Amino acid dipepetide frequency for Chitiniphilus eburneus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.212AlaAla: 16.212 ± 0.169	1.305AlaCys: 1.305 ± 0.035	6.745AlaAsp: 6.745 ± 0.081	7.044AlaGlu: 7.044 ± 0.099	3.827AlaPhe: 3.827 ± 0.062	10.328AlaGly: 10.328 ± 0.116	2.595AlaHis: 2.595 ± 0.049	5.404AlaIle: 5.404 ± 0.075	3.262AlaLys: 3.262 ± 0.067	14.9AlaLeu: 14.9 ± 0.135	3.091AlaMet: 3.091 ± 0.056	3.066AlaAsn: 3.066 ± 0.055	5.805AlaPro: 5.805 ± 0.097	5.587AlaGln: 5.587 ± 0.077	9.198AlaArg: 9.198 ± 0.098	6.066AlaSer: 6.066 ± 0.089	6.283AlaThr: 6.283 ± 0.082	8.18AlaVal: 8.18 ± 0.097	1.915AlaTrp: 1.915 ± 0.043	2.527AlaTyr: 2.527 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.093CysAla: 1.093 ± 0.029	0.142CysCys: 0.142 ± 0.012	0.545CysAsp: 0.545 ± 0.021	0.458CysGlu: 0.458 ± 0.019	0.339CysPhe: 0.339 ± 0.016	1.001CysGly: 1.001 ± 0.031	0.309CysHis: 0.309 ± 0.015	0.397CysIle: 0.397 ± 0.018	0.221CysLys: 0.221 ± 0.012	0.927CysLeu: 0.927 ± 0.029	0.181CysMet: 0.181 ± 0.011	0.272CysAsn: 0.272 ± 0.015	0.494CysPro: 0.494 ± 0.022	0.261CysGln: 0.261 ± 0.014	0.66CysArg: 0.66 ± 0.023	0.475CysSer: 0.475 ± 0.022	0.432CysThr: 0.432 ± 0.018	0.622CysVal: 0.622 ± 0.021	0.145CysTrp: 0.145 ± 0.011	0.263CysTyr: 0.263 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.247AspAla: 7.247 ± 0.091	0.529AspCys: 0.529 ± 0.025	3.34AspAsp: 3.34 ± 0.059	3.424AspGlu: 3.424 ± 0.056	2.303AspPhe: 2.303 ± 0.046	4.901AspGly: 4.901 ± 0.075	1.265AspHis: 1.265 ± 0.036	2.666AspIle: 2.666 ± 0.048	1.769AspLys: 1.769 ± 0.047	5.546AspLeu: 5.546 ± 0.079	1.038AspMet: 1.038 ± 0.03	1.478AspAsn: 1.478 ± 0.042	3.024AspPro: 3.024 ± 0.054	1.919AspGln: 1.919 ± 0.04	3.453AspArg: 3.453 ± 0.053	2.488AspSer: 2.488 ± 0.044	2.914AspThr: 2.914 ± 0.051	3.972AspVal: 3.972 ± 0.057	1.143AspTrp: 1.143 ± 0.034	1.89AspTyr: 1.89 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	6.881GluAla: 6.881 ± 0.099	0.422GluCys: 0.422 ± 0.019	2.276GluAsp: 2.276 ± 0.053	2.729GluGlu: 2.729 ± 0.063	1.762GluPhe: 1.762 ± 0.042	3.632GluGly: 3.632 ± 0.052	1.411GluHis: 1.411 ± 0.034	2.902GluIle: 2.902 ± 0.056	1.86GluLys: 1.86 ± 0.048	6.269GluLeu: 6.269 ± 0.091	1.261GluMet: 1.261 ± 0.031	1.435GluAsn: 1.435 ± 0.032	2.412GluPro: 2.412 ± 0.053	2.758GluGln: 2.758 ± 0.059	4.736GluArg: 4.736 ± 0.079	2.439GluSer: 2.439 ± 0.052	2.877GluThr: 2.877 ± 0.054	3.944GluVal: 3.944 ± 0.059	0.777GluTrp: 0.777 ± 0.029	1.324GluTyr: 1.324 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.151PheAla: 4.151 ± 0.063	0.392PheCys: 0.392 ± 0.019	2.661PheAsp: 2.661 ± 0.051	2.01PheGlu: 2.01 ± 0.054	1.331PhePhe: 1.331 ± 0.04	3.177PheGly: 3.177 ± 0.053	0.762PheHis: 0.762 ± 0.025	1.549PheIle: 1.549 ± 0.04	1.125PheLys: 1.125 ± 0.031	3.121PheLeu: 3.121 ± 0.059	0.718PheMet: 0.718 ± 0.027	1.176PheAsn: 1.176 ± 0.035	1.447PhePro: 1.447 ± 0.036	1.145PheGln: 1.145 ± 0.031	1.868PheArg: 1.868 ± 0.04	2.155PheSer: 2.155 ± 0.043	1.87PheThr: 1.87 ± 0.043	2.633PheVal: 2.633 ± 0.05	0.536PheTrp: 0.536 ± 0.023	0.976PheTyr: 0.976 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.482GlyAla: 8.482 ± 0.1	0.881GlyCys: 0.881 ± 0.026	4.559GlyAsp: 4.559 ± 0.074	4.913GlyGlu: 4.913 ± 0.069	3.142GlyPhe: 3.142 ± 0.054	6.832GlyGly: 6.832 ± 0.12	1.903GlyHis: 1.903 ± 0.041	4.008GlyIle: 4.008 ± 0.062	3.267GlyLys: 3.267 ± 0.057	8.415GlyLeu: 8.415 ± 0.096	2.281GlyMet: 2.281 ± 0.044	2.534GlyAsn: 2.534 ± 0.065	2.651GlyPro: 2.651 ± 0.049	3.291GlyGln: 3.291 ± 0.065	5.47GlyArg: 5.47 ± 0.075	4.134GlySer: 4.134 ± 0.083	4.268GlyThr: 4.268 ± 0.085	6.422GlyVal: 6.422 ± 0.093	1.576GlyTrp: 1.576 ± 0.036	2.432GlyTyr: 2.432 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.946HisAla: 2.946 ± 0.052	0.301HisCys: 0.301 ± 0.018	1.318HisAsp: 1.318 ± 0.041	1.082HisGlu: 1.082 ± 0.036	0.957HisPhe: 0.957 ± 0.027	2.207HisGly: 2.207 ± 0.046	0.675HisHis: 0.675 ± 0.029	0.934HisIle: 0.934 ± 0.026	0.545HisLys: 0.545 ± 0.024	2.395HisLeu: 2.395 ± 0.048	0.418HisMet: 0.418 ± 0.018	0.548HisAsn: 0.548 ± 0.021	1.503HisPro: 1.503 ± 0.037	0.819HisGln: 0.819 ± 0.027	1.59HisArg: 1.59 ± 0.041	0.961HisSer: 0.961 ± 0.03	1.061HisThr: 1.061 ± 0.026	1.503HisVal: 1.503 ± 0.038	0.443HisTrp: 0.443 ± 0.017	0.727HisTyr: 0.727 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.218IleAla: 6.218 ± 0.079	0.41IleCys: 0.41 ± 0.019	3.46IleAsp: 3.46 ± 0.047	3.084IleGlu: 3.084 ± 0.054	1.213IlePhe: 1.213 ± 0.037	4.247IleGly: 4.247 ± 0.069	0.959IleHis: 0.959 ± 0.027	1.421IleIle: 1.421 ± 0.041	1.509IleLys: 1.509 ± 0.035	3.639IleLeu: 3.639 ± 0.064	0.685IleMet: 0.685 ± 0.028	1.479IleAsn: 1.479 ± 0.039	2.1IlePro: 2.1 ± 0.043	1.499IleGln: 1.499 ± 0.037	2.818IleArg: 2.818 ± 0.053	2.34IleSer: 2.34 ± 0.045	2.359IleThr: 2.359 ± 0.049	3.607IleVal: 3.607 ± 0.058	0.515IleTrp: 0.515 ± 0.022	1.028IleTyr: 1.028 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.526LysAla: 3.526 ± 0.065	0.179LysCys: 0.179 ± 0.013	1.454LysAsp: 1.454 ± 0.039	1.532LysGlu: 1.532 ± 0.04	0.859LysPhe: 0.859 ± 0.03	2.198LysGly: 2.198 ± 0.05	0.673LysHis: 0.673 ± 0.025	1.398LysIle: 1.398 ± 0.039	1.326LysLys: 1.326 ± 0.042	3.751LysLeu: 3.751 ± 0.063	0.746LysMet: 0.746 ± 0.024	0.973LysAsn: 0.973 ± 0.03	1.912LysPro: 1.912 ± 0.044	1.51LysGln: 1.51 ± 0.037	2.117LysArg: 2.117 ± 0.049	1.629LysSer: 1.629 ± 0.04	1.72LysThr: 1.72 ± 0.042	2.433LysVal: 2.433 ± 0.048	0.4LysTrp: 0.4 ± 0.019	0.734LysTyr: 0.734 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	16.02LeuAla: 16.02 ± 0.159	0.997LeuCys: 0.997 ± 0.03	6.715LeuAsp: 6.715 ± 0.093	5.428LeuGlu: 5.428 ± 0.087	3.687LeuPhe: 3.687 ± 0.065	8.693LeuGly: 8.693 ± 0.107	2.33LeuHis: 2.33 ± 0.051	4.937LeuIle: 4.937 ± 0.072	3.83LeuLys: 3.83 ± 0.057	12.325LeuLeu: 12.325 ± 0.135	2.2LeuMet: 2.2 ± 0.047	3.07LeuAsn: 3.07 ± 0.058	6.553LeuPro: 6.553 ± 0.085	3.609LeuGln: 3.609 ± 0.058	7.488LeuArg: 7.488 ± 0.092	6.202LeuSer: 6.202 ± 0.073	5.944LeuThr: 5.944 ± 0.102	7.656LeuVal: 7.656 ± 0.081	1.414LeuTrp: 1.414 ± 0.04	2.465LeuTyr: 2.465 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.657MetAla: 2.657 ± 0.054	0.134MetCys: 0.134 ± 0.011	1.022MetAsp: 1.022 ± 0.03	0.92MetGlu: 0.92 ± 0.029	0.644MetPhe: 0.644 ± 0.023	1.466MetGly: 1.466 ± 0.036	0.503MetHis: 0.503 ± 0.021	0.989MetIle: 0.989 ± 0.031	0.966MetLys: 0.966 ± 0.031	2.629MetLeu: 2.629 ± 0.049	0.544MetMet: 0.544 ± 0.027	0.761MetAsn: 0.761 ± 0.022	1.343MetPro: 1.343 ± 0.033	1.014MetGln: 1.014 ± 0.03	1.56MetArg: 1.56 ± 0.039	1.419MetSer: 1.419 ± 0.034	1.341MetThr: 1.341 ± 0.036	1.541MetVal: 1.541 ± 0.039	0.187MetTrp: 0.187 ± 0.013	0.338MetTyr: 0.338 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.239AsnAla: 3.239 ± 0.058	0.256AsnCys: 0.256 ± 0.015	1.518AsnAsp: 1.518 ± 0.033	1.38AsnGlu: 1.38 ± 0.035	0.95AsnPhe: 0.95 ± 0.024	2.544AsnGly: 2.544 ± 0.057	0.594AsnHis: 0.594 ± 0.022	1.253AsnIle: 1.253 ± 0.038	0.907AsnLys: 0.907 ± 0.029	2.905AsnLeu: 2.905 ± 0.053	0.553AsnMet: 0.553 ± 0.021	0.849AsnAsn: 0.849 ± 0.034	1.907AsnPro: 1.907 ± 0.038	1.107AsnGln: 1.107 ± 0.039	1.913AsnArg: 1.913 ± 0.043	1.263AsnSer: 1.263 ± 0.039	1.446AsnThr: 1.446 ± 0.04	2.124AsnVal: 2.124 ± 0.045	0.517AsnTrp: 0.517 ± 0.023	0.804AsnTyr: 0.804 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.823ProAla: 6.823 ± 0.087	0.402ProCys: 0.402 ± 0.02	3.504ProAsp: 3.504 ± 0.058	3.211ProGlu: 3.211 ± 0.054	1.77ProPhe: 1.77 ± 0.045	4.37ProGly: 4.37 ± 0.067	1.098ProHis: 1.098 ± 0.032	1.922ProIle: 1.922 ± 0.04	1.32ProLys: 1.32 ± 0.034	5.583ProLeu: 5.583 ± 0.086	1.088ProMet: 1.088 ± 0.031	1.338ProAsn: 1.338 ± 0.036	2.795ProPro: 2.795 ± 0.07	2.228ProGln: 2.228 ± 0.043	3.111ProArg: 3.111 ± 0.059	2.38ProSer: 2.38 ± 0.05	3.204ProThr: 3.204 ± 0.109	4.288ProVal: 4.288 ± 0.076	0.808ProTrp: 0.808 ± 0.028	1.282ProTyr: 1.282 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	5.181GlnAla: 5.181 ± 0.079	0.332GlnCys: 0.332 ± 0.017	1.752GlnAsp: 1.752 ± 0.039	1.656GlnGlu: 1.656 ± 0.04	1.33GlnPhe: 1.33 ± 0.033	3.088GlnGly: 3.088 ± 0.055	0.945GlnHis: 0.945 ± 0.028	1.857GlnIle: 1.857 ± 0.038	1.133GlnLys: 1.133 ± 0.032	4.741GlnLeu: 4.741 ± 0.073	0.948GlnMet: 0.948 ± 0.028	0.927GlnAsn: 0.927 ± 0.029	2.525GlnPro: 2.525 ± 0.05	2.289GlnGln: 2.289 ± 0.051	3.539GlnArg: 3.539 ± 0.058	2.005GlnSer: 2.005 ± 0.043	1.964GlnThr: 1.964 ± 0.043	3.117GlnVal: 3.117 ± 0.053	0.644GlnTrp: 0.644 ± 0.022	1.072GlnTyr: 1.072 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	7.475ArgAla: 7.475 ± 0.088	0.596ArgCys: 0.596 ± 0.024	4.031ArgAsp: 4.031 ± 0.064	4.303ArgGlu: 4.303 ± 0.061	2.91ArgPhe: 2.91 ± 0.053	4.622ArgGly: 4.622 ± 0.07	2.134ArgHis: 2.134 ± 0.051	3.623ArgIle: 3.623 ± 0.059	1.984ArgLys: 1.984 ± 0.047	8.38ArgLeu: 8.38 ± 0.105	1.692ArgMet: 1.692 ± 0.036	2.004ArgAsn: 2.004 ± 0.045	3.219ArgPro: 3.219 ± 0.057	3.403ArgGln: 3.403 ± 0.058	5.061ArgArg: 5.061 ± 0.081	2.95ArgSer: 2.95 ± 0.056	3.018ArgThr: 3.018 ± 0.051	5.046ArgVal: 5.046 ± 0.071	1.195ArgTrp: 1.195 ± 0.038	2.289ArgTyr: 2.289 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.761SerAla: 5.761 ± 0.076	0.422SerCys: 0.422 ± 0.019	2.618SerAsp: 2.618 ± 0.044	2.437SerGlu: 2.437 ± 0.052	1.849SerPhe: 1.849 ± 0.037	5.008SerGly: 5.008 ± 0.081	1.174SerHis: 1.174 ± 0.034	2.219SerIle: 2.219 ± 0.048	1.385SerLys: 1.385 ± 0.036	5.556SerLeu: 5.556 ± 0.075	1.12SerMet: 1.12 ± 0.033	1.488SerAsn: 1.488 ± 0.039	2.654SerPro: 2.654 ± 0.047	1.921SerGln: 1.921 ± 0.04	3.441SerArg: 3.441 ± 0.056	2.768SerSer: 2.768 ± 0.065	2.595SerThr: 2.595 ± 0.044	3.653SerVal: 3.653 ± 0.059	0.719SerTrp: 0.719 ± 0.027	1.395SerTyr: 1.395 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.829ThrAla: 5.829 ± 0.075	0.434ThrCys: 0.434 ± 0.021	2.642ThrAsp: 2.642 ± 0.049	2.44ThrGlu: 2.44 ± 0.051	1.63ThrPhe: 1.63 ± 0.036	4.471ThrGly: 4.471 ± 0.071	1.125ThrHis: 1.125 ± 0.029	2.158ThrIle: 2.158 ± 0.046	1.142ThrLys: 1.142 ± 0.038	7.04ThrLeu: 7.04 ± 0.089	0.975ThrMet: 0.975 ± 0.03	1.208ThrAsn: 1.208 ± 0.04	4.21ThrPro: 4.21 ± 0.141	2.097ThrGln: 2.097 ± 0.043	3.461ThrArg: 3.461 ± 0.062	2.416ThrSer: 2.416 ± 0.058	2.693ThrThr: 2.693 ± 0.057	4.275ThrVal: 4.275 ± 0.074	0.755ThrTrp: 0.755 ± 0.027	1.177ThrTyr: 1.177 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	9.433ValAla: 9.433 ± 0.098	0.693ValCys: 0.693 ± 0.022	4.009ValAsp: 4.009 ± 0.06	4.262ValGlu: 4.262 ± 0.061	2.641ValPhe: 2.641 ± 0.049	5.531ValGly: 5.531 ± 0.081	1.439ValHis: 1.439 ± 0.034	3.518ValIle: 3.518 ± 0.058	2.438ValLys: 2.438 ± 0.052	8.148ValLeu: 8.148 ± 0.099	1.646ValMet: 1.646 ± 0.044	2.199ValAsn: 2.199 ± 0.044	3.816ValPro: 3.816 ± 0.054	2.408ValGln: 2.408 ± 0.044	4.725ValArg: 4.725 ± 0.06	4.058ValSer: 4.058 ± 0.055	4.226ValThr: 4.226 ± 0.079	6.111ValVal: 6.111 ± 0.08	0.931ValTrp: 0.931 ± 0.031	1.634ValTyr: 1.634 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.351TrpAla: 1.351 ± 0.036	0.154TrpCys: 0.154 ± 0.01	0.639TrpAsp: 0.639 ± 0.026	0.635TrpGlu: 0.635 ± 0.023	0.592TrpPhe: 0.592 ± 0.025	0.981TrpGly: 0.981 ± 0.03	0.461TrpHis: 0.461 ± 0.019	0.594TrpIle: 0.594 ± 0.022	0.411TrpLys: 0.411 ± 0.018	2.413TrpLeu: 2.413 ± 0.049	0.359TrpMet: 0.359 ± 0.021	0.46TrpAsn: 0.46 ± 0.02	0.76TrpPro: 0.76 ± 0.026	1.011TrpGln: 1.011 ± 0.029	1.506TrpArg: 1.506 ± 0.046	0.749TrpSer: 0.749 ± 0.022	0.623TrpThr: 0.623 ± 0.021	0.999TrpVal: 0.999 ± 0.026	0.339TrpTrp: 0.339 ± 0.018	0.371TrpTyr: 0.371 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.814TyrAla: 2.814 ± 0.047	0.257TyrCys: 0.257 ± 0.015	1.504TyrAsp: 1.504 ± 0.039	1.155TyrGlu: 1.155 ± 0.031	1.067TyrPhe: 1.067 ± 0.034	2.164TyrGly: 2.164 ± 0.044	0.577TyrHis: 0.577 ± 0.021	0.842TyrIle: 0.842 ± 0.026	0.667TyrLys: 0.667 ± 0.025	2.88TyrLeu: 2.88 ± 0.05	0.434TyrMet: 0.434 ± 0.022	0.764TyrAsn: 0.764 ± 0.033	1.394TyrPro: 1.394 ± 0.032	1.17TyrGln: 1.17 ± 0.031	2.219TyrArg: 2.219 ± 0.046	1.286TyrSer: 1.286 ± 0.037	1.34TyrThr: 1.34 ± 0.034	1.741TyrVal: 1.741 ± 0.037	0.451TyrTrp: 0.451 ± 0.019	0.722TyrTyr: 0.722 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3883 proteins (1243141 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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