Amino acid dipepetide frequency for Corynebacterium riegelii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.465AlaAla: 15.465 ± 0.221	0.98AlaCys: 0.98 ± 0.035	7.027AlaAsp: 7.027 ± 0.119	7.969AlaGlu: 7.969 ± 0.137	3.754AlaPhe: 3.754 ± 0.084	9.911AlaGly: 9.911 ± 0.129	2.369AlaHis: 2.369 ± 0.064	5.471AlaIle: 5.471 ± 0.093	4.263AlaLys: 4.263 ± 0.095	11.83AlaLeu: 11.83 ± 0.172	2.916AlaMet: 2.916 ± 0.062	3.294AlaAsn: 3.294 ± 0.072	5.369AlaPro: 5.369 ± 0.111	4.569AlaGln: 4.569 ± 0.095	7.001AlaArg: 7.001 ± 0.113	6.315AlaSer: 6.315 ± 0.102	6.943AlaThr: 6.943 ± 0.104	9.589AlaVal: 9.589 ± 0.149	1.616AlaTrp: 1.616 ± 0.052	2.489AlaTyr: 2.489 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.843CysAla: 0.843 ± 0.037	0.064CysCys: 0.064 ± 0.011	0.367CysAsp: 0.367 ± 0.023	0.392CysGlu: 0.392 ± 0.022	0.228CysPhe: 0.228 ± 0.019	0.697CysGly: 0.697 ± 0.035	0.147CysHis: 0.147 ± 0.014	0.293CysIle: 0.293 ± 0.021	0.141CysLys: 0.141 ± 0.015	0.549CysLeu: 0.549 ± 0.027	0.134CysMet: 0.134 ± 0.013	0.187CysAsn: 0.187 ± 0.017	0.389CysPro: 0.389 ± 0.027	0.228CysGln: 0.228 ± 0.02	0.349CysArg: 0.349 ± 0.028	0.408CysSer: 0.408 ± 0.022	0.437CysThr: 0.437 ± 0.022	0.585CysVal: 0.585 ± 0.028	0.096CysTrp: 0.096 ± 0.011	0.14CysTyr: 0.14 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.798AspAla: 7.798 ± 0.129	0.363AspCys: 0.363 ± 0.019	3.244AspAsp: 3.244 ± 0.078	4.394AspGlu: 4.394 ± 0.086	2.178AspPhe: 2.178 ± 0.063	5.264AspGly: 5.264 ± 0.113	1.166AspHis: 1.166 ± 0.046	2.824AspIle: 2.824 ± 0.068	1.912AspLys: 1.912 ± 0.069	5.384AspLeu: 5.384 ± 0.09	1.185AspMet: 1.185 ± 0.038	1.797AspAsn: 1.797 ± 0.06	3.843AspPro: 3.843 ± 0.077	1.94AspGln: 1.94 ± 0.057	3.209AspArg: 3.209 ± 0.08	2.733AspSer: 2.733 ± 0.06	3.477AspThr: 3.477 ± 0.073	5.045AspVal: 5.045 ± 0.091	0.847AspTrp: 0.847 ± 0.039	1.538AspTyr: 1.538 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	7.502GluAla: 7.502 ± 0.144	0.306GluCys: 0.306 ± 0.02	3.724GluAsp: 3.724 ± 0.085	4.622GluGlu: 4.622 ± 0.103	2.179GluPhe: 2.179 ± 0.061	4.466GluGly: 4.466 ± 0.088	1.63GluHis: 1.63 ± 0.045	3.366GluIle: 3.366 ± 0.078	2.299GluLys: 2.299 ± 0.066	6.982GluLeu: 6.982 ± 0.117	1.506GluMet: 1.506 ± 0.046	1.935GluAsn: 1.935 ± 0.049	2.982GluPro: 2.982 ± 0.083	2.82GluGln: 2.82 ± 0.069	4.424GluArg: 4.424 ± 0.089	2.93GluSer: 2.93 ± 0.066	3.554GluThr: 3.554 ± 0.081	5.433GluVal: 5.433 ± 0.091	0.8GluTrp: 0.8 ± 0.036	1.473GluTyr: 1.473 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	4.171PheAla: 4.171 ± 0.086	0.24PheCys: 0.24 ± 0.019	2.522PheAsp: 2.522 ± 0.06	2.014PheGlu: 2.014 ± 0.051	1.157PhePhe: 1.157 ± 0.05	3.417PheGly: 3.417 ± 0.068	0.678PheHis: 0.678 ± 0.036	1.572PheIle: 1.572 ± 0.05	0.912PheLys: 0.912 ± 0.045	2.904PheLeu: 2.904 ± 0.067	0.722PheMet: 0.722 ± 0.032	1.149PheAsn: 1.149 ± 0.038	1.449PhePro: 1.449 ± 0.054	0.867PheGln: 0.867 ± 0.035	1.656PheArg: 1.656 ± 0.052	2.013PheSer: 2.013 ± 0.054	2.344PheThr: 2.344 ± 0.055	2.712PheVal: 2.712 ± 0.073	0.507PheTrp: 0.507 ± 0.032	0.847PheTyr: 0.847 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	8.959GlyAla: 8.959 ± 0.146	0.595GlyCys: 0.595 ± 0.035	4.387GlyAsp: 4.387 ± 0.075	5.374GlyGlu: 5.374 ± 0.093	3.185GlyPhe: 3.185 ± 0.075	6.734GlyGly: 6.734 ± 0.131	1.707GlyHis: 1.707 ± 0.053	4.284GlyIle: 4.284 ± 0.087	3.194GlyLys: 3.194 ± 0.087	7.636GlyLeu: 7.636 ± 0.121	2.077GlyMet: 2.077 ± 0.062	2.475GlyAsn: 2.475 ± 0.071	3.34GlyPro: 3.34 ± 0.07	2.934GlyGln: 2.934 ± 0.067	4.835GlyArg: 4.835 ± 0.094	4.581GlySer: 4.581 ± 0.097	5.158GlyThr: 5.158 ± 0.073	7.344GlyVal: 7.344 ± 0.112	1.343GlyTrp: 1.343 ± 0.049	2.134GlyTyr: 2.134 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	2.143HisAla: 2.143 ± 0.063	0.162HisCys: 0.162 ± 0.017	1.316HisAsp: 1.316 ± 0.044	1.258HisGlu: 1.258 ± 0.045	0.669HisPhe: 0.669 ± 0.034	1.876HisGly: 1.876 ± 0.05	0.547HisHis: 0.547 ± 0.028	0.97HisIle: 0.97 ± 0.038	0.543HisLys: 0.543 ± 0.024	2.023HisLeu: 2.023 ± 0.048	0.486HisMet: 0.486 ± 0.029	0.637HisAsn: 0.637 ± 0.032	1.402HisPro: 1.402 ± 0.044	0.685HisGln: 0.685 ± 0.032	1.221HisArg: 1.221 ± 0.04	1.012HisSer: 1.012 ± 0.044	1.262HisThr: 1.262 ± 0.036	1.759HisVal: 1.759 ± 0.053	0.278HisTrp: 0.278 ± 0.021	0.512HisTyr: 0.512 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.536IleAla: 6.536 ± 0.124	0.364IleCys: 0.364 ± 0.024	3.653IleAsp: 3.653 ± 0.079	3.103IleGlu: 3.103 ± 0.083	1.484IlePhe: 1.484 ± 0.059	4.172IleGly: 4.172 ± 0.091	0.899IleHis: 0.899 ± 0.034	2.359IleIle: 2.359 ± 0.069	1.279IleLys: 1.279 ± 0.048	3.73IleLeu: 3.73 ± 0.081	0.987IleMet: 0.987 ± 0.045	1.556IleAsn: 1.556 ± 0.052	2.588IlePro: 2.588 ± 0.067	1.402IleGln: 1.402 ± 0.044	2.691IleArg: 2.691 ± 0.061	2.634IleSer: 2.634 ± 0.065	3.455IleThr: 3.455 ± 0.083	4.184IleVal: 4.184 ± 0.089	0.521IleTrp: 0.521 ± 0.028	1.034IleTyr: 1.034 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	3.61LysAla: 3.61 ± 0.089	0.152LysCys: 0.152 ± 0.013	2.042LysAsp: 2.042 ± 0.075	2.027LysGlu: 2.027 ± 0.064	0.865LysPhe: 0.865 ± 0.037	2.217LysGly: 2.217 ± 0.063	0.736LysHis: 0.736 ± 0.032	1.58LysIle: 1.58 ± 0.051	1.533LysLys: 1.533 ± 0.068	3.144LysLeu: 3.144 ± 0.077	0.762LysMet: 0.762 ± 0.032	1.047LysAsn: 1.047 ± 0.04	1.804LysPro: 1.804 ± 0.071	1.392LysGln: 1.392 ± 0.045	2.468LysArg: 2.468 ± 0.059	1.548LysSer: 1.548 ± 0.055	2.065LysThr: 2.065 ± 0.062	2.592LysVal: 2.592 ± 0.073	0.366LysTrp: 0.366 ± 0.02	0.684LysTyr: 0.684 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	11.998LeuAla: 11.998 ± 0.158	0.609LeuCys: 0.609 ± 0.033	5.973LeuAsp: 5.973 ± 0.093	5.648LeuGlu: 5.648 ± 0.093	2.984LeuPhe: 2.984 ± 0.076	7.994LeuGly: 7.994 ± 0.137	1.917LeuHis: 1.917 ± 0.048	4.87LeuIle: 4.87 ± 0.093	2.817LeuLys: 2.817 ± 0.065	8.912LeuLeu: 8.912 ± 0.15	1.978LeuMet: 1.978 ± 0.064	2.62LeuAsn: 2.62 ± 0.065	5.064LeuPro: 5.064 ± 0.087	2.828LeuGln: 2.828 ± 0.063	6.216LeuArg: 6.216 ± 0.1	5.363LeuSer: 5.363 ± 0.099	6.0LeuThr: 6.0 ± 0.094	7.605LeuVal: 7.605 ± 0.126	1.099LeuTrp: 1.099 ± 0.042	1.896LeuTyr: 1.896 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.689MetAla: 2.689 ± 0.061	0.161MetCys: 0.161 ± 0.015	1.233MetAsp: 1.233 ± 0.045	1.168MetGlu: 1.168 ± 0.042	0.761MetPhe: 0.761 ± 0.036	1.737MetGly: 1.737 ± 0.059	0.469MetHis: 0.469 ± 0.028	1.177MetIle: 1.177 ± 0.048	0.704MetLys: 0.704 ± 0.025	2.288MetLeu: 2.288 ± 0.064	0.558MetMet: 0.558 ± 0.028	0.671MetAsn: 0.671 ± 0.036	1.301MetPro: 1.301 ± 0.043	0.821MetGln: 0.821 ± 0.035	1.596MetArg: 1.596 ± 0.052	1.577MetSer: 1.577 ± 0.051	1.527MetThr: 1.527 ± 0.051	1.77MetVal: 1.77 ± 0.046	0.279MetTrp: 0.279 ± 0.021	0.415MetTyr: 0.415 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.42AsnAla: 3.42 ± 0.078	0.152AsnCys: 0.152 ± 0.014	1.544AsnAsp: 1.544 ± 0.049	1.632AsnGlu: 1.632 ± 0.058	0.932AsnPhe: 0.932 ± 0.041	2.363AsnGly: 2.363 ± 0.073	0.649AsnHis: 0.649 ± 0.03	1.418AsnIle: 1.418 ± 0.05	0.973AsnLys: 0.973 ± 0.043	2.725AsnLeu: 2.725 ± 0.068	0.659AsnMet: 0.659 ± 0.031	0.97AsnAsn: 0.97 ± 0.053	2.387AsnPro: 2.387 ± 0.062	1.133AsnGln: 1.133 ± 0.049	1.635AsnArg: 1.635 ± 0.05	1.475AsnSer: 1.475 ± 0.05	1.824AsnThr: 1.824 ± 0.062	2.422AsnVal: 2.422 ± 0.068	0.437AsnTrp: 0.437 ± 0.025	0.801AsnTyr: 0.801 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	5.75ProAla: 5.75 ± 0.111	0.254ProCys: 0.254 ± 0.018	3.479ProAsp: 3.479 ± 0.082	4.443ProGlu: 4.443 ± 0.091	1.667ProPhe: 1.667 ± 0.048	4.45ProGly: 4.45 ± 0.094	1.085ProHis: 1.085 ± 0.037	2.046ProIle: 2.046 ± 0.053	1.854ProLys: 1.854 ± 0.056	4.41ProLeu: 4.41 ± 0.086	1.005ProMet: 1.005 ± 0.042	1.633ProAsn: 1.633 ± 0.055	1.838ProPro: 1.838 ± 0.056	1.981ProGln: 1.981 ± 0.052	2.701ProArg: 2.701 ± 0.061	2.756ProSer: 2.756 ± 0.066	3.286ProThr: 3.286 ± 0.07	4.548ProVal: 4.548 ± 0.097	0.702ProTrp: 0.702 ± 0.036	1.196ProTyr: 1.196 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	4.318GlnAla: 4.318 ± 0.096	0.183GlnCys: 0.183 ± 0.017	1.721GlnAsp: 1.721 ± 0.054	2.12GlnGlu: 2.12 ± 0.061	1.203GlnPhe: 1.203 ± 0.043	2.347GlnGly: 2.347 ± 0.06	0.78GlnHis: 0.78 ± 0.034	1.776GlnIle: 1.776 ± 0.051	1.032GlnLys: 1.032 ± 0.043	3.987GlnLeu: 3.987 ± 0.082	0.935GlnMet: 0.935 ± 0.04	0.884GlnAsn: 0.884 ± 0.032	1.811GlnPro: 1.811 ± 0.061	1.622GlnGln: 1.622 ± 0.071	2.837GlnArg: 2.837 ± 0.065	1.644GlnSer: 1.644 ± 0.054	1.695GlnThr: 1.695 ± 0.051	2.899GlnVal: 2.899 ± 0.065	0.528GlnTrp: 0.528 ± 0.03	0.769GlnTyr: 0.769 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	6.653ArgAla: 6.653 ± 0.125	0.35ArgCys: 0.35 ± 0.021	3.741ArgAsp: 3.741 ± 0.081	4.699ArgGlu: 4.699 ± 0.102	2.257ArgPhe: 2.257 ± 0.048	4.609ArgGly: 4.609 ± 0.082	1.28ArgHis: 1.28 ± 0.038	3.141ArgIle: 3.141 ± 0.074	2.185ArgLys: 2.185 ± 0.061	5.451ArgLeu: 5.451 ± 0.092	1.749ArgMet: 1.749 ± 0.039	1.831ArgAsn: 1.831 ± 0.055	2.789ArgPro: 2.789 ± 0.06	2.19ArgGln: 2.19 ± 0.06	4.732ArgArg: 4.732 ± 0.101	3.185ArgSer: 3.185 ± 0.071	3.551ArgThr: 3.551 ± 0.076	4.887ArgVal: 4.887 ± 0.082	0.906ArgTrp: 0.906 ± 0.038	1.607ArgTyr: 1.607 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	6.04SerAla: 6.04 ± 0.092	0.338SerCys: 0.338 ± 0.024	2.729SerAsp: 2.729 ± 0.06	3.038SerGlu: 3.038 ± 0.065	1.896SerPhe: 1.896 ± 0.052	5.081SerGly: 5.081 ± 0.087	1.075SerHis: 1.075 ± 0.04	2.478SerIle: 2.478 ± 0.063	1.753SerLys: 1.753 ± 0.055	4.904SerLeu: 4.904 ± 0.089	1.348SerMet: 1.348 ± 0.042	1.558SerAsn: 1.558 ± 0.052	2.743SerPro: 2.743 ± 0.064	1.961SerGln: 1.961 ± 0.061	3.294SerArg: 3.294 ± 0.072	3.162SerSer: 3.162 ± 0.079	3.595SerThr: 3.595 ± 0.074	4.294SerVal: 4.294 ± 0.079	0.847SerTrp: 0.847 ± 0.032	1.307SerTyr: 1.307 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	6.795ThrAla: 6.795 ± 0.108	0.43ThrCys: 0.43 ± 0.027	3.514ThrAsp: 3.514 ± 0.076	3.354ThrGlu: 3.354 ± 0.07	2.194ThrPhe: 2.194 ± 0.062	5.413ThrGly: 5.413 ± 0.076	1.365ThrHis: 1.365 ± 0.039	3.035ThrIle: 3.035 ± 0.073	1.83ThrLys: 1.83 ± 0.055	5.786ThrLeu: 5.786 ± 0.098	1.28ThrMet: 1.28 ± 0.041	1.731ThrAsn: 1.731 ± 0.056	3.924ThrPro: 3.924 ± 0.088	2.025ThrGln: 2.025 ± 0.058	3.547ThrArg: 3.547 ± 0.074	3.4ThrSer: 3.4 ± 0.071	4.245ThrThr: 4.245 ± 0.098	5.744ThrVal: 5.744 ± 0.095	0.899ThrTrp: 0.899 ± 0.037	1.522ThrTyr: 1.522 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	10.433ValAla: 10.433 ± 0.149	0.656ValCys: 0.656 ± 0.029	5.751ValAsp: 5.751 ± 0.092	5.529ValGlu: 5.529 ± 0.113	2.775ValPhe: 2.775 ± 0.065	6.582ValGly: 6.582 ± 0.109	1.538ValHis: 1.538 ± 0.042	4.312ValIle: 4.312 ± 0.078	2.361ValLys: 2.361 ± 0.063	7.957ValLeu: 7.957 ± 0.121	1.817ValMet: 1.817 ± 0.061	2.362ValAsn: 2.362 ± 0.058	4.238ValPro: 4.238 ± 0.075	2.287ValGln: 2.287 ± 0.066	4.914ValArg: 4.914 ± 0.092	4.602ValSer: 4.602 ± 0.076	5.512ValThr: 5.512 ± 0.085	7.735ValVal: 7.735 ± 0.101	1.053ValTrp: 1.053 ± 0.038	1.637ValTyr: 1.637 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.481TrpAla: 1.481 ± 0.05	0.131TrpCys: 0.131 ± 0.012	0.736TrpAsp: 0.736 ± 0.033	0.73TrpGlu: 0.73 ± 0.034	0.556TrpPhe: 0.556 ± 0.032	0.921TrpGly: 0.921 ± 0.043	0.303TrpHis: 0.303 ± 0.02	0.716TrpIle: 0.716 ± 0.033	0.424TrpLys: 0.424 ± 0.027	1.573TrpLeu: 1.573 ± 0.053	0.381TrpMet: 0.381 ± 0.026	0.451TrpAsn: 0.451 ± 0.026	0.634TrpPro: 0.634 ± 0.028	0.567TrpGln: 0.567 ± 0.028	0.949TrpArg: 0.949 ± 0.038	0.745TrpSer: 0.745 ± 0.036	0.759TrpThr: 0.759 ± 0.035	1.168TrpVal: 1.168 ± 0.041	0.327TrpTrp: 0.327 ± 0.025	0.244TrpTyr: 0.244 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.538TyrAla: 2.538 ± 0.057	0.183TyrCys: 0.183 ± 0.018	1.438TyrAsp: 1.438 ± 0.047	1.415TyrGlu: 1.415 ± 0.049	0.928TyrPhe: 0.928 ± 0.038	2.027TyrGly: 2.027 ± 0.059	0.42TyrHis: 0.42 ± 0.023	0.944TyrIle: 0.944 ± 0.047	0.625TyrLys: 0.625 ± 0.029	2.22TyrLeu: 2.22 ± 0.057	0.412TyrMet: 0.412 ± 0.023	0.765TyrAsn: 0.765 ± 0.032	1.189TyrPro: 1.189 ± 0.041	0.838TyrGln: 0.838 ± 0.036	1.52TyrArg: 1.52 ± 0.045	1.354TyrSer: 1.354 ± 0.044	1.346TyrThr: 1.346 ± 0.046	1.737TyrVal: 1.737 ± 0.049	0.348TyrTrp: 0.348 ± 0.022	0.578TyrTyr: 0.578 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2204 proteins (716373 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---