Amino acid dipepetide frequency for Streptomyces taklimakanensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.701AlaAla: 20.701 ± 0.194	1.07AlaCys: 1.07 ± 0.032	8.303AlaAsp: 8.303 ± 0.083	9.508AlaGlu: 9.508 ± 0.11	3.232AlaPhe: 3.232 ± 0.042	13.295AlaGly: 13.295 ± 0.104	2.795AlaHis: 2.795 ± 0.043	2.958AlaIle: 2.958 ± 0.056	2.231AlaLys: 2.231 ± 0.047	13.927AlaLeu: 13.927 ± 0.138	2.304AlaMet: 2.304 ± 0.033	1.721AlaAsn: 1.721 ± 0.034	7.592AlaPro: 7.592 ± 0.096	2.838AlaGln: 2.838 ± 0.045	11.543AlaArg: 11.543 ± 0.107	5.497AlaSer: 5.497 ± 0.067	6.597AlaThr: 6.597 ± 0.075	12.686AlaVal: 12.686 ± 0.104	1.837AlaTrp: 1.837 ± 0.032	2.508AlaTyr: 2.508 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.117CysAla: 1.117 ± 0.03	0.096CysCys: 0.096 ± 0.009	0.532CysAsp: 0.532 ± 0.018	0.455CysGlu: 0.455 ± 0.017	0.211CysPhe: 0.211 ± 0.012	0.994CysGly: 0.994 ± 0.025	0.219CysHis: 0.219 ± 0.011	0.12CysIle: 0.12 ± 0.009	0.096CysLys: 0.096 ± 0.008	0.759CysLeu: 0.759 ± 0.026	0.102CysMet: 0.102 ± 0.007	0.125CysAsn: 0.125 ± 0.008	0.521CysPro: 0.521 ± 0.017	0.13CysGln: 0.13 ± 0.009	0.694CysArg: 0.694 ± 0.021	0.439CysSer: 0.439 ± 0.018	0.456CysThr: 0.456 ± 0.016	0.68CysVal: 0.68 ± 0.018	0.125CysTrp: 0.125 ± 0.01	0.131CysTyr: 0.131 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.707AspAla: 7.707 ± 0.081	0.409AspCys: 0.409 ± 0.018	3.797AspAsp: 3.797 ± 0.053	4.121AspGlu: 4.121 ± 0.057	1.587AspPhe: 1.587 ± 0.033	7.35AspGly: 7.35 ± 0.078	1.553AspHis: 1.553 ± 0.029	1.634AspIle: 1.634 ± 0.032	0.887AspLys: 0.887 ± 0.028	6.151AspLeu: 6.151 ± 0.067	0.749AspMet: 0.749 ± 0.023	0.876AspAsn: 0.876 ± 0.026	4.871AspPro: 4.871 ± 0.059	1.13AspGln: 1.13 ± 0.029	5.645AspArg: 5.645 ± 0.064	2.364AspSer: 2.364 ± 0.038	3.465AspThr: 3.465 ± 0.048	4.853AspVal: 4.853 ± 0.052	0.997AspTrp: 0.997 ± 0.025	1.064AspTyr: 1.064 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	7.999GluAla: 7.999 ± 0.089	0.436GluCys: 0.436 ± 0.018	3.259GluAsp: 3.259 ± 0.058	4.764GluGlu: 4.764 ± 0.072	1.501GluPhe: 1.501 ± 0.031	5.115GluGly: 5.115 ± 0.052	1.733GluHis: 1.733 ± 0.03	2.268GluIle: 2.268 ± 0.042	1.496GluLys: 1.496 ± 0.038	7.161GluLeu: 7.161 ± 0.088	0.943GluMet: 0.943 ± 0.023	1.107GluAsn: 1.107 ± 0.029	4.064GluPro: 4.064 ± 0.055	1.952GluGln: 1.952 ± 0.036	6.782GluArg: 6.782 ± 0.085	2.557GluSer: 2.557 ± 0.043	3.179GluThr: 3.179 ± 0.047	5.124GluVal: 5.124 ± 0.062	0.806GluTrp: 0.806 ± 0.023	1.223GluTyr: 1.223 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	3.416PheAla: 3.416 ± 0.046	0.254PheCys: 0.254 ± 0.012	1.955PheAsp: 1.955 ± 0.04	1.473PheGlu: 1.473 ± 0.027	0.815PhePhe: 0.815 ± 0.027	2.864PheGly: 2.864 ± 0.044	0.635PheHis: 0.635 ± 0.02	0.531PheIle: 0.531 ± 0.016	0.421PheLys: 0.421 ± 0.019	2.481PheLeu: 2.481 ± 0.048	0.362PheMet: 0.362 ± 0.013	0.477PheAsn: 0.477 ± 0.017	1.365PhePro: 1.365 ± 0.029	0.542PheGln: 0.542 ± 0.016	1.912PheArg: 1.912 ± 0.037	1.328PheSer: 1.328 ± 0.027	1.86PheThr: 1.86 ± 0.036	2.219PheVal: 2.219 ± 0.036	0.404PheTrp: 0.404 ± 0.018	0.493PheTyr: 0.493 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	11.695GlyAla: 11.695 ± 0.099	0.872GlyCys: 0.872 ± 0.027	5.725GlyAsp: 5.725 ± 0.076	6.195GlyGlu: 6.195 ± 0.059	2.734GlyPhe: 2.734 ± 0.039	10.34GlyGly: 10.34 ± 0.117	2.477GlyHis: 2.477 ± 0.037	3.065GlyIle: 3.065 ± 0.051	2.01GlyLys: 2.01 ± 0.039	9.058GlyLeu: 9.058 ± 0.067	1.947GlyMet: 1.947 ± 0.028	1.693GlyAsn: 1.693 ± 0.04	5.886GlyPro: 5.886 ± 0.068	2.235GlyGln: 2.235 ± 0.042	9.333GlyArg: 9.333 ± 0.081	5.224GlySer: 5.224 ± 0.064	6.925GlyThr: 6.925 ± 0.075	7.911GlyVal: 7.911 ± 0.078	1.676GlyTrp: 1.676 ± 0.032	2.113GlyTyr: 2.113 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.6HisAla: 2.6 ± 0.045	0.24HisCys: 0.24 ± 0.012	1.401HisAsp: 1.401 ± 0.027	1.209HisGlu: 1.209 ± 0.027	0.616HisPhe: 0.616 ± 0.019	2.6HisGly: 2.6 ± 0.042	0.793HisHis: 0.793 ± 0.028	0.621HisIle: 0.621 ± 0.018	0.287HisLys: 0.287 ± 0.014	2.536HisLeu: 2.536 ± 0.039	0.322HisMet: 0.322 ± 0.015	0.368HisAsn: 0.368 ± 0.013	1.916HisPro: 1.916 ± 0.039	0.594HisGln: 0.594 ± 0.019	2.485HisArg: 2.485 ± 0.043	0.981HisSer: 0.981 ± 0.022	1.37HisThr: 1.37 ± 0.03	1.761HisVal: 1.761 ± 0.036	0.38HisTrp: 0.38 ± 0.016	0.478HisTyr: 0.478 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	4.24IleAla: 4.24 ± 0.049	0.233IleCys: 0.233 ± 0.012	2.12IleAsp: 2.12 ± 0.04	1.866IleGlu: 1.866 ± 0.037	0.589IlePhe: 0.589 ± 0.022	3.208IleGly: 3.208 ± 0.041	0.552IleHis: 0.552 ± 0.02	0.695IleIle: 0.695 ± 0.023	0.536IleLys: 0.536 ± 0.021	2.014IleLeu: 2.014 ± 0.04	0.39IleMet: 0.39 ± 0.017	0.575IleAsn: 0.575 ± 0.018	1.517IlePro: 1.517 ± 0.034	0.534IleGln: 0.534 ± 0.017	2.09IleArg: 2.09 ± 0.04	1.33IleSer: 1.33 ± 0.032	2.017IleThr: 2.017 ± 0.038	2.518IleVal: 2.518 ± 0.044	0.297IleTrp: 0.297 ± 0.014	0.429IleTyr: 0.429 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	2.272LysAla: 2.272 ± 0.047	0.108LysCys: 0.108 ± 0.008	1.034LysAsp: 1.034 ± 0.028	1.168LysGlu: 1.168 ± 0.034	0.371LysPhe: 0.371 ± 0.016	1.575LysGly: 1.575 ± 0.034	0.343LysHis: 0.343 ± 0.014	0.683LysIle: 0.683 ± 0.025	0.657LysLys: 0.657 ± 0.029	1.701LysLeu: 1.701 ± 0.039	0.298LysMet: 0.298 ± 0.014	0.391LysAsn: 0.391 ± 0.018	1.134LysPro: 1.134 ± 0.033	0.472LysGln: 0.472 ± 0.018	1.344LysArg: 1.344 ± 0.034	0.859LysSer: 0.859 ± 0.026	1.059LysThr: 1.059 ± 0.029	1.599LysVal: 1.599 ± 0.034	0.209LysTrp: 0.209 ± 0.01	0.359LysTyr: 0.359 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	14.404LeuAla: 14.404 ± 0.131	0.839LeuCys: 0.839 ± 0.023	6.56LeuAsp: 6.56 ± 0.073	5.249LeuGlu: 5.249 ± 0.064	2.499LeuPhe: 2.499 ± 0.039	9.067LeuGly: 9.067 ± 0.086	2.198LeuHis: 2.198 ± 0.038	2.634LeuIle: 2.634 ± 0.048	1.583LeuLys: 1.583 ± 0.037	11.078LeuLeu: 11.078 ± 0.104	1.484LeuMet: 1.484 ± 0.031	1.482LeuAsn: 1.482 ± 0.029	6.599LeuPro: 6.599 ± 0.077	1.816LeuGln: 1.816 ± 0.037	9.381LeuArg: 9.381 ± 0.093	4.941LeuSer: 4.941 ± 0.058	6.479LeuThr: 6.479 ± 0.068	9.11LeuVal: 9.11 ± 0.087	1.292LeuTrp: 1.292 ± 0.029	1.796LeuTyr: 1.796 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.173MetAla: 2.173 ± 0.039	0.13MetCys: 0.13 ± 0.009	0.856MetAsp: 0.856 ± 0.024	0.777MetGlu: 0.777 ± 0.024	0.43MetPhe: 0.43 ± 0.017	1.305MetGly: 1.305 ± 0.03	0.291MetHis: 0.291 ± 0.013	0.562MetIle: 0.562 ± 0.022	0.336MetLys: 0.336 ± 0.015	1.529MetLeu: 1.529 ± 0.032	0.278MetMet: 0.278 ± 0.015	0.347MetAsn: 0.347 ± 0.015	1.054MetPro: 1.054 ± 0.026	0.373MetGln: 0.373 ± 0.016	1.475MetArg: 1.475 ± 0.031	1.181MetSer: 1.181 ± 0.024	1.388MetThr: 1.388 ± 0.028	1.311MetVal: 1.311 ± 0.033	0.207MetTrp: 0.207 ± 0.013	0.299MetTyr: 0.299 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	1.989AsnAla: 1.989 ± 0.036	0.154AsnCys: 0.154 ± 0.009	0.922AsnAsp: 0.922 ± 0.028	0.8AsnGlu: 0.8 ± 0.022	0.446AsnPhe: 0.446 ± 0.017	1.822AsnGly: 1.822 ± 0.037	0.41AsnHis: 0.41 ± 0.015	0.55AsnIle: 0.55 ± 0.02	0.306AsnLys: 0.306 ± 0.014	1.51AsnLeu: 1.51 ± 0.031	0.279AsnMet: 0.279 ± 0.013	0.387AsnAsn: 0.387 ± 0.017	1.273AsnPro: 1.273 ± 0.032	0.413AsnGln: 0.413 ± 0.017	1.303AsnArg: 1.303 ± 0.028	0.815AsnSer: 0.815 ± 0.025	1.041AsnThr: 1.041 ± 0.031	1.314AsnVal: 1.314 ± 0.027	0.274AsnTrp: 0.274 ± 0.014	0.379AsnTyr: 0.379 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	8.703ProAla: 8.703 ± 0.09	0.369ProCys: 0.369 ± 0.015	4.891ProAsp: 4.891 ± 0.062	4.986ProGlu: 4.986 ± 0.055	1.488ProPhe: 1.488 ± 0.03	7.337ProGly: 7.337 ± 0.077	1.515ProHis: 1.515 ± 0.032	1.259ProIle: 1.259 ± 0.028	1.017ProLys: 1.017 ± 0.026	5.375ProLeu: 5.375 ± 0.065	0.948ProMet: 0.948 ± 0.024	0.938ProAsn: 0.938 ± 0.028	4.25ProPro: 4.25 ± 0.08	1.444ProGln: 1.444 ± 0.032	4.776ProArg: 4.776 ± 0.059	3.439ProSer: 3.439 ± 0.047	3.492ProThr: 3.492 ± 0.054	5.764ProVal: 5.764 ± 0.069	0.93ProTrp: 0.93 ± 0.027	1.383ProTyr: 1.383 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	2.978GlnAla: 2.978 ± 0.05	0.143GlnCys: 0.143 ± 0.009	1.132GlnAsp: 1.132 ± 0.03	1.323GlnGlu: 1.323 ± 0.031	0.533GlnPhe: 0.533 ± 0.018	1.938GlnGly: 1.938 ± 0.036	0.498GlnHis: 0.498 ± 0.018	0.841GlnIle: 0.841 ± 0.022	0.455GlnLys: 0.455 ± 0.018	2.227GlnLeu: 2.227 ± 0.038	0.387GlnMet: 0.387 ± 0.015	0.402GlnAsn: 0.402 ± 0.016	1.355GlnPro: 1.355 ± 0.038	0.92GlnGln: 0.92 ± 0.035	2.195GlnArg: 2.195 ± 0.036	0.984GlnSer: 0.984 ± 0.02	1.109GlnThr: 1.109 ± 0.025	1.996GlnVal: 1.996 ± 0.036	0.41GlnTrp: 0.41 ± 0.017	0.5GlnTyr: 0.5 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	11.069ArgAla: 11.069 ± 0.115	0.671ArgCys: 0.671 ± 0.022	4.789ArgAsp: 4.789 ± 0.05	5.804ArgGlu: 5.804 ± 0.072	2.426ArgPhe: 2.426 ± 0.041	6.904ArgGly: 6.904 ± 0.064	2.453ArgHis: 2.453 ± 0.041	3.184ArgIle: 3.184 ± 0.048	1.599ArgLys: 1.599 ± 0.033	9.662ArgLeu: 9.662 ± 0.096	1.831ArgMet: 1.831 ± 0.03	1.445ArgAsn: 1.445 ± 0.029	5.926ArgPro: 5.926 ± 0.077	2.253ArgGln: 2.253 ± 0.041	9.465ArgArg: 9.465 ± 0.111	4.286ArgSer: 4.286 ± 0.054	5.85ArgThr: 5.85 ± 0.071	6.823ArgVal: 6.823 ± 0.069	1.468ArgTrp: 1.468 ± 0.028	1.912ArgTyr: 1.912 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.075SerAla: 6.075 ± 0.064	0.384SerCys: 0.384 ± 0.018	2.678SerAsp: 2.678 ± 0.047	2.447SerGlu: 2.447 ± 0.043	1.422SerPhe: 1.422 ± 0.031	5.838SerGly: 5.838 ± 0.065	1.018SerHis: 1.018 ± 0.024	1.257SerIle: 1.257 ± 0.029	0.792SerLys: 0.792 ± 0.023	4.469SerLeu: 4.469 ± 0.059	0.956SerMet: 0.956 ± 0.025	0.773SerAsn: 0.773 ± 0.022	3.276SerPro: 3.276 ± 0.051	0.939SerGln: 0.939 ± 0.028	3.807SerArg: 3.807 ± 0.048	2.549SerSer: 2.549 ± 0.05	2.78SerThr: 2.78 ± 0.045	4.253SerVal: 4.253 ± 0.05	0.818SerTrp: 0.818 ± 0.024	1.079SerTyr: 1.079 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	8.986ThrAla: 8.986 ± 0.09	0.4ThrCys: 0.4 ± 0.016	3.793ThrAsp: 3.793 ± 0.048	3.62ThrGlu: 3.62 ± 0.051	1.489ThrPhe: 1.489 ± 0.033	7.201ThrGly: 7.201 ± 0.072	1.157ThrHis: 1.157 ± 0.024	1.549ThrIle: 1.549 ± 0.033	0.852ThrLys: 0.852 ± 0.024	5.363ThrLeu: 5.363 ± 0.059	0.848ThrMet: 0.848 ± 0.023	0.89ThrAsn: 0.89 ± 0.024	4.061ThrPro: 4.061 ± 0.053	1.041ThrGln: 1.041 ± 0.025	4.039ThrArg: 4.039 ± 0.049	2.863ThrSer: 2.863 ± 0.047	3.843ThrThr: 3.843 ± 0.058	6.666ThrVal: 6.666 ± 0.07	0.826ThrTrp: 0.826 ± 0.023	1.181ThrTyr: 1.181 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	10.91ValAla: 10.91 ± 0.092	0.864ValCys: 0.864 ± 0.022	5.262ValAsp: 5.262 ± 0.064	5.601ValGlu: 5.601 ± 0.068	2.364ValPhe: 2.364 ± 0.035	7.045ValGly: 7.045 ± 0.08	2.109ValHis: 2.109 ± 0.034	2.422ValIle: 2.422 ± 0.041	1.44ValLys: 1.44 ± 0.036	9.855ValLeu: 9.855 ± 0.088	1.386ValMet: 1.386 ± 0.027	1.616ValAsn: 1.616 ± 0.036	5.871ValPro: 5.871 ± 0.062	1.695ValGln: 1.695 ± 0.033	8.157ValArg: 8.157 ± 0.079	4.194ValSer: 4.194 ± 0.057	5.596ValThr: 5.596 ± 0.061	8.73ValVal: 8.73 ± 0.088	1.209ValTrp: 1.209 ± 0.026	1.581ValTyr: 1.581 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.553TrpAla: 1.553 ± 0.03	0.156TrpCys: 0.156 ± 0.01	0.791TrpAsp: 0.791 ± 0.023	0.875TrpGlu: 0.875 ± 0.022	0.497TrpPhe: 0.497 ± 0.017	1.064TrpGly: 1.064 ± 0.026	0.376TrpHis: 0.376 ± 0.016	0.517TrpIle: 0.517 ± 0.019	0.334TrpLys: 0.334 ± 0.017	1.633TrpLeu: 1.633 ± 0.035	0.272TrpMet: 0.272 ± 0.013	0.404TrpAsn: 0.404 ± 0.014	0.754TrpPro: 0.754 ± 0.022	0.504TrpGln: 0.504 ± 0.02	1.446TrpArg: 1.446 ± 0.03	0.935TrpSer: 0.935 ± 0.026	1.047TrpThr: 1.047 ± 0.027	0.979TrpVal: 0.979 ± 0.026	0.348TrpTrp: 0.348 ± 0.015	0.359TrpTyr: 0.359 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.555TyrAla: 2.555 ± 0.038	0.174TyrCys: 0.174 ± 0.01	1.41TyrAsp: 1.41 ± 0.032	1.229TyrGlu: 1.229 ± 0.029	0.557TyrPhe: 0.557 ± 0.018	2.25TyrGly: 2.25 ± 0.033	0.435TyrHis: 0.435 ± 0.018	0.4TyrIle: 0.4 ± 0.017	0.305TyrLys: 0.305 ± 0.013	2.002TyrLeu: 2.002 ± 0.034	0.215TyrMet: 0.215 ± 0.012	0.369TyrAsn: 0.369 ± 0.016	1.017TyrPro: 1.017 ± 0.027	0.501TyrGln: 0.501 ± 0.019	1.949TyrArg: 1.949 ± 0.036	0.846TyrSer: 0.846 ± 0.022	1.115TyrThr: 1.115 ± 0.023	1.61TyrVal: 1.61 ± 0.034	0.33TyrTrp: 0.33 ± 0.014	0.391TyrTyr: 0.391 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5063 proteins (1706788 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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