Amino acid dipepetide frequency for Mycobacteroides abscessus subsp. abscessus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.106AlaAla: 17.106 ± 0.164	1.514AlaCys: 1.514 ± 0.039	6.428AlaAsp: 6.428 ± 0.077	6.039AlaGlu: 6.039 ± 0.068	3.103AlaPhe: 3.103 ± 0.055	10.229AlaGly: 10.229 ± 0.09	2.557AlaHis: 2.557 ± 0.043	5.35AlaIle: 5.35 ± 0.074	2.955AlaLys: 2.955 ± 0.049	10.736AlaLeu: 10.736 ± 0.098	3.447AlaMet: 3.447 ± 0.056	2.612AlaAsn: 2.612 ± 0.044	6.672AlaPro: 6.672 ± 0.082	3.834AlaGln: 3.834 ± 0.054	8.762AlaArg: 8.762 ± 0.104	8.596AlaSer: 8.596 ± 0.098	7.397AlaThr: 7.397 ± 0.08	10.306AlaVal: 10.306 ± 0.103	1.417AlaTrp: 1.417 ± 0.036	2.003AlaTyr: 2.003 ± 0.04	0.009AlaXaa: 0.009 ± 0.003
Cys	1.752CysAla: 1.752 ± 0.04	0.346CysCys: 0.346 ± 0.018	0.583CysAsp: 0.583 ± 0.023	0.499CysGlu: 0.499 ± 0.018	0.319CysPhe: 0.319 ± 0.017	1.386CysGly: 1.386 ± 0.036	0.355CysHis: 0.355 ± 0.018	0.338CysIle: 0.338 ± 0.017	0.191CysLys: 0.191 ± 0.014	0.972CysLeu: 0.972 ± 0.032	0.307CysMet: 0.307 ± 0.015	0.266CysAsn: 0.266 ± 0.014	0.937CysPro: 0.937 ± 0.026	0.478CysGln: 0.478 ± 0.02	1.316CysArg: 1.316 ± 0.034	1.488CysSer: 1.488 ± 0.036	1.012CysThr: 1.012 ± 0.032	0.843CysVal: 0.843 ± 0.023	0.238CysTrp: 0.238 ± 0.013	0.161CysTyr: 0.161 ± 0.01	0.002CysXaa: 0.002 ± 0.001
Asp	5.871AspAla: 5.871 ± 0.085	0.508AspCys: 0.508 ± 0.021	3.229AspAsp: 3.229 ± 0.06	3.243AspGlu: 3.243 ± 0.047	1.434AspPhe: 1.434 ± 0.033	4.932AspGly: 4.932 ± 0.067	1.421AspHis: 1.421 ± 0.036	2.518AspIle: 2.518 ± 0.049	1.25AspLys: 1.25 ± 0.03	4.836AspLeu: 4.836 ± 0.061	1.012AspMet: 1.012 ± 0.032	1.161AspAsn: 1.161 ± 0.032	3.532AspPro: 3.532 ± 0.057	1.726AspGln: 1.726 ± 0.038	4.036AspArg: 4.036 ± 0.056	3.155AspSer: 3.155 ± 0.053	2.824AspThr: 2.824 ± 0.046	4.069AspVal: 4.069 ± 0.063	0.711AspTrp: 0.711 ± 0.027	0.965AspTyr: 0.965 ± 0.029	0.002AspXaa: 0.002 ± 0.001
Glu	4.867GluAla: 4.867 ± 0.057	0.507GluCys: 0.507 ± 0.022	2.027GluAsp: 2.027 ± 0.044	2.071GluGlu: 2.071 ± 0.042	1.556GluPhe: 1.556 ± 0.041	3.037GluGly: 3.037 ± 0.05	1.401GluHis: 1.401 ± 0.038	2.362GluIle: 2.362 ± 0.039	1.355GluLys: 1.355 ± 0.034	5.255GluLeu: 5.255 ± 0.074	1.133GluMet: 1.133 ± 0.032	1.191GluAsn: 1.191 ± 0.03	2.791GluPro: 2.791 ± 0.049	1.965GluGln: 1.965 ± 0.04	3.884GluArg: 3.884 ± 0.06	3.019GluSer: 3.019 ± 0.052	2.371GluThr: 2.371 ± 0.039	3.692GluVal: 3.692 ± 0.057	0.566GluTrp: 0.566 ± 0.019	1.029GluTyr: 1.029 ± 0.03	0.001GluXaa: 0.001 ± 0.001
Phe	3.238PheAla: 3.238 ± 0.051	0.452PheCys: 0.452 ± 0.02	1.93PheAsp: 1.93 ± 0.04	1.311PheGlu: 1.311 ± 0.035	0.921PhePhe: 0.921 ± 0.027	3.194PheGly: 3.194 ± 0.049	0.631PheHis: 0.631 ± 0.022	1.087PheIle: 1.087 ± 0.031	0.492PheLys: 0.492 ± 0.021	2.277PheLeu: 2.277 ± 0.043	0.544PheMet: 0.544 ± 0.02	0.669PheAsn: 0.669 ± 0.023	1.337PhePro: 1.337 ± 0.035	0.826PheGln: 0.826 ± 0.023	1.773PheArg: 1.773 ± 0.038	2.146PheSer: 2.146 ± 0.048	1.961PheThr: 1.961 ± 0.035	2.131PheVal: 2.131 ± 0.043	0.448PheTrp: 0.448 ± 0.019	0.523PheTyr: 0.523 ± 0.02	0.002PheXaa: 0.002 ± 0.001
Gly	9.268GlyAla: 9.268 ± 0.097	1.198GlyCys: 1.198 ± 0.03	4.499GlyAsp: 4.499 ± 0.064	4.023GlyGlu: 4.023 ± 0.058	2.64GlyPhe: 2.64 ± 0.047	6.958GlyGly: 6.958 ± 0.094	2.184GlyHis: 2.184 ± 0.046	4.026GlyIle: 4.026 ± 0.056	2.3GlyLys: 2.3 ± 0.045	7.583GlyLeu: 7.583 ± 0.092	2.394GlyMet: 2.394 ± 0.045	2.061GlyAsn: 2.061 ± 0.042	4.43GlyPro: 4.43 ± 0.064	3.09GlyGln: 3.09 ± 0.057	6.38GlyArg: 6.38 ± 0.077	6.083GlySer: 6.083 ± 0.07	5.088GlyThr: 5.088 ± 0.063	7.072GlyVal: 7.072 ± 0.078	1.403GlyTrp: 1.403 ± 0.038	1.949GlyTyr: 1.949 ± 0.04	0.006GlyXaa: 0.006 ± 0.002
His	2.411HisAla: 2.411 ± 0.04	0.345HisCys: 0.345 ± 0.016	1.269HisAsp: 1.269 ± 0.032	1.013HisGlu: 1.013 ± 0.03	0.586HisPhe: 0.586 ± 0.021	2.232HisGly: 2.232 ± 0.044	0.927HisHis: 0.927 ± 0.032	0.938HisIle: 0.938 ± 0.028	0.438HisLys: 0.438 ± 0.018	2.092HisLeu: 2.092 ± 0.046	0.5HisMet: 0.5 ± 0.022	0.462HisAsn: 0.462 ± 0.018	1.643HisPro: 1.643 ± 0.036	0.954HisGln: 0.954 ± 0.031	2.444HisArg: 2.444 ± 0.056	1.337HisSer: 1.337 ± 0.033	1.245HisThr: 1.245 ± 0.033	1.685HisVal: 1.685 ± 0.04	0.319HisTrp: 0.319 ± 0.016	0.421HisTyr: 0.421 ± 0.016	0.001HisXaa: 0.001 ± 0.001
Ile	6.114IleAla: 6.114 ± 0.068	0.7IleCys: 0.7 ± 0.024	3.009IleAsp: 3.009 ± 0.05	2.44IleGlu: 2.44 ± 0.041	1.148IlePhe: 1.148 ± 0.033	4.473IleGly: 4.473 ± 0.061	0.838IleHis: 0.838 ± 0.028	1.47IleIle: 1.47 ± 0.037	0.919IleLys: 0.919 ± 0.029	2.958IleLeu: 2.958 ± 0.054	0.759IleMet: 0.759 ± 0.023	1.123IleAsn: 1.123 ± 0.031	2.767IlePro: 2.767 ± 0.045	1.137IleGln: 1.137 ± 0.029	3.076IleArg: 3.076 ± 0.048	3.338IleSer: 3.338 ± 0.052	2.983IleThr: 2.983 ± 0.051	3.271IleVal: 3.271 ± 0.05	0.541IleTrp: 0.541 ± 0.022	0.645IleTyr: 0.645 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	2.742LysAla: 2.742 ± 0.06	0.275LysCys: 0.275 ± 0.014	1.093LysAsp: 1.093 ± 0.032	0.977LysGlu: 0.977 ± 0.031	0.673LysPhe: 0.673 ± 0.024	1.562LysGly: 1.562 ± 0.041	0.549LysHis: 0.549 ± 0.023	1.135LysIle: 1.135 ± 0.03	0.767LysLys: 0.767 ± 0.032	2.066LysLeu: 2.066 ± 0.043	0.692LysMet: 0.692 ± 0.023	0.644LysAsn: 0.644 ± 0.025	1.749LysPro: 1.749 ± 0.037	0.718LysGln: 0.718 ± 0.024	1.716LysArg: 1.716 ± 0.039	1.759LysSer: 1.759 ± 0.039	1.443LysThr: 1.443 ± 0.033	1.951LysVal: 1.951 ± 0.036	0.292LysTrp: 0.292 ± 0.016	0.577LysTyr: 0.577 ± 0.019	0.001LysXaa: 0.001 ± 0.001
Leu	11.56LeuAla: 11.56 ± 0.108	0.973LeuCys: 0.973 ± 0.029	5.215LeuAsp: 5.215 ± 0.073	3.661LeuGlu: 3.661 ± 0.063	2.292LeuPhe: 2.292 ± 0.047	7.943LeuGly: 7.943 ± 0.097	1.914LeuHis: 1.914 ± 0.039	3.886LeuIle: 3.886 ± 0.051	1.782LeuLys: 1.782 ± 0.04	8.211LeuLeu: 8.211 ± 0.107	2.008LeuMet: 2.008 ± 0.043	1.968LeuAsn: 1.968 ± 0.04	5.696LeuPro: 5.696 ± 0.064	2.352LeuGln: 2.352 ± 0.041	7.218LeuArg: 7.218 ± 0.085	6.045LeuSer: 6.045 ± 0.067	5.67LeuThr: 5.67 ± 0.068	7.543LeuVal: 7.543 ± 0.086	1.036LeuTrp: 1.036 ± 0.027	1.4LeuTyr: 1.4 ± 0.035	0.005LeuXaa: 0.005 ± 0.002
Met	3.134MetAla: 3.134 ± 0.055	0.369MetCys: 0.369 ± 0.017	0.968MetAsp: 0.968 ± 0.031	0.762MetGlu: 0.762 ± 0.022	0.745MetPhe: 0.745 ± 0.025	1.701MetGly: 1.701 ± 0.042	0.538MetHis: 0.538 ± 0.022	1.218MetIle: 1.218 ± 0.031	0.675MetLys: 0.675 ± 0.024	2.361MetLeu: 2.361 ± 0.047	0.687MetMet: 0.687 ± 0.024	0.741MetAsn: 0.741 ± 0.026	2.02MetPro: 2.02 ± 0.04	0.64MetGln: 0.64 ± 0.022	2.252MetArg: 2.252 ± 0.037	2.392MetSer: 2.392 ± 0.042	2.153MetThr: 2.153 ± 0.037	2.123MetVal: 2.123 ± 0.038	0.336MetTrp: 0.336 ± 0.017	0.454MetTyr: 0.454 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.763AsnAla: 2.763 ± 0.051	0.363AsnCys: 0.363 ± 0.016	1.161AsnAsp: 1.161 ± 0.029	0.981AsnGlu: 0.981 ± 0.026	0.598AsnPhe: 0.598 ± 0.022	2.133AsnGly: 2.133 ± 0.045	0.494AsnHis: 0.494 ± 0.022	1.026AsnIle: 1.026 ± 0.028	0.515AsnLys: 0.515 ± 0.02	1.904AsnLeu: 1.904 ± 0.041	0.542AsnMet: 0.542 ± 0.023	0.616AsnAsn: 0.616 ± 0.024	1.875AsnPro: 1.875 ± 0.039	0.727AsnGln: 0.727 ± 0.025	1.948AsnArg: 1.948 ± 0.043	1.907AsnSer: 1.907 ± 0.037	1.62AsnThr: 1.62 ± 0.036	1.676AsnVal: 1.676 ± 0.031	0.38AsnTrp: 0.38 ± 0.016	0.435AsnTyr: 0.435 ± 0.022	0.005AsnXaa: 0.005 ± 0.002
Pro	7.6ProAla: 7.6 ± 0.08	0.819ProCys: 0.819 ± 0.03	3.526ProAsp: 3.526 ± 0.055	3.414ProGlu: 3.414 ± 0.057	1.515ProPhe: 1.515 ± 0.033	5.718ProGly: 5.718 ± 0.075	1.299ProHis: 1.299 ± 0.033	2.484ProIle: 2.484 ± 0.049	1.593ProLys: 1.593 ± 0.036	4.888ProLeu: 4.888 ± 0.066	1.897ProMet: 1.897 ± 0.04	1.603ProAsn: 1.603 ± 0.038	3.944ProPro: 3.944 ± 0.083	1.781ProGln: 1.781 ± 0.038	4.37ProArg: 4.37 ± 0.057	5.046ProSer: 5.046 ± 0.069	3.785ProThr: 3.785 ± 0.061	5.182ProVal: 5.182 ± 0.062	0.909ProTrp: 0.909 ± 0.03	1.052ProTyr: 1.052 ± 0.026	0.003ProXaa: 0.003 ± 0.001
Gln	3.174GlnAla: 3.174 ± 0.055	0.451GlnCys: 0.451 ± 0.019	1.207GlnAsp: 1.207 ± 0.031	1.177GlnGlu: 1.177 ± 0.032	1.033GlnPhe: 1.033 ± 0.025	2.12GlnGly: 2.12 ± 0.043	0.991GlnHis: 0.991 ± 0.032	1.622GlnIle: 1.622 ± 0.036	0.681GlnLys: 0.681 ± 0.025	3.427GlnLeu: 3.427 ± 0.049	0.891GlnMet: 0.891 ± 0.027	0.654GlnAsn: 0.654 ± 0.023	2.077GlnPro: 2.077 ± 0.04	1.461GlnGln: 1.461 ± 0.043	3.208GlnArg: 3.208 ± 0.053	1.745GlnSer: 1.745 ± 0.036	1.551GlnThr: 1.551 ± 0.035	2.525GlnVal: 2.525 ± 0.044	0.525GlnTrp: 0.525 ± 0.021	0.697GlnTyr: 0.697 ± 0.022	0.001GlnXaa: 0.001 ± 0.001
Arg	8.481ArgAla: 8.481 ± 0.09	1.301ArgCys: 1.301 ± 0.032	3.833ArgAsp: 3.833 ± 0.058	3.557ArgGlu: 3.557 ± 0.053	2.372ArgPhe: 2.372 ± 0.042	5.512ArgGly: 5.512 ± 0.071	2.046ArgHis: 2.046 ± 0.045	3.767ArgIle: 3.767 ± 0.048	1.956ArgLys: 1.956 ± 0.044	7.071ArgLeu: 7.071 ± 0.073	2.725ArgMet: 2.725 ± 0.049	1.985ArgAsn: 1.985 ± 0.035	4.967ArgPro: 4.967 ± 0.071	2.639ArgGln: 2.639 ± 0.047	7.495ArgArg: 7.495 ± 0.09	6.457ArgSer: 6.457 ± 0.096	4.764ArgThr: 4.764 ± 0.056	5.718ArgVal: 5.718 ± 0.067	1.318ArgTrp: 1.318 ± 0.037	1.881ArgTyr: 1.881 ± 0.036	0.007ArgXaa: 0.007 ± 0.002
Ser	9.816SerAla: 9.816 ± 0.107	1.302SerCys: 1.302 ± 0.033	3.113SerAsp: 3.113 ± 0.045	2.877SerGlu: 2.877 ± 0.05	1.805SerPhe: 1.805 ± 0.044	6.75SerGly: 6.75 ± 0.083	1.363SerHis: 1.363 ± 0.03	2.928SerIle: 2.928 ± 0.052	1.567SerLys: 1.567 ± 0.033	5.461SerLeu: 5.461 ± 0.061	2.358SerMet: 2.358 ± 0.048	1.579SerAsn: 1.579 ± 0.037	4.83SerPro: 4.83 ± 0.07	1.789SerGln: 1.789 ± 0.038	6.302SerArg: 6.302 ± 0.09	7.654SerSer: 7.654 ± 0.112	5.619SerThr: 5.619 ± 0.078	5.533SerVal: 5.533 ± 0.072	1.254SerTrp: 1.254 ± 0.029	1.135SerTyr: 1.135 ± 0.03	0.002SerXaa: 0.002 ± 0.001
Thr	8.014ThrAla: 8.014 ± 0.073	0.853ThrCys: 0.853 ± 0.022	3.106ThrAsp: 3.106 ± 0.047	2.907ThrGlu: 2.907 ± 0.048	1.738ThrPhe: 1.738 ± 0.038	5.616ThrGly: 5.616 ± 0.068	1.216ThrHis: 1.216 ± 0.035	2.552ThrIle: 2.552 ± 0.048	1.495ThrLys: 1.495 ± 0.038	5.067ThrLeu: 5.067 ± 0.07	1.661ThrMet: 1.661 ± 0.037	1.485ThrAsn: 1.485 ± 0.037	4.284ThrPro: 4.284 ± 0.073	1.602ThrGln: 1.602 ± 0.036	4.53ThrArg: 4.53 ± 0.062	4.941ThrSer: 4.941 ± 0.079	4.359ThrThr: 4.359 ± 0.074	5.634ThrVal: 5.634 ± 0.069	0.873ThrTrp: 0.873 ± 0.028	1.147ThrTyr: 1.147 ± 0.029	0.004ThrXaa: 0.004 ± 0.002
Val	9.692ValAla: 9.692 ± 0.09	1.029ValCys: 1.029 ± 0.028	4.71ValAsp: 4.71 ± 0.07	3.724ValGlu: 3.724 ± 0.053	2.247ValPhe: 2.247 ± 0.043	6.643ValGly: 6.643 ± 0.068	1.796ValHis: 1.796 ± 0.041	3.745ValIle: 3.745 ± 0.055	1.759ValLys: 1.759 ± 0.045	7.749ValLeu: 7.749 ± 0.081	1.909ValMet: 1.909 ± 0.042	2.032ValAsn: 2.032 ± 0.04	4.713ValPro: 4.713 ± 0.061	2.293ValGln: 2.293 ± 0.043	6.06ValArg: 6.06 ± 0.063	5.64ValSer: 5.64 ± 0.074	5.368ValThr: 5.368 ± 0.058	7.461ValVal: 7.461 ± 0.09	0.917ValTrp: 0.917 ± 0.03	1.357ValTyr: 1.357 ± 0.035	0.002ValXaa: 0.002 ± 0.001
Trp	1.476TrpAla: 1.476 ± 0.035	0.219TrpCys: 0.219 ± 0.014	0.567TrpAsp: 0.567 ± 0.019	0.527TrpGlu: 0.527 ± 0.021	0.481TrpPhe: 0.481 ± 0.018	0.801TrpGly: 0.801 ± 0.024	0.353TrpHis: 0.353 ± 0.016	0.644TrpIle: 0.644 ± 0.024	0.36TrpLys: 0.36 ± 0.018	1.453TrpLeu: 1.453 ± 0.034	0.487TrpMet: 0.487 ± 0.02	0.408TrpAsn: 0.408 ± 0.02	0.958TrpPro: 0.958 ± 0.026	0.516TrpGln: 0.516 ± 0.02	1.209TrpArg: 1.209 ± 0.03	1.023TrpSer: 1.023 ± 0.028	0.848TrpThr: 0.848 ± 0.028	1.134TrpVal: 1.134 ± 0.028	0.316TrpTrp: 0.316 ± 0.017	0.33TrpTyr: 0.33 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.988TyrAla: 1.988 ± 0.04	0.265TyrCys: 0.265 ± 0.015	0.958TyrAsp: 0.958 ± 0.025	0.874TyrGlu: 0.874 ± 0.027	0.686TyrPhe: 0.686 ± 0.022	1.693TyrGly: 1.693 ± 0.038	0.387TyrHis: 0.387 ± 0.015	0.613TyrIle: 0.613 ± 0.022	0.329TyrLys: 0.329 ± 0.019	2.008TyrLeu: 2.008 ± 0.042	0.313TyrMet: 0.313 ± 0.014	0.409TyrAsn: 0.409 ± 0.018	1.202TyrPro: 1.202 ± 0.032	0.687TyrGln: 0.687 ± 0.022	1.863TyrArg: 1.863 ± 0.039	1.26TyrSer: 1.26 ± 0.035	1.021TyrThr: 1.021 ± 0.031	1.296TyrVal: 1.296 ± 0.035	0.309TyrTrp: 0.309 ± 0.014	0.358TyrTyr: 0.358 ± 0.018	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.005XaaAla: 0.005 ± 0.002	0.002XaaCys: 0.002 ± 0.001	0.004XaaAsp: 0.004 ± 0.002	0.002XaaGlu: 0.002 ± 0.001	0.002XaaPhe: 0.002 ± 0.001	0.003XaaGly: 0.003 ± 0.002	0.002XaaHis: 0.002 ± 0.001	0.002XaaIle: 0.002 ± 0.001	0.001XaaLys: 0.001 ± 0.001	0.003XaaLeu: 0.003 ± 0.002	0.002XaaMet: 0.002 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.007XaaPro: 0.007 ± 0.002	0.001XaaGln: 0.001 ± 0.001	0.009XaaArg: 0.009 ± 0.003	0.005XaaSer: 0.005 ± 0.002	0.002XaaThr: 0.002 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.002XaaTrp: 0.002 ± 0.001	0.001XaaTyr: 0.001 ± 0.001	0.278XaaXaa: 0.278 ± 0.049

Statistics based on 9486 proteins (1295986 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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