Amino acid dipepetide frequency for Frangipani mosaic virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.341AlaAla: 4.341 ± 0.9
1.24AlaCys: 1.24 ± 0.407
2.481AlaAsp: 2.481 ± 0.308
3.101AlaGlu: 3.101 ± 0.37
2.481AlaPhe: 2.481 ± 0.458
4.031AlaGly: 4.031 ± 0.627
1.86AlaHis: 1.86 ± 0.51
2.171AlaIle: 2.171 ± 0.373
3.411AlaLys: 3.411 ± 0.861
8.062AlaLeu: 8.062 ± 0.712
0.93AlaMet: 0.93 ± 0.395
0.31AlaAsn: 0.31 ± 0.653
1.55AlaPro: 1.55 ± 0.391
0.0AlaGln: 0.0 ± 0.0
2.171AlaArg: 2.171 ± 1.308
5.271AlaSer: 5.271 ± 0.219
5.891AlaThr: 5.891 ± 1.411
6.512AlaVal: 6.512 ± 1.347
0.62AlaTrp: 0.62 ± 0.17
1.86AlaTyr: 1.86 ± 0.51
0.0AlaXaa: 0.0 ± 0.0
Cys
1.86CysAla: 1.86 ± 0.495
1.55CysCys: 1.55 ± 0.38
1.86CysAsp: 1.86 ± 0.332
0.93CysGlu: 0.93 ± 0.247
0.0CysPhe: 0.0 ± 0.0
1.55CysGly: 1.55 ± 0.465
0.0CysHis: 0.0 ± 0.0
0.93CysIle: 0.93 ± 0.247
2.481CysLys: 2.481 ± 0.679
1.86CysLeu: 1.86 ± 0.495
0.62CysMet: 0.62 ± 0.38
1.86CysAsn: 1.86 ± 0.51
2.171CysPro: 2.171 ± 0.534
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
2.481CysSer: 2.481 ± 0.618
1.86CysThr: 1.86 ± 0.51
0.93CysVal: 0.93 ± 0.471
0.62CysTrp: 0.62 ± 0.17
0.93CysTyr: 0.93 ± 0.247
0.0CysXaa: 0.0 ± 0.0
Asp
3.101AspAla: 3.101 ± 1.641
1.24AspCys: 1.24 ± 0.407
3.721AspAsp: 3.721 ± 0.874
2.481AspGlu: 2.481 ± 0.594
2.481AspPhe: 2.481 ± 1.12
2.171AspGly: 2.171 ± 0.376
0.62AspHis: 0.62 ± 0.17
7.442AspIle: 7.442 ± 0.895
6.512AspLys: 6.512 ± 1.104
5.581AspLeu: 5.581 ± 1.045
1.55AspMet: 1.55 ± 0.38
2.171AspAsn: 2.171 ± 0.373
2.171AspPro: 2.171 ± 0.646
0.62AspGln: 0.62 ± 0.17
3.411AspArg: 3.411 ± 0.359
3.411AspSer: 3.411 ± 0.861
3.411AspThr: 3.411 ± 0.667
5.581AspVal: 5.581 ± 1.195
0.31AspTrp: 0.31 ± 0.19
1.55AspTyr: 1.55 ± 0.38
0.0AspXaa: 0.0 ± 0.0
Glu
2.171GluAla: 2.171 ± 1.062
1.24GluCys: 1.24 ± 0.34
3.411GluAsp: 3.411 ± 0.943
2.481GluGlu: 2.481 ± 0.458
4.341GluPhe: 4.341 ± 0.709
2.791GluGly: 2.791 ± 0.433
3.101GluHis: 3.101 ± 0.849
3.411GluIle: 3.411 ± 0.539
6.822GluLys: 6.822 ± 1.668
4.961GluLeu: 4.961 ± 1.711
2.481GluMet: 2.481 ± 0.618
2.171GluAsn: 2.171 ± 0.48
1.86GluPro: 1.86 ± 0.332
0.93GluGln: 0.93 ± 0.471
3.721GluArg: 3.721 ± 0.91
7.752GluSer: 7.752 ± 1.898
2.791GluThr: 2.791 ± 0.477
3.101GluVal: 3.101 ± 0.517
1.55GluTrp: 1.55 ± 0.38
2.481GluTyr: 2.481 ± 0.618
0.0GluXaa: 0.0 ± 0.0
Phe
1.24PheAla: 1.24 ± 1.055
2.481PheCys: 2.481 ± 0.618
2.791PheAsp: 2.791 ± 1.054
3.411PheGlu: 3.411 ± 0.667
2.481PhePhe: 2.481 ± 0.49
0.93PheGly: 0.93 ± 0.247
0.93PheHis: 0.93 ± 0.247
3.101PheIle: 3.101 ± 0.416
4.961PheLys: 4.961 ± 1.65
3.721PheLeu: 3.721 ± 0.91
1.24PheMet: 1.24 ± 0.34
1.86PheAsn: 1.86 ± 0.51
2.481PhePro: 2.481 ± 0.458
2.791PheGln: 2.791 ± 1.191
2.791PheArg: 2.791 ± 0.595
4.961PheSer: 4.961 ± 1.227
4.031PheThr: 4.031 ± 1.026
2.481PheVal: 2.481 ± 0.308
0.0PheTrp: 0.0 ± 0.0
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
1.55GlyAla: 1.55 ± 0.465
1.24GlyCys: 1.24 ± 0.428
4.341GlyAsp: 4.341 ± 0.588
2.481GlyGlu: 2.481 ± 0.679
1.86GlyPhe: 1.86 ± 0.332
2.481GlyGly: 2.481 ± 1.12
0.93GlyHis: 0.93 ± 0.247
3.411GlyIle: 3.411 ± 0.86
3.101GlyLys: 3.101 ± 0.37
4.651GlyLeu: 4.651 ± 2.306
0.0GlyMet: 0.0 ± 0.0
2.481GlyAsn: 2.481 ± 0.49
1.55GlyPro: 1.55 ± 0.38
1.24GlyGln: 1.24 ± 0.517
1.86GlyArg: 1.86 ± 0.51
3.721GlySer: 3.721 ± 0.987
3.721GlyThr: 3.721 ± 2.208
4.031GlyVal: 4.031 ± 2.06
0.0GlyTrp: 0.0 ± 0.0
4.341GlyTyr: 4.341 ± 0.629
0.0GlyXaa: 0.0 ± 0.0
His
1.55HisAla: 1.55 ± 0.54
2.171HisCys: 2.171 ± 0.534
1.24HisAsp: 1.24 ± 0.34
1.86HisGlu: 1.86 ± 0.51
0.62HisPhe: 0.62 ± 0.17
0.31HisGly: 0.31 ± 0.591
0.0HisHis: 0.0 ± 0.0
1.86HisIle: 1.86 ± 0.51
1.55HisLys: 1.55 ± 0.465
0.31HisLeu: 0.31 ± 0.19
1.55HisMet: 1.55 ± 0.38
0.62HisAsn: 0.62 ± 0.17
0.93HisPro: 0.93 ± 0.247
0.62HisGln: 0.62 ± 0.17
1.86HisArg: 1.86 ± 0.51
1.55HisSer: 1.55 ± 0.38
1.86HisThr: 1.86 ± 0.51
3.721HisVal: 3.721 ± 1.019
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
4.341IleAla: 4.341 ± 0.588
0.62IleCys: 0.62 ± 0.17
3.411IleAsp: 3.411 ± 0.53
3.411IleGlu: 3.411 ± 1.535
1.55IlePhe: 1.55 ± 0.38
3.101IleGly: 3.101 ± 0.517
0.62IleHis: 0.62 ± 0.17
3.101IleIle: 3.101 ± 1.81
4.031IleLys: 4.031 ± 1.135
4.341IleLeu: 4.341 ± 1.152
0.31IleMet: 0.31 ± 0.445
1.24IleAsn: 1.24 ± 0.428
3.721IlePro: 3.721 ± 0.471
0.0IleGln: 0.0 ± 0.0
4.031IleArg: 4.031 ± 0.293
8.372IleSer: 8.372 ± 1.531
1.55IleThr: 1.55 ± 0.38
3.411IleVal: 3.411 ± 0.623
0.31IleTrp: 0.31 ± 0.19
2.481IleTyr: 2.481 ± 1.059
0.0IleXaa: 0.0 ± 0.0
Lys
3.411LysAla: 3.411 ± 0.53
0.93LysCys: 0.93 ± 0.247
2.791LysAsp: 2.791 ± 0.742
4.031LysGlu: 4.031 ± 0.506
4.651LysPhe: 4.651 ± 0.82
5.581LysGly: 5.581 ± 1.038
2.171LysHis: 2.171 ± 0.534
6.822LysIle: 6.822 ± 1.266
4.961LysLys: 4.961 ± 0.792
5.581LysLeu: 5.581 ± 0.943
1.24LysMet: 1.24 ± 0.514
4.031LysAsn: 4.031 ± 0.659
2.481LysPro: 2.481 ± 0.618
2.791LysGln: 2.791 ± 0.347
6.822LysArg: 6.822 ± 1.399
5.891LysSer: 5.891 ± 1.479
3.721LysThr: 3.721 ± 1.469
3.411LysVal: 3.411 ± 0.359
0.0LysTrp: 0.0 ± 0.0
1.86LysTyr: 1.86 ± 0.945
0.31LysXaa: 0.31 ± 0.19
Leu
6.512LeuAla: 6.512 ± 0.71
4.031LeuCys: 4.031 ± 1.026
7.132LeuAsp: 7.132 ± 0.676
5.581LeuGlu: 5.581 ± 0.941
4.031LeuPhe: 4.031 ± 0.293
2.791LeuGly: 2.791 ± 0.595
1.86LeuHis: 1.86 ± 0.458
3.721LeuIle: 3.721 ± 0.987
6.202LeuLys: 6.202 ± 1.468
5.581LeuLeu: 5.581 ± 0.962
4.031LeuMet: 4.031 ± 0.506
6.202LeuAsn: 6.202 ± 0.741
3.101LeuPro: 3.101 ± 0.746
4.341LeuGln: 4.341 ± 0.689
3.721LeuArg: 3.721 ± 0.663
10.853LeuSer: 10.853 ± 0.954
3.721LeuThr: 3.721 ± 0.503
8.372LeuVal: 8.372 ± 1.194
0.31LeuTrp: 0.31 ± 0.653
2.171LeuTyr: 2.171 ± 0.48
0.0LeuXaa: 0.0 ± 0.0
Met
1.55MetAla: 1.55 ± 0.391
0.31MetCys: 0.31 ± 0.591
3.101MetAsp: 3.101 ± 0.37
0.31MetGlu: 0.31 ± 0.19
0.31MetPhe: 0.31 ± 0.19
1.55MetGly: 1.55 ± 0.585
0.0MetHis: 0.0 ± 0.0
0.62MetIle: 0.62 ± 0.38
3.101MetLys: 3.101 ± 0.37
3.101MetLeu: 3.101 ± 0.849
0.62MetMet: 0.62 ± 0.17
0.62MetAsn: 0.62 ± 0.17
1.24MetPro: 1.24 ± 0.407
0.62MetGln: 0.62 ± 0.17
0.0MetArg: 0.0 ± 0.0
2.481MetSer: 2.481 ± 0.594
0.93MetThr: 0.93 ± 0.247
2.171MetVal: 2.171 ± 0.376
0.93MetTrp: 0.93 ± 0.247
0.62MetTyr: 0.62 ± 0.17
0.0MetXaa: 0.0 ± 0.0
Asn
2.171AsnAla: 2.171 ± 0.534
0.31AsnCys: 0.31 ± 0.19
1.86AsnAsp: 1.86 ± 0.942
1.55AsnGlu: 1.55 ± 0.465
3.101AsnPhe: 3.101 ± 0.467
3.721AsnGly: 3.721 ± 0.487
1.24AsnHis: 1.24 ± 0.428
2.791AsnIle: 2.791 ± 1.608
1.24AsnLys: 1.24 ± 0.407
6.512AsnLeu: 6.512 ± 1.104
0.0AsnMet: 0.0 ± 0.0
2.481AsnAsn: 2.481 ± 0.569
1.86AsnPro: 1.86 ± 1.121
0.0AsnGln: 0.0 ± 0.0
1.55AsnArg: 1.55 ± 0.51
3.721AsnSer: 3.721 ± 0.825
2.171AsnThr: 2.171 ± 0.619
4.651AsnVal: 4.651 ± 0.326
0.93AsnTrp: 0.93 ± 0.247
0.93AsnTyr: 0.93 ± 0.471
0.0AsnXaa: 0.0 ± 0.0
Pro
2.481ProAla: 2.481 ± 0.618
0.31ProCys: 0.31 ± 0.19
0.31ProAsp: 0.31 ± 0.19
6.512ProGlu: 6.512 ± 0.491
0.62ProPhe: 0.62 ± 0.17
2.481ProGly: 2.481 ± 0.569
0.93ProHis: 0.93 ± 0.247
2.171ProIle: 2.171 ± 0.376
4.031ProLys: 4.031 ± 0.506
3.721ProLeu: 3.721 ± 0.267
1.55ProMet: 1.55 ± 0.38
1.24ProAsn: 1.24 ± 1.055
0.62ProPro: 0.62 ± 0.17
0.0ProGln: 0.0 ± 0.0
0.62ProArg: 0.62 ± 0.56
3.101ProSer: 3.101 ± 0.37
3.101ProThr: 3.101 ± 1.021
2.171ProVal: 2.171 ± 0.954
0.31ProTrp: 0.31 ± 0.591
0.62ProTyr: 0.62 ± 0.17
0.0ProXaa: 0.0 ± 0.0
Gln
2.171GlnAla: 2.171 ± 0.514
0.62GlnCys: 0.62 ± 0.17
0.62GlnAsp: 0.62 ± 0.38
3.411GlnGlu: 3.411 ± 0.86
0.93GlnPhe: 0.93 ± 0.471
2.171GlnGly: 2.171 ± 0.534
0.0GlnHis: 0.0 ± 0.0
1.86GlnIle: 1.86 ± 0.51
1.24GlnLys: 1.24 ± 0.34
4.341GlnLeu: 4.341 ± 1.566
0.62GlnMet: 0.62 ± 0.17
0.93GlnAsn: 0.93 ± 0.247
1.24GlnPro: 1.24 ± 0.407
0.62GlnGln: 0.62 ± 0.17
0.31GlnArg: 0.31 ± 0.19
1.55GlnSer: 1.55 ± 1.435
3.411GlnThr: 3.411 ± 0.53
0.0GlnVal: 0.0 ± 0.0
0.0GlnTrp: 0.0 ± 0.0
0.31GlnTyr: 0.31 ± 0.19
0.0GlnXaa: 0.0 ± 0.0
Arg
2.791ArgAla: 2.791 ± 1.413
2.171ArgCys: 2.171 ± 0.376
2.481ArgAsp: 2.481 ± 0.594
2.481ArgGlu: 2.481 ± 0.458
2.171ArgPhe: 2.171 ± 0.48
2.481ArgGly: 2.481 ± 0.849
2.171ArgHis: 2.171 ± 0.534
0.31ArgIle: 0.31 ± 0.653
2.481ArgLys: 2.481 ± 1.208
4.961ArgLeu: 4.961 ± 0.862
0.31ArgMet: 0.31 ± 0.591
2.171ArgAsn: 2.171 ± 0.48
0.93ArgPro: 0.93 ± 0.561
0.93ArgGln: 0.93 ± 0.247
1.24ArgArg: 1.24 ± 0.908
7.132ArgSer: 7.132 ± 1.157
3.101ArgThr: 3.101 ± 0.746
5.271ArgVal: 5.271 ± 0.426
0.0ArgTrp: 0.0 ± 0.0
1.24ArgTyr: 1.24 ± 0.34
0.0ArgXaa: 0.0 ± 0.0
Ser
6.822SerAla: 6.822 ± 1.218
1.24SerCys: 1.24 ± 0.407
4.341SerAsp: 4.341 ± 0.588
6.512SerGlu: 6.512 ± 2.158
5.891SerPhe: 5.891 ± 0.34
4.961SerGly: 4.961 ± 3.543
0.62SerHis: 0.62 ± 0.17
3.721SerIle: 3.721 ± 0.825
7.442SerLys: 7.442 ± 0.328
9.612SerLeu: 9.612 ± 1.816
2.481SerMet: 2.481 ± 0.324
4.651SerAsn: 4.651 ± 0.632
0.62SerPro: 0.62 ± 0.17
2.171SerGln: 2.171 ± 1.135
5.581SerArg: 5.581 ± 0.66
4.031SerSer: 4.031 ± 0.748
4.341SerThr: 4.341 ± 0.89
8.062SerVal: 8.062 ± 1.598
1.24SerTrp: 1.24 ± 0.34
3.411SerTyr: 3.411 ± 1.573
0.0SerXaa: 0.0 ± 0.0
Thr
3.101ThrAla: 3.101 ± 0.961
1.86ThrCys: 1.86 ± 0.51
1.86ThrAsp: 1.86 ± 0.495
2.791ThrGlu: 2.791 ± 0.433
4.031ThrPhe: 4.031 ± 1.026
2.171ThrGly: 2.171 ± 0.514
2.171ThrHis: 2.171 ± 0.376
3.411ThrIle: 3.411 ± 2.106
2.791ThrLys: 2.791 ± 0.433
8.062ThrLeu: 8.062 ± 1.112
0.62ThrMet: 0.62 ± 0.17
2.481ThrAsn: 2.481 ± 1.941
1.86ThrPro: 1.86 ± 0.768
3.411ThrGln: 3.411 ± 0.667
3.411ThrArg: 3.411 ± 2.119
3.101ThrSer: 3.101 ± 0.961
4.341ThrThr: 4.341 ± 1.474
4.961ThrVal: 4.961 ± 1.647
0.62ThrTrp: 0.62 ± 0.17
3.101ThrTyr: 3.101 ± 0.849
0.0ThrXaa: 0.0 ± 0.0
Val
4.651ValAla: 4.651 ± 0.326
0.93ValCys: 0.93 ± 0.247
7.132ValAsp: 7.132 ± 0.796
6.512ValGlu: 6.512 ± 0.326
4.961ValPhe: 4.961 ± 0.801
0.62ValGly: 0.62 ± 0.991
3.411ValHis: 3.411 ± 0.86
0.93ValIle: 0.93 ± 0.471
3.101ValLys: 3.101 ± 1.345
5.581ValLeu: 5.581 ± 0.84
0.62ValMet: 0.62 ± 0.17
4.031ValAsn: 4.031 ± 0.748
3.721ValPro: 3.721 ± 1.241
3.411ValGln: 3.411 ± 0.86
3.411ValArg: 3.411 ± 0.951
6.512ValSer: 6.512 ± 0.263
4.031ValThr: 4.031 ± 0.659
5.891ValVal: 5.891 ± 2.027
3.101ValTrp: 3.101 ± 0.416
5.581ValTyr: 5.581 ± 1.484
0.0ValXaa: 0.0 ± 0.0
Trp
0.31TrpAla: 0.31 ± 0.653
0.0TrpCys: 0.0 ± 0.0
1.24TrpAsp: 1.24 ± 0.34
2.481TrpGlu: 2.481 ± 0.577
0.62TrpPhe: 0.62 ± 0.17
0.62TrpGly: 0.62 ± 0.17
0.0TrpHis: 0.0 ± 0.0
0.31TrpIle: 0.31 ± 0.19
0.62TrpLys: 0.62 ± 0.17
1.55TrpLeu: 1.55 ± 0.38
0.93TrpMet: 0.93 ± 0.471
0.62TrpAsn: 0.62 ± 0.38
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
1.24TrpVal: 1.24 ± 0.34
0.0TrpTrp: 0.0 ± 0.0
0.31TrpTyr: 0.31 ± 0.19
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.481TyrAla: 2.481 ± 0.679
0.0TyrCys: 0.0 ± 0.0
3.411TyrAsp: 3.411 ± 0.53
1.24TyrGlu: 1.24 ± 0.407
1.55TyrPhe: 1.55 ± 0.38
2.481TyrGly: 2.481 ± 0.679
1.55TyrHis: 1.55 ± 0.38
1.86TyrIle: 1.86 ± 0.458
3.411TyrLys: 3.411 ± 0.53
2.171TyrLeu: 2.171 ± 1.135
2.171TyrMet: 2.171 ± 0.646
0.62TyrAsn: 0.62 ± 0.17
2.791TyrPro: 2.791 ± 0.347
1.55TyrGln: 1.55 ± 0.38
0.31TyrArg: 0.31 ± 0.19
1.86TyrSer: 1.86 ± 0.332
2.171TyrThr: 2.171 ± 0.514
2.171TyrVal: 2.171 ± 0.373
0.0TyrTrp: 0.0 ± 0.0
2.481TyrTyr: 2.481 ± 0.49
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.31XaaGln: 0.31 ± 0.19
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3226 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski