Amino acid dipepetide frequency for Spongiibacter sp. IMCC21906

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.808AlaAla: 10.808 ± 0.128
1.175AlaCys: 1.175 ± 0.039
5.669AlaAsp: 5.669 ± 0.085
6.861AlaGlu: 6.861 ± 0.092
3.475AlaPhe: 3.475 ± 0.056
7.458AlaGly: 7.458 ± 0.105
1.693AlaHis: 1.693 ± 0.042
5.792AlaIle: 5.792 ± 0.076
4.602AlaLys: 4.602 ± 0.068
11.292AlaLeu: 11.292 ± 0.128
3.012AlaMet: 3.012 ± 0.053
3.354AlaAsn: 3.354 ± 0.062
3.568AlaPro: 3.568 ± 0.07
4.015AlaGln: 4.015 ± 0.077
4.765AlaArg: 4.765 ± 0.069
6.214AlaSer: 6.214 ± 0.076
4.527AlaThr: 4.527 ± 0.075
7.186AlaVal: 7.186 ± 0.097
1.167AlaTrp: 1.167 ± 0.039
2.495AlaTyr: 2.495 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.95CysAla: 0.95 ± 0.032
0.185CysCys: 0.185 ± 0.015
0.675CysAsp: 0.675 ± 0.029
0.656CysGlu: 0.656 ± 0.027
0.434CysPhe: 0.434 ± 0.025
1.027CysGly: 1.027 ± 0.029
0.397CysHis: 0.397 ± 0.021
0.554CysIle: 0.554 ± 0.023
0.404CysLys: 0.404 ± 0.019
1.056CysLeu: 1.056 ± 0.035
0.206CysMet: 0.206 ± 0.015
0.348CysAsn: 0.348 ± 0.019
0.527CysPro: 0.527 ± 0.027
0.497CysGln: 0.497 ± 0.027
0.629CysArg: 0.629 ± 0.027
0.679CysSer: 0.679 ± 0.025
0.446CysThr: 0.446 ± 0.022
0.705CysVal: 0.705 ± 0.027
0.137CysTrp: 0.137 ± 0.011
0.346CysTyr: 0.346 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
5.512AspAla: 5.512 ± 0.083
0.611AspCys: 0.611 ± 0.027
3.493AspAsp: 3.493 ± 0.077
3.856AspGlu: 3.856 ± 0.072
2.439AspPhe: 2.439 ± 0.051
4.449AspGly: 4.449 ± 0.07
1.164AspHis: 1.164 ± 0.036
3.939AspIle: 3.939 ± 0.063
2.624AspLys: 2.624 ± 0.05
5.522AspLeu: 5.522 ± 0.076
1.434AspMet: 1.434 ± 0.042
2.256AspAsn: 2.256 ± 0.046
2.591AspPro: 2.591 ± 0.054
2.212AspGln: 2.212 ± 0.054
2.985AspArg: 2.985 ± 0.047
3.55AspSer: 3.55 ± 0.067
2.748AspThr: 2.748 ± 0.055
3.924AspVal: 3.924 ± 0.059
0.897AspTrp: 0.897 ± 0.028
1.994AspTyr: 1.994 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
6.125GluAla: 6.125 ± 0.081
0.474GluCys: 0.474 ± 0.026
3.161GluAsp: 3.161 ± 0.057
3.756GluGlu: 3.756 ± 0.086
2.186GluPhe: 2.186 ± 0.044
4.033GluGly: 4.033 ± 0.064
1.457GluHis: 1.457 ± 0.041
3.495GluIle: 3.495 ± 0.054
3.073GluLys: 3.073 ± 0.06
7.107GluLeu: 7.107 ± 0.084
1.604GluMet: 1.604 ± 0.038
2.303GluAsn: 2.303 ± 0.05
2.186GluPro: 2.186 ± 0.047
3.474GluGln: 3.474 ± 0.064
3.656GluArg: 3.656 ± 0.067
3.592GluSer: 3.592 ± 0.063
2.935GluThr: 2.935 ± 0.049
4.214GluVal: 4.214 ± 0.076
0.739GluTrp: 0.739 ± 0.027
1.624GluTyr: 1.624 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.605PheAla: 3.605 ± 0.073
0.51PheCys: 0.51 ± 0.024
2.656PheAsp: 2.656 ± 0.054
2.201PheGlu: 2.201 ± 0.047
1.579PhePhe: 1.579 ± 0.044
2.988PheGly: 2.988 ± 0.052
0.791PheHis: 0.791 ± 0.027
2.154PheIle: 2.154 ± 0.047
1.593PheLys: 1.593 ± 0.039
3.576PheLeu: 3.576 ± 0.072
0.934PheMet: 0.934 ± 0.032
1.532PheAsn: 1.532 ± 0.041
1.456PhePro: 1.456 ± 0.037
1.266PheGln: 1.266 ± 0.032
1.844PheArg: 1.844 ± 0.046
3.103PheSer: 3.103 ± 0.06
1.954PheThr: 1.954 ± 0.046
2.536PheVal: 2.536 ± 0.055
0.54PheTrp: 0.54 ± 0.026
1.278PheTyr: 1.278 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
6.193GlyAla: 6.193 ± 0.096
0.844GlyCys: 0.844 ± 0.033
4.5GlyAsp: 4.5 ± 0.077
4.749GlyGlu: 4.749 ± 0.071
3.305GlyPhe: 3.305 ± 0.066
6.073GlyGly: 6.073 ± 0.108
1.667GlyHis: 1.667 ± 0.044
4.69GlyIle: 4.69 ± 0.087
3.557GlyLys: 3.557 ± 0.069
8.041GlyLeu: 8.041 ± 0.105
2.133GlyMet: 2.133 ± 0.061
2.634GlyAsn: 2.634 ± 0.054
2.334GlyPro: 2.334 ± 0.044
3.055GlyGln: 3.055 ± 0.059
4.258GlyArg: 4.258 ± 0.071
4.775GlySer: 4.775 ± 0.072
3.241GlyThr: 3.241 ± 0.069
5.636GlyVal: 5.636 ± 0.092
1.023GlyTrp: 1.023 ± 0.034
2.31GlyTyr: 2.31 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.69HisAla: 1.69 ± 0.041
0.438HisCys: 0.438 ± 0.022
1.065HisAsp: 1.065 ± 0.035
0.921HisGlu: 0.921 ± 0.029
1.097HisPhe: 1.097 ± 0.034
1.663HisGly: 1.663 ± 0.044
0.723HisHis: 0.723 ± 0.034
1.302HisIle: 1.302 ± 0.036
0.795HisLys: 0.795 ± 0.032
2.119HisLeu: 2.119 ± 0.047
0.527HisMet: 0.527 ± 0.025
0.794HisAsn: 0.794 ± 0.029
1.26HisPro: 1.26 ± 0.039
0.98HisGln: 0.98 ± 0.034
1.438HisArg: 1.438 ± 0.04
1.435HisSer: 1.435 ± 0.044
0.94HisThr: 0.94 ± 0.035
1.194HisVal: 1.194 ± 0.035
0.436HisTrp: 0.436 ± 0.022
0.868HisTyr: 0.868 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.413IleAla: 6.413 ± 0.089
0.681IleCys: 0.681 ± 0.028
3.942IleAsp: 3.942 ± 0.057
3.779IleGlu: 3.779 ± 0.067
1.916IlePhe: 1.916 ± 0.039
4.193IleGly: 4.193 ± 0.08
1.187IleHis: 1.187 ± 0.034
2.906IleIle: 2.906 ± 0.062
2.439IleLys: 2.439 ± 0.061
4.825IleLeu: 4.825 ± 0.072
1.041IleMet: 1.041 ± 0.034
2.45IleAsn: 2.45 ± 0.055
2.662IlePro: 2.662 ± 0.054
1.918IleGln: 1.918 ± 0.047
2.986IleArg: 2.986 ± 0.054
4.011IleSer: 4.011 ± 0.066
3.059IleThr: 3.059 ± 0.066
3.728IleVal: 3.728 ± 0.064
0.575IleTrp: 0.575 ± 0.026
1.441IleTyr: 1.441 ± 0.039
0.0IleXaa: 0.0 ± 0.0
Lys
4.564LysAla: 4.564 ± 0.086
0.273LysCys: 0.273 ± 0.02
2.383LysAsp: 2.383 ± 0.056
2.587LysGlu: 2.587 ± 0.054
1.071LysPhe: 1.071 ± 0.031
2.846LysGly: 2.846 ± 0.057
0.969LysHis: 0.969 ± 0.029
2.311LysIle: 2.311 ± 0.052
2.26LysLys: 2.26 ± 0.064
4.642LysLeu: 4.642 ± 0.076
1.058LysMet: 1.058 ± 0.031
1.657LysAsn: 1.657 ± 0.042
2.284LysPro: 2.284 ± 0.056
2.163LysGln: 2.163 ± 0.05
2.669LysArg: 2.669 ± 0.053
2.6LysSer: 2.6 ± 0.047
2.448LysThr: 2.448 ± 0.054
2.894LysVal: 2.894 ± 0.059
0.414LysTrp: 0.414 ± 0.022
1.004LysTyr: 1.004 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
11.658LeuAla: 11.658 ± 0.135
1.209LeuCys: 1.209 ± 0.035
6.272LeuAsp: 6.272 ± 0.082
6.127LeuGlu: 6.127 ± 0.077
3.923LeuPhe: 3.923 ± 0.076
7.784LeuGly: 7.784 ± 0.091
2.158LeuHis: 2.158 ± 0.048
5.651LeuIle: 5.651 ± 0.092
4.753LeuLys: 4.753 ± 0.077
11.852LeuLeu: 11.852 ± 0.166
2.6LeuMet: 2.6 ± 0.049
4.123LeuAsn: 4.123 ± 0.062
5.409LeuPro: 5.409 ± 0.08
4.612LeuGln: 4.612 ± 0.085
6.315LeuArg: 6.315 ± 0.085
8.296LeuSer: 8.296 ± 0.106
4.926LeuThr: 4.926 ± 0.075
6.73LeuVal: 6.73 ± 0.101
1.201LeuTrp: 1.201 ± 0.034
2.468LeuTyr: 2.468 ± 0.052
0.0LeuXaa: 0.0 ± 0.0
Met
2.824MetAla: 2.824 ± 0.053
0.201MetCys: 0.201 ± 0.016
1.297MetAsp: 1.297 ± 0.038
1.26MetGlu: 1.26 ± 0.035
0.707MetPhe: 0.707 ± 0.027
1.812MetGly: 1.812 ± 0.046
0.496MetHis: 0.496 ± 0.023
1.311MetIle: 1.311 ± 0.036
1.131MetLys: 1.131 ± 0.036
2.717MetLeu: 2.717 ± 0.059
0.702MetMet: 0.702 ± 0.033
0.972MetAsn: 0.972 ± 0.029
1.31MetPro: 1.31 ± 0.036
1.026MetGln: 1.026 ± 0.031
1.383MetArg: 1.383 ± 0.038
1.951MetSer: 1.951 ± 0.039
1.482MetThr: 1.482 ± 0.034
1.614MetVal: 1.614 ± 0.038
0.207MetTrp: 0.207 ± 0.014
0.43MetTyr: 0.43 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.51AsnAla: 3.51 ± 0.052
0.395AsnCys: 0.395 ± 0.023
2.13AsnAsp: 2.13 ± 0.051
1.969AsnGlu: 1.969 ± 0.042
1.316AsnPhe: 1.316 ± 0.034
2.841AsnGly: 2.841 ± 0.057
0.822AsnHis: 0.822 ± 0.03
2.413AsnIle: 2.413 ± 0.055
1.563AsnLys: 1.563 ± 0.045
3.413AsnLeu: 3.413 ± 0.064
0.878AsnMet: 0.878 ± 0.024
1.529AsnAsn: 1.529 ± 0.046
2.098AsnPro: 2.098 ± 0.049
1.425AsnGln: 1.425 ± 0.035
2.149AsnArg: 2.149 ± 0.052
2.289AsnSer: 2.289 ± 0.047
2.039AsnThr: 2.039 ± 0.05
2.208AsnVal: 2.208 ± 0.054
0.528AsnTrp: 0.528 ± 0.024
1.147AsnTyr: 1.147 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
4.236ProAla: 4.236 ± 0.063
0.368ProCys: 0.368 ± 0.02
2.752ProAsp: 2.752 ± 0.06
3.607ProGlu: 3.607 ± 0.068
1.607ProPhe: 1.607 ± 0.039
3.484ProGly: 3.484 ± 0.059
0.858ProHis: 0.858 ± 0.033
2.24ProIle: 2.24 ± 0.056
1.866ProLys: 1.866 ± 0.045
4.679ProLeu: 4.679 ± 0.075
1.058ProMet: 1.058 ± 0.033
1.531ProAsn: 1.531 ± 0.041
1.793ProPro: 1.793 ± 0.051
1.738ProGln: 1.738 ± 0.049
2.043ProArg: 2.043 ± 0.05
2.868ProSer: 2.868 ± 0.053
1.921ProThr: 1.921 ± 0.05
3.486ProVal: 3.486 ± 0.06
0.565ProTrp: 0.565 ± 0.026
1.138ProTyr: 1.138 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
4.523GlnAla: 4.523 ± 0.072
0.459GlnCys: 0.459 ± 0.021
2.1GlnAsp: 2.1 ± 0.043
2.252GlnGlu: 2.252 ± 0.05
1.622GlnPhe: 1.622 ± 0.039
2.974GlnGly: 2.974 ± 0.057
1.155GlnHis: 1.155 ± 0.036
2.128GlnIle: 2.128 ± 0.047
1.653GlnLys: 1.653 ± 0.041
5.43GlnLeu: 5.43 ± 0.089
0.973GlnMet: 0.973 ± 0.034
1.417GlnAsn: 1.417 ± 0.042
1.738GlnPro: 1.738 ± 0.04
2.967GlnGln: 2.967 ± 0.074
3.395GlnArg: 3.395 ± 0.072
2.622GlnSer: 2.622 ± 0.054
1.95GlnThr: 1.95 ± 0.047
2.596GlnVal: 2.596 ± 0.05
0.746GlnTrp: 0.746 ± 0.029
1.161GlnTyr: 1.161 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
4.513ArgAla: 4.513 ± 0.072
0.665ArgCys: 0.665 ± 0.03
3.217ArgAsp: 3.217 ± 0.057
3.547ArgGlu: 3.547 ± 0.063
2.572ArgPhe: 2.572 ± 0.044
3.728ArgGly: 3.728 ± 0.07
1.451ArgHis: 1.451 ± 0.035
3.283ArgIle: 3.283 ± 0.058
2.334ArgLys: 2.334 ± 0.054
6.422ArgLeu: 6.422 ± 0.091
1.367ArgMet: 1.367 ± 0.035
2.047ArgAsn: 2.047 ± 0.043
2.212ArgPro: 2.212 ± 0.053
3.046ArgGln: 3.046 ± 0.056
3.936ArgArg: 3.936 ± 0.078
3.631ArgSer: 3.631 ± 0.064
2.002ArgThr: 2.002 ± 0.045
3.763ArgVal: 3.763 ± 0.063
0.884ArgTrp: 0.884 ± 0.027
2.159ArgTyr: 2.159 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
6.535SerAla: 6.535 ± 0.091
0.692SerCys: 0.692 ± 0.028
3.842SerAsp: 3.842 ± 0.058
3.837SerGlu: 3.837 ± 0.058
2.575SerPhe: 2.575 ± 0.054
5.63SerGly: 5.63 ± 0.081
1.44SerHis: 1.44 ± 0.039
3.444SerIle: 3.444 ± 0.055
2.583SerLys: 2.583 ± 0.057
7.31SerLeu: 7.31 ± 0.103
1.589SerMet: 1.589 ± 0.041
2.396SerAsn: 2.396 ± 0.048
2.939SerPro: 2.939 ± 0.061
2.898SerGln: 2.898 ± 0.055
3.749SerArg: 3.749 ± 0.063
4.331SerSer: 4.331 ± 0.072
3.007SerThr: 3.007 ± 0.064
4.444SerVal: 4.444 ± 0.073
0.871SerTrp: 0.871 ± 0.029
1.904SerTyr: 1.904 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
5.069ThrAla: 5.069 ± 0.075
0.384ThrCys: 0.384 ± 0.024
2.616ThrAsp: 2.616 ± 0.049
2.998ThrGlu: 2.998 ± 0.052
1.591ThrPhe: 1.591 ± 0.045
4.208ThrGly: 4.208 ± 0.078
0.899ThrHis: 0.899 ± 0.027
2.49ThrIle: 2.49 ± 0.053
1.583ThrLys: 1.583 ± 0.036
5.923ThrLeu: 5.923 ± 0.08
0.969ThrMet: 0.969 ± 0.032
1.438ThrAsn: 1.438 ± 0.04
2.68ThrPro: 2.68 ± 0.055
1.772ThrGln: 1.772 ± 0.038
2.335ThrArg: 2.335 ± 0.054
2.666ThrSer: 2.666 ± 0.059
2.479ThrThr: 2.479 ± 0.057
3.662ThrVal: 3.662 ± 0.064
0.5ThrTrp: 0.5 ± 0.021
1.101ThrTyr: 1.101 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
7.166ValAla: 7.166 ± 0.099
0.763ValCys: 0.763 ± 0.03
4.315ValAsp: 4.315 ± 0.063
4.256ValGlu: 4.256 ± 0.072
2.846ValPhe: 2.846 ± 0.049
4.825ValGly: 4.825 ± 0.088
1.303ValHis: 1.303 ± 0.035
3.994ValIle: 3.994 ± 0.062
2.819ValLys: 2.819 ± 0.056
7.191ValLeu: 7.191 ± 0.095
1.877ValMet: 1.877 ± 0.043
2.644ValAsn: 2.644 ± 0.051
2.909ValPro: 2.909 ± 0.061
2.118ValGln: 2.118 ± 0.054
3.221ValArg: 3.221 ± 0.064
4.82ValSer: 4.82 ± 0.076
3.434ValThr: 3.434 ± 0.063
5.395ValVal: 5.395 ± 0.096
0.765ValTrp: 0.765 ± 0.031
1.754ValTyr: 1.754 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
0.971TrpAla: 0.971 ± 0.033
0.138TrpCys: 0.138 ± 0.012
0.593TrpAsp: 0.593 ± 0.025
0.58TrpGlu: 0.58 ± 0.025
0.534TrpPhe: 0.534 ± 0.022
0.843TrpGly: 0.843 ± 0.025
0.372TrpHis: 0.372 ± 0.018
0.655TrpIle: 0.655 ± 0.025
0.43TrpLys: 0.43 ± 0.021
1.768TrpLeu: 1.768 ± 0.05
0.317TrpMet: 0.317 ± 0.018
0.374TrpAsn: 0.374 ± 0.021
0.577TrpPro: 0.577 ± 0.022
1.066TrpGln: 1.066 ± 0.037
0.974TrpArg: 0.974 ± 0.034
0.754TrpSer: 0.754 ± 0.028
0.517TrpThr: 0.517 ± 0.024
0.856TrpVal: 0.856 ± 0.029
0.224TrpTrp: 0.224 ± 0.015
0.347TrpTyr: 0.347 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.266TyrAla: 2.266 ± 0.051
0.394TyrCys: 0.394 ± 0.021
1.522TyrAsp: 1.522 ± 0.044
1.397TyrGlu: 1.397 ± 0.039
1.3TyrPhe: 1.3 ± 0.039
2.158TyrGly: 2.158 ± 0.045
0.681TyrHis: 0.681 ± 0.026
1.403TyrIle: 1.403 ± 0.035
1.036TyrLys: 1.036 ± 0.033
3.18TyrLeu: 3.18 ± 0.066
0.553TyrMet: 0.553 ± 0.024
0.863TyrAsn: 0.863 ± 0.03
1.308TyrPro: 1.308 ± 0.035
1.612TyrGln: 1.612 ± 0.041
2.046TyrArg: 2.046 ± 0.045
1.829TyrSer: 1.829 ± 0.053
1.308TyrThr: 1.308 ± 0.04
1.643TyrVal: 1.643 ± 0.042
0.471TyrTrp: 0.471 ± 0.022
0.879TyrTyr: 0.879 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3192 proteins (1018612 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski