ± 0.054
1.023AspLys: 1.023 ± 0.035
5.49AspLeu: 5.49 ± 0.074
0.871AspMet: 0.871 ± 0.032
0.979AspAsn: 0.979 ± 0.036
3.876AspPro: 3.876 ± 0.071
1.38AspGln: 1.38 ± 0.043
4.054AspArg: 4.054 ± 0.067
2.769AspSer: 2.769 ± 0.059
3.186AspThr: 3.186 ± 0.072
4.43AspVal: 4.43 ± 0.066
0.836AspTrp: 0.836 ± 0.029
1.188AspTyr: 1.188 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
7.668GluAla: 7.668 ± 0.102
0.277GluCys: 0.277 ± 0.015
2.763GluAsp: 2.763 ± 0.057
3.235GluGlu: 3.235 ± 0.072
2.06GluPhe: 2.06 ± 0.05
4.307GluGly: 4.307 ± 0.079
1.642GluHis: 1.642 ± 0.046
3.249GluIle: 3.249 ± 0.066
1.412GluLys: 1.412 ± 0.048
7.737GluLeu: 7.737 ± 0.092
1.199GluMet: 1.199 ± 0.033
1.357GluAsn: 1.357 ± 0.037
3.034GluPro: 3.034 ± 0.061
2.721GluGln: 2.721 ± 0.058
5.585GluArg: 5.585 ± 0.085
3.177GluSer: 3.177 ± 0.058
3.489GluThr: 3.489 ± 0.061
4.757GluVal: 4.757 ± 0.074
0.914GluTrp: 0.914 ± 0.034
1.238GluTyr: 1.238 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
4.529PheAla: 4.529 ± 0.072
0.201PheCys: 0.201 ± 0.016
2.289PheAsp: 2.289 ± 0.046
1.992PheGlu: 1.992 ± 0.055
1.162PhePhe: 1.162 ± 0.036
3.664PheGly: 3.664 ± 0.071
0.509PheHis: 0.509 ± 0.023
1.398PheIle: 1.398 ± 0.044
0.583PheLys: 0.583 ± 0.024
2.849PheLeu: 2.849 ± 0.06
0.548PheMet: 0.548 ± 0.026
0.771PheAsn: 0.771 ± 0.029
1.44PhePro: 1.44 ± 0.038
0.802PheGln: 0.802 ± 0.029
1.657PheArg: 1.657 ± 0.043
1.99PheSer: 1.99 ± 0.055
2.38PheThr: 2.38 ± 0.059
2.793PheVal: 2.793 ± 0.048
0.498PheTrp: 0.498 ± 0.024
0.614PheTyr: 0.614 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
11.225GlyAla: 11.225 ± 0.124
0.537GlyCys: 0.537 ± 0.025
4.883GlyAsp: 4.883 ± 0.074
5.627GlyGlu: 5.627 ± 0.077
3.432GlyPhe: 3.432 ± 0.06
8.073GlyGly: 8.073 ± 0.133
1.724GlyHis: 1.724 ± 0.045
4.894GlyIle: 4.894 ± 0.073
2.578GlyLys: 2.578 ± 0.067
9.083GlyLeu: 9.083 ± 0.108
1.995GlyMet: 1.995 ± 0.049
1.906GlyAsn: 1.906 ± 0.054
3.615GlyPro: 3.615 ± 0.07
2.578GlyGln: 2.578 ± 0.048
5.383GlyArg: 5.383 ± 0.073
5.769GlySer: 5.769 ± 0.08
5.48GlyThr: 5.48 ± 0.081
7.937GlyVal: 7.937 ± 0.105
1.559GlyTrp: 1.559 ± 0.046
2.234GlyTyr: 2.234 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.438HisAla: 2.438 ± 0.053
0.12HisCys: 0.12 ± 0.013
1.21HisAsp: 1.21 ± 0.04
1.257HisGlu: 1.257 ± 0.037
0.63HisPhe: 0.63 ± 0.026
1.95HisGly: 1.95 ± 0.045
0.494HisHis: 0.494 ± 0.025
0.786HisIle: 0.786 ± 0.024
0.317HisLys: 0.317 ± 0.02
1.971HisLeu: 1.971 ± 0.044
0.347HisMet: 0.347 ± 0.018
0.369HisAsn: 0.369 ± 0.02
1.4HisPro: 1.4 ± 0.046
0.542HisGln: 0.542 ± 0.026
1.47HisArg: 1.47 ± 0.039
1.148HisSer: 1.148 ± 0.043
1.233HisThr: 1.233 ± 0.038
1.416HisVal: 1.416 ± 0.038
0.284HisTrp: 0.284 ± 0.018
0.406HisTyr: 0.406 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
7.529IleAla: 7.529 ± 0.093
0.244IleCys: 0.244 ± 0.016
3.263IleAsp: 3.263 ± 0.054
3.125IleGlu: 3.125 ± 0.068
1.22IlePhe: 1.22 ± 0.04
4.804IleGly: 4.804 ± 0.073
0.82IleHis: 0.82 ± 0.032
2.168IleIle: 2.168 ± 0.053
0.849IleLys: 0.849 ± 0.035
3.869IleLeu: 3.869 ± 0.078
0.806IleMet: 0.806 ± 0.029
1.002IleAsn: 1.002 ± 0.032
2.517IlePro: 2.517 ± 0.049
1.028IleGln: 1.028 ± 0.03
2.699IleArg: 2.699 ± 0.051
2.696IleSer: 2.696 ± 0.051
3.245IleThr: 3.245 ± 0.055
4.728IleVal: 4.728 ± 0.085
0.507IleTrp: 0.507 ± 0.022
0.774IleTyr: 0.774 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
2.292LysAla: 2.292 ± 0.061
0.078LysCys: 0.078 ± 0.009
1.082LysAsp: 1.082 ± 0.044
1.02LysGlu: 1.02 ± 0.035
0.597LysPhe: 0.597 ± 0.029
1.621LysGly: 1.621 ± 0.045
0.566LysHis: 0.566 ± 0.026
1.155LysIle: 1.155 ± 0.04
0.862LysLys: 0.862 ± 0.037
2.489LysLeu: 2.489 ± 0.062
0.486LysMet: 0.486 ± 0.023
0.622LysAsn: 0.622 ± 0.026
1.398LysPro: 1.398 ± 0.044
0.934LysGln: 0.934 ± 0.035
1.844LysArg: 1.844 ± 0.046
1.304LysSer: 1.304 ± 0.04
1.434LysThr: 1.434 ± 0.041
1.737LysVal: 1.737 ± 0.045
0.29LysTrp: 0.29 ± 0.018
0.483LysTyr: 0.483 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
15.036LeuAla: 15.036 ± 0.183
0.539LeuCys: 0.539 ± 0.023
6.032LeuAsp: 6.032 ± 0.09
5.639LeuGlu: 5.639 ± 0.091
3.099LeuPhe: 3.099 ± 0.066
9.821LeuGly: 9.821 ± 0.117
1.813LeuHis: 1.813 ± 0.044
4.849LeuIle: 4.849 ± 0.082
1.959LeuLys: 1.959 ± 0.05
10.716LeuLeu: 10.716 ± 0.156
1.824LeuMet: 1.824 ± 0.044
1.982LeuAsn: 1.982 ± 0.05
5.647LeuPro: 5.647 ± 0.083
2.61LeuGln: 2.61 ± 0.055
7.187LeuArg: 7.187 ± 0.108
6.35LeuSer: 6.35 ± 0.089
6.919LeuThr: 6.919 ± 0.087
8.955LeuVal: 8.955 ± 0.123
1.234LeuTrp: 1.234 ± 0.033
1.536LeuTyr: 1.536 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
1.992MetAla: 1.992 ± 0.049
0.1MetCys: 0.1 ± 0.01
0.769MetAsp: 0.769 ± 0.029
0.694MetGlu: 0.694 ± 0.025
0.597MetPhe: 0.597 ± 0.028
1.375MetGly: 1.375 ± 0.038
0.425MetHis: 0.425 ± 0.022
0.931MetIle: 0.931 ± 0.034
0.467MetLys: 0.467 ± 0.022
2.369MetLeu: 2.369 ± 0.051
0.364MetMet: 0.364 ± 0.018
0.663MetAsn: 0.663 ± 0.025
1.123MetPro: 1.123 ± 0.037
0.646MetGln: 0.646 ± 0.025
1.532MetArg: 1.532 ± 0.043
1.636MetSer: 1.636 ± 0.045
1.604MetThr: 1.604 ± 0.049
1.391MetVal: 1.391 ± 0.036
0.217MetTrp: 0.217 ± 0.014
0.342MetTyr: 0.342 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.757AsnAla: 2.757 ± 0.055
0.126AsnCys: 0.126 ± 0.01
1.194AsnAsp: 1.194 ± 0.036
1.222AsnGlu: 1.222 ± 0.038
0.681AsnPhe: 0.681 ± 0.023
1.973AsnGly: 1.973 ± 0.044
0.386AsnHis: 0.386 ± 0.022
0.945AsnIle: 0.945 ± 0.03
0.462AsnLys: 0.462 ± 0.024
1.963AsnLeu: 1.963 ± 0.048
0.401AsnMet: 0.401 ± 0.021
0.467AsnAsn: 0.467 ± 0.021
1.656AsnPro: 1.656 ± 0.043
0.651AsnGln: 0.651 ± 0.027
1.309AsnArg: 1.309 ± 0.042
1.193AsnSer: 1.193 ± 0.047
1.421AsnThr: 1.421 ± 0.046
1.835AsnVal: 1.835 ± 0.042
0.338AsnTrp: 0.338 ± 0.02
0.483AsnTyr: 0.483 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
6.924ProAla: 6.924 ± 0.106
0.183ProCys: 0.183 ± 0.012
3.13ProAsp: 3.13 ± 0.057
4.45ProGlu: 4.45 ± 0.075
1.615ProPhe: 1.615 ± 0.046
5.024ProGly: 5.024 ± 0.085
1.091ProHis: 1.091 ± 0.035
2.264ProIle: 2.264 ± 0.04
1.329ProLys: 1.329 ± 0.039
4.879ProLeu: 4.879 ± 0.089
0.866ProMet: 0.866 ± 0.032
1.258ProAsn: 1.258 ± 0.038
2.024ProPro: 2.024 ± 0.06
1.633ProGln: 1.633 ± 0.043
3.02ProArg: 3.02 ± 0.059
2.854ProSer: 2.854 ± 0.059
3.068ProThr: 3.068 ± 0.067
4.679ProVal: 4.679 ± 0.065
0.712ProTrp: 0.712 ± 0.026
0.905ProTyr: 0.905 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.802GlnAla: 3.802 ± 0.069
0.122GlnCys: 0.122 ± 0.011
1.26GlnAsp: 1.26 ± 0.033
1.524GlnGlu: 1.524 ± 0.042
0.921GlnPhe: 0.921 ± 0.029
2.194GlnGly: 2.194 ± 0.046
0.771GlnHis: 0.771 ± 0.031
1.539GlnIle: 1.539 ± 0.038
0.629GlnLys: 0.629 ± 0.026
3.785GlnLeu: 3.785 ± 0.067
0.591GlnMet: 0.591 ± 0.025
0.651GlnAsn: 0.651 ± 0.028
1.686GlnPro: 1.686 ± 0.043
1.409GlnGln: 1.409 ± 0.041
2.613GlnArg: 2.613 ± 0.053
1.629GlnSer: 1.629 ± 0.043
1.533GlnThr: 1.533 ± 0.037
2.257GlnVal: 2.257 ± 0.047
0.437GlnTrp: 0.437 ± 0.022
0.594GlnTyr: 0.594 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
8.481ArgAla: 8.481 ± 0.108
0.303ArgCys: 0.303 ± 0.017
3.918ArgAsp: 3.918 ± 0.066
4.775ArgGlu: 4.775 ± 0.074
2.368ArgPhe: 2.368 ± 0.048
5.462ArgGly: 5.462 ± 0.083
1.261ArgHis: 1.261 ± 0.04
3.573ArgIle: 3.573 ± 0.068
1.531ArgLys: 1.531 ± 0.046
6.627ArgLeu: 6.627 ± 0.098
1.573ArgMet: 1.573 ± 0.041
1.351ArgAsn: 1.351 ± 0.034
3.136ArgPro: 3.136 ± 0.058
1.912ArgGln: 1.912 ± 0.046
5.056ArgArg: 5.056 ± 0.094
4.036ArgSer: 4.036 ± 0.07
3.82ArgThr: 3.82 ± 0.057
5.808ArgVal: 5.808 ± 0.077
1.026ArgTrp: 1.026 ± 0.03
1.394ArgTyr: 1.394 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
7.232SerAla: 7.232 ± 0.085
0.287SerCys: 0.287 ± 0.018
3.173SerAsp: 3.173 ± 0.072
3.47SerGlu: 3.47 ± 0.057
2.143SerPhe: 2.143 ± 0.051
6.24SerGly: 6.24 ± 0.087
1.081SerHis: 1.081 ± 0.033
2.63SerIle: 2.63 ± 0.051
1.375SerLys: 1.375 ± 0.039
5.7SerLeu: 5.7 ± 0.078
1.244SerMet: 1.244 ± 0.039
1.255SerAsn: 1.255 ± 0.036
3.044SerPro: 3.044 ± 0.055
1.656SerGln: 1.656 ± 0.039
3.745SerArg: 3.745 ± 0.067
3.318SerSer: 3.318 ± 0.066
3.385SerThr: 3.385 ± 0.064
4.74SerVal: 4.74 ± 0.068
0.924SerTrp: 0.924 ± 0.029
1.277SerTyr: 1.277 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
7.802ThrAla: 7.802 ± 0.099
0.274ThrCys: 0.274 ± 0.017
3.259ThrAsp: 3.259 ± 0.067
3.617ThrGlu: 3.617 ± 0.064
1.921ThrPhe: 1.921 ± 0.05
6.005ThrGly: 6.005 ± 0.085
1.262ThrHis: 1.262 ± 0.037
2.849ThrIle: 2.849 ± 0.062
1.362ThrLys: 1.362 ± 0.045
6.641ThrLeu: 6.641 ± 0.093
1.073ThrMet: 1.073 ± 0.032
1.282ThrAsn: 1.282 ± 0.043
3.931ThrPro: 3.931 ± 0.071
1.826ThrGln: 1.826 ± 0.045
3.631ThrArg: 3.631 ± 0.059
3.427ThrSer: 3.427 ± 0.062
3.536ThrThr: 3.536 ± 0.068
5.813ThrVal: 5.813 ± 0.096
0.768ThrTrp: 0.768 ± 0.033
1.062ThrTyr: 1.062 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
11.087ValAla: 11.087 ± 0.132
0.497ValCys: 0.497 ± 0.023
4.74ValAsp: 4.74 ± 0.079
4.777ValGlu: 4.777 ± 0.062
2.979ValPhe: 2.979 ± 0.067
6.759ValGly: 6.759 ± 0.104
1.534ValHis: 1.534 ± 0.042
4.4ValIle: 4.4 ± 0.069
1.684ValLys: 1.684 ± 0.05
9.22ValLeu: 9.22 ± 0.123
1.61ValMet: 1.61 ± 0.046
1.999ValAsn: 1.999 ± 0.049
4.337ValPro: 4.337 ± 0.065
2.28ValGln: 2.28 ± 0.047
5.479ValArg: 5.479 ± 0.102
5.296ValSer: 5.296 ± 0.072
5.936ValThr: 5.936 ± 0.084
7.372ValVal: 7.372 ± 0.109
1.082ValTrp: 1.082 ± 0.03
1.411ValTyr: 1.411 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.576TrpAla: 1.576 ± 0.039
0.109TrpCys: 0.109 ± 0.01
0.718TrpAsp: 0.718 ± 0.028
0.711TrpGlu: 0.711 ± 0.026
0.57TrpPhe: 0.57 ± 0.025
1.079TrpGly: 1.079 ± 0.032
0.282TrpHis: 0.282 ± 0.017
0.746TrpIle: 0.746 ± 0.029
0.318TrpLys: 0.318 ± 0.018
1.662TrpLeu: 1.662 ± 0.047
0.321TrpMet: 0.321 ± 0.02
0.432TrpAsn: 0.432 ± 0.02
0.641TrpPro: 0.641 ± 0.027
0.568TrpGln: 0.568 ± 0.025
1.049TrpArg: 1.049 ± 0.031
0.794TrpSer: 0.794 ± 0.032
0.733TrpThr: 0.733 ± 0.028
1.084TrpVal: 1.084 ± 0.036
0.296TrpTrp: 0.296 ± 0.018
0.25TrpTyr: 0.25 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.28TyrAla: 2.28 ± 0.047
0.133TyrCys: 0.133 ± 0.01
1.17TyrAsp: 1.17 ± 0.04
1.203TyrGlu: 1.203 ± 0.036
0.708TyrPhe: 0.708 ± 0.026
1.879TyrGly: 1.879 ± 0.039
0.315TyrHis: 0.315 ± 0.019
0.704TyrIle: 0.704 ± 0.028
0.347TyrLys: 0.347 ± 0.018
2.006TyrLeu: 2.006 ± 0.045
0.288TyrMet: 0.288 ± 0.016
0.423TyrAsn: 0.423 ± 0.019
0.989TyrPro: 0.989 ± 0.03
0.541TyrGln: 0.541 ± 0.022
1.477TyrArg: 1.477 ± 0.039
1.12TyrSer: 1.12 ± 0.036
1.167TyrThr: 1.167 ± 0.04
1.489TyrVal: 1.489 ± 0.042
0.286TyrTrp: 0.286 ± 0.018
0.406TyrTyr: 0.406 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3093 proteins (999509 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski