Amino acid dipepetide frequency for Aureliella helgolandensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.503AlaAla: 11.503 ± 0.097	1.247AlaCys: 1.247 ± 0.025	5.499AlaAsp: 5.499 ± 0.061	6.653AlaGlu: 6.653 ± 0.072	3.269AlaPhe: 3.269 ± 0.038	7.917AlaGly: 7.917 ± 0.079	1.719AlaHis: 1.719 ± 0.027	5.628AlaIle: 5.628 ± 0.054	3.672AlaLys: 3.672 ± 0.045	8.946AlaLeu: 8.946 ± 0.078	2.432AlaMet: 2.432 ± 0.038	3.17AlaAsn: 3.17 ± 0.043	4.445AlaPro: 4.445 ± 0.048	4.087AlaGln: 4.087 ± 0.047	5.533AlaArg: 5.533 ± 0.056	7.135AlaSer: 7.135 ± 0.064	6.086AlaThr: 6.086 ± 0.056	6.663AlaVal: 6.663 ± 0.065	1.479AlaTrp: 1.479 ± 0.027	2.103AlaTyr: 2.103 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	0.881CysAla: 0.881 ± 0.02	0.292CysCys: 0.292 ± 0.013	0.704CysAsp: 0.704 ± 0.023	0.679CysGlu: 0.679 ± 0.021	0.477CysPhe: 0.477 ± 0.015	1.089CysGly: 1.089 ± 0.029	0.443CysHis: 0.443 ± 0.017	0.549CysIle: 0.549 ± 0.014	0.353CysLys: 0.353 ± 0.014	1.307CysLeu: 1.307 ± 0.025	0.242CysMet: 0.242 ± 0.012	0.384CysAsn: 0.384 ± 0.014	0.618CysPro: 0.618 ± 0.019	0.511CysGln: 0.511 ± 0.017	0.779CysArg: 0.779 ± 0.022	0.824CysSer: 0.824 ± 0.02	0.564CysThr: 0.564 ± 0.016	0.862CysVal: 0.862 ± 0.021	0.206CysTrp: 0.206 ± 0.009	0.321CysTyr: 0.321 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	5.758AspAla: 5.758 ± 0.055	0.64AspCys: 0.64 ± 0.018	3.07AspAsp: 3.07 ± 0.055	3.426AspGlu: 3.426 ± 0.045	2.41AspPhe: 2.41 ± 0.035	4.921AspGly: 4.921 ± 0.091	1.244AspHis: 1.244 ± 0.029	2.403AspIle: 2.403 ± 0.034	1.51AspLys: 1.51 ± 0.026	5.536AspLeu: 5.536 ± 0.066	0.953AspMet: 0.953 ± 0.022	1.612AspAsn: 1.612 ± 0.037	3.075AspPro: 3.075 ± 0.04	2.316AspGln: 2.316 ± 0.032	3.769AspArg: 3.769 ± 0.04	4.005AspSer: 4.005 ± 0.048	2.564AspThr: 2.564 ± 0.046	3.661AspVal: 3.661 ± 0.052	1.088AspTrp: 1.088 ± 0.022	1.565AspTyr: 1.565 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	5.769GluAla: 5.769 ± 0.056	0.561GluCys: 0.561 ± 0.017	2.808GluAsp: 2.808 ± 0.034	3.592GluGlu: 3.592 ± 0.05	2.492GluPhe: 2.492 ± 0.031	3.664GluGly: 3.664 ± 0.039	1.501GluHis: 1.501 ± 0.03	3.435GluIle: 3.435 ± 0.045	2.263GluLys: 2.263 ± 0.034	7.408GluLeu: 7.408 ± 0.062	1.509GluMet: 1.509 ± 0.029	2.005GluAsn: 2.005 ± 0.031	2.741GluPro: 2.741 ± 0.041	3.411GluGln: 3.411 ± 0.049	4.06GluArg: 4.06 ± 0.052	4.39GluSer: 4.39 ± 0.046	3.414GluThr: 3.414 ± 0.038	4.133GluVal: 4.133 ± 0.045	0.802GluTrp: 0.802 ± 0.019	1.5GluTyr: 1.5 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	3.566PheAla: 3.566 ± 0.04	0.489PheCys: 0.489 ± 0.016	2.537PheAsp: 2.537 ± 0.035	2.391PheGlu: 2.391 ± 0.033	1.322PhePhe: 1.322 ± 0.027	3.052PheGly: 3.052 ± 0.044	0.792PheHis: 0.792 ± 0.021	1.415PheIle: 1.415 ± 0.028	1.004PheLys: 1.004 ± 0.021	3.443PheLeu: 3.443 ± 0.046	0.632PheMet: 0.632 ± 0.016	1.23PheAsn: 1.23 ± 0.026	1.756PhePro: 1.756 ± 0.031	1.551PheGln: 1.551 ± 0.024	2.275PheArg: 2.275 ± 0.03	2.638PheSer: 2.638 ± 0.037	2.023PheThr: 2.023 ± 0.04	2.644PheVal: 2.644 ± 0.034	0.542PheTrp: 0.542 ± 0.016	0.929PheTyr: 0.929 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	6.278GlyAla: 6.278 ± 0.064	1.111GlyCys: 1.111 ± 0.027	4.253GlyAsp: 4.253 ± 0.075	4.59GlyGlu: 4.59 ± 0.045	2.866GlyPhe: 2.866 ± 0.036	6.491GlyGly: 6.491 ± 0.107	1.636GlyHis: 1.636 ± 0.031	3.996GlyIle: 3.996 ± 0.045	3.401GlyLys: 3.401 ± 0.043	7.158GlyLeu: 7.158 ± 0.066	1.913GlyMet: 1.913 ± 0.037	2.826GlyAsn: 2.826 ± 0.061	2.992GlyPro: 2.992 ± 0.041	3.314GlyGln: 3.314 ± 0.046	4.745GlyArg: 4.745 ± 0.05	5.108GlySer: 5.108 ± 0.067	4.455GlyThr: 4.455 ± 0.066	5.223GlyVal: 5.223 ± 0.051	1.4GlyTrp: 1.4 ± 0.027	2.098GlyTyr: 2.098 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.15HisAla: 2.15 ± 0.034	0.364HisCys: 0.364 ± 0.013	1.216HisAsp: 1.216 ± 0.026	1.251HisGlu: 1.251 ± 0.024	0.99HisPhe: 0.99 ± 0.019	1.762HisGly: 1.762 ± 0.031	0.636HisHis: 0.636 ± 0.021	0.855HisIle: 0.855 ± 0.019	0.546HisLys: 0.546 ± 0.015	2.308HisLeu: 2.308 ± 0.037	0.423HisMet: 0.423 ± 0.013	0.662HisAsn: 0.662 ± 0.017	1.448HisPro: 1.448 ± 0.028	0.975HisGln: 0.975 ± 0.026	1.645HisArg: 1.645 ± 0.031	1.526HisSer: 1.526 ± 0.027	1.042HisThr: 1.042 ± 0.021	1.452HisVal: 1.452 ± 0.026	0.491HisTrp: 0.491 ± 0.014	0.619HisTyr: 0.619 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.714IleAla: 5.714 ± 0.054	0.645IleCys: 0.645 ± 0.016	3.61IleAsp: 3.61 ± 0.047	3.63IleGlu: 3.63 ± 0.041	1.435IlePhe: 1.435 ± 0.024	3.898IleGly: 3.898 ± 0.045	1.062IleHis: 1.062 ± 0.02	1.758IleIle: 1.758 ± 0.03	1.36IleLys: 1.36 ± 0.027	4.414IleLeu: 4.414 ± 0.043	0.683IleMet: 0.683 ± 0.02	1.439IleAsn: 1.439 ± 0.029	2.539IlePro: 2.539 ± 0.035	1.972IleGln: 1.972 ± 0.033	3.096IleArg: 3.096 ± 0.04	3.192IleSer: 3.192 ± 0.041	2.435IleThr: 2.435 ± 0.038	3.888IleVal: 3.888 ± 0.046	0.588IleTrp: 0.588 ± 0.016	1.168IleTyr: 1.168 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	2.787LysAla: 2.787 ± 0.042	0.327LysCys: 0.327 ± 0.013	1.437LysAsp: 1.437 ± 0.025	1.696LysGlu: 1.696 ± 0.029	1.234LysPhe: 1.234 ± 0.024	1.853LysGly: 1.853 ± 0.032	0.836LysHis: 0.836 ± 0.021	1.824LysIle: 1.824 ± 0.029	1.402LysLys: 1.402 ± 0.038	4.04LysLeu: 4.04 ± 0.046	0.798LysMet: 0.798 ± 0.02	1.077LysAsn: 1.077 ± 0.022	2.03LysPro: 2.03 ± 0.033	1.727LysGln: 1.727 ± 0.028	2.299LysArg: 2.299 ± 0.037	2.388LysSer: 2.388 ± 0.038	1.956LysThr: 1.956 ± 0.035	2.21LysVal: 2.21 ± 0.031	0.512LysTrp: 0.512 ± 0.014	0.911LysTyr: 0.911 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	11.512LeuAla: 11.512 ± 0.088	1.218LeuCys: 1.218 ± 0.024	5.767LeuAsp: 5.767 ± 0.06	6.457LeuGlu: 6.457 ± 0.068	3.354LeuPhe: 3.354 ± 0.044	7.548LeuGly: 7.548 ± 0.066	2.198LeuHis: 2.198 ± 0.036	4.348LeuIle: 4.348 ± 0.046	3.623LeuLys: 3.623 ± 0.046	11.042LeuLeu: 11.042 ± 0.093	1.992LeuMet: 1.992 ± 0.033	3.196LeuAsn: 3.196 ± 0.044	6.102LeuPro: 6.102 ± 0.054	4.711LeuGln: 4.711 ± 0.059	6.654LeuArg: 6.654 ± 0.062	7.268LeuSer: 7.268 ± 0.06	5.705LeuThr: 5.705 ± 0.058	7.224LeuVal: 7.224 ± 0.06	1.34LeuTrp: 1.34 ± 0.028	2.124LeuTyr: 2.124 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.059MetAla: 2.059 ± 0.031	0.207MetCys: 0.207 ± 0.009	0.945MetAsp: 0.945 ± 0.023	1.112MetGlu: 1.112 ± 0.027	0.67MetPhe: 0.67 ± 0.017	1.471MetGly: 1.471 ± 0.033	0.561MetHis: 0.561 ± 0.015	1.003MetIle: 1.003 ± 0.021	0.86MetLys: 0.86 ± 0.023	2.507MetLeu: 2.507 ± 0.039	0.497MetMet: 0.497 ± 0.017	0.775MetAsn: 0.775 ± 0.017	1.268MetPro: 1.268 ± 0.024	1.133MetGln: 1.133 ± 0.022	1.426MetArg: 1.426 ± 0.027	1.478MetSer: 1.478 ± 0.026	1.279MetThr: 1.279 ± 0.024	1.386MetVal: 1.386 ± 0.03	0.245MetTrp: 0.245 ± 0.01	0.362MetTyr: 0.362 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.184AsnAla: 3.184 ± 0.04	0.427AsnCys: 0.427 ± 0.016	1.69AsnAsp: 1.69 ± 0.043	1.681AsnGlu: 1.681 ± 0.03	1.216AsnPhe: 1.216 ± 0.025	2.619AsnGly: 2.619 ± 0.05	0.758AsnHis: 0.758 ± 0.019	1.437AsnIle: 1.437 ± 0.024	0.772AsnLys: 0.772 ± 0.02	3.267AsnLeu: 3.267 ± 0.039	0.61AsnMet: 0.61 ± 0.016	1.051AsnAsn: 1.051 ± 0.029	2.055AsnPro: 2.055 ± 0.032	1.443AsnGln: 1.443 ± 0.021	2.29AsnArg: 2.29 ± 0.035	2.402AsnSer: 2.402 ± 0.039	1.676AsnThr: 1.676 ± 0.034	2.222AsnVal: 2.222 ± 0.041	0.621AsnTrp: 0.621 ± 0.016	0.937AsnTyr: 0.937 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	5.46ProAla: 5.46 ± 0.061	0.409ProCys: 0.409 ± 0.015	2.97ProAsp: 2.97 ± 0.038	3.776ProGlu: 3.776 ± 0.039	1.77ProPhe: 1.77 ± 0.029	3.701ProGly: 3.701 ± 0.041	1.195ProHis: 1.195 ± 0.024	2.612ProIle: 2.612 ± 0.034	1.788ProLys: 1.788 ± 0.033	4.996ProLeu: 4.996 ± 0.05	1.075ProMet: 1.075 ± 0.022	2.012ProAsn: 2.012 ± 0.028	3.114ProPro: 3.114 ± 0.05	2.516ProGln: 2.516 ± 0.037	2.724ProArg: 2.724 ± 0.038	3.851ProSer: 3.851 ± 0.048	3.411ProThr: 3.411 ± 0.04	3.61ProVal: 3.61 ± 0.044	0.776ProTrp: 0.776 ± 0.017	1.145ProTyr: 1.145 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	4.878GlnAla: 4.878 ± 0.054	0.463GlnCys: 0.463 ± 0.014	1.941GlnAsp: 1.941 ± 0.031	2.423GlnGlu: 2.423 ± 0.039	1.71GlnPhe: 1.71 ± 0.027	2.851GlnGly: 2.851 ± 0.037	1.116GlnHis: 1.116 ± 0.022	2.306GlnIle: 2.306 ± 0.032	1.323GlnLys: 1.323 ± 0.025	5.498GlnLeu: 5.498 ± 0.063	0.966GlnMet: 0.966 ± 0.02	1.252GlnAsn: 1.252 ± 0.021	2.632GlnPro: 2.632 ± 0.037	2.727GlnGln: 2.727 ± 0.053	3.363GlnArg: 3.363 ± 0.048	3.125GlnSer: 3.125 ± 0.039	2.557GlnThr: 2.557 ± 0.038	3.104GlnVal: 3.104 ± 0.04	0.795GlnTrp: 0.795 ± 0.02	1.018GlnTyr: 1.018 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	4.988ArgAla: 4.988 ± 0.055	0.795ArgCys: 0.795 ± 0.019	3.432ArgAsp: 3.432 ± 0.043	4.025ArgGlu: 4.025 ± 0.049	2.648ArgPhe: 2.648 ± 0.035	4.198ArgGly: 4.198 ± 0.042	1.35ArgHis: 1.35 ± 0.026	3.598ArgIle: 3.598 ± 0.039	2.324ArgLys: 2.324 ± 0.04	7.038ArgLeu: 7.038 ± 0.074	1.679ArgMet: 1.679 ± 0.027	2.108ArgAsn: 2.108 ± 0.027	3.015ArgPro: 3.015 ± 0.036	3.087ArgGln: 3.087 ± 0.039	4.757ArgArg: 4.757 ± 0.058	4.399ArgSer: 4.399 ± 0.045	3.24ArgThr: 3.24 ± 0.037	4.439ArgVal: 4.439 ± 0.046	1.217ArgTrp: 1.217 ± 0.023	1.808ArgTyr: 1.808 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.24SerAla: 6.24 ± 0.062	0.756SerCys: 0.756 ± 0.022	4.003SerAsp: 4.003 ± 0.038	4.126SerGlu: 4.126 ± 0.046	2.399SerPhe: 2.399 ± 0.038	6.041SerGly: 6.041 ± 0.067	1.561SerHis: 1.561 ± 0.029	3.437SerIle: 3.437 ± 0.044	2.236SerLys: 2.236 ± 0.029	7.167SerLeu: 7.167 ± 0.057	1.545SerMet: 1.545 ± 0.028	2.365SerAsn: 2.365 ± 0.038	4.122SerPro: 4.122 ± 0.041	3.305SerGln: 3.305 ± 0.044	4.151SerArg: 4.151 ± 0.047	5.276SerSer: 5.276 ± 0.061	4.084SerThr: 4.084 ± 0.054	4.746SerVal: 4.746 ± 0.049	1.062SerTrp: 1.062 ± 0.023	1.592SerTyr: 1.592 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.702ThrAla: 5.702 ± 0.065	0.588ThrCys: 0.588 ± 0.016	3.109ThrAsp: 3.109 ± 0.054	3.097ThrGlu: 3.097 ± 0.038	1.901ThrPhe: 1.901 ± 0.037	4.489ThrGly: 4.489 ± 0.058	1.193ThrHis: 1.193 ± 0.024	2.968ThrIle: 2.968 ± 0.045	1.643ThrLys: 1.643 ± 0.029	5.962ThrLeu: 5.962 ± 0.064	1.062ThrMet: 1.062 ± 0.025	1.721ThrAsn: 1.721 ± 0.036	3.531ThrPro: 3.531 ± 0.036	2.328ThrGln: 2.328 ± 0.038	3.135ThrArg: 3.135 ± 0.04	3.844ThrSer: 3.844 ± 0.048	3.325ThrThr: 3.325 ± 0.051	3.953ThrVal: 3.953 ± 0.065	0.835ThrTrp: 0.835 ± 0.02	1.296ThrTyr: 1.296 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	7.381ValAla: 7.381 ± 0.057	0.943ValCys: 0.943 ± 0.022	4.252ValAsp: 4.252 ± 0.055	4.621ValGlu: 4.621 ± 0.049	2.414ValPhe: 2.414 ± 0.035	5.234ValGly: 5.234 ± 0.058	1.522ValHis: 1.522 ± 0.03	3.187ValIle: 3.187 ± 0.043	2.044ValLys: 2.044 ± 0.03	6.871ValLeu: 6.871 ± 0.061	1.361ValMet: 1.361 ± 0.024	2.104ValAsn: 2.104 ± 0.035	3.498ValPro: 3.498 ± 0.042	2.818ValGln: 2.818 ± 0.036	4.427ValArg: 4.427 ± 0.044	4.641ValSer: 4.641 ± 0.05	3.859ValThr: 3.859 ± 0.056	5.503ValVal: 5.503 ± 0.06	1.042ValTrp: 1.042 ± 0.023	1.648ValTyr: 1.648 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.142TrpAla: 1.142 ± 0.02	0.231TrpCys: 0.231 ± 0.011	0.797TrpAsp: 0.797 ± 0.019	0.805TrpGlu: 0.805 ± 0.02	0.588TrpPhe: 0.588 ± 0.016	1.052TrpGly: 1.052 ± 0.021	0.43TrpHis: 0.43 ± 0.014	0.9TrpIle: 0.9 ± 0.022	0.626TrpLys: 0.626 ± 0.017	1.97TrpLeu: 1.97 ± 0.035	0.441TrpMet: 0.441 ± 0.015	0.598TrpAsn: 0.598 ± 0.017	0.757TrpPro: 0.757 ± 0.02	0.904TrpGln: 0.904 ± 0.023	1.019TrpArg: 1.019 ± 0.022	1.074TrpSer: 1.074 ± 0.023	0.863TrpThr: 0.863 ± 0.02	0.915TrpVal: 0.915 ± 0.022	0.304TrpTrp: 0.304 ± 0.013	0.389TrpTyr: 0.389 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.231TyrAla: 2.231 ± 0.033	0.375TyrCys: 0.375 ± 0.014	1.486TyrAsp: 1.486 ± 0.036	1.43TyrGlu: 1.43 ± 0.027	1.067TyrPhe: 1.067 ± 0.02	2.002TyrGly: 2.002 ± 0.04	0.608TyrHis: 0.608 ± 0.017	0.862TyrIle: 0.862 ± 0.02	0.594TyrLys: 0.594 ± 0.017	2.502TyrLeu: 2.502 ± 0.032	0.431TyrMet: 0.431 ± 0.014	0.773TyrAsn: 0.773 ± 0.018	1.175TyrPro: 1.175 ± 0.022	1.211TyrGln: 1.211 ± 0.021	1.998TyrArg: 1.998 ± 0.034	1.649TyrSer: 1.649 ± 0.026	1.145TyrThr: 1.145 ± 0.028	1.533TyrVal: 1.533 ± 0.029	0.461TyrTrp: 0.461 ± 0.015	0.736TyrTyr: 0.736 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6357 proteins (2352101 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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