Amino acid dipepetide frequency for Oceanomicrobium pacificus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.059AlaAla: 19.059 ± 0.227	1.196AlaCys: 1.196 ± 0.041	8.458AlaAsp: 8.458 ± 0.118	8.601AlaGlu: 8.601 ± 0.112	4.269AlaPhe: 4.269 ± 0.076	11.455AlaGly: 11.455 ± 0.15	2.298AlaHis: 2.298 ± 0.059	5.701AlaIle: 5.701 ± 0.085	3.186AlaLys: 3.186 ± 0.083	14.359AlaLeu: 14.359 ± 0.182	3.695AlaMet: 3.695 ± 0.065	2.653AlaAsn: 2.653 ± 0.057	6.552AlaPro: 6.552 ± 0.111	4.132AlaGln: 4.132 ± 0.067	9.51AlaArg: 9.51 ± 0.141	5.384AlaSer: 5.384 ± 0.097	6.119AlaThr: 6.119 ± 0.126	8.469AlaVal: 8.469 ± 0.116	1.401AlaTrp: 1.401 ± 0.036	2.6AlaTyr: 2.6 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.12CysAla: 1.12 ± 0.041	0.078CysCys: 0.078 ± 0.009	0.599CysAsp: 0.599 ± 0.03	0.372CysGlu: 0.372 ± 0.023	0.322CysPhe: 0.322 ± 0.019	0.997CysGly: 0.997 ± 0.037	0.251CysHis: 0.251 ± 0.02	0.414CysIle: 0.414 ± 0.022	0.182CysLys: 0.182 ± 0.012	0.881CysLeu: 0.881 ± 0.035	0.164CysMet: 0.164 ± 0.012	0.208CysAsn: 0.208 ± 0.015	0.492CysPro: 0.492 ± 0.029	0.227CysGln: 0.227 ± 0.015	0.57CysArg: 0.57 ± 0.025	0.414CysSer: 0.414 ± 0.019	0.455CysThr: 0.455 ± 0.021	0.595CysVal: 0.595 ± 0.026	0.106CysTrp: 0.106 ± 0.01	0.194CysTyr: 0.194 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.928AspAla: 8.928 ± 0.113	0.517AspCys: 0.517 ± 0.025	3.286AspAsp: 3.286 ± 0.081	3.388AspGlu: 3.388 ± 0.066	2.401AspPhe: 2.401 ± 0.055	6.636AspGly: 6.636 ± 0.101	1.47AspHis: 1.47 ± 0.049	3.235AspIle: 3.235 ± 0.078	1.424AspLys: 1.424 ± 0.042	7.265AspLeu: 7.265 ± 0.101	1.846AspMet: 1.846 ± 0.043	1.296AspAsn: 1.296 ± 0.057	4.281AspPro: 4.281 ± 0.069	1.835AspGln: 1.835 ± 0.055	5.679AspArg: 5.679 ± 0.104	2.416AspSer: 2.416 ± 0.061	3.246AspThr: 3.246 ± 0.075	4.295AspVal: 4.295 ± 0.091	1.249AspTrp: 1.249 ± 0.039	1.584AspTyr: 1.584 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	8.074GluAla: 8.074 ± 0.122	0.344GluCys: 0.344 ± 0.019	3.347GluAsp: 3.347 ± 0.065	3.678GluGlu: 3.678 ± 0.087	1.682GluPhe: 1.682 ± 0.044	4.756GluGly: 4.756 ± 0.085	0.989GluHis: 0.989 ± 0.033	3.502GluIle: 3.502 ± 0.069	1.939GluLys: 1.939 ± 0.053	5.019GluLeu: 5.019 ± 0.085	1.678GluMet: 1.678 ± 0.045	1.52GluAsn: 1.52 ± 0.04	2.526GluPro: 2.526 ± 0.06	1.831GluGln: 1.831 ± 0.045	4.107GluArg: 4.107 ± 0.074	2.144GluSer: 2.144 ± 0.052	3.548GluThr: 3.548 ± 0.067	3.947GluVal: 3.947 ± 0.074	0.563GluTrp: 0.563 ± 0.022	0.942GluTyr: 0.942 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.385PheAla: 4.385 ± 0.069	0.427PheCys: 0.427 ± 0.024	2.993PheAsp: 2.993 ± 0.061	2.172PheGlu: 2.172 ± 0.049	1.434PhePhe: 1.434 ± 0.042	3.833PheGly: 3.833 ± 0.069	0.754PheHis: 0.754 ± 0.029	1.711PheIle: 1.711 ± 0.044	0.888PheLys: 0.888 ± 0.028	3.68PheLeu: 3.68 ± 0.08	0.796PheMet: 0.796 ± 0.033	1.065PheAsn: 1.065 ± 0.034	1.543PhePro: 1.543 ± 0.046	0.982PheGln: 0.982 ± 0.034	2.254PheArg: 2.254 ± 0.052	2.074PheSer: 2.074 ± 0.05	2.088PheThr: 2.088 ± 0.061	2.583PheVal: 2.583 ± 0.055	0.568PheTrp: 0.568 ± 0.026	0.923PheTyr: 0.923 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	10.688GlyAla: 10.688 ± 0.137	0.863GlyCys: 0.863 ± 0.035	5.073GlyAsp: 5.073 ± 0.101	4.36GlyGlu: 4.36 ± 0.068	3.779GlyPhe: 3.779 ± 0.068	7.901GlyGly: 7.901 ± 0.15	1.901GlyHis: 1.901 ± 0.045	4.629GlyIle: 4.629 ± 0.068	2.733GlyLys: 2.733 ± 0.06	9.87GlyLeu: 9.87 ± 0.128	2.558GlyMet: 2.558 ± 0.059	2.014GlyAsn: 2.014 ± 0.064	4.235GlyPro: 4.235 ± 0.075	3.323GlyGln: 3.323 ± 0.061	6.332GlyArg: 6.332 ± 0.113	4.406GlySer: 4.406 ± 0.107	4.992GlyThr: 4.992 ± 0.121	6.137GlyVal: 6.137 ± 0.091	1.614GlyTrp: 1.614 ± 0.053	2.221GlyTyr: 2.221 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.295HisAla: 2.295 ± 0.055	0.198HisCys: 0.198 ± 0.015	1.282HisAsp: 1.282 ± 0.048	0.93HisGlu: 0.93 ± 0.031	0.782HisPhe: 0.782 ± 0.027	1.889HisGly: 1.889 ± 0.049	0.542HisHis: 0.542 ± 0.031	0.84HisIle: 0.84 ± 0.029	0.464HisLys: 0.464 ± 0.022	2.118HisLeu: 2.118 ± 0.049	0.53HisMet: 0.53 ± 0.029	0.41HisAsn: 0.41 ± 0.022	1.29HisPro: 1.29 ± 0.042	0.537HisGln: 0.537 ± 0.024	1.354HisArg: 1.354 ± 0.041	0.777HisSer: 0.777 ± 0.026	0.755HisThr: 0.755 ± 0.027	1.588HisVal: 1.588 ± 0.045	0.323HisTrp: 0.323 ± 0.016	0.508HisTyr: 0.508 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.726IleAla: 6.726 ± 0.095	0.626IleCys: 0.626 ± 0.025	3.69IleAsp: 3.69 ± 0.075	3.211IleGlu: 3.211 ± 0.065	1.823IlePhe: 1.823 ± 0.052	4.872IleGly: 4.872 ± 0.084	0.858IleHis: 0.858 ± 0.032	2.188IleIle: 2.188 ± 0.06	1.192IleLys: 1.192 ± 0.034	4.99IleLeu: 4.99 ± 0.084	1.049IleMet: 1.049 ± 0.038	1.323IleAsn: 1.323 ± 0.045	2.105IlePro: 2.105 ± 0.044	1.007IleGln: 1.007 ± 0.033	3.299IleArg: 3.299 ± 0.053	2.663IleSer: 2.663 ± 0.056	2.686IleThr: 2.686 ± 0.085	3.813IleVal: 3.813 ± 0.068	0.733IleTrp: 0.733 ± 0.027	1.16IleTyr: 1.16 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.602LysAla: 3.602 ± 0.075	0.14LysCys: 0.14 ± 0.012	1.582LysAsp: 1.582 ± 0.045	1.267LysGlu: 1.267 ± 0.053	0.893LysPhe: 0.893 ± 0.034	2.403LysGly: 2.403 ± 0.059	0.448LysHis: 0.448 ± 0.021	1.512LysIle: 1.512 ± 0.04	1.05LysLys: 1.05 ± 0.042	2.734LysLeu: 2.734 ± 0.057	0.722LysMet: 0.722 ± 0.03	0.694LysAsn: 0.694 ± 0.027	1.688LysPro: 1.688 ± 0.047	0.78LysGln: 0.78 ± 0.025	1.956LysArg: 1.956 ± 0.052	1.672LysSer: 1.672 ± 0.047	1.583LysThr: 1.583 ± 0.042	2.07LysVal: 2.07 ± 0.054	0.317LysTrp: 0.317 ± 0.019	0.569LysTyr: 0.569 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.363LeuAla: 13.363 ± 0.189	0.952LeuCys: 0.952 ± 0.033	7.223LeuAsp: 7.223 ± 0.087	5.038LeuGlu: 5.038 ± 0.079	3.814LeuPhe: 3.814 ± 0.078	8.654LeuGly: 8.654 ± 0.11	1.88LeuHis: 1.88 ± 0.049	4.842LeuIle: 4.842 ± 0.084	2.924LeuLys: 2.924 ± 0.062	9.424LeuLeu: 9.424 ± 0.178	2.543LeuMet: 2.543 ± 0.05	2.494LeuAsn: 2.494 ± 0.047	5.767LeuPro: 5.767 ± 0.087	2.669LeuGln: 2.669 ± 0.049	7.065LeuArg: 7.065 ± 0.107	6.73LeuSer: 6.73 ± 0.098	5.854LeuThr: 5.854 ± 0.092	7.509LeuVal: 7.509 ± 0.104	1.298LeuTrp: 1.298 ± 0.041	2.007LeuTyr: 2.007 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.53MetAla: 3.53 ± 0.069	0.173MetCys: 0.173 ± 0.013	1.421MetAsp: 1.421 ± 0.04	1.266MetGlu: 1.266 ± 0.037	0.831MetPhe: 0.831 ± 0.031	2.067MetGly: 2.067 ± 0.048	0.417MetHis: 0.417 ± 0.018	1.459MetIle: 1.459 ± 0.04	0.93MetLys: 0.93 ± 0.032	2.59MetLeu: 2.59 ± 0.049	0.715MetMet: 0.715 ± 0.03	0.77MetAsn: 0.77 ± 0.031	1.504MetPro: 1.504 ± 0.036	0.888MetGln: 0.888 ± 0.03	1.834MetArg: 1.834 ± 0.046	1.682MetSer: 1.682 ± 0.041	1.899MetThr: 1.899 ± 0.048	1.952MetVal: 1.952 ± 0.047	0.192MetTrp: 0.192 ± 0.013	0.315MetTyr: 0.315 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.902AsnAla: 2.902 ± 0.068	0.223AsnCys: 0.223 ± 0.017	1.311AsnAsp: 1.311 ± 0.05	1.071AsnGlu: 1.071 ± 0.035	0.937AsnPhe: 0.937 ± 0.032	2.353AsnGly: 2.353 ± 0.066	0.463AsnHis: 0.463 ± 0.022	1.298AsnIle: 1.298 ± 0.044	0.556AsnLys: 0.556 ± 0.026	2.48AsnLeu: 2.48 ± 0.056	0.7AsnMet: 0.7 ± 0.03	0.657AsnAsn: 0.657 ± 0.03	1.815AsnPro: 1.815 ± 0.045	0.637AsnGln: 0.637 ± 0.025	1.755AsnArg: 1.755 ± 0.039	1.136AsnSer: 1.136 ± 0.048	1.169AsnThr: 1.169 ± 0.04	1.736AsnVal: 1.736 ± 0.056	0.434AsnTrp: 0.434 ± 0.021	0.624AsnTyr: 0.624 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.532ProAla: 6.532 ± 0.107	0.343ProCys: 0.343 ± 0.021	5.055ProAsp: 5.055 ± 0.085	3.994ProGlu: 3.994 ± 0.08	2.067ProPhe: 2.067 ± 0.047	4.654ProGly: 4.654 ± 0.075	1.059ProHis: 1.059 ± 0.037	2.028ProIle: 2.028 ± 0.053	1.519ProLys: 1.519 ± 0.047	4.78ProLeu: 4.78 ± 0.082	1.234ProMet: 1.234 ± 0.037	1.241ProAsn: 1.241 ± 0.032	2.564ProPro: 2.564 ± 0.075	1.519ProGln: 1.519 ± 0.035	2.919ProArg: 2.919 ± 0.071	2.375ProSer: 2.375 ± 0.052	2.33ProThr: 2.33 ± 0.055	4.797ProVal: 4.797 ± 0.082	0.675ProTrp: 0.675 ± 0.031	1.19ProTyr: 1.19 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.955GlnAla: 3.955 ± 0.072	0.204GlnCys: 0.204 ± 0.015	1.719GlnAsp: 1.719 ± 0.046	1.514GlnGlu: 1.514 ± 0.043	1.062GlnPhe: 1.062 ± 0.034	2.323GlnGly: 2.323 ± 0.056	0.485GlnHis: 0.485 ± 0.024	1.836GlnIle: 1.836 ± 0.046	1.024GlnLys: 1.024 ± 0.037	2.621GlnLeu: 2.621 ± 0.057	0.99GlnMet: 0.99 ± 0.031	0.795GlnAsn: 0.795 ± 0.028	1.535GlnPro: 1.535 ± 0.045	0.892GlnGln: 0.892 ± 0.038	2.008GlnArg: 2.008 ± 0.052	1.669GlnSer: 1.669 ± 0.044	1.732GlnThr: 1.732 ± 0.044	2.319GlnVal: 2.319 ± 0.049	0.348GlnTrp: 0.348 ± 0.019	0.492GlnTyr: 0.492 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.588ArgAla: 8.588 ± 0.13	0.501ArgCys: 0.501 ± 0.024	5.122ArgAsp: 5.122 ± 0.095	3.45ArgGlu: 3.45 ± 0.07	2.975ArgPhe: 2.975 ± 0.067	4.809ArgGly: 4.809 ± 0.084	1.54ArgHis: 1.54 ± 0.05	4.195ArgIle: 4.195 ± 0.065	2.098ArgLys: 2.098 ± 0.054	7.575ArgLeu: 7.575 ± 0.126	1.967ArgMet: 1.967 ± 0.048	1.801ArgAsn: 1.801 ± 0.043	3.737ArgPro: 3.737 ± 0.073	2.291ArgGln: 2.291 ± 0.06	5.402ArgArg: 5.402 ± 0.122	3.503ArgSer: 3.503 ± 0.068	3.224ArgThr: 3.224 ± 0.064	4.834ArgVal: 4.834 ± 0.067	0.982ArgTrp: 0.982 ± 0.034	1.547ArgTyr: 1.547 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.936SerAla: 5.936 ± 0.109	0.411SerCys: 0.411 ± 0.02	3.608SerAsp: 3.608 ± 0.075	2.594SerGlu: 2.594 ± 0.058	2.174SerPhe: 2.174 ± 0.054	5.656SerGly: 5.656 ± 0.109	0.941SerHis: 0.941 ± 0.03	2.34SerIle: 2.34 ± 0.059	1.338SerLys: 1.338 ± 0.04	4.729SerLeu: 4.729 ± 0.082	1.205SerMet: 1.205 ± 0.035	1.307SerAsn: 1.307 ± 0.05	2.355SerPro: 2.355 ± 0.049	1.443SerGln: 1.443 ± 0.042	3.347SerArg: 3.347 ± 0.068	2.267SerSer: 2.267 ± 0.049	2.37SerThr: 2.37 ± 0.061	3.825SerVal: 3.825 ± 0.075	0.676SerTrp: 0.676 ± 0.03	1.228SerTyr: 1.228 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.205ThrAla: 6.205 ± 0.118	0.471ThrCys: 0.471 ± 0.025	3.512ThrAsp: 3.512 ± 0.097	2.909ThrGlu: 2.909 ± 0.054	1.915ThrPhe: 1.915 ± 0.05	5.818ThrGly: 5.818 ± 0.114	1.042ThrHis: 1.042 ± 0.035	2.678ThrIle: 2.678 ± 0.082	1.272ThrLys: 1.272 ± 0.036	5.885ThrLeu: 5.885 ± 0.087	1.187ThrMet: 1.187 ± 0.033	1.186ThrAsn: 1.186 ± 0.047	3.256ThrPro: 3.256 ± 0.07	1.322ThrGln: 1.322 ± 0.038	3.454ThrArg: 3.454 ± 0.064	2.506ThrSer: 2.506 ± 0.078	2.386ThrThr: 2.386 ± 0.068	4.479ThrVal: 4.479 ± 0.117	0.62ThrTrp: 0.62 ± 0.026	1.227ThrTyr: 1.227 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	9.357ValAla: 9.357 ± 0.112	0.618ValCys: 0.618 ± 0.03	4.648ValAsp: 4.648 ± 0.083	4.543ValGlu: 4.543 ± 0.078	2.501ValPhe: 2.501 ± 0.055	5.49ValGly: 5.49 ± 0.085	1.31ValHis: 1.31 ± 0.046	4.005ValIle: 4.005 ± 0.065	1.97ValLys: 1.97 ± 0.05	7.146ValLeu: 7.146 ± 0.1	1.978ValMet: 1.978 ± 0.046	1.898ValAsn: 1.898 ± 0.048	3.867ValPro: 3.867 ± 0.057	1.98ValGln: 1.98 ± 0.046	4.494ValArg: 4.494 ± 0.077	4.027ValSer: 4.027 ± 0.085	4.98ValThr: 4.98 ± 0.128	4.942ValVal: 4.942 ± 0.081	1.031ValTrp: 1.031 ± 0.033	1.471ValTyr: 1.471 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.378TrpAla: 1.378 ± 0.048	0.119TrpCys: 0.119 ± 0.01	0.827TrpAsp: 0.827 ± 0.032	0.574TrpGlu: 0.574 ± 0.027	0.57TrpPhe: 0.57 ± 0.026	0.974TrpGly: 0.974 ± 0.031	0.295TrpHis: 0.295 ± 0.02	0.719TrpIle: 0.719 ± 0.032	0.422TrpLys: 0.422 ± 0.024	1.659TrpLeu: 1.659 ± 0.046	0.404TrpMet: 0.404 ± 0.023	0.36TrpAsn: 0.36 ± 0.019	0.71TrpPro: 0.71 ± 0.029	0.545TrpGln: 0.545 ± 0.027	1.121TrpArg: 1.121 ± 0.036	0.824TrpSer: 0.824 ± 0.031	0.857TrpThr: 0.857 ± 0.03	0.854TrpVal: 0.854 ± 0.03	0.227TrpTrp: 0.227 ± 0.017	0.274TrpTyr: 0.274 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.476TyrAla: 2.476 ± 0.057	0.237TyrCys: 0.237 ± 0.014	1.522TyrAsp: 1.522 ± 0.037	1.202TyrGlu: 1.202 ± 0.039	0.923TyrPhe: 0.923 ± 0.032	2.091TyrGly: 2.091 ± 0.05	0.472TyrHis: 0.472 ± 0.02	0.884TyrIle: 0.884 ± 0.029	0.573TyrLys: 0.573 ± 0.023	2.244TyrLeu: 2.244 ± 0.049	0.471TyrMet: 0.471 ± 0.019	0.566TyrAsn: 0.566 ± 0.027	1.051TyrPro: 1.051 ± 0.032	0.683TyrGln: 0.683 ± 0.027	1.682TyrArg: 1.682 ± 0.046	1.082TyrSer: 1.082 ± 0.038	1.057TyrThr: 1.057 ± 0.039	1.507TyrVal: 1.507 ± 0.04	0.353TyrTrp: 0.353 ± 0.017	0.554TyrTyr: 0.554 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3093 proteins (998086 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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