Amino acid dipepetide frequency for Golden Marseillevirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.099AlaAla: 3.099 ± 0.277
1.351AlaCys: 1.351 ± 0.166
2.184AlaAsp: 2.184 ± 0.155
3.631AlaGlu: 3.631 ± 0.208
3.208AlaPhe: 3.208 ± 0.212
2.498AlaGly: 2.498 ± 0.236
1.065AlaHis: 1.065 ± 0.102
2.525AlaIle: 2.525 ± 0.201
4.955AlaLys: 4.955 ± 0.308
4.969AlaLeu: 4.969 ± 0.317
1.01AlaMet: 1.01 ± 0.124
1.952AlaAsn: 1.952 ± 0.177
1.938AlaPro: 1.938 ± 0.173
2.007AlaGln: 2.007 ± 0.16
2.798AlaArg: 2.798 ± 0.206
3.904AlaSer: 3.904 ± 0.305
2.662AlaThr: 2.662 ± 0.235
3.89AlaVal: 3.89 ± 0.211
0.614AlaTrp: 0.614 ± 0.094
1.802AlaTyr: 1.802 ± 0.18
0.0AlaXaa: 0.0 ± 0.0
Cys
1.215CysAla: 1.215 ± 0.141
0.819CysCys: 0.819 ± 0.11
1.215CysAsp: 1.215 ± 0.133
1.433CysGlu: 1.433 ± 0.188
1.747CysPhe: 1.747 ± 0.193
1.734CysGly: 1.734 ± 0.21
0.56CysHis: 0.56 ± 0.098
1.106CysIle: 1.106 ± 0.119
1.884CysLys: 1.884 ± 0.182
2.621CysLeu: 2.621 ± 0.172
0.45CysMet: 0.45 ± 0.075
0.915CysAsn: 0.915 ± 0.116
1.679CysPro: 1.679 ± 0.177
0.969CysGln: 0.969 ± 0.114
1.638CysArg: 1.638 ± 0.159
2.703CysSer: 2.703 ± 0.228
1.051CysThr: 1.051 ± 0.119
1.529CysVal: 1.529 ± 0.162
0.341CysTrp: 0.341 ± 0.065
0.723CysTyr: 0.723 ± 0.115
0.0CysXaa: 0.0 ± 0.0
Asp
2.785AspAla: 2.785 ± 0.203
1.433AspCys: 1.433 ± 0.176
2.321AspAsp: 2.321 ± 0.188
4.423AspGlu: 4.423 ± 0.288
2.976AspPhe: 2.976 ± 0.179
3.331AspGly: 3.331 ± 0.22
0.71AspHis: 0.71 ± 0.1
3.126AspIle: 3.126 ± 0.173
3.904AspLys: 3.904 ± 0.222
3.918AspLeu: 3.918 ± 0.249
0.969AspMet: 0.969 ± 0.103
1.529AspAsn: 1.529 ± 0.136
1.802AspPro: 1.802 ± 0.179
1.31AspGln: 1.31 ± 0.157
2.252AspArg: 2.252 ± 0.195
3.276AspSer: 3.276 ± 0.198
1.966AspThr: 1.966 ± 0.17
3.235AspVal: 3.235 ± 0.199
0.696AspTrp: 0.696 ± 0.089
1.556AspTyr: 1.556 ± 0.182
0.0AspXaa: 0.0 ± 0.0
Glu
3.672GluAla: 3.672 ± 0.196
1.27GluCys: 1.27 ± 0.139
3.795GluAsp: 3.795 ± 0.265
7.781GluGlu: 7.781 ± 0.508
4.163GluPhe: 4.163 ± 0.233
3.781GluGly: 3.781 ± 0.224
1.283GluHis: 1.283 ± 0.144
4.273GluIle: 4.273 ± 0.251
9.378GluLys: 9.378 ± 0.523
5.679GluLeu: 5.679 ± 0.302
2.089GluMet: 2.089 ± 0.18
3.426GluAsn: 3.426 ± 0.223
1.706GluPro: 1.706 ± 0.155
2.867GluGln: 2.867 ± 0.218
5.474GluArg: 5.474 ± 0.316
3.863GluSer: 3.863 ± 0.285
4.546GluThr: 4.546 ± 0.272
4.191GluVal: 4.191 ± 0.24
1.27GluTrp: 1.27 ± 0.184
2.566GluTyr: 2.566 ± 0.173
0.0GluXaa: 0.0 ± 0.0
Phe
4.027PheAla: 4.027 ± 0.223
2.362PheCys: 2.362 ± 0.273
2.744PheAsp: 2.744 ± 0.187
4.286PheGlu: 4.286 ± 0.237
3.222PhePhe: 3.222 ± 0.209
4.123PheGly: 4.123 ± 0.229
1.283PheHis: 1.283 ± 0.134
1.979PheIle: 1.979 ± 0.171
2.089PheLys: 2.089 ± 0.181
6.32PheLeu: 6.32 ± 0.343
1.147PheMet: 1.147 ± 0.156
1.037PheAsn: 1.037 ± 0.122
2.539PhePro: 2.539 ± 0.175
1.734PheGln: 1.734 ± 0.142
2.976PheArg: 2.976 ± 0.22
5.351PheSer: 5.351 ± 0.291
2.184PheThr: 2.184 ± 0.183
5.051PheVal: 5.051 ± 0.278
1.065PheTrp: 1.065 ± 0.132
1.979PheTyr: 1.979 ± 0.19
0.0PheXaa: 0.0 ± 0.0
Gly
2.73GlyAla: 2.73 ± 0.231
1.638GlyCys: 1.638 ± 0.157
2.839GlyAsp: 2.839 ± 0.21
4.423GlyGlu: 4.423 ± 0.284
2.676GlyPhe: 2.676 ± 0.168
2.525GlyGly: 2.525 ± 0.25
1.229GlyHis: 1.229 ± 0.151
3.522GlyIle: 3.522 ± 0.262
6.402GlyLys: 6.402 ± 0.325
4.082GlyLeu: 4.082 ± 0.259
1.433GlyMet: 1.433 ± 0.139
2.512GlyAsn: 2.512 ± 0.168
1.502GlyPro: 1.502 ± 0.161
2.293GlyGln: 2.293 ± 0.237
3.222GlyArg: 3.222 ± 0.205
3.74GlySer: 3.74 ± 0.266
3.754GlyThr: 3.754 ± 0.311
3.918GlyVal: 3.918 ± 0.222
0.874GlyTrp: 0.874 ± 0.118
2.362GlyTyr: 2.362 ± 0.152
0.0GlyXaa: 0.0 ± 0.0
His
0.915HisAla: 0.915 ± 0.125
0.683HisCys: 0.683 ± 0.109
0.56HisAsp: 0.56 ± 0.092
1.188HisGlu: 1.188 ± 0.154
1.283HisPhe: 1.283 ± 0.139
1.283HisGly: 1.283 ± 0.149
0.396HisHis: 0.396 ± 0.076
1.106HisIle: 1.106 ± 0.135
1.652HisLys: 1.652 ± 0.155
1.706HisLeu: 1.706 ± 0.172
0.437HisMet: 0.437 ± 0.088
0.792HisAsn: 0.792 ± 0.083
0.833HisPro: 0.833 ± 0.113
0.601HisGln: 0.601 ± 0.101
1.283HisArg: 1.283 ± 0.145
1.392HisSer: 1.392 ± 0.145
0.874HisThr: 0.874 ± 0.112
1.065HisVal: 1.065 ± 0.123
0.177HisTrp: 0.177 ± 0.043
0.532HisTyr: 0.532 ± 0.08
0.0HisXaa: 0.0 ± 0.0
Ile
2.757IleAla: 2.757 ± 0.178
1.283IleCys: 1.283 ± 0.167
2.266IleAsp: 2.266 ± 0.2
2.99IleGlu: 2.99 ± 0.223
3.153IlePhe: 3.153 ± 0.216
2.553IleGly: 2.553 ± 0.203
0.819IleHis: 0.819 ± 0.111
2.211IleIle: 2.211 ± 0.207
3.235IleLys: 3.235 ± 0.239
5.433IleLeu: 5.433 ± 0.26
0.956IleMet: 0.956 ± 0.114
1.461IleAsn: 1.461 ± 0.145
2.635IlePro: 2.635 ± 0.151
1.925IleGln: 1.925 ± 0.178
2.73IleArg: 2.73 ± 0.19
4.71IleSer: 4.71 ± 0.255
2.089IleThr: 2.089 ± 0.222
3.29IleVal: 3.29 ± 0.221
0.819IleTrp: 0.819 ± 0.109
1.242IleTyr: 1.242 ± 0.118
0.0IleXaa: 0.0 ± 0.0
Lys
3.931LysAla: 3.931 ± 0.279
1.406LysCys: 1.406 ± 0.171
4.778LysAsp: 4.778 ± 0.213
8.15LysGlu: 8.15 ± 0.444
3.795LysPhe: 3.795 ± 0.248
4.737LysGly: 4.737 ± 0.224
1.761LysHis: 1.761 ± 0.17
4.396LysIle: 4.396 ± 0.279
10.088LysLys: 10.088 ± 0.565
6.238LysLeu: 6.238 ± 0.384
2.13LysMet: 2.13 ± 0.202
4.0LysAsn: 4.0 ± 0.269
2.498LysPro: 2.498 ± 0.199
3.044LysGln: 3.044 ± 0.217
5.883LysArg: 5.883 ± 0.316
5.174LysSer: 5.174 ± 0.287
5.242LysThr: 5.242 ± 0.263
4.969LysVal: 4.969 ± 0.323
0.997LysTrp: 0.997 ± 0.182
3.372LysTyr: 3.372 ± 0.237
0.0LysXaa: 0.0 ± 0.0
Leu
4.983LeuAla: 4.983 ± 0.277
3.112LeuCys: 3.112 ± 0.231
4.382LeuAsp: 4.382 ± 0.235
6.894LeuGlu: 6.894 ± 0.367
6.156LeuPhe: 6.156 ± 0.325
4.532LeuGly: 4.532 ± 0.243
1.816LeuHis: 1.816 ± 0.159
2.757LeuIle: 2.757 ± 0.193
5.624LeuLys: 5.624 ± 0.296
8.9LeuLeu: 8.9 ± 0.402
1.693LeuMet: 1.693 ± 0.166
2.812LeuAsn: 2.812 ± 0.194
4.464LeuPro: 4.464 ± 0.268
4.123LeuGln: 4.123 ± 0.363
4.559LeuArg: 4.559 ± 0.265
8.477LeuSer: 8.477 ± 0.343
3.59LeuThr: 3.59 ± 0.218
6.047LeuVal: 6.047 ± 0.281
2.116LeuTrp: 2.116 ± 0.173
2.635LeuTyr: 2.635 ± 0.207
0.0LeuXaa: 0.0 ± 0.0
Met
1.27MetAla: 1.27 ± 0.131
0.423MetCys: 0.423 ± 0.083
1.16MetAsp: 1.16 ± 0.14
1.679MetGlu: 1.679 ± 0.151
1.147MetPhe: 1.147 ± 0.119
1.488MetGly: 1.488 ± 0.143
0.41MetHis: 0.41 ± 0.077
0.792MetIle: 0.792 ± 0.114
1.447MetLys: 1.447 ± 0.139
1.611MetLeu: 1.611 ± 0.149
0.587MetMet: 0.587 ± 0.096
0.928MetAsn: 0.928 ± 0.098
0.737MetPro: 0.737 ± 0.094
1.188MetGln: 1.188 ± 0.151
1.174MetArg: 1.174 ± 0.119
2.225MetSer: 2.225 ± 0.186
1.174MetThr: 1.174 ± 0.142
1.051MetVal: 1.051 ± 0.132
0.205MetTrp: 0.205 ± 0.044
0.56MetTyr: 0.56 ± 0.086
0.0MetXaa: 0.0 ± 0.0
Asn
2.034AsnAla: 2.034 ± 0.162
0.846AsnCys: 0.846 ± 0.127
1.242AsnAsp: 1.242 ± 0.126
2.17AsnGlu: 2.17 ± 0.178
2.839AsnPhe: 2.839 ± 0.188
2.976AsnGly: 2.976 ± 0.219
0.437AsnHis: 0.437 ± 0.081
3.112AsnIle: 3.112 ± 0.281
2.839AsnLys: 2.839 ± 0.203
3.576AsnLeu: 3.576 ± 0.203
0.928AsnMet: 0.928 ± 0.114
1.502AsnAsn: 1.502 ± 0.151
2.321AsnPro: 2.321 ± 0.196
0.915AsnGln: 0.915 ± 0.109
1.679AsnArg: 1.679 ± 0.154
3.071AsnSer: 3.071 ± 0.224
2.198AsnThr: 2.198 ± 0.286
2.58AsnVal: 2.58 ± 0.195
0.519AsnTrp: 0.519 ± 0.086
1.365AsnTyr: 1.365 ± 0.147
0.0AsnXaa: 0.0 ± 0.0
Pro
1.392ProAla: 1.392 ± 0.154
1.01ProCys: 1.01 ± 0.125
1.993ProAsp: 1.993 ± 0.164
3.863ProGlu: 3.863 ± 0.238
2.034ProPhe: 2.034 ± 0.18
1.938ProGly: 1.938 ± 0.168
0.696ProHis: 0.696 ± 0.09
1.706ProIle: 1.706 ± 0.168
3.413ProLys: 3.413 ± 0.261
3.522ProLeu: 3.522 ± 0.273
0.792ProMet: 0.792 ± 0.1
1.87ProAsn: 1.87 ± 0.164
1.857ProPro: 1.857 ± 0.196
2.075ProGln: 2.075 ± 0.178
2.007ProArg: 2.007 ± 0.219
3.413ProSer: 3.413 ± 0.72
2.457ProThr: 2.457 ± 0.228
2.443ProVal: 2.443 ± 0.206
0.546ProTrp: 0.546 ± 0.1
1.092ProTyr: 1.092 ± 0.131
0.0ProXaa: 0.0 ± 0.0
Gln
1.843GlnAla: 1.843 ± 0.158
0.532GlnCys: 0.532 ± 0.096
1.652GlnAsp: 1.652 ± 0.118
3.153GlnGlu: 3.153 ± 0.247
0.956GlnPhe: 0.956 ± 0.124
2.403GlnGly: 2.403 ± 0.257
0.819GlnHis: 0.819 ± 0.11
2.116GlnIle: 2.116 ± 0.207
4.682GlnLys: 4.682 ± 0.28
2.375GlnLeu: 2.375 ± 0.167
1.01GlnMet: 1.01 ± 0.125
2.539GlnAsn: 2.539 ± 0.206
1.065GlnPro: 1.065 ± 0.134
1.638GlnGln: 1.638 ± 0.206
2.839GlnArg: 2.839 ± 0.203
2.443GlnSer: 2.443 ± 0.196
2.594GlnThr: 2.594 ± 0.347
2.293GlnVal: 2.293 ± 0.182
0.519GlnTrp: 0.519 ± 0.101
0.956GlnTyr: 0.956 ± 0.122
0.0GlnXaa: 0.0 ± 0.0
Arg
2.498ArgAla: 2.498 ± 0.179
1.106ArgCys: 1.106 ± 0.137
2.785ArgAsp: 2.785 ± 0.19
4.901ArgGlu: 4.901 ± 0.292
2.484ArgPhe: 2.484 ± 0.175
3.249ArgGly: 3.249 ± 0.225
1.529ArgHis: 1.529 ± 0.166
3.604ArgIle: 3.604 ± 0.218
6.184ArgLys: 6.184 ± 0.335
4.955ArgLeu: 4.955 ± 0.261
1.051ArgMet: 1.051 ± 0.116
2.73ArgAsn: 2.73 ± 0.209
1.665ArgPro: 1.665 ± 0.156
2.58ArgGln: 2.58 ± 0.204
3.358ArgArg: 3.358 ± 0.223
3.249ArgSer: 3.249 ± 0.232
3.331ArgThr: 3.331 ± 0.254
3.754ArgVal: 3.754 ± 0.267
0.819ArgTrp: 0.819 ± 0.097
2.007ArgTyr: 2.007 ± 0.188
0.0ArgXaa: 0.0 ± 0.0
Ser
4.123SerAla: 4.123 ± 0.273
2.198SerCys: 2.198 ± 0.186
3.303SerAsp: 3.303 ± 0.216
4.86SerGlu: 4.86 ± 0.239
5.092SerPhe: 5.092 ± 0.293
5.064SerGly: 5.064 ± 0.246
1.229SerHis: 1.229 ± 0.123
2.826SerIle: 2.826 ± 0.198
5.679SerLys: 5.679 ± 0.315
7.754SerLeu: 7.754 ± 0.358
1.379SerMet: 1.379 ± 0.11
2.949SerAsn: 2.949 ± 0.237
3.481SerPro: 3.481 ± 0.609
3.331SerGln: 3.331 ± 0.218
4.737SerArg: 4.737 ± 0.247
7.481SerSer: 7.481 ± 0.489
3.986SerThr: 3.986 ± 0.292
4.505SerVal: 4.505 ± 0.26
1.174SerTrp: 1.174 ± 0.13
2.13SerTyr: 2.13 ± 0.169
0.0SerXaa: 0.0 ± 0.0
Thr
2.498ThrAla: 2.498 ± 0.252
1.365ThrCys: 1.365 ± 0.147
2.13ThrAsp: 2.13 ± 0.197
3.14ThrGlu: 3.14 ± 0.22
3.085ThrPhe: 3.085 ± 0.205
3.167ThrGly: 3.167 ± 0.265
0.723ThrHis: 0.723 ± 0.101
2.252ThrIle: 2.252 ± 0.192
5.051ThrLys: 5.051 ± 0.248
4.983ThrLeu: 4.983 ± 0.348
1.024ThrMet: 1.024 ± 0.14
2.362ThrAsn: 2.362 ± 0.326
2.662ThrPro: 2.662 ± 0.283
1.597ThrGln: 1.597 ± 0.147
3.413ThrArg: 3.413 ± 0.228
3.972ThrSer: 3.972 ± 0.346
3.508ThrThr: 3.508 ± 0.39
3.372ThrVal: 3.372 ± 0.21
0.628ThrTrp: 0.628 ± 0.094
1.597ThrTyr: 1.597 ± 0.177
0.0ThrXaa: 0.0 ± 0.0
Val
3.508ValAla: 3.508 ± 0.284
2.089ValCys: 2.089 ± 0.195
3.413ValAsp: 3.413 ± 0.222
4.819ValGlu: 4.819 ± 0.298
4.245ValPhe: 4.245 ± 0.234
3.085ValGly: 3.085 ± 0.208
1.27ValHis: 1.27 ± 0.14
2.908ValIle: 2.908 ± 0.201
4.505ValLys: 4.505 ± 0.259
6.566ValLeu: 6.566 ± 0.337
1.256ValMet: 1.256 ± 0.15
1.966ValAsn: 1.966 ± 0.155
2.908ValPro: 2.908 ± 0.196
2.607ValGln: 2.607 ± 0.19
3.112ValArg: 3.112 ± 0.188
5.474ValSer: 5.474 ± 0.29
2.607ValThr: 2.607 ± 0.196
4.641ValVal: 4.641 ± 0.284
1.242ValTrp: 1.242 ± 0.126
2.061ValTyr: 2.061 ± 0.148
0.0ValXaa: 0.0 ± 0.0
Trp
0.792TrpAla: 0.792 ± 0.116
0.56TrpCys: 0.56 ± 0.11
0.969TrpAsp: 0.969 ± 0.133
1.024TrpGlu: 1.024 ± 0.106
1.01TrpPhe: 1.01 ± 0.116
0.723TrpGly: 0.723 ± 0.122
0.246TrpHis: 0.246 ± 0.06
0.751TrpIle: 0.751 ± 0.099
1.42TrpLys: 1.42 ± 0.152
1.556TrpLeu: 1.556 ± 0.237
0.328TrpMet: 0.328 ± 0.06
0.642TrpAsn: 0.642 ± 0.086
0.396TrpPro: 0.396 ± 0.083
0.41TrpGln: 0.41 ± 0.075
0.901TrpArg: 0.901 ± 0.103
1.188TrpSer: 1.188 ± 0.138
0.833TrpThr: 0.833 ± 0.125
0.696TrpVal: 0.696 ± 0.095
0.232TrpTrp: 0.232 ± 0.05
0.546TrpTyr: 0.546 ± 0.09
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.993TyrAla: 1.993 ± 0.157
0.846TyrCys: 0.846 ± 0.122
1.788TyrAsp: 1.788 ± 0.166
2.266TyrGlu: 2.266 ± 0.192
2.225TyrPhe: 2.225 ± 0.172
2.484TyrGly: 2.484 ± 0.175
0.478TyrHis: 0.478 ± 0.092
1.488TyrIle: 1.488 ± 0.132
2.17TyrLys: 2.17 ± 0.167
2.908TyrLeu: 2.908 ± 0.179
0.573TyrMet: 0.573 ± 0.081
1.229TyrAsn: 1.229 ± 0.112
1.433TyrPro: 1.433 ± 0.132
1.215TyrGln: 1.215 ± 0.135
1.802TyrArg: 1.802 ± 0.156
2.17TyrSer: 2.17 ± 0.185
1.884TyrThr: 1.884 ± 0.207
1.761TyrVal: 1.761 ± 0.161
0.369TyrTrp: 0.369 ± 0.081
1.092TyrTyr: 1.092 ± 0.144
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 296 proteins (73257 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski