Amino acid dipepetide frequency for Flavobacteriaceae bacterium F202Z8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.168AlaAla: 5.168 ± 0.08	0.61AlaCys: 0.61 ± 0.024	4.107AlaAsp: 4.107 ± 0.073	4.587AlaGlu: 4.587 ± 0.072	3.504AlaPhe: 3.504 ± 0.056	4.619AlaGly: 4.619 ± 0.073	1.281AlaHis: 1.281 ± 0.032	5.528AlaIle: 5.528 ± 0.073	4.719AlaLys: 4.719 ± 0.079	7.124AlaLeu: 7.124 ± 0.081	1.736AlaMet: 1.736 ± 0.041	3.621AlaAsn: 3.621 ± 0.06	2.352AlaPro: 2.352 ± 0.05	2.687AlaGln: 2.687 ± 0.051	2.408AlaArg: 2.408 ± 0.043	4.434AlaSer: 4.434 ± 0.068	4.216AlaThr: 4.216 ± 0.085	4.594AlaVal: 4.594 ± 0.059	0.678AlaTrp: 0.678 ± 0.022	2.646AlaTyr: 2.646 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.515CysAla: 0.515 ± 0.019	0.109CysCys: 0.109 ± 0.01	0.442CysAsp: 0.442 ± 0.026	0.47CysGlu: 0.47 ± 0.024	0.397CysPhe: 0.397 ± 0.019	0.607CysGly: 0.607 ± 0.023	0.167CysHis: 0.167 ± 0.013	0.541CysIle: 0.541 ± 0.02	0.398CysLys: 0.398 ± 0.018	0.624CysLeu: 0.624 ± 0.022	0.135CysMet: 0.135 ± 0.01	0.382CysAsn: 0.382 ± 0.02	0.326CysPro: 0.326 ± 0.019	0.231CysGln: 0.231 ± 0.016	0.229CysArg: 0.229 ± 0.014	0.609CysSer: 0.609 ± 0.023	0.506CysThr: 0.506 ± 0.028	0.404CysVal: 0.404 ± 0.021	0.07CysTrp: 0.07 ± 0.007	0.29CysTyr: 0.29 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.454AspAla: 4.454 ± 0.074	0.453AspCys: 0.453 ± 0.027	3.437AspAsp: 3.437 ± 0.074	3.87AspGlu: 3.87 ± 0.058	3.831AspPhe: 3.831 ± 0.052	4.973AspGly: 4.973 ± 0.15	0.972AspHis: 0.972 ± 0.029	4.424AspIle: 4.424 ± 0.064	3.57AspLys: 3.57 ± 0.069	5.161AspLeu: 5.161 ± 0.068	1.301AspMet: 1.301 ± 0.033	3.069AspAsn: 3.069 ± 0.143	2.046AspPro: 2.046 ± 0.055	1.648AspGln: 1.648 ± 0.034	2.187AspArg: 2.187 ± 0.041	3.688AspSer: 3.688 ± 0.061	3.306AspThr: 3.306 ± 0.062	3.727AspVal: 3.727 ± 0.067	0.876AspTrp: 0.876 ± 0.025	2.789AspTyr: 2.789 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	4.709GluAla: 4.709 ± 0.07	0.354GluCys: 0.354 ± 0.019	3.632GluAsp: 3.632 ± 0.049	4.936GluGlu: 4.936 ± 0.078	2.809GluPhe: 2.809 ± 0.04	4.31GluGly: 4.31 ± 0.058	1.233GluHis: 1.233 ± 0.032	5.166GluIle: 5.166 ± 0.074	5.556GluLys: 5.556 ± 0.078	6.223GluLeu: 6.223 ± 0.069	1.689GluMet: 1.689 ± 0.035	4.396GluAsn: 4.396 ± 0.061	1.772GluPro: 1.772 ± 0.038	2.442GluGln: 2.442 ± 0.047	3.018GluArg: 3.018 ± 0.048	3.318GluSer: 3.318 ± 0.052	3.757GluThr: 3.757 ± 0.062	4.618GluVal: 4.618 ± 0.059	0.698GluTrp: 0.698 ± 0.025	2.285GluTyr: 2.285 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.2PheAla: 3.2 ± 0.05	0.402PheCys: 0.402 ± 0.017	3.397PheAsp: 3.397 ± 0.056	3.493PheGlu: 3.493 ± 0.043	2.686PhePhe: 2.686 ± 0.057	3.733PheGly: 3.733 ± 0.062	0.8PheHis: 0.8 ± 0.026	3.289PheIle: 3.289 ± 0.059	3.189PheLys: 3.189 ± 0.052	4.712PheLeu: 4.712 ± 0.08	1.136PheMet: 1.136 ± 0.033	2.699PheAsn: 2.699 ± 0.057	1.786PhePro: 1.786 ± 0.037	1.564PheGln: 1.564 ± 0.034	1.875PheArg: 1.875 ± 0.036	3.745PheSer: 3.745 ± 0.058	3.021PheThr: 3.021 ± 0.053	3.034PheVal: 3.034 ± 0.053	0.613PheTrp: 0.613 ± 0.023	2.058PheTyr: 2.058 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.784GlyAla: 4.784 ± 0.082	0.675GlyCys: 0.675 ± 0.04	4.047GlyAsp: 4.047 ± 0.095	4.144GlyGlu: 4.144 ± 0.067	3.725GlyPhe: 3.725 ± 0.062	5.079GlyGly: 5.079 ± 0.107	1.232GlyHis: 1.232 ± 0.034	5.628GlyIle: 5.628 ± 0.078	4.909GlyLys: 4.909 ± 0.077	6.27GlyLeu: 6.27 ± 0.092	1.802GlyMet: 1.802 ± 0.043	3.94GlyAsn: 3.94 ± 0.076	1.673GlyPro: 1.673 ± 0.04	2.203GlyGln: 2.203 ± 0.041	2.531GlyArg: 2.531 ± 0.047	4.304GlySer: 4.304 ± 0.072	4.643GlyThr: 4.643 ± 0.139	4.524GlyVal: 4.524 ± 0.068	0.879GlyTrp: 0.879 ± 0.031	2.912GlyTyr: 2.912 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.041HisAla: 1.041 ± 0.029	0.184HisCys: 0.184 ± 0.012	0.838HisAsp: 0.838 ± 0.027	0.981HisGlu: 0.981 ± 0.034	1.107HisPhe: 1.107 ± 0.03	1.098HisGly: 1.098 ± 0.027	0.509HisHis: 0.509 ± 0.02	1.369HisIle: 1.369 ± 0.033	1.074HisLys: 1.074 ± 0.03	1.826HisLeu: 1.826 ± 0.039	0.39HisMet: 0.39 ± 0.016	0.794HisAsn: 0.794 ± 0.025	0.939HisPro: 0.939 ± 0.025	0.711HisGln: 0.711 ± 0.024	0.862HisArg: 0.862 ± 0.025	1.101HisSer: 1.101 ± 0.033	1.019HisThr: 1.019 ± 0.028	0.936HisVal: 0.936 ± 0.029	0.233HisTrp: 0.233 ± 0.015	0.795HisTyr: 0.795 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.88IleAla: 5.88 ± 0.073	0.602IleCys: 0.602 ± 0.02	4.796IleAsp: 4.796 ± 0.06	4.611IleGlu: 4.611 ± 0.066	3.245IlePhe: 3.245 ± 0.062	5.137IleGly: 5.137 ± 0.063	1.196IleHis: 1.196 ± 0.034	4.605IleIle: 4.605 ± 0.07	4.528IleLys: 4.528 ± 0.068	6.475IleLeu: 6.475 ± 0.086	1.299IleMet: 1.299 ± 0.029	3.589IleAsn: 3.589 ± 0.058	3.221IlePro: 3.221 ± 0.056	2.284IleGln: 2.284 ± 0.045	2.744IleArg: 2.744 ± 0.046	4.997IleSer: 4.997 ± 0.069	4.452IleThr: 4.452 ± 0.089	4.483IleVal: 4.483 ± 0.06	0.706IleTrp: 0.706 ± 0.024	2.384IleTyr: 2.384 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.872LysAla: 4.872 ± 0.074	0.267LysCys: 0.267 ± 0.013	3.867LysAsp: 3.867 ± 0.059	5.508LysGlu: 5.508 ± 0.087	2.536LysPhe: 2.536 ± 0.047	4.485LysGly: 4.485 ± 0.075	1.201LysHis: 1.201 ± 0.033	4.876LysIle: 4.876 ± 0.074	6.049LysLys: 6.049 ± 0.102	5.752LysLeu: 5.752 ± 0.076	1.808LysMet: 1.808 ± 0.048	4.213LysAsn: 4.213 ± 0.069	2.16LysPro: 2.16 ± 0.046	2.174LysGln: 2.174 ± 0.043	2.994LysArg: 2.994 ± 0.057	4.105LysSer: 4.105 ± 0.064	4.156LysThr: 4.156 ± 0.063	4.34LysVal: 4.34 ± 0.072	0.785LysTrp: 0.785 ± 0.029	2.433LysTyr: 2.433 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	6.546LeuAla: 6.546 ± 0.078	0.714LeuCys: 0.714 ± 0.026	5.257LeuAsp: 5.257 ± 0.069	6.221LeuGlu: 6.221 ± 0.085	4.784LeuPhe: 4.784 ± 0.074	6.251LeuGly: 6.251 ± 0.074	1.623LeuHis: 1.623 ± 0.042	5.936LeuIle: 5.936 ± 0.081	6.91LeuLys: 6.91 ± 0.09	9.103LeuLeu: 9.103 ± 0.121	2.075LeuMet: 2.075 ± 0.045	5.019LeuAsn: 5.019 ± 0.065	3.782LeuPro: 3.782 ± 0.054	3.451LeuGln: 3.451 ± 0.056	3.837LeuArg: 3.837 ± 0.048	6.483LeuSer: 6.483 ± 0.079	5.184LeuThr: 5.184 ± 0.078	5.772LeuVal: 5.772 ± 0.069	0.966LeuTrp: 0.966 ± 0.03	3.146LeuTyr: 3.146 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.926MetAla: 1.926 ± 0.043	0.138MetCys: 0.138 ± 0.01	1.281MetAsp: 1.281 ± 0.032	1.511MetGlu: 1.511 ± 0.035	0.835MetPhe: 0.835 ± 0.03	1.712MetGly: 1.712 ± 0.042	0.432MetHis: 0.432 ± 0.016	1.351MetIle: 1.351 ± 0.035	1.973MetLys: 1.973 ± 0.036	1.966MetLeu: 1.966 ± 0.039	0.586MetMet: 0.586 ± 0.021	1.309MetAsn: 1.309 ± 0.03	0.915MetPro: 0.915 ± 0.031	0.927MetGln: 0.927 ± 0.028	1.026MetArg: 1.026 ± 0.028	1.27MetSer: 1.27 ± 0.033	1.233MetThr: 1.233 ± 0.028	1.648MetVal: 1.648 ± 0.035	0.162MetTrp: 0.162 ± 0.012	0.652MetTyr: 0.652 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.862AsnAla: 3.862 ± 0.066	0.423AsnCys: 0.423 ± 0.02	3.382AsnAsp: 3.382 ± 0.105	3.4AsnGlu: 3.4 ± 0.064	2.692AsnPhe: 2.692 ± 0.051	4.333AsnGly: 4.333 ± 0.091	0.92AsnHis: 0.92 ± 0.028	3.775AsnIle: 3.775 ± 0.055	3.133AsnLys: 3.133 ± 0.056	4.891AsnLeu: 4.891 ± 0.077	1.15AsnMet: 1.15 ± 0.03	2.884AsnAsn: 2.884 ± 0.064	2.709AsnPro: 2.709 ± 0.052	1.808AsnGln: 1.808 ± 0.044	2.327AsnArg: 2.327 ± 0.047	3.376AsnSer: 3.376 ± 0.055	3.468AsnThr: 3.468 ± 0.067	3.346AsnVal: 3.346 ± 0.068	0.712AsnTrp: 0.712 ± 0.025	2.293AsnTyr: 2.293 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	2.195ProAla: 2.195 ± 0.045	0.199ProCys: 0.199 ± 0.014	2.517ProAsp: 2.517 ± 0.054	3.215ProGlu: 3.215 ± 0.046	1.974ProPhe: 1.974 ± 0.041	2.218ProGly: 2.218 ± 0.047	0.641ProHis: 0.641 ± 0.024	2.623ProIle: 2.623 ± 0.045	2.512ProLys: 2.512 ± 0.049	3.162ProLeu: 3.162 ± 0.055	0.847ProMet: 0.847 ± 0.026	2.196ProAsn: 2.196 ± 0.056	1.028ProPro: 1.028 ± 0.034	1.199ProGln: 1.199 ± 0.028	1.102ProArg: 1.102 ± 0.026	2.397ProSer: 2.397 ± 0.052	2.179ProThr: 2.179 ± 0.047	2.406ProVal: 2.406 ± 0.047	0.429ProTrp: 0.429 ± 0.02	1.432ProTyr: 1.432 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.091GlnAla: 2.091 ± 0.037	0.18GlnCys: 0.18 ± 0.011	1.813GlnAsp: 1.813 ± 0.036	2.54GlnGlu: 2.54 ± 0.051	1.54GlnPhe: 1.54 ± 0.04	2.055GlnGly: 2.055 ± 0.046	0.66GlnHis: 0.66 ± 0.025	2.363GlnIle: 2.363 ± 0.042	2.614GlnLys: 2.614 ± 0.049	3.616GlnLeu: 3.616 ± 0.057	0.869GlnMet: 0.869 ± 0.025	1.987GlnAsn: 1.987 ± 0.043	1.131GlnPro: 1.131 ± 0.03	1.411GlnGln: 1.411 ± 0.038	1.431GlnArg: 1.431 ± 0.036	1.938GlnSer: 1.938 ± 0.043	1.866GlnThr: 1.866 ± 0.046	2.024GlnVal: 2.024 ± 0.038	0.423GlnTrp: 0.423 ± 0.016	1.246GlnTyr: 1.246 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.443ArgAla: 2.443 ± 0.046	0.218ArgCys: 0.218 ± 0.012	2.069ArgAsp: 2.069 ± 0.036	2.473ArgGlu: 2.473 ± 0.05	2.162ArgPhe: 2.162 ± 0.043	2.211ArgGly: 2.211 ± 0.044	0.74ArgHis: 0.74 ± 0.026	3.151ArgIle: 3.151 ± 0.053	3.054ArgLys: 3.054 ± 0.054	3.837ArgLeu: 3.837 ± 0.059	1.107ArgMet: 1.107 ± 0.027	2.363ArgAsn: 2.363 ± 0.043	1.44ArgPro: 1.44 ± 0.032	1.313ArgGln: 1.313 ± 0.034	1.598ArgArg: 1.598 ± 0.04	2.243ArgSer: 2.243 ± 0.045	2.261ArgThr: 2.261 ± 0.044	2.271ArgVal: 2.271 ± 0.043	0.459ArgTrp: 0.459 ± 0.018	1.775ArgTyr: 1.775 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	4.155SerAla: 4.155 ± 0.062	0.688SerCys: 0.688 ± 0.027	3.825SerAsp: 3.825 ± 0.067	4.295SerGlu: 4.295 ± 0.059	3.467SerPhe: 3.467 ± 0.059	4.981SerGly: 4.981 ± 0.084	1.057SerHis: 1.057 ± 0.025	4.635SerIle: 4.635 ± 0.062	4.18SerLys: 4.18 ± 0.061	5.831SerLeu: 5.831 ± 0.079	1.302SerMet: 1.302 ± 0.034	3.298SerAsn: 3.298 ± 0.056	2.277SerPro: 2.277 ± 0.043	1.976SerGln: 1.976 ± 0.037	2.319SerArg: 2.319 ± 0.045	4.079SerSer: 4.079 ± 0.066	3.565SerThr: 3.565 ± 0.063	4.143SerVal: 4.143 ± 0.064	0.752SerTrp: 0.752 ± 0.027	2.528SerTyr: 2.528 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.576ThrAla: 4.576 ± 0.075	0.307ThrCys: 0.307 ± 0.015	3.915ThrAsp: 3.915 ± 0.149	3.731ThrGlu: 3.731 ± 0.055	2.954ThrPhe: 2.954 ± 0.049	4.269ThrGly: 4.269 ± 0.082	0.984ThrHis: 0.984 ± 0.03	4.678ThrIle: 4.678 ± 0.089	3.421ThrLys: 3.421 ± 0.059	5.483ThrLeu: 5.483 ± 0.072	1.115ThrMet: 1.115 ± 0.027	3.026ThrAsn: 3.026 ± 0.077	2.632ThrPro: 2.632 ± 0.063	1.787ThrGln: 1.787 ± 0.038	1.867ThrArg: 1.867 ± 0.035	3.653ThrSer: 3.653 ± 0.065	3.682ThrThr: 3.682 ± 0.086	4.427ThrVal: 4.427 ± 0.13	0.592ThrTrp: 0.592 ± 0.024	2.434ThrTyr: 2.434 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	4.945ValAla: 4.945 ± 0.072	0.511ValCys: 0.511 ± 0.021	3.899ValAsp: 3.899 ± 0.07	3.74ValGlu: 3.74 ± 0.056	3.375ValPhe: 3.375 ± 0.053	4.256ValGly: 4.256 ± 0.069	1.131ValHis: 1.131 ± 0.029	4.293ValIle: 4.293 ± 0.064	3.669ValLys: 3.669 ± 0.062	6.401ValLeu: 6.401 ± 0.072	1.433ValMet: 1.433 ± 0.036	3.32ValAsn: 3.32 ± 0.074	2.486ValPro: 2.486 ± 0.043	2.103ValGln: 2.103 ± 0.041	2.457ValArg: 2.457 ± 0.049	4.541ValSer: 4.541 ± 0.067	3.986ValThr: 3.986 ± 0.11	4.573ValVal: 4.573 ± 0.073	0.713ValTrp: 0.713 ± 0.027	2.344ValTyr: 2.344 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.683TrpAla: 0.683 ± 0.023	0.106TrpCys: 0.106 ± 0.009	0.732TrpAsp: 0.732 ± 0.026	0.772TrpGlu: 0.772 ± 0.027	0.554TrpPhe: 0.554 ± 0.023	0.794TrpGly: 0.794 ± 0.024	0.247TrpHis: 0.247 ± 0.015	0.69TrpIle: 0.69 ± 0.022	0.8TrpLys: 0.8 ± 0.03	1.023TrpLeu: 1.023 ± 0.03	0.346TrpMet: 0.346 ± 0.018	0.689TrpAsn: 0.689 ± 0.026	0.322TrpPro: 0.322 ± 0.018	0.447TrpGln: 0.447 ± 0.02	0.5TrpArg: 0.5 ± 0.021	0.707TrpSer: 0.707 ± 0.025	0.62TrpThr: 0.62 ± 0.026	0.733TrpVal: 0.733 ± 0.022	0.18TrpTrp: 0.18 ± 0.013	0.456TrpTyr: 0.456 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.574TyrAla: 2.574 ± 0.041	0.311TyrCys: 0.311 ± 0.015	2.529TyrAsp: 2.529 ± 0.05	2.422TyrGlu: 2.422 ± 0.046	2.256TyrPhe: 2.256 ± 0.043	2.784TyrGly: 2.784 ± 0.049	0.783TyrHis: 0.783 ± 0.03	2.313TyrIle: 2.313 ± 0.041	2.326TyrLys: 2.326 ± 0.051	3.579TyrLeu: 3.579 ± 0.058	0.725TyrMet: 0.725 ± 0.023	2.09TyrAsn: 2.09 ± 0.041	1.476TyrPro: 1.476 ± 0.03	1.43TyrGln: 1.43 ± 0.035	1.875TyrArg: 1.875 ± 0.04	2.363TyrSer: 2.363 ± 0.043	2.411TyrThr: 2.411 ± 0.058	2.173TyrVal: 2.173 ± 0.041	0.475TyrTrp: 0.475 ± 0.019	1.656TyrTyr: 1.656 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3847 proteins (1374296 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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