Amino acid dipepetide frequency for Bacteroides phage B40-8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.494AlaAla: 4.494 ± 0.876
0.722AlaCys: 0.722 ± 0.196
2.889AlaAsp: 2.889 ± 0.429
4.574AlaGlu: 4.574 ± 0.728
3.21AlaPhe: 3.21 ± 0.438
3.531AlaGly: 3.531 ± 0.621
0.401AlaHis: 0.401 ± 0.166
5.136AlaIle: 5.136 ± 0.606
6.34AlaLys: 6.34 ± 0.809
4.414AlaLeu: 4.414 ± 0.622
1.364AlaMet: 1.364 ± 0.384
4.494AlaAsn: 4.494 ± 0.782
0.963AlaPro: 0.963 ± 0.32
2.568AlaGln: 2.568 ± 0.597
2.327AlaArg: 2.327 ± 0.634
2.969AlaSer: 2.969 ± 0.485
4.334AlaThr: 4.334 ± 0.641
3.05AlaVal: 3.05 ± 0.489
0.883AlaTrp: 0.883 ± 0.231
2.087AlaTyr: 2.087 ± 0.338
0.0AlaXaa: 0.0 ± 0.0
Cys
0.482CysAla: 0.482 ± 0.215
0.161CysCys: 0.161 ± 0.135
0.883CysAsp: 0.883 ± 0.277
1.204CysGlu: 1.204 ± 0.412
0.482CysPhe: 0.482 ± 0.226
1.445CysGly: 1.445 ± 0.417
0.401CysHis: 0.401 ± 0.189
0.963CysIle: 0.963 ± 0.255
0.883CysLys: 0.883 ± 0.279
1.284CysLeu: 1.284 ± 0.355
0.241CysMet: 0.241 ± 0.191
0.722CysAsn: 0.722 ± 0.26
0.803CysPro: 0.803 ± 0.307
0.321CysGln: 0.321 ± 0.154
0.562CysArg: 0.562 ± 0.185
0.562CysSer: 0.562 ± 0.224
0.401CysThr: 0.401 ± 0.173
0.562CysVal: 0.562 ± 0.198
0.0CysTrp: 0.0 ± 0.0
0.803CysTyr: 0.803 ± 0.253
0.0CysXaa: 0.0 ± 0.0
Asp
2.167AspAla: 2.167 ± 0.467
0.803AspCys: 0.803 ± 0.28
2.729AspAsp: 2.729 ± 0.562
4.093AspGlu: 4.093 ± 0.568
2.568AspPhe: 2.568 ± 0.407
4.334AspGly: 4.334 ± 0.798
0.321AspHis: 0.321 ± 0.16
3.611AspIle: 3.611 ± 0.477
4.815AspLys: 4.815 ± 0.711
6.821AspLeu: 6.821 ± 0.976
1.204AspMet: 1.204 ± 0.314
3.611AspAsn: 3.611 ± 0.549
1.846AspPro: 1.846 ± 0.383
1.525AspGln: 1.525 ± 0.271
2.648AspArg: 2.648 ± 0.564
5.216AspSer: 5.216 ± 0.654
3.932AspThr: 3.932 ± 0.494
3.531AspVal: 3.531 ± 0.47
0.722AspTrp: 0.722 ± 0.279
2.488AspTyr: 2.488 ± 0.406
0.0AspXaa: 0.0 ± 0.0
Glu
5.698GluAla: 5.698 ± 0.796
0.562GluCys: 0.562 ± 0.196
2.568GluAsp: 2.568 ± 0.425
6.42GluGlu: 6.42 ± 0.869
4.013GluPhe: 4.013 ± 0.538
3.531GluGly: 3.531 ± 0.47
1.846GluHis: 1.846 ± 0.481
5.537GluIle: 5.537 ± 0.54
6.902GluLys: 6.902 ± 0.988
7.544GluLeu: 7.544 ± 0.736
1.605GluMet: 1.605 ± 0.389
4.013GluAsn: 4.013 ± 0.519
2.087GluPro: 2.087 ± 0.397
2.648GluGln: 2.648 ± 0.619
4.735GluArg: 4.735 ± 0.966
4.655GluSer: 4.655 ± 0.532
4.093GluThr: 4.093 ± 0.481
4.013GluVal: 4.013 ± 0.45
0.722GluTrp: 0.722 ± 0.199
4.735GluTyr: 4.735 ± 0.572
0.0GluXaa: 0.0 ± 0.0
Phe
3.531PheAla: 3.531 ± 0.476
0.562PheCys: 0.562 ± 0.199
3.531PheAsp: 3.531 ± 0.441
3.371PheGlu: 3.371 ± 0.623
1.364PhePhe: 1.364 ± 0.295
3.05PheGly: 3.05 ± 0.51
0.642PheHis: 0.642 ± 0.23
2.969PheIle: 2.969 ± 0.609
3.451PheLys: 3.451 ± 0.489
2.729PheLeu: 2.729 ± 0.551
1.043PheMet: 1.043 ± 0.286
2.488PheAsn: 2.488 ± 0.451
1.525PhePro: 1.525 ± 0.383
1.525PheGln: 1.525 ± 0.338
2.087PheArg: 2.087 ± 0.526
2.969PheSer: 2.969 ± 0.461
2.889PheThr: 2.889 ± 0.454
2.729PheVal: 2.729 ± 0.477
0.321PheTrp: 0.321 ± 0.19
2.006PheTyr: 2.006 ± 0.528
0.0PheXaa: 0.0 ± 0.0
Gly
3.13GlyAla: 3.13 ± 0.61
0.803GlyCys: 0.803 ± 0.272
4.013GlyAsp: 4.013 ± 0.551
5.136GlyGlu: 5.136 ± 0.613
3.371GlyPhe: 3.371 ± 0.618
4.735GlyGly: 4.735 ± 0.609
0.401GlyHis: 0.401 ± 0.181
4.013GlyIle: 4.013 ± 0.547
6.661GlyLys: 6.661 ± 0.618
3.531GlyLeu: 3.531 ± 0.455
1.605GlyMet: 1.605 ± 0.403
3.611GlyAsn: 3.611 ± 0.61
0.0GlyPro: 0.0 ± 0.0
1.846GlyGln: 1.846 ± 0.425
2.648GlyArg: 2.648 ± 0.508
4.173GlySer: 4.173 ± 0.496
3.611GlyThr: 3.611 ± 0.654
4.574GlyVal: 4.574 ± 0.799
0.803GlyTrp: 0.803 ± 0.341
3.05GlyTyr: 3.05 ± 0.526
0.0GlyXaa: 0.0 ± 0.0
His
0.321HisAla: 0.321 ± 0.127
0.321HisCys: 0.321 ± 0.18
0.963HisAsp: 0.963 ± 0.256
1.364HisGlu: 1.364 ± 0.348
0.642HisPhe: 0.642 ± 0.247
1.284HisGly: 1.284 ± 0.298
0.241HisHis: 0.241 ± 0.189
1.284HisIle: 1.284 ± 0.355
0.642HisLys: 0.642 ± 0.242
1.204HisLeu: 1.204 ± 0.248
0.241HisMet: 0.241 ± 0.131
0.963HisAsn: 0.963 ± 0.293
0.722HisPro: 0.722 ± 0.227
0.161HisGln: 0.161 ± 0.124
0.321HisArg: 0.321 ± 0.158
0.642HisSer: 0.642 ± 0.194
0.803HisThr: 0.803 ± 0.219
0.803HisVal: 0.803 ± 0.265
0.0HisTrp: 0.0 ± 0.0
0.963HisTyr: 0.963 ± 0.252
0.0HisXaa: 0.0 ± 0.0
Ile
4.735IleAla: 4.735 ± 0.701
1.685IleCys: 1.685 ± 0.414
6.099IleAsp: 6.099 ± 0.63
6.34IleGlu: 6.34 ± 0.607
2.408IlePhe: 2.408 ± 0.527
3.29IleGly: 3.29 ± 0.49
1.204IleHis: 1.204 ± 0.346
3.772IleIle: 3.772 ± 0.615
5.297IleLys: 5.297 ± 0.877
4.013IleLeu: 4.013 ± 0.488
1.445IleMet: 1.445 ± 0.309
3.451IleAsn: 3.451 ± 0.602
2.408IlePro: 2.408 ± 0.441
2.969IleGln: 2.969 ± 0.352
3.29IleArg: 3.29 ± 0.573
5.377IleSer: 5.377 ± 0.626
4.655IleThr: 4.655 ± 0.711
3.772IleVal: 3.772 ± 0.655
0.482IleTrp: 0.482 ± 0.157
2.167IleTyr: 2.167 ± 0.401
0.0IleXaa: 0.0 ± 0.0
Lys
6.099LysAla: 6.099 ± 0.823
0.642LysCys: 0.642 ± 0.233
4.013LysAsp: 4.013 ± 0.593
8.266LysGlu: 8.266 ± 1.107
2.969LysPhe: 2.969 ± 0.459
4.895LysGly: 4.895 ± 0.542
1.364LysHis: 1.364 ± 0.393
5.939LysIle: 5.939 ± 0.642
5.618LysLys: 5.618 ± 0.81
6.902LysLeu: 6.902 ± 0.808
2.327LysMet: 2.327 ± 0.53
3.852LysAsn: 3.852 ± 0.586
2.408LysPro: 2.408 ± 0.448
3.852LysGln: 3.852 ± 0.766
4.574LysArg: 4.574 ± 0.584
4.173LysSer: 4.173 ± 0.508
5.216LysThr: 5.216 ± 0.606
4.976LysVal: 4.976 ± 0.919
1.043LysTrp: 1.043 ± 0.315
4.895LysTyr: 4.895 ± 0.678
0.0LysXaa: 0.0 ± 0.0
Leu
3.692LeuAla: 3.692 ± 0.614
0.803LeuCys: 0.803 ± 0.282
4.976LeuAsp: 4.976 ± 0.6
3.772LeuGlu: 3.772 ± 0.541
3.531LeuPhe: 3.531 ± 0.511
3.05LeuGly: 3.05 ± 0.406
0.642LeuHis: 0.642 ± 0.268
5.618LeuIle: 5.618 ± 0.539
6.821LeuLys: 6.821 ± 0.786
4.815LeuLeu: 4.815 ± 0.628
1.525LeuMet: 1.525 ± 0.353
5.858LeuAsn: 5.858 ± 0.592
3.05LeuPro: 3.05 ± 0.486
2.488LeuGln: 2.488 ± 0.333
5.136LeuArg: 5.136 ± 0.591
8.266LeuSer: 8.266 ± 0.633
5.939LeuThr: 5.939 ± 0.757
4.574LeuVal: 4.574 ± 0.623
0.401LeuTrp: 0.401 ± 0.139
3.05LeuTyr: 3.05 ± 0.41
0.0LeuXaa: 0.0 ± 0.0
Met
1.364MetAla: 1.364 ± 0.368
0.482MetCys: 0.482 ± 0.18
0.963MetAsp: 0.963 ± 0.241
1.284MetGlu: 1.284 ± 0.403
0.963MetPhe: 0.963 ± 0.298
1.525MetGly: 1.525 ± 0.39
0.401MetHis: 0.401 ± 0.2
1.204MetIle: 1.204 ± 0.328
2.729MetLys: 2.729 ± 0.619
1.685MetLeu: 1.685 ± 0.335
0.562MetMet: 0.562 ± 0.173
1.846MetAsn: 1.846 ± 0.356
0.642MetPro: 0.642 ± 0.234
1.525MetGln: 1.525 ± 0.318
0.642MetArg: 0.642 ± 0.204
1.124MetSer: 1.124 ± 0.261
1.043MetThr: 1.043 ± 0.39
1.204MetVal: 1.204 ± 0.352
0.241MetTrp: 0.241 ± 0.125
1.364MetTyr: 1.364 ± 0.31
0.0MetXaa: 0.0 ± 0.0
Asn
3.932AsnAla: 3.932 ± 0.661
0.642AsnCys: 0.642 ± 0.243
3.21AsnAsp: 3.21 ± 0.575
4.574AsnGlu: 4.574 ± 0.633
2.006AsnPhe: 2.006 ± 0.44
4.976AsnGly: 4.976 ± 0.842
0.963AsnHis: 0.963 ± 0.295
4.494AsnIle: 4.494 ± 0.495
4.253AsnLys: 4.253 ± 0.607
4.093AsnLeu: 4.093 ± 0.533
1.445AsnMet: 1.445 ± 0.43
3.692AsnAsn: 3.692 ± 0.486
2.408AsnPro: 2.408 ± 0.502
1.204AsnGln: 1.204 ± 0.326
2.006AsnArg: 2.006 ± 0.332
3.371AsnSer: 3.371 ± 0.59
2.809AsnThr: 2.809 ± 0.401
4.815AsnVal: 4.815 ± 0.588
0.562AsnTrp: 0.562 ± 0.186
2.327AsnTyr: 2.327 ± 0.558
0.0AsnXaa: 0.0 ± 0.0
Pro
1.926ProAla: 1.926 ± 0.384
0.321ProCys: 0.321 ± 0.167
2.408ProAsp: 2.408 ± 0.429
3.13ProGlu: 3.13 ± 0.549
1.284ProPhe: 1.284 ± 0.315
1.685ProGly: 1.685 ± 0.373
0.401ProHis: 0.401 ± 0.209
1.766ProIle: 1.766 ± 0.511
1.926ProLys: 1.926 ± 0.454
2.247ProLeu: 2.247 ± 0.672
0.722ProMet: 0.722 ± 0.232
1.605ProAsn: 1.605 ± 0.316
0.241ProPro: 0.241 ± 0.137
1.124ProGln: 1.124 ± 0.267
0.803ProArg: 0.803 ± 0.35
2.247ProSer: 2.247 ± 0.489
2.087ProThr: 2.087 ± 0.454
1.846ProVal: 1.846 ± 0.404
0.0ProTrp: 0.0 ± 0.0
1.445ProTyr: 1.445 ± 0.328
0.0ProXaa: 0.0 ± 0.0
Gln
2.327GlnAla: 2.327 ± 0.621
0.401GlnCys: 0.401 ± 0.23
1.284GlnAsp: 1.284 ± 0.285
2.167GlnGlu: 2.167 ± 0.395
1.926GlnPhe: 1.926 ± 0.404
1.685GlnGly: 1.685 ± 0.377
0.241GlnHis: 0.241 ± 0.155
2.729GlnIle: 2.729 ± 0.437
4.013GlnLys: 4.013 ± 0.839
3.692GlnLeu: 3.692 ± 0.483
1.043GlnMet: 1.043 ± 0.261
2.488GlnAsn: 2.488 ± 0.306
1.124GlnPro: 1.124 ± 0.356
2.087GlnGln: 2.087 ± 0.601
1.605GlnArg: 1.605 ± 0.303
2.167GlnSer: 2.167 ± 0.417
2.408GlnThr: 2.408 ± 0.522
2.006GlnVal: 2.006 ± 0.369
0.482GlnTrp: 0.482 ± 0.18
2.006GlnTyr: 2.006 ± 0.468
0.0GlnXaa: 0.0 ± 0.0
Arg
2.568ArgAla: 2.568 ± 0.527
0.562ArgCys: 0.562 ± 0.244
2.568ArgAsp: 2.568 ± 0.445
3.772ArgGlu: 3.772 ± 0.602
2.408ArgPhe: 2.408 ± 0.418
2.889ArgGly: 2.889 ± 0.433
0.401ArgHis: 0.401 ± 0.165
3.611ArgIle: 3.611 ± 0.476
3.451ArgLys: 3.451 ± 0.618
4.735ArgLeu: 4.735 ± 0.607
1.204ArgMet: 1.204 ± 0.268
2.488ArgAsn: 2.488 ± 0.419
1.124ArgPro: 1.124 ± 0.282
1.525ArgGln: 1.525 ± 0.316
1.926ArgArg: 1.926 ± 0.509
2.809ArgSer: 2.809 ± 0.403
1.846ArgThr: 1.846 ± 0.331
3.05ArgVal: 3.05 ± 0.444
0.722ArgTrp: 0.722 ± 0.194
2.488ArgTyr: 2.488 ± 0.499
0.0ArgXaa: 0.0 ± 0.0
Ser
4.173SerAla: 4.173 ± 0.732
0.642SerCys: 0.642 ± 0.238
4.414SerAsp: 4.414 ± 0.572
5.216SerGlu: 5.216 ± 0.928
2.969SerPhe: 2.969 ± 0.523
4.173SerGly: 4.173 ± 0.614
0.803SerHis: 0.803 ± 0.223
5.377SerIle: 5.377 ± 0.65
4.494SerLys: 4.494 ± 0.399
5.698SerLeu: 5.698 ± 0.528
1.525SerMet: 1.525 ± 0.287
3.692SerAsn: 3.692 ± 0.554
2.087SerPro: 2.087 ± 0.437
2.408SerGln: 2.408 ± 0.467
2.488SerArg: 2.488 ± 0.375
2.889SerSer: 2.889 ± 0.588
3.772SerThr: 3.772 ± 0.493
4.815SerVal: 4.815 ± 0.59
0.241SerTrp: 0.241 ± 0.158
2.568SerTyr: 2.568 ± 0.438
0.0SerXaa: 0.0 ± 0.0
Thr
4.815ThrAla: 4.815 ± 1.017
0.883ThrCys: 0.883 ± 0.299
4.093ThrAsp: 4.093 ± 0.508
4.253ThrGlu: 4.253 ± 0.626
2.729ThrPhe: 2.729 ± 0.397
5.537ThrGly: 5.537 ± 1.065
0.963ThrHis: 0.963 ± 0.236
3.692ThrIle: 3.692 ± 0.526
5.216ThrLys: 5.216 ± 0.628
3.21ThrLeu: 3.21 ± 0.416
1.124ThrMet: 1.124 ± 0.268
2.648ThrAsn: 2.648 ± 0.461
2.568ThrPro: 2.568 ± 0.554
3.13ThrGln: 3.13 ± 0.397
2.087ThrArg: 2.087 ± 0.371
3.531ThrSer: 3.531 ± 0.591
3.451ThrThr: 3.451 ± 0.492
4.655ThrVal: 4.655 ± 0.598
0.642ThrTrp: 0.642 ± 0.272
1.926ThrTyr: 1.926 ± 0.385
0.0ThrXaa: 0.0 ± 0.0
Val
1.846ValAla: 1.846 ± 0.384
1.364ValCys: 1.364 ± 0.328
4.494ValAsp: 4.494 ± 0.684
5.056ValGlu: 5.056 ± 0.498
2.969ValPhe: 2.969 ± 0.592
2.969ValGly: 2.969 ± 0.567
1.284ValHis: 1.284 ± 0.291
2.889ValIle: 2.889 ± 0.576
6.5ValLys: 6.5 ± 0.6
5.056ValLeu: 5.056 ± 0.425
0.883ValMet: 0.883 ± 0.275
2.809ValAsn: 2.809 ± 0.434
1.846ValPro: 1.846 ± 0.336
2.087ValGln: 2.087 ± 0.475
3.05ValArg: 3.05 ± 0.5
4.334ValSer: 4.334 ± 0.661
4.735ValThr: 4.735 ± 0.656
3.611ValVal: 3.611 ± 0.664
0.562ValTrp: 0.562 ± 0.206
3.852ValTyr: 3.852 ± 0.592
0.0ValXaa: 0.0 ± 0.0
Trp
0.562TrpAla: 0.562 ± 0.194
0.161TrpCys: 0.161 ± 0.105
0.482TrpAsp: 0.482 ± 0.155
1.124TrpGlu: 1.124 ± 0.337
0.642TrpPhe: 0.642 ± 0.247
0.642TrpGly: 0.642 ± 0.229
0.161TrpHis: 0.161 ± 0.104
0.562TrpIle: 0.562 ± 0.227
0.803TrpLys: 0.803 ± 0.184
0.883TrpLeu: 0.883 ± 0.268
0.321TrpMet: 0.321 ± 0.14
0.642TrpAsn: 0.642 ± 0.209
0.0TrpPro: 0.0 ± 0.0
0.321TrpGln: 0.321 ± 0.158
0.562TrpArg: 0.562 ± 0.233
0.562TrpSer: 0.562 ± 0.247
0.161TrpThr: 0.161 ± 0.117
0.562TrpVal: 0.562 ± 0.208
0.0TrpTrp: 0.0 ± 0.0
0.401TrpTyr: 0.401 ± 0.185
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.889TyrAla: 2.889 ± 0.416
0.642TyrCys: 0.642 ± 0.262
2.408TyrAsp: 2.408 ± 0.427
2.809TyrGlu: 2.809 ± 0.381
2.327TyrPhe: 2.327 ± 0.348
2.488TyrGly: 2.488 ± 0.331
0.803TyrHis: 0.803 ± 0.275
3.692TyrIle: 3.692 ± 0.497
3.21TyrLys: 3.21 ± 0.581
3.451TyrLeu: 3.451 ± 0.502
1.284TyrMet: 1.284 ± 0.438
2.809TyrAsn: 2.809 ± 0.351
1.364TyrPro: 1.364 ± 0.261
2.568TyrGln: 2.568 ± 0.359
2.648TyrArg: 2.648 ± 0.576
2.408TyrSer: 2.408 ± 0.373
2.969TyrThr: 2.969 ± 0.501
3.05TyrVal: 3.05 ± 0.582
0.722TyrTrp: 0.722 ± 0.19
2.247TyrTyr: 2.247 ± 0.384
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 46 proteins (12462 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski