Amino acid dipepetide frequency for Litorivita pollutaquae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.65AlaAla: 17.65 ± 0.205	1.036AlaCys: 1.036 ± 0.036	7.046AlaAsp: 7.046 ± 0.087	8.062AlaGlu: 8.062 ± 0.106	4.13AlaPhe: 4.13 ± 0.076	10.836AlaGly: 10.836 ± 0.121	2.43AlaHis: 2.43 ± 0.053	5.857AlaIle: 5.857 ± 0.079	4.582AlaLys: 4.582 ± 0.089	13.586AlaLeu: 13.586 ± 0.146	4.02AlaMet: 4.02 ± 0.064	2.81AlaAsn: 2.81 ± 0.047	6.328AlaPro: 6.328 ± 0.105	5.175AlaGln: 5.175 ± 0.074	8.838AlaArg: 8.838 ± 0.122	5.672AlaSer: 5.672 ± 0.081	5.877AlaThr: 5.877 ± 0.077	8.428AlaVal: 8.428 ± 0.099	1.305AlaTrp: 1.305 ± 0.035	2.653AlaTyr: 2.653 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.135CysAla: 1.135 ± 0.035	0.124CysCys: 0.124 ± 0.012	0.688CysAsp: 0.688 ± 0.026	0.447CysGlu: 0.447 ± 0.021	0.342CysPhe: 0.342 ± 0.017	0.972CysGly: 0.972 ± 0.038	0.255CysHis: 0.255 ± 0.017	0.424CysIle: 0.424 ± 0.021	0.243CysLys: 0.243 ± 0.015	0.812CysLeu: 0.812 ± 0.033	0.169CysMet: 0.169 ± 0.015	0.238CysAsn: 0.238 ± 0.014	0.482CysPro: 0.482 ± 0.022	0.201CysGln: 0.201 ± 0.014	0.512CysArg: 0.512 ± 0.024	0.453CysSer: 0.453 ± 0.021	0.457CysThr: 0.457 ± 0.021	0.638CysVal: 0.638 ± 0.024	0.086CysTrp: 0.086 ± 0.01	0.216CysTyr: 0.216 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.784AspAla: 7.784 ± 0.108	0.516AspCys: 0.516 ± 0.024	3.603AspAsp: 3.603 ± 0.088	3.626AspGlu: 3.626 ± 0.07	2.303AspPhe: 2.303 ± 0.047	5.663AspGly: 5.663 ± 0.107	1.388AspHis: 1.388 ± 0.043	3.354AspIle: 3.354 ± 0.061	1.827AspLys: 1.827 ± 0.044	6.33AspLeu: 6.33 ± 0.083	1.896AspMet: 1.896 ± 0.043	1.275AspAsn: 1.275 ± 0.037	3.457AspPro: 3.457 ± 0.065	1.722AspGln: 1.722 ± 0.044	3.774AspArg: 3.774 ± 0.067	2.193AspSer: 2.193 ± 0.052	3.212AspThr: 3.212 ± 0.09	4.511AspVal: 4.511 ± 0.068	1.007AspTrp: 1.007 ± 0.038	1.554AspTyr: 1.554 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	8.351GluAla: 8.351 ± 0.114	0.37GluCys: 0.37 ± 0.019	3.412GluAsp: 3.412 ± 0.066	3.494GluGlu: 3.494 ± 0.073	1.898GluPhe: 1.898 ± 0.044	4.845GluGly: 4.845 ± 0.071	1.122GluHis: 1.122 ± 0.038	3.844GluIle: 3.844 ± 0.064	2.34GluLys: 2.34 ± 0.048	4.803GluLeu: 4.803 ± 0.076	1.922GluMet: 1.922 ± 0.05	1.863GluAsn: 1.863 ± 0.043	2.127GluPro: 2.127 ± 0.05	1.967GluGln: 1.967 ± 0.048	4.01GluArg: 4.01 ± 0.082	2.243GluSer: 2.243 ± 0.048	3.795GluThr: 3.795 ± 0.068	4.578GluVal: 4.578 ± 0.068	0.712GluTrp: 0.712 ± 0.031	1.139GluTyr: 1.139 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.525PheAla: 4.525 ± 0.077	0.436PheCys: 0.436 ± 0.021	2.852PheAsp: 2.852 ± 0.055	2.293PheGlu: 2.293 ± 0.048	1.404PhePhe: 1.404 ± 0.043	3.778PheGly: 3.778 ± 0.067	0.754PheHis: 0.754 ± 0.027	1.74PheIle: 1.74 ± 0.049	1.07PheLys: 1.07 ± 0.036	3.299PheLeu: 3.299 ± 0.068	0.874PheMet: 0.874 ± 0.029	1.088PheAsn: 1.088 ± 0.035	1.398PhePro: 1.398 ± 0.036	0.935PheGln: 0.935 ± 0.029	1.93PheArg: 1.93 ± 0.046	2.228PheSer: 2.228 ± 0.053	2.131PheThr: 2.131 ± 0.046	2.482PheVal: 2.482 ± 0.049	0.501PheTrp: 0.501 ± 0.024	0.975PheTyr: 0.975 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.804GlyAla: 10.804 ± 0.123	0.811GlyCys: 0.811 ± 0.032	4.966GlyAsp: 4.966 ± 0.113	4.72GlyGlu: 4.72 ± 0.079	3.728GlyPhe: 3.728 ± 0.073	7.796GlyGly: 7.796 ± 0.128	1.944GlyHis: 1.944 ± 0.046	4.391GlyIle: 4.391 ± 0.079	3.442GlyLys: 3.442 ± 0.072	8.883GlyLeu: 8.883 ± 0.118	2.667GlyMet: 2.667 ± 0.055	2.22GlyAsn: 2.22 ± 0.068	3.403GlyPro: 3.403 ± 0.067	3.028GlyGln: 3.028 ± 0.059	5.442GlyArg: 5.442 ± 0.075	4.147GlySer: 4.147 ± 0.076	4.737GlyThr: 4.737 ± 0.088	6.468GlyVal: 6.468 ± 0.085	1.33GlyTrp: 1.33 ± 0.04	2.355GlyTyr: 2.355 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.402HisAla: 2.402 ± 0.054	0.242HisCys: 0.242 ± 0.018	1.277HisAsp: 1.277 ± 0.039	1.049HisGlu: 1.049 ± 0.033	0.881HisPhe: 0.881 ± 0.031	1.915HisGly: 1.915 ± 0.043	0.629HisHis: 0.629 ± 0.031	1.129HisIle: 1.129 ± 0.035	0.596HisLys: 0.596 ± 0.026	2.014HisLeu: 2.014 ± 0.045	0.615HisMet: 0.615 ± 0.024	0.479HisAsn: 0.479 ± 0.021	1.349HisPro: 1.349 ± 0.036	0.524HisGln: 0.524 ± 0.022	1.303HisArg: 1.303 ± 0.038	0.985HisSer: 0.985 ± 0.033	0.94HisThr: 0.94 ± 0.028	1.468HisVal: 1.468 ± 0.042	0.328HisTrp: 0.328 ± 0.018	0.553HisTyr: 0.553 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	7.196IleAla: 7.196 ± 0.095	0.672IleCys: 0.672 ± 0.03	3.739IleAsp: 3.739 ± 0.077	3.839IleGlu: 3.839 ± 0.065	1.829IlePhe: 1.829 ± 0.045	5.124IleGly: 5.124 ± 0.078	0.922IleHis: 0.922 ± 0.029	2.464IleIle: 2.464 ± 0.055	1.719IleLys: 1.719 ± 0.041	4.788IleLeu: 4.788 ± 0.08	1.142IleMet: 1.142 ± 0.037	1.545IleAsn: 1.545 ± 0.041	2.236IlePro: 2.236 ± 0.051	1.117IleGln: 1.117 ± 0.038	2.975IleArg: 2.975 ± 0.053	3.218IleSer: 3.218 ± 0.066	3.233IleThr: 3.233 ± 0.051	3.566IleVal: 3.566 ± 0.057	0.742IleTrp: 0.742 ± 0.031	1.289IleTyr: 1.289 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.144LysAla: 4.144 ± 0.081	0.225LysCys: 0.225 ± 0.015	1.967LysAsp: 1.967 ± 0.044	1.708LysGlu: 1.708 ± 0.042	1.052LysPhe: 1.052 ± 0.032	2.917LysGly: 2.917 ± 0.059	0.672LysHis: 0.672 ± 0.024	2.033LysIle: 2.033 ± 0.045	1.359LysLys: 1.359 ± 0.048	3.085LysLeu: 3.085 ± 0.061	1.096LysMet: 1.096 ± 0.036	1.012LysAsn: 1.012 ± 0.035	1.93LysPro: 1.93 ± 0.051	0.98LysGln: 0.98 ± 0.03	2.459LysArg: 2.459 ± 0.059	2.183LysSer: 2.183 ± 0.049	2.339LysThr: 2.339 ± 0.058	2.368LysVal: 2.368 ± 0.053	0.443LysTrp: 0.443 ± 0.022	0.728LysTyr: 0.728 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	12.113LeuAla: 12.113 ± 0.126	0.982LeuCys: 0.982 ± 0.034	5.773LeuAsp: 5.773 ± 0.085	5.401LeuGlu: 5.401 ± 0.075	3.369LeuPhe: 3.369 ± 0.061	8.306LeuGly: 8.306 ± 0.107	1.858LeuHis: 1.858 ± 0.044	5.128LeuIle: 5.128 ± 0.079	3.356LeuLys: 3.356 ± 0.062	8.348LeuLeu: 8.348 ± 0.126	2.72LeuMet: 2.72 ± 0.055	2.652LeuAsn: 2.652 ± 0.051	5.303LeuPro: 5.303 ± 0.081	2.668LeuGln: 2.668 ± 0.06	7.005LeuArg: 7.005 ± 0.099	6.346LeuSer: 6.346 ± 0.088	5.948LeuThr: 5.948 ± 0.078	6.265LeuVal: 6.265 ± 0.095	1.226LeuTrp: 1.226 ± 0.036	2.002LeuTyr: 2.002 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	3.631MetAla: 3.631 ± 0.067	0.199MetCys: 0.199 ± 0.015	1.452MetAsp: 1.452 ± 0.044	1.484MetGlu: 1.484 ± 0.042	0.872MetPhe: 0.872 ± 0.028	2.534MetGly: 2.534 ± 0.057	0.511MetHis: 0.511 ± 0.024	1.743MetIle: 1.743 ± 0.037	1.12MetLys: 1.12 ± 0.034	2.742MetLeu: 2.742 ± 0.062	0.94MetMet: 0.94 ± 0.035	0.906MetAsn: 0.906 ± 0.03	1.576MetPro: 1.576 ± 0.043	1.122MetGln: 1.122 ± 0.039	2.102MetArg: 2.102 ± 0.051	1.907MetSer: 1.907 ± 0.046	2.135MetThr: 2.135 ± 0.047	1.939MetVal: 1.939 ± 0.052	0.239MetTrp: 0.239 ± 0.015	0.373MetTyr: 0.373 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.348AsnAla: 3.348 ± 0.066	0.292AsnCys: 0.292 ± 0.016	1.536AsnAsp: 1.536 ± 0.06	1.292AsnGlu: 1.292 ± 0.037	0.986AsnPhe: 0.986 ± 0.034	2.546AsnGly: 2.546 ± 0.056	0.534AsnHis: 0.534 ± 0.025	1.492AsnIle: 1.492 ± 0.035	0.767AsnLys: 0.767 ± 0.029	2.556AsnLeu: 2.556 ± 0.048	0.806AsnMet: 0.806 ± 0.03	0.698AsnAsn: 0.698 ± 0.028	1.796AsnPro: 1.796 ± 0.046	0.72AsnGln: 0.72 ± 0.028	1.714AsnArg: 1.714 ± 0.045	1.18AsnSer: 1.18 ± 0.037	1.434AsnThr: 1.434 ± 0.042	1.877AsnVal: 1.877 ± 0.051	0.408AsnTrp: 0.408 ± 0.021	0.68AsnTyr: 0.68 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.931ProAla: 5.931 ± 0.086	0.362ProCys: 0.362 ± 0.016	3.796ProAsp: 3.796 ± 0.064	3.936ProGlu: 3.936 ± 0.069	1.813ProPhe: 1.813 ± 0.041	3.072ProGly: 3.072 ± 0.064	1.107ProHis: 1.107 ± 0.032	2.175ProIle: 2.175 ± 0.05	1.91ProLys: 1.91 ± 0.047	4.481ProLeu: 4.481 ± 0.066	1.439ProMet: 1.439 ± 0.037	1.306ProAsn: 1.306 ± 0.036	2.083ProPro: 2.083 ± 0.059	1.879ProGln: 1.879 ± 0.045	2.759ProArg: 2.759 ± 0.064	2.446ProSer: 2.446 ± 0.047	2.384ProThr: 2.384 ± 0.049	4.175ProVal: 4.175 ± 0.065	0.569ProTrp: 0.569 ± 0.029	1.142ProTyr: 1.142 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.787GlnAla: 3.787 ± 0.07	0.207GlnCys: 0.207 ± 0.013	1.711GlnAsp: 1.711 ± 0.049	1.599GlnGlu: 1.599 ± 0.041	1.121GlnPhe: 1.121 ± 0.035	2.635GlnGly: 2.635 ± 0.057	0.609GlnHis: 0.609 ± 0.025	2.13GlnIle: 2.13 ± 0.045	1.173GlnLys: 1.173 ± 0.031	2.721GlnLeu: 2.721 ± 0.052	1.22GlnMet: 1.22 ± 0.034	1.065GlnAsn: 1.065 ± 0.031	1.358GlnPro: 1.358 ± 0.042	1.015GlnGln: 1.015 ± 0.033	2.057GlnArg: 2.057 ± 0.047	2.091GlnSer: 2.091 ± 0.049	1.924GlnThr: 1.924 ± 0.047	2.367GlnVal: 2.367 ± 0.046	0.403GlnTrp: 0.403 ± 0.02	0.637GlnTyr: 0.637 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	8.388ArgAla: 8.388 ± 0.119	0.467ArgCys: 0.467 ± 0.025	4.088ArgAsp: 4.088 ± 0.056	3.59ArgGlu: 3.59 ± 0.061	2.538ArgPhe: 2.538 ± 0.047	4.676ArgGly: 4.676 ± 0.062	1.451ArgHis: 1.451 ± 0.043	3.857ArgIle: 3.857 ± 0.06	2.416ArgLys: 2.416 ± 0.052	6.809ArgLeu: 6.809 ± 0.111	1.962ArgMet: 1.962 ± 0.043	1.689ArgAsn: 1.689 ± 0.043	3.041ArgPro: 3.041 ± 0.065	2.068ArgGln: 2.068 ± 0.044	4.818ArgArg: 4.818 ± 0.098	3.282ArgSer: 3.282 ± 0.059	2.753ArgThr: 2.753 ± 0.048	4.458ArgVal: 4.458 ± 0.07	0.803ArgTrp: 0.803 ± 0.025	1.507ArgTyr: 1.507 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.161SerAla: 6.161 ± 0.086	0.432SerCys: 0.432 ± 0.021	3.407SerAsp: 3.407 ± 0.065	2.907SerGlu: 2.907 ± 0.054	2.229SerPhe: 2.229 ± 0.053	5.584SerGly: 5.584 ± 0.095	1.125SerHis: 1.125 ± 0.035	2.64SerIle: 2.64 ± 0.05	1.74SerLys: 1.74 ± 0.046	4.78SerLeu: 4.78 ± 0.073	1.496SerMet: 1.496 ± 0.04	1.507SerAsn: 1.507 ± 0.042	2.341SerPro: 2.341 ± 0.048	1.575SerGln: 1.575 ± 0.035	3.081SerArg: 3.081 ± 0.054	2.615SerSer: 2.615 ± 0.056	2.644SerThr: 2.644 ± 0.052	3.734SerVal: 3.734 ± 0.062	0.588SerTrp: 0.588 ± 0.028	1.361SerTyr: 1.361 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	6.573ThrAla: 6.573 ± 0.085	0.526ThrCys: 0.526 ± 0.025	3.228ThrAsp: 3.228 ± 0.066	3.084ThrGlu: 3.084 ± 0.058	1.897ThrPhe: 1.897 ± 0.045	5.643ThrGly: 5.643 ± 0.08	1.169ThrHis: 1.169 ± 0.04	2.748ThrIle: 2.748 ± 0.053	1.604ThrLys: 1.604 ± 0.044	5.815ThrLeu: 5.815 ± 0.086	1.289ThrMet: 1.289 ± 0.038	1.303ThrAsn: 1.303 ± 0.036	3.389ThrPro: 3.389 ± 0.067	1.717ThrGln: 1.717 ± 0.043	3.476ThrArg: 3.476 ± 0.058	2.78ThrSer: 2.78 ± 0.055	2.919ThrThr: 2.919 ± 0.062	4.137ThrVal: 4.137 ± 0.078	0.682ThrTrp: 0.682 ± 0.028	1.293ThrTyr: 1.293 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.425ValAla: 8.425 ± 0.093	0.608ValCys: 0.608 ± 0.025	4.107ValAsp: 4.107 ± 0.068	4.416ValGlu: 4.416 ± 0.072	2.903ValPhe: 2.903 ± 0.059	5.181ValGly: 5.181 ± 0.081	1.348ValHis: 1.348 ± 0.036	4.492ValIle: 4.492 ± 0.079	2.373ValLys: 2.373 ± 0.058	7.191ValLeu: 7.191 ± 0.093	2.334ValMet: 2.334 ± 0.052	2.002ValAsn: 2.002 ± 0.049	3.507ValPro: 3.507 ± 0.053	2.153ValGln: 2.153 ± 0.05	3.901ValArg: 3.901 ± 0.064	4.085ValSer: 4.085 ± 0.067	4.548ValThr: 4.548 ± 0.071	5.397ValVal: 5.397 ± 0.085	0.826ValTrp: 0.826 ± 0.033	1.48ValTyr: 1.48 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.332TrpAla: 1.332 ± 0.04	0.132TrpCys: 0.132 ± 0.012	0.689TrpAsp: 0.689 ± 0.027	0.608TrpGlu: 0.608 ± 0.028	0.48TrpPhe: 0.48 ± 0.024	1.018TrpGly: 1.018 ± 0.033	0.307TrpHis: 0.307 ± 0.019	0.669TrpIle: 0.669 ± 0.027	0.425TrpLys: 0.425 ± 0.023	1.396TrpLeu: 1.396 ± 0.042	0.407TrpMet: 0.407 ± 0.02	0.394TrpAsn: 0.394 ± 0.021	0.599TrpPro: 0.599 ± 0.026	0.569TrpGln: 0.569 ± 0.023	1.008TrpArg: 1.008 ± 0.035	0.707TrpSer: 0.707 ± 0.029	0.729TrpThr: 0.729 ± 0.027	0.835TrpVal: 0.835 ± 0.032	0.187TrpTrp: 0.187 ± 0.013	0.251TrpTyr: 0.251 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.641TyrAla: 2.641 ± 0.055	0.254TyrCys: 0.254 ± 0.017	1.659TyrAsp: 1.659 ± 0.045	1.281TyrGlu: 1.281 ± 0.04	0.919TyrPhe: 0.919 ± 0.033	2.243TyrGly: 2.243 ± 0.046	0.542TyrHis: 0.542 ± 0.023	1.045TyrIle: 1.045 ± 0.031	0.638TyrLys: 0.638 ± 0.03	2.33TyrLeu: 2.33 ± 0.05	0.512TyrMet: 0.512 ± 0.027	0.61TyrAsn: 0.61 ± 0.028	1.059TyrPro: 1.059 ± 0.034	0.694TyrGln: 0.694 ± 0.024	1.497TyrArg: 1.497 ± 0.04	1.188TyrSer: 1.188 ± 0.035	1.132TyrThr: 1.132 ± 0.034	1.586TyrVal: 1.586 ± 0.041	0.358TyrTrp: 0.358 ± 0.02	0.615TyrTyr: 0.615 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3171 proteins (989163 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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