Amino acid dipepetide frequency for Paracoccus laeviglucosivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.86AlaAla: 17.86 ± 0.16	1.059AlaCys: 1.059 ± 0.031	7.297AlaAsp: 7.297 ± 0.083	8.065AlaGlu: 8.065 ± 0.092	4.08AlaPhe: 4.08 ± 0.061	11.219AlaGly: 11.219 ± 0.12	2.357AlaHis: 2.357 ± 0.052	6.267AlaIle: 6.267 ± 0.076	3.549AlaLys: 3.549 ± 0.057	14.353AlaLeu: 14.353 ± 0.121	4.225AlaMet: 4.225 ± 0.061	2.84AlaAsn: 2.84 ± 0.051	6.151AlaPro: 6.151 ± 0.084	5.27AlaGln: 5.27 ± 0.071	9.522AlaArg: 9.522 ± 0.109	5.685AlaSer: 5.685 ± 0.067	6.231AlaThr: 6.231 ± 0.075	8.527AlaVal: 8.527 ± 0.09	1.54AlaTrp: 1.54 ± 0.037	2.336AlaTyr: 2.336 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.001CysAla: 1.001 ± 0.029	0.108CysCys: 0.108 ± 0.009	0.577CysAsp: 0.577 ± 0.023	0.375CysGlu: 0.375 ± 0.017	0.307CysPhe: 0.307 ± 0.015	0.907CysGly: 0.907 ± 0.029	0.254CysHis: 0.254 ± 0.016	0.414CysIle: 0.414 ± 0.017	0.175CysLys: 0.175 ± 0.012	0.77CysLeu: 0.77 ± 0.026	0.171CysMet: 0.171 ± 0.011	0.205CysAsn: 0.205 ± 0.012	0.467CysPro: 0.467 ± 0.021	0.244CysGln: 0.244 ± 0.013	0.545CysArg: 0.545 ± 0.023	0.418CysSer: 0.418 ± 0.018	0.367CysThr: 0.367 ± 0.016	0.554CysVal: 0.554 ± 0.02	0.118CysTrp: 0.118 ± 0.009	0.187CysTyr: 0.187 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.804AspAla: 7.804 ± 0.091	0.485AspCys: 0.485 ± 0.019	3.467AspAsp: 3.467 ± 0.066	3.276AspGlu: 3.276 ± 0.056	2.279AspPhe: 2.279 ± 0.049	5.406AspGly: 5.406 ± 0.068	1.391AspHis: 1.391 ± 0.039	2.882AspIle: 2.882 ± 0.054	1.553AspLys: 1.553 ± 0.038	6.519AspLeu: 6.519 ± 0.082	1.674AspMet: 1.674 ± 0.036	1.259AspAsn: 1.259 ± 0.034	3.842AspPro: 3.842 ± 0.051	2.156AspGln: 2.156 ± 0.04	4.638AspArg: 4.638 ± 0.067	2.077AspSer: 2.077 ± 0.048	2.793AspThr: 2.793 ± 0.067	3.688AspVal: 3.688 ± 0.053	1.212AspTrp: 1.212 ± 0.026	1.53AspTyr: 1.53 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.952GluAla: 6.952 ± 0.085	0.332GluCys: 0.332 ± 0.018	2.649GluAsp: 2.649 ± 0.046	2.582GluGlu: 2.582 ± 0.05	1.825GluPhe: 1.825 ± 0.037	4.123GluGly: 4.123 ± 0.058	1.115GluHis: 1.115 ± 0.033	3.467GluIle: 3.467 ± 0.052	1.881GluLys: 1.881 ± 0.045	5.217GluLeu: 5.217 ± 0.058	1.645GluMet: 1.645 ± 0.032	1.621GluAsn: 1.621 ± 0.038	2.549GluPro: 2.549 ± 0.056	1.913GluGln: 1.913 ± 0.043	4.166GluArg: 4.166 ± 0.063	2.118GluSer: 2.118 ± 0.038	3.293GluThr: 3.293 ± 0.05	3.615GluVal: 3.615 ± 0.055	0.807GluTrp: 0.807 ± 0.025	1.091GluTyr: 1.091 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.535PheAla: 4.535 ± 0.062	0.382PheCys: 0.382 ± 0.017	2.677PheAsp: 2.677 ± 0.052	1.634PheGlu: 1.634 ± 0.036	1.29PhePhe: 1.29 ± 0.038	3.601PheGly: 3.601 ± 0.057	0.78PheHis: 0.78 ± 0.025	1.591PheIle: 1.591 ± 0.035	0.74PheLys: 0.74 ± 0.025	3.421PheLeu: 3.421 ± 0.059	0.883PheMet: 0.883 ± 0.028	0.939PheAsn: 0.939 ± 0.028	1.588PhePro: 1.588 ± 0.032	1.069PheGln: 1.069 ± 0.028	2.264PheArg: 2.264 ± 0.047	2.031PheSer: 2.031 ± 0.036	1.936PheThr: 1.936 ± 0.038	2.517PheVal: 2.517 ± 0.05	0.582PheTrp: 0.582 ± 0.024	0.81PheTyr: 0.81 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.136GlyAla: 10.136 ± 0.121	0.804GlyCys: 0.804 ± 0.027	4.774GlyAsp: 4.774 ± 0.069	4.259GlyGlu: 4.259 ± 0.058	3.688GlyPhe: 3.688 ± 0.054	7.582GlyGly: 7.582 ± 0.107	2.003GlyHis: 2.003 ± 0.044	4.927GlyIle: 4.927 ± 0.064	3.0GlyLys: 3.0 ± 0.052	9.503GlyLeu: 9.503 ± 0.095	2.699GlyMet: 2.699 ± 0.045	2.43GlyAsn: 2.43 ± 0.085	3.879GlyPro: 3.879 ± 0.062	3.588GlyGln: 3.588 ± 0.066	6.256GlyArg: 6.256 ± 0.075	4.189GlySer: 4.189 ± 0.055	4.626GlyThr: 4.626 ± 0.075	6.189GlyVal: 6.189 ± 0.071	1.588GlyTrp: 1.588 ± 0.035	2.204GlyTyr: 2.204 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.438HisAla: 2.438 ± 0.046	0.23HisCys: 0.23 ± 0.016	1.47HisAsp: 1.47 ± 0.037	1.104HisGlu: 1.104 ± 0.03	0.79HisPhe: 0.79 ± 0.024	2.042HisGly: 2.042 ± 0.043	0.572HisHis: 0.572 ± 0.024	0.993HisIle: 0.993 ± 0.027	0.433HisLys: 0.433 ± 0.017	2.13HisLeu: 2.13 ± 0.042	0.562HisMet: 0.562 ± 0.022	0.422HisAsn: 0.422 ± 0.016	1.456HisPro: 1.456 ± 0.038	0.616HisGln: 0.616 ± 0.021	1.528HisArg: 1.528 ± 0.034	0.949HisSer: 0.949 ± 0.029	0.662HisThr: 0.662 ± 0.019	1.5HisVal: 1.5 ± 0.037	0.36HisTrp: 0.36 ± 0.021	0.507HisTyr: 0.507 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	7.784IleAla: 7.784 ± 0.079	0.588IleCys: 0.588 ± 0.021	3.463IleAsp: 3.463 ± 0.045	3.254IleGlu: 3.254 ± 0.047	1.791IlePhe: 1.791 ± 0.04	5.191IleGly: 5.191 ± 0.061	1.01IleHis: 1.01 ± 0.03	2.277IleIle: 2.277 ± 0.048	1.249IleLys: 1.249 ± 0.031	4.801IleLeu: 4.801 ± 0.064	1.219IleMet: 1.219 ± 0.033	1.299IleAsn: 1.299 ± 0.037	2.569IlePro: 2.569 ± 0.043	1.304IleGln: 1.304 ± 0.032	3.688IleArg: 3.688 ± 0.059	3.068IleSer: 3.068 ± 0.049	2.806IleThr: 2.806 ± 0.049	3.937IleVal: 3.937 ± 0.058	0.777IleTrp: 0.777 ± 0.025	1.103IleTyr: 1.103 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.528LysAla: 3.528 ± 0.063	0.133LysCys: 0.133 ± 0.01	1.538LysAsp: 1.538 ± 0.037	1.139LysGlu: 1.139 ± 0.033	0.833LysPhe: 0.833 ± 0.029	2.554LysGly: 2.554 ± 0.046	0.546LysHis: 0.546 ± 0.022	1.421LysIle: 1.421 ± 0.034	0.929LysLys: 0.929 ± 0.032	2.925LysLeu: 2.925 ± 0.05	0.747LysMet: 0.747 ± 0.025	0.721LysAsn: 0.721 ± 0.025	1.738LysPro: 1.738 ± 0.043	0.879LysGln: 0.879 ± 0.029	1.945LysArg: 1.945 ± 0.045	1.644LysSer: 1.644 ± 0.038	1.607LysThr: 1.607 ± 0.035	1.971LysVal: 1.971 ± 0.038	0.368LysTrp: 0.368 ± 0.015	0.55LysTyr: 0.55 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.047LeuAla: 14.047 ± 0.131	0.905LeuCys: 0.905 ± 0.029	6.025LeuAsp: 6.025 ± 0.067	4.758LeuGlu: 4.758 ± 0.064	3.25LeuPhe: 3.25 ± 0.054	8.805LeuGly: 8.805 ± 0.083	2.027LeuHis: 2.027 ± 0.045	5.839LeuIle: 5.839 ± 0.082	2.802LeuLys: 2.802 ± 0.051	9.187LeuLeu: 9.187 ± 0.121	2.83LeuMet: 2.83 ± 0.05	2.682LeuAsn: 2.682 ± 0.047	6.214LeuPro: 6.214 ± 0.077	2.875LeuGln: 2.875 ± 0.054	7.926LeuArg: 7.926 ± 0.106	6.294LeuSer: 6.294 ± 0.069	6.297LeuThr: 6.297 ± 0.076	6.939LeuVal: 6.939 ± 0.085	1.249LeuTrp: 1.249 ± 0.034	1.889LeuTyr: 1.889 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.731MetAla: 3.731 ± 0.053	0.164MetCys: 0.164 ± 0.013	1.42MetAsp: 1.42 ± 0.038	1.092MetGlu: 1.092 ± 0.027	0.804MetPhe: 0.804 ± 0.023	2.373MetGly: 2.373 ± 0.044	0.471MetHis: 0.471 ± 0.018	1.643MetIle: 1.643 ± 0.036	0.929MetLys: 0.929 ± 0.027	2.908MetLeu: 2.908 ± 0.048	0.774MetMet: 0.774 ± 0.023	0.864MetAsn: 0.864 ± 0.024	1.688MetPro: 1.688 ± 0.037	1.143MetGln: 1.143 ± 0.031	2.135MetArg: 2.135 ± 0.039	1.708MetSer: 1.708 ± 0.037	2.237MetThr: 2.237 ± 0.039	1.882MetVal: 1.882 ± 0.037	0.237MetTrp: 0.237 ± 0.013	0.302MetTyr: 0.302 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.177AsnAla: 3.177 ± 0.061	0.232AsnCys: 0.232 ± 0.016	1.631AsnAsp: 1.631 ± 0.061	1.082AsnGlu: 1.082 ± 0.031	0.896AsnPhe: 0.896 ± 0.022	2.363AsnGly: 2.363 ± 0.054	0.492AsnHis: 0.492 ± 0.019	1.334AsnIle: 1.334 ± 0.036	0.57AsnLys: 0.57 ± 0.023	2.565AsnLeu: 2.565 ± 0.047	0.699AsnMet: 0.699 ± 0.024	0.588AsnAsn: 0.588 ± 0.024	1.925AsnPro: 1.925 ± 0.043	0.727AsnGln: 0.727 ± 0.026	1.845AsnArg: 1.845 ± 0.038	1.2AsnSer: 1.2 ± 0.032	1.172AsnThr: 1.172 ± 0.033	1.741AsnVal: 1.741 ± 0.044	0.434AsnTrp: 0.434 ± 0.019	0.574AsnTyr: 0.574 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.789ProAla: 6.789 ± 0.095	0.329ProCys: 0.329 ± 0.016	4.162ProAsp: 4.162 ± 0.064	4.094ProGlu: 4.094 ± 0.065	1.918ProPhe: 1.918 ± 0.04	4.847ProGly: 4.847 ± 0.08	1.109ProHis: 1.109 ± 0.03	2.41ProIle: 2.41 ± 0.046	1.533ProLys: 1.533 ± 0.035	4.932ProLeu: 4.932 ± 0.057	1.442ProMet: 1.442 ± 0.035	1.291ProAsn: 1.291 ± 0.028	2.557ProPro: 2.557 ± 0.056	2.124ProGln: 2.124 ± 0.041	3.241ProArg: 3.241 ± 0.052	2.452ProSer: 2.452 ± 0.044	2.493ProThr: 2.493 ± 0.04	4.358ProVal: 4.358 ± 0.068	0.704ProTrp: 0.704 ± 0.024	1.036ProTyr: 1.036 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.631GlnAla: 4.631 ± 0.075	0.186GlnCys: 0.186 ± 0.013	1.878GlnAsp: 1.878 ± 0.037	1.506GlnGlu: 1.506 ± 0.035	1.06GlnPhe: 1.06 ± 0.029	3.273GlnGly: 3.273 ± 0.058	0.636GlnHis: 0.636 ± 0.023	2.277GlnIle: 2.277 ± 0.042	1.053GlnLys: 1.053 ± 0.027	3.158GlnLeu: 3.158 ± 0.048	1.136GlnMet: 1.136 ± 0.03	0.999GlnAsn: 0.999 ± 0.03	2.121GlnPro: 2.121 ± 0.046	1.345GlnGln: 1.345 ± 0.052	2.551GlnArg: 2.551 ± 0.05	1.876GlnSer: 1.876 ± 0.041	1.971GlnThr: 1.971 ± 0.035	2.612GlnVal: 2.612 ± 0.05	0.364GlnTrp: 0.364 ± 0.018	0.583GlnTyr: 0.583 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.864ArgAla: 8.864 ± 0.097	0.467ArgCys: 0.467 ± 0.02	4.794ArgAsp: 4.794 ± 0.067	3.947ArgGlu: 3.947 ± 0.067	2.7ArgPhe: 2.7 ± 0.047	5.07ArgGly: 5.07 ± 0.068	1.724ArgHis: 1.724 ± 0.038	4.511ArgIle: 4.511 ± 0.064	2.187ArgLys: 2.187 ± 0.044	8.009ArgLeu: 8.009 ± 0.105	2.21ArgMet: 2.21 ± 0.04	1.844ArgAsn: 1.844 ± 0.034	3.707ArgPro: 3.707 ± 0.056	2.729ArgGln: 2.729 ± 0.049	5.549ArgArg: 5.549 ± 0.09	3.298ArgSer: 3.298 ± 0.049	2.923ArgThr: 2.923 ± 0.046	4.791ArgVal: 4.791 ± 0.074	1.021ArgTrp: 1.021 ± 0.03	1.522ArgTyr: 1.522 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.945SerAla: 5.945 ± 0.074	0.401SerCys: 0.401 ± 0.02	3.083SerAsp: 3.083 ± 0.054	2.406SerGlu: 2.406 ± 0.038	2.092SerPhe: 2.092 ± 0.04	5.352SerGly: 5.352 ± 0.066	1.09SerHis: 1.09 ± 0.028	2.39SerIle: 2.39 ± 0.044	1.187SerLys: 1.187 ± 0.03	4.944SerLeu: 4.944 ± 0.068	1.294SerMet: 1.294 ± 0.032	1.169SerAsn: 1.169 ± 0.03	2.583SerPro: 2.583 ± 0.049	1.721SerGln: 1.721 ± 0.04	3.549SerArg: 3.549 ± 0.051	2.396SerSer: 2.396 ± 0.049	2.367SerThr: 2.367 ± 0.045	3.7SerVal: 3.7 ± 0.052	0.739SerTrp: 0.739 ± 0.025	1.238SerTyr: 1.238 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.364ThrAla: 6.364 ± 0.075	0.47ThrCys: 0.47 ± 0.02	3.101ThrAsp: 3.101 ± 0.054	2.809ThrGlu: 2.809 ± 0.054	1.769ThrPhe: 1.769 ± 0.045	5.306ThrGly: 5.306 ± 0.076	1.122ThrHis: 1.122 ± 0.033	2.727ThrIle: 2.727 ± 0.053	1.209ThrLys: 1.209 ± 0.03	5.719ThrLeu: 5.719 ± 0.067	1.249ThrMet: 1.249 ± 0.031	1.236ThrAsn: 1.236 ± 0.033	3.504ThrPro: 3.504 ± 0.051	1.734ThrGln: 1.734 ± 0.036	3.661ThrArg: 3.661 ± 0.051	2.476ThrSer: 2.476 ± 0.041	2.756ThrThr: 2.756 ± 0.054	4.06ThrVal: 4.06 ± 0.057	0.597ThrTrp: 0.597 ± 0.024	1.132ThrTyr: 1.132 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	8.979ValAla: 8.979 ± 0.1	0.564ValCys: 0.564 ± 0.02	3.633ValAsp: 3.633 ± 0.06	3.945ValGlu: 3.945 ± 0.06	2.516ValPhe: 2.516 ± 0.047	5.243ValGly: 5.243 ± 0.067	1.219ValHis: 1.219 ± 0.033	4.237ValIle: 4.237 ± 0.055	1.84ValLys: 1.84 ± 0.035	7.691ValLeu: 7.691 ± 0.086	2.213ValMet: 2.213 ± 0.043	1.894ValAsn: 1.894 ± 0.041	3.537ValPro: 3.537 ± 0.049	2.329ValGln: 2.329 ± 0.045	4.135ValArg: 4.135 ± 0.058	3.903ValSer: 3.903 ± 0.064	4.727ValThr: 4.727 ± 0.063	5.429ValVal: 5.429 ± 0.073	0.957ValTrp: 0.957 ± 0.03	1.259ValTyr: 1.259 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.416TrpAla: 1.416 ± 0.036	0.124TrpCys: 0.124 ± 0.011	0.768TrpAsp: 0.768 ± 0.024	0.537TrpGlu: 0.537 ± 0.02	0.566TrpPhe: 0.566 ± 0.022	1.054TrpGly: 1.054 ± 0.029	0.366TrpHis: 0.366 ± 0.015	0.718TrpIle: 0.718 ± 0.024	0.417TrpLys: 0.417 ± 0.019	1.893TrpLeu: 1.893 ± 0.04	0.397TrpMet: 0.397 ± 0.018	0.407TrpAsn: 0.407 ± 0.017	0.691TrpPro: 0.691 ± 0.024	0.77TrpGln: 0.77 ± 0.021	1.173TrpArg: 1.173 ± 0.031	0.803TrpSer: 0.803 ± 0.028	0.783TrpThr: 0.783 ± 0.027	0.844TrpVal: 0.844 ± 0.028	0.24TrpTrp: 0.24 ± 0.014	0.253TrpTyr: 0.253 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.451TyrAla: 2.451 ± 0.047	0.201TyrCys: 0.201 ± 0.013	1.522TyrAsp: 1.522 ± 0.034	1.096TyrGlu: 1.096 ± 0.031	0.816TyrPhe: 0.816 ± 0.029	2.013TyrGly: 2.013 ± 0.043	0.482TyrHis: 0.482 ± 0.02	0.856TyrIle: 0.856 ± 0.028	0.481TyrLys: 0.481 ± 0.022	2.196TyrLeu: 2.196 ± 0.041	0.434TyrMet: 0.434 ± 0.018	0.538TyrAsn: 0.538 ± 0.022	1.052TyrPro: 1.052 ± 0.029	0.683TyrGln: 0.683 ± 0.026	1.551TyrArg: 1.551 ± 0.032	1.06TyrSer: 1.06 ± 0.029	0.954TyrThr: 0.954 ± 0.029	1.395TyrVal: 1.395 ± 0.033	0.327TyrTrp: 0.327 ± 0.014	0.54TyrTyr: 0.54 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4217 proteins (1300680 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---