Amino acid dipepetide frequency for Gordonia phage GordDuk1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.799AlaAla: 11.799 ± 2.694
0.648AlaCys: 0.648 ± 0.223
5.835AlaAsp: 5.835 ± 0.563
6.18AlaGlu: 6.18 ± 0.632
2.939AlaPhe: 2.939 ± 0.334
7.952AlaGly: 7.952 ± 1.531
1.037AlaHis: 1.037 ± 0.174
4.754AlaIle: 4.754 ± 0.758
4.235AlaLys: 4.235 ± 0.558
7.218AlaLeu: 7.218 ± 0.783
1.815AlaMet: 1.815 ± 0.427
3.674AlaAsn: 3.674 ± 0.452
4.408AlaPro: 4.408 ± 0.662
3.976AlaGln: 3.976 ± 1.049
4.192AlaArg: 4.192 ± 0.412
5.705AlaSer: 5.705 ± 0.692
4.797AlaThr: 4.797 ± 0.608
6.224AlaVal: 6.224 ± 0.592
1.08AlaTrp: 1.08 ± 0.209
2.118AlaTyr: 2.118 ± 0.239
0.0AlaXaa: 0.0 ± 0.0
Cys
0.519CysAla: 0.519 ± 0.181
0.173CysCys: 0.173 ± 0.114
0.735CysAsp: 0.735 ± 0.2
0.778CysGlu: 0.778 ± 0.233
0.389CysPhe: 0.389 ± 0.146
0.821CysGly: 0.821 ± 0.227
0.13CysHis: 0.13 ± 0.117
0.519CysIle: 0.519 ± 0.171
0.605CysLys: 0.605 ± 0.193
0.562CysLeu: 0.562 ± 0.218
0.216CysMet: 0.216 ± 0.088
0.432CysAsn: 0.432 ± 0.146
0.648CysPro: 0.648 ± 0.21
0.432CysGln: 0.432 ± 0.161
0.778CysArg: 0.778 ± 0.236
0.735CysSer: 0.735 ± 0.229
0.475CysThr: 0.475 ± 0.167
0.562CysVal: 0.562 ± 0.163
0.173CysTrp: 0.173 ± 0.093
0.173CysTyr: 0.173 ± 0.105
0.0CysXaa: 0.0 ± 0.0
Asp
4.452AspAla: 4.452 ± 0.414
0.346AspCys: 0.346 ± 0.136
3.933AspAsp: 3.933 ± 0.545
4.538AspGlu: 4.538 ± 0.498
2.507AspPhe: 2.507 ± 0.333
4.322AspGly: 4.322 ± 0.47
1.902AspHis: 1.902 ± 0.461
4.063AspIle: 4.063 ± 0.337
3.674AspLys: 3.674 ± 0.398
5.057AspLeu: 5.057 ± 0.41
1.426AspMet: 1.426 ± 0.249
2.939AspAsn: 2.939 ± 0.553
4.668AspPro: 4.668 ± 0.616
2.247AspGln: 2.247 ± 0.459
2.939AspArg: 2.939 ± 0.417
5.186AspSer: 5.186 ± 1.341
3.328AspThr: 3.328 ± 0.337
3.76AspVal: 3.76 ± 0.457
1.469AspTrp: 1.469 ± 0.246
2.377AspTyr: 2.377 ± 0.434
0.0AspXaa: 0.0 ± 0.0
Glu
4.841GluAla: 4.841 ± 0.52
0.692GluCys: 0.692 ± 0.221
3.76GluAsp: 3.76 ± 0.482
3.846GluGlu: 3.846 ± 0.518
2.896GluPhe: 2.896 ± 0.545
2.939GluGly: 2.939 ± 0.322
0.864GluHis: 0.864 ± 0.234
4.927GluIle: 4.927 ± 0.514
4.322GluLys: 4.322 ± 0.446
5.532GluLeu: 5.532 ± 0.691
2.334GluMet: 2.334 ± 0.244
4.884GluAsn: 4.884 ± 0.555
2.377GluPro: 2.377 ± 0.445
2.68GluGln: 2.68 ± 0.48
2.939GluArg: 2.939 ± 0.427
4.063GluSer: 4.063 ± 0.494
3.328GluThr: 3.328 ± 0.366
3.803GluVal: 3.803 ± 0.448
1.513GluTrp: 1.513 ± 0.238
1.686GluTyr: 1.686 ± 0.318
0.0GluXaa: 0.0 ± 0.0
Phe
2.982PheAla: 2.982 ± 0.421
0.432PheCys: 0.432 ± 0.156
2.982PheAsp: 2.982 ± 0.359
2.247PheGlu: 2.247 ± 0.342
1.945PhePhe: 1.945 ± 0.27
3.155PheGly: 3.155 ± 0.369
0.778PheHis: 0.778 ± 0.174
1.988PheIle: 1.988 ± 0.335
2.118PheLys: 2.118 ± 0.368
2.593PheLeu: 2.593 ± 0.321
1.469PheMet: 1.469 ± 0.268
2.463PheAsn: 2.463 ± 0.249
1.599PhePro: 1.599 ± 0.336
1.08PheGln: 1.08 ± 0.294
1.858PheArg: 1.858 ± 0.253
3.587PheSer: 3.587 ± 0.568
2.377PheThr: 2.377 ± 0.389
2.377PheVal: 2.377 ± 0.317
0.605PheTrp: 0.605 ± 0.163
0.864PheTyr: 0.864 ± 0.178
0.0PheXaa: 0.0 ± 0.0
Gly
6.007GlyAla: 6.007 ± 0.998
0.519GlyCys: 0.519 ± 0.21
4.711GlyAsp: 4.711 ± 0.47
4.408GlyGlu: 4.408 ± 0.404
2.809GlyPhe: 2.809 ± 0.414
5.921GlyGly: 5.921 ± 1.274
1.297GlyHis: 1.297 ± 0.299
5.186GlyIle: 5.186 ± 0.383
5.273GlyLys: 5.273 ± 0.459
5.316GlyLeu: 5.316 ± 0.672
2.68GlyMet: 2.68 ± 0.288
3.63GlyAsn: 3.63 ± 0.35
3.112GlyPro: 3.112 ± 0.321
2.723GlyGln: 2.723 ± 0.329
3.458GlyArg: 3.458 ± 0.429
4.884GlySer: 4.884 ± 0.495
5.878GlyThr: 5.878 ± 0.649
4.538GlyVal: 4.538 ± 0.653
1.556GlyTrp: 1.556 ± 0.279
2.723GlyTyr: 2.723 ± 0.26
0.0GlyXaa: 0.0 ± 0.0
His
1.426HisAla: 1.426 ± 0.334
0.173HisCys: 0.173 ± 0.077
1.426HisAsp: 1.426 ± 0.342
1.253HisGlu: 1.253 ± 0.249
0.475HisPhe: 0.475 ± 0.177
1.21HisGly: 1.21 ± 0.298
0.216HisHis: 0.216 ± 0.095
0.735HisIle: 0.735 ± 0.212
1.124HisLys: 1.124 ± 0.251
0.994HisLeu: 0.994 ± 0.276
0.605HisMet: 0.605 ± 0.157
0.778HisAsn: 0.778 ± 0.155
1.297HisPro: 1.297 ± 0.273
0.562HisGln: 0.562 ± 0.132
0.994HisArg: 0.994 ± 0.312
0.821HisSer: 0.821 ± 0.179
0.821HisThr: 0.821 ± 0.147
0.994HisVal: 0.994 ± 0.235
0.389HisTrp: 0.389 ± 0.129
0.432HisTyr: 0.432 ± 0.201
0.0HisXaa: 0.0 ± 0.0
Ile
5.1IleAla: 5.1 ± 0.466
0.735IleCys: 0.735 ± 0.262
3.458IleAsp: 3.458 ± 0.317
3.63IleGlu: 3.63 ± 0.407
2.161IlePhe: 2.161 ± 0.351
4.149IleGly: 4.149 ± 0.869
1.167IleHis: 1.167 ± 0.246
3.328IleIle: 3.328 ± 0.339
3.155IleLys: 3.155 ± 0.266
4.322IleLeu: 4.322 ± 0.414
1.513IleMet: 1.513 ± 0.286
3.025IleAsn: 3.025 ± 0.386
3.458IlePro: 3.458 ± 0.469
2.161IleGln: 2.161 ± 0.254
3.112IleArg: 3.112 ± 0.423
3.933IleSer: 3.933 ± 0.441
4.019IleThr: 4.019 ± 0.439
3.112IleVal: 3.112 ± 0.372
0.951IleTrp: 0.951 ± 0.192
1.556IleTyr: 1.556 ± 0.362
0.0IleXaa: 0.0 ± 0.0
Lys
4.797LysAla: 4.797 ± 0.902
0.475LysCys: 0.475 ± 0.215
3.069LysAsp: 3.069 ± 0.511
2.42LysGlu: 2.42 ± 0.351
3.025LysPhe: 3.025 ± 0.338
3.371LysGly: 3.371 ± 0.578
1.556LysHis: 1.556 ± 0.262
3.198LysIle: 3.198 ± 0.362
4.063LysLys: 4.063 ± 0.547
4.192LysLeu: 4.192 ± 0.518
1.858LysMet: 1.858 ± 0.301
3.241LysAsn: 3.241 ± 0.287
2.204LysPro: 2.204 ± 0.415
2.507LysGln: 2.507 ± 0.295
3.587LysArg: 3.587 ± 0.472
3.717LysSer: 3.717 ± 0.346
3.501LysThr: 3.501 ± 0.41
3.458LysVal: 3.458 ± 0.345
1.167LysTrp: 1.167 ± 0.222
1.426LysTyr: 1.426 ± 0.324
0.0LysXaa: 0.0 ± 0.0
Leu
6.872LeuAla: 6.872 ± 0.613
0.994LeuCys: 0.994 ± 0.302
5.402LeuAsp: 5.402 ± 0.478
5.359LeuGlu: 5.359 ± 0.531
2.68LeuPhe: 2.68 ± 0.327
5.964LeuGly: 5.964 ± 0.672
0.908LeuHis: 0.908 ± 0.239
3.976LeuIle: 3.976 ± 0.426
3.717LeuLys: 3.717 ± 0.482
4.797LeuLeu: 4.797 ± 0.517
1.858LeuMet: 1.858 ± 0.245
4.063LeuAsn: 4.063 ± 0.441
4.235LeuPro: 4.235 ± 0.443
2.377LeuGln: 2.377 ± 0.355
3.155LeuArg: 3.155 ± 0.42
5.1LeuSer: 5.1 ± 0.423
4.797LeuThr: 4.797 ± 0.385
4.754LeuVal: 4.754 ± 0.513
0.821LeuTrp: 0.821 ± 0.155
1.772LeuTyr: 1.772 ± 0.34
0.0LeuXaa: 0.0 ± 0.0
Met
2.852MetAla: 2.852 ± 0.363
0.346MetCys: 0.346 ± 0.172
1.729MetAsp: 1.729 ± 0.272
1.556MetGlu: 1.556 ± 0.3
0.821MetPhe: 0.821 ± 0.158
2.118MetGly: 2.118 ± 0.39
0.432MetHis: 0.432 ± 0.171
1.469MetIle: 1.469 ± 0.294
1.686MetLys: 1.686 ± 0.367
2.463MetLeu: 2.463 ± 0.324
0.605MetMet: 0.605 ± 0.189
1.599MetAsn: 1.599 ± 0.242
1.297MetPro: 1.297 ± 0.285
0.908MetGln: 0.908 ± 0.207
1.642MetArg: 1.642 ± 0.283
2.463MetSer: 2.463 ± 0.252
2.031MetThr: 2.031 ± 0.272
1.556MetVal: 1.556 ± 0.259
0.303MetTrp: 0.303 ± 0.136
0.303MetTyr: 0.303 ± 0.115
0.0MetXaa: 0.0 ± 0.0
Asn
4.538AsnAla: 4.538 ± 0.792
0.346AsnCys: 0.346 ± 0.168
2.982AsnAsp: 2.982 ± 0.347
2.852AsnGlu: 2.852 ± 0.43
2.247AsnPhe: 2.247 ± 0.37
4.408AsnGly: 4.408 ± 0.422
0.951AsnHis: 0.951 ± 0.232
2.852AsnIle: 2.852 ± 0.377
2.636AsnLys: 2.636 ± 0.352
3.544AsnLeu: 3.544 ± 0.481
1.469AsnMet: 1.469 ± 0.28
2.334AsnAsn: 2.334 ± 0.381
2.723AsnPro: 2.723 ± 0.253
1.988AsnGln: 1.988 ± 0.247
2.463AsnArg: 2.463 ± 0.334
3.803AsnSer: 3.803 ± 0.487
3.112AsnThr: 3.112 ± 0.335
3.155AsnVal: 3.155 ± 0.455
0.389AsnTrp: 0.389 ± 0.099
1.426AsnTyr: 1.426 ± 0.247
0.0AsnXaa: 0.0 ± 0.0
Pro
4.797ProAla: 4.797 ± 0.6
0.562ProCys: 0.562 ± 0.195
3.241ProAsp: 3.241 ± 0.521
3.846ProGlu: 3.846 ± 0.502
1.686ProPhe: 1.686 ± 0.299
4.365ProGly: 4.365 ± 0.357
0.908ProHis: 0.908 ± 0.198
2.68ProIle: 2.68 ± 0.368
2.55ProLys: 2.55 ± 0.351
2.852ProLeu: 2.852 ± 0.417
1.167ProMet: 1.167 ± 0.233
2.247ProAsn: 2.247 ± 0.335
2.334ProPro: 2.334 ± 0.484
1.772ProGln: 1.772 ± 0.216
1.902ProArg: 1.902 ± 0.276
2.852ProSer: 2.852 ± 0.38
2.42ProThr: 2.42 ± 0.326
4.235ProVal: 4.235 ± 0.699
0.605ProTrp: 0.605 ± 0.181
1.167ProTyr: 1.167 ± 0.178
0.0ProXaa: 0.0 ± 0.0
Gln
4.106GlnAla: 4.106 ± 0.641
0.475GlnCys: 0.475 ± 0.168
2.68GlnAsp: 2.68 ± 0.707
2.896GlnGlu: 2.896 ± 0.381
2.031GlnPhe: 2.031 ± 0.286
2.291GlnGly: 2.291 ± 0.299
0.389GlnHis: 0.389 ± 0.157
2.291GlnIle: 2.291 ± 0.355
2.075GlnLys: 2.075 ± 0.298
2.723GlnLeu: 2.723 ± 0.399
1.21GlnMet: 1.21 ± 0.244
1.815GlnAsn: 1.815 ± 0.267
1.729GlnPro: 1.729 ± 0.37
1.599GlnGln: 1.599 ± 0.399
2.031GlnArg: 2.031 ± 0.254
1.556GlnSer: 1.556 ± 0.237
1.642GlnThr: 1.642 ± 0.433
2.334GlnVal: 2.334 ± 0.352
0.605GlnTrp: 0.605 ± 0.148
1.513GlnTyr: 1.513 ± 0.33
0.0GlnXaa: 0.0 ± 0.0
Arg
4.754ArgAla: 4.754 ± 0.704
0.475ArgCys: 0.475 ± 0.157
3.285ArgAsp: 3.285 ± 0.412
3.328ArgGlu: 3.328 ± 0.48
1.902ArgPhe: 1.902 ± 0.31
3.198ArgGly: 3.198 ± 0.393
0.821ArgHis: 0.821 ± 0.19
3.501ArgIle: 3.501 ± 0.387
3.89ArgLys: 3.89 ± 0.517
3.285ArgLeu: 3.285 ± 0.413
1.599ArgMet: 1.599 ± 0.375
2.55ArgAsn: 2.55 ± 0.433
2.377ArgPro: 2.377 ± 0.339
1.426ArgGln: 1.426 ± 0.239
2.852ArgArg: 2.852 ± 0.265
2.852ArgSer: 2.852 ± 0.314
2.377ArgThr: 2.377 ± 0.436
3.674ArgVal: 3.674 ± 0.398
0.562ArgTrp: 0.562 ± 0.145
2.118ArgTyr: 2.118 ± 0.328
0.0ArgXaa: 0.0 ± 0.0
Ser
6.31SerAla: 6.31 ± 0.747
0.821SerCys: 0.821 ± 0.225
4.495SerAsp: 4.495 ± 0.669
3.587SerGlu: 3.587 ± 0.642
2.42SerPhe: 2.42 ± 0.309
6.699SerGly: 6.699 ± 0.596
0.908SerHis: 0.908 ± 0.205
3.501SerIle: 3.501 ± 0.431
3.89SerLys: 3.89 ± 0.509
5.359SerLeu: 5.359 ± 0.421
2.031SerMet: 2.031 ± 0.262
2.463SerAsn: 2.463 ± 0.436
2.55SerPro: 2.55 ± 0.468
3.112SerGln: 3.112 ± 0.37
3.328SerArg: 3.328 ± 0.372
3.933SerSer: 3.933 ± 0.479
3.674SerThr: 3.674 ± 0.412
4.581SerVal: 4.581 ± 0.4
0.821SerTrp: 0.821 ± 0.211
2.247SerTyr: 2.247 ± 0.295
0.0SerXaa: 0.0 ± 0.0
Thr
6.31ThrAla: 6.31 ± 1.008
0.432ThrCys: 0.432 ± 0.16
3.587ThrAsp: 3.587 ± 0.483
4.452ThrGlu: 4.452 ± 0.378
1.858ThrPhe: 1.858 ± 0.242
5.402ThrGly: 5.402 ± 0.603
0.821ThrHis: 0.821 ± 0.211
2.247ThrIle: 2.247 ± 0.37
2.766ThrLys: 2.766 ± 0.37
3.63ThrLeu: 3.63 ± 0.37
1.469ThrMet: 1.469 ± 0.226
2.68ThrAsn: 2.68 ± 0.385
2.896ThrPro: 2.896 ± 0.337
2.507ThrGln: 2.507 ± 0.253
2.896ThrArg: 2.896 ± 0.363
3.717ThrSer: 3.717 ± 0.373
2.68ThrThr: 2.68 ± 0.435
4.754ThrVal: 4.754 ± 0.487
0.778ThrTrp: 0.778 ± 0.189
1.556ThrTyr: 1.556 ± 0.238
0.0ThrXaa: 0.0 ± 0.0
Val
4.884ValAla: 4.884 ± 0.799
0.605ValCys: 0.605 ± 0.155
4.581ValAsp: 4.581 ± 0.463
4.624ValGlu: 4.624 ± 0.507
2.896ValPhe: 2.896 ± 0.432
4.149ValGly: 4.149 ± 0.6
1.167ValHis: 1.167 ± 0.234
3.89ValIle: 3.89 ± 0.44
2.636ValLys: 2.636 ± 0.379
5.489ValLeu: 5.489 ± 0.622
1.686ValMet: 1.686 ± 0.304
3.414ValAsn: 3.414 ± 0.378
2.896ValPro: 2.896 ± 0.374
2.247ValGln: 2.247 ± 0.303
3.414ValArg: 3.414 ± 0.396
4.927ValSer: 4.927 ± 0.479
4.019ValThr: 4.019 ± 0.4
4.408ValVal: 4.408 ± 0.433
0.778ValTrp: 0.778 ± 0.187
2.291ValTyr: 2.291 ± 0.292
0.0ValXaa: 0.0 ± 0.0
Trp
1.21TrpAla: 1.21 ± 0.252
0.259TrpCys: 0.259 ± 0.117
1.167TrpAsp: 1.167 ± 0.191
0.778TrpGlu: 0.778 ± 0.208
0.735TrpPhe: 0.735 ± 0.191
1.08TrpGly: 1.08 ± 0.234
0.173TrpHis: 0.173 ± 0.088
1.037TrpIle: 1.037 ± 0.307
0.605TrpLys: 0.605 ± 0.157
1.124TrpLeu: 1.124 ± 0.212
0.432TrpMet: 0.432 ± 0.144
0.994TrpAsn: 0.994 ± 0.193
0.389TrpPro: 0.389 ± 0.16
0.648TrpGln: 0.648 ± 0.148
1.124TrpArg: 1.124 ± 0.201
1.21TrpSer: 1.21 ± 0.248
0.648TrpThr: 0.648 ± 0.173
0.692TrpVal: 0.692 ± 0.154
0.0TrpTrp: 0.0 ± 0.0
0.692TrpTyr: 0.692 ± 0.179
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.031TyrAla: 2.031 ± 0.313
0.346TyrCys: 0.346 ± 0.126
2.075TyrAsp: 2.075 ± 0.269
1.642TyrGlu: 1.642 ± 0.292
1.08TyrPhe: 1.08 ± 0.221
3.112TyrGly: 3.112 ± 0.342
0.303TyrHis: 0.303 ± 0.113
1.902TyrIle: 1.902 ± 0.342
1.815TyrLys: 1.815 ± 0.239
2.55TyrLeu: 2.55 ± 0.388
0.692TyrMet: 0.692 ± 0.161
0.994TyrAsn: 0.994 ± 0.225
0.994TyrPro: 0.994 ± 0.251
1.037TyrGln: 1.037 ± 0.258
2.204TyrArg: 2.204 ± 0.367
1.686TyrSer: 1.686 ± 0.311
1.513TyrThr: 1.513 ± 0.314
2.031TyrVal: 2.031 ± 0.359
0.432TyrTrp: 0.432 ± 0.144
0.864TyrTyr: 0.864 ± 0.191
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 97 proteins (23139 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski