Amino acid dipepetide frequency for Sphingomonas lacunae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.222AlaAla: 19.222 ± 0.228	1.026AlaCys: 1.026 ± 0.035	8.013AlaAsp: 8.013 ± 0.101	7.654AlaGlu: 7.654 ± 0.096	4.181AlaPhe: 4.181 ± 0.077	11.894AlaGly: 11.894 ± 0.107	2.399AlaHis: 2.399 ± 0.055	6.913AlaIle: 6.913 ± 0.098	3.537AlaLys: 3.537 ± 0.071	13.633AlaLeu: 13.633 ± 0.183	4.411AlaMet: 4.411 ± 0.079	3.443AlaAsn: 3.443 ± 0.063	6.108AlaPro: 6.108 ± 0.097	4.341AlaGln: 4.341 ± 0.074	9.651AlaArg: 9.651 ± 0.131	6.77AlaSer: 6.77 ± 0.089	6.899AlaThr: 6.899 ± 0.077	8.701AlaVal: 8.701 ± 0.105	1.66AlaTrp: 1.66 ± 0.041	2.481AlaTyr: 2.481 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.018CysAla: 1.018 ± 0.034	0.109CysCys: 0.109 ± 0.012	0.598CysAsp: 0.598 ± 0.026	0.428CysGlu: 0.428 ± 0.022	0.306CysPhe: 0.306 ± 0.019	0.888CysGly: 0.888 ± 0.033	0.192CysHis: 0.192 ± 0.015	0.394CysIle: 0.394 ± 0.021	0.133CysLys: 0.133 ± 0.013	0.712CysLeu: 0.712 ± 0.027	0.152CysMet: 0.152 ± 0.012	0.205CysAsn: 0.205 ± 0.016	0.464CysPro: 0.464 ± 0.029	0.236CysGln: 0.236 ± 0.016	0.554CysArg: 0.554 ± 0.023	0.488CysSer: 0.488 ± 0.023	0.414CysThr: 0.414 ± 0.021	0.548CysVal: 0.548 ± 0.024	0.107CysTrp: 0.107 ± 0.01	0.185CysTyr: 0.185 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	7.649AspAla: 7.649 ± 0.105	0.488AspCys: 0.488 ± 0.024	3.288AspAsp: 3.288 ± 0.068	3.427AspGlu: 3.427 ± 0.072	2.131AspPhe: 2.131 ± 0.052	5.921AspGly: 5.921 ± 0.089	1.338AspHis: 1.338 ± 0.039	2.973AspIle: 2.973 ± 0.064	1.484AspLys: 1.484 ± 0.047	5.364AspLeu: 5.364 ± 0.071	1.617AspMet: 1.617 ± 0.048	1.476AspAsn: 1.476 ± 0.04	3.611AspPro: 3.611 ± 0.061	1.93AspGln: 1.93 ± 0.048	4.963AspArg: 4.963 ± 0.068	2.781AspSer: 2.781 ± 0.058	2.498AspThr: 2.498 ± 0.061	4.238AspVal: 4.238 ± 0.079	1.28AspTrp: 1.28 ± 0.039	1.526AspTyr: 1.526 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	7.693GluAla: 7.693 ± 0.106	0.354GluCys: 0.354 ± 0.023	2.63GluAsp: 2.63 ± 0.065	2.91GluGlu: 2.91 ± 0.064	1.554GluPhe: 1.554 ± 0.045	4.387GluGly: 4.387 ± 0.081	1.065GluHis: 1.065 ± 0.037	2.564GluIle: 2.564 ± 0.053	1.498GluLys: 1.498 ± 0.041	4.883GluLeu: 4.883 ± 0.086	1.473GluMet: 1.473 ± 0.042	1.168GluAsn: 1.168 ± 0.037	2.469GluPro: 2.469 ± 0.057	2.221GluGln: 2.221 ± 0.052	4.94GluArg: 4.94 ± 0.093	2.484GluSer: 2.484 ± 0.054	2.908GluThr: 2.908 ± 0.051	3.564GluVal: 3.564 ± 0.072	0.849GluTrp: 0.849 ± 0.037	0.86GluTyr: 0.86 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.917PheAla: 4.917 ± 0.077	0.338PheCys: 0.338 ± 0.02	2.733PheAsp: 2.733 ± 0.051	1.783PheGlu: 1.783 ± 0.041	1.26PhePhe: 1.26 ± 0.044	3.737PheGly: 3.737 ± 0.063	0.665PheHis: 0.665 ± 0.027	1.621PheIle: 1.621 ± 0.048	0.736PheLys: 0.736 ± 0.031	2.977PheLeu: 2.977 ± 0.065	0.736PheMet: 0.736 ± 0.031	1.111PheAsn: 1.111 ± 0.039	1.522PhePro: 1.522 ± 0.041	0.851PheGln: 0.851 ± 0.027	2.164PheArg: 2.164 ± 0.054	2.049PheSer: 2.049 ± 0.051	1.928PheThr: 1.928 ± 0.052	2.564PheVal: 2.564 ± 0.054	0.494PheTrp: 0.494 ± 0.025	0.831PheTyr: 0.831 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.71GlyAla: 9.71 ± 0.115	0.892GlyCys: 0.892 ± 0.031	5.019GlyAsp: 5.019 ± 0.076	5.07GlyGlu: 5.07 ± 0.08	3.629GlyPhe: 3.629 ± 0.065	8.37GlyGly: 8.37 ± 0.143	2.026GlyHis: 2.026 ± 0.05	4.721GlyIle: 4.721 ± 0.076	2.867GlyLys: 2.867 ± 0.072	9.046GlyLeu: 9.046 ± 0.106	2.587GlyMet: 2.587 ± 0.069	2.469GlyAsn: 2.469 ± 0.067	3.951GlyPro: 3.951 ± 0.057	3.508GlyGln: 3.508 ± 0.07	6.629GlyArg: 6.629 ± 0.098	5.064GlySer: 5.064 ± 0.078	4.928GlyThr: 4.928 ± 0.085	6.228GlyVal: 6.228 ± 0.088	1.804GlyTrp: 1.804 ± 0.048	2.316GlyTyr: 2.316 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.357HisAla: 2.357 ± 0.06	0.241HisCys: 0.241 ± 0.017	1.18HisAsp: 1.18 ± 0.036	0.976HisGlu: 0.976 ± 0.034	0.907HisPhe: 0.907 ± 0.03	2.213HisGly: 2.213 ± 0.054	0.576HisHis: 0.576 ± 0.027	1.061HisIle: 1.061 ± 0.033	0.43HisLys: 0.43 ± 0.023	1.908HisLeu: 1.908 ± 0.054	0.499HisMet: 0.499 ± 0.026	0.484HisAsn: 0.484 ± 0.022	1.333HisPro: 1.333 ± 0.042	0.61HisGln: 0.61 ± 0.024	1.463HisArg: 1.463 ± 0.045	0.988HisSer: 0.988 ± 0.04	0.646HisThr: 0.646 ± 0.027	1.615HisVal: 1.615 ± 0.045	0.385HisTrp: 0.385 ± 0.019	0.572HisTyr: 0.572 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.929IleAla: 7.929 ± 0.099	0.465IleCys: 0.465 ± 0.025	4.157IleAsp: 4.157 ± 0.069	3.249IleGlu: 3.249 ± 0.07	1.582IlePhe: 1.582 ± 0.048	5.145IleGly: 5.145 ± 0.087	0.968IleHis: 0.968 ± 0.033	2.728IleIle: 2.728 ± 0.062	1.156IleLys: 1.156 ± 0.042	3.965IleLeu: 3.965 ± 0.067	1.011IleMet: 1.011 ± 0.035	1.657IleAsn: 1.657 ± 0.047	2.228IlePro: 2.228 ± 0.048	1.055IleGln: 1.055 ± 0.037	3.437IleArg: 3.437 ± 0.061	2.855IleSer: 2.855 ± 0.06	2.625IleThr: 2.625 ± 0.054	3.951IleVal: 3.951 ± 0.076	0.66IleTrp: 0.66 ± 0.028	0.962IleTyr: 0.962 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.704LysAla: 3.704 ± 0.089	0.129LysCys: 0.129 ± 0.013	1.289LysAsp: 1.289 ± 0.044	1.07LysGlu: 1.07 ± 0.035	0.707LysPhe: 0.707 ± 0.028	2.295LysGly: 2.295 ± 0.055	0.475LysHis: 0.475 ± 0.023	1.175LysIle: 1.175 ± 0.043	0.788LysLys: 0.788 ± 0.036	2.534LysLeu: 2.534 ± 0.064	0.663LysMet: 0.663 ± 0.035	0.528LysAsn: 0.528 ± 0.027	1.557LysPro: 1.557 ± 0.043	0.802LysGln: 0.802 ± 0.032	1.877LysArg: 1.877 ± 0.047	1.343LysSer: 1.343 ± 0.042	1.333LysThr: 1.333 ± 0.043	1.956LysVal: 1.956 ± 0.056	0.329LysTrp: 0.329 ± 0.021	0.501LysTyr: 0.501 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	14.276LeuAla: 14.276 ± 0.167	0.782LeuCys: 0.782 ± 0.031	5.87LeuAsp: 5.87 ± 0.068	4.25LeuGlu: 4.25 ± 0.082	3.792LeuPhe: 3.792 ± 0.09	8.135LeuGly: 8.135 ± 0.097	1.833LeuHis: 1.833 ± 0.053	5.088LeuIle: 5.088 ± 0.081	2.562LeuLys: 2.562 ± 0.062	9.449LeuLeu: 9.449 ± 0.149	2.302LeuMet: 2.302 ± 0.05	2.449LeuAsn: 2.449 ± 0.049	5.658LeuPro: 5.658 ± 0.075	2.288LeuGln: 2.288 ± 0.051	6.467LeuArg: 6.467 ± 0.095	6.123LeuSer: 6.123 ± 0.082	5.79LeuThr: 5.79 ± 0.078	7.357LeuVal: 7.357 ± 0.11	1.368LeuTrp: 1.368 ± 0.039	1.841LeuTyr: 1.841 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.866MetAla: 3.866 ± 0.077	0.169MetCys: 0.169 ± 0.015	1.238MetAsp: 1.238 ± 0.04	1.136MetGlu: 1.136 ± 0.033	0.68MetPhe: 0.68 ± 0.034	2.121MetGly: 2.121 ± 0.044	0.478MetHis: 0.478 ± 0.023	1.483MetIle: 1.483 ± 0.042	0.786MetLys: 0.786 ± 0.036	2.82MetLeu: 2.82 ± 0.069	0.725MetMet: 0.725 ± 0.029	0.695MetAsn: 0.695 ± 0.029	1.573MetPro: 1.573 ± 0.04	0.845MetGln: 0.845 ± 0.034	1.888MetArg: 1.888 ± 0.051	1.547MetSer: 1.547 ± 0.039	1.947MetThr: 1.947 ± 0.046	1.916MetVal: 1.916 ± 0.046	0.247MetTrp: 0.247 ± 0.017	0.253MetTyr: 0.253 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.429AsnAla: 3.429 ± 0.065	0.248AsnCys: 0.248 ± 0.016	1.478AsnAsp: 1.478 ± 0.046	1.136AsnGlu: 1.136 ± 0.033	0.944AsnPhe: 0.944 ± 0.039	2.647AsnGly: 2.647 ± 0.064	0.519AsnHis: 0.519 ± 0.022	1.389AsnIle: 1.389 ± 0.041	0.564AsnLys: 0.564 ± 0.024	2.418AsnLeu: 2.418 ± 0.059	0.595AsnMet: 0.595 ± 0.027	0.704AsnAsn: 0.704 ± 0.032	1.859AsnPro: 1.859 ± 0.051	0.837AsnGln: 0.837 ± 0.03	2.043AsnArg: 2.043 ± 0.055	1.359AsnSer: 1.359 ± 0.038	1.039AsnThr: 1.039 ± 0.039	1.921AsnVal: 1.921 ± 0.046	0.469AsnTrp: 0.469 ± 0.026	0.666AsnTyr: 0.666 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.114ProAla: 7.114 ± 0.104	0.316ProCys: 0.316 ± 0.016	3.922ProAsp: 3.922 ± 0.055	3.31ProGlu: 3.31 ± 0.066	1.911ProPhe: 1.911 ± 0.05	4.96ProGly: 4.96 ± 0.081	1.124ProHis: 1.124 ± 0.039	2.33ProIle: 2.33 ± 0.048	1.211ProLys: 1.211 ± 0.041	5.164ProLeu: 5.164 ± 0.075	1.348ProMet: 1.348 ± 0.034	1.259ProAsn: 1.259 ± 0.039	2.886ProPro: 2.886 ± 0.085	1.669ProGln: 1.669 ± 0.047	3.008ProArg: 3.008 ± 0.06	2.698ProSer: 2.698 ± 0.061	2.585ProThr: 2.585 ± 0.058	4.701ProVal: 4.701 ± 0.068	0.749ProTrp: 0.749 ± 0.03	1.047ProTyr: 1.047 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.08GlnAla: 4.08 ± 0.066	0.268GlnCys: 0.268 ± 0.018	1.423GlnAsp: 1.423 ± 0.039	1.237GlnGlu: 1.237 ± 0.039	1.135GlnPhe: 1.135 ± 0.037	2.615GlnGly: 2.615 ± 0.06	0.66GlnHis: 0.66 ± 0.027	1.698GlnIle: 1.698 ± 0.047	0.662GlnLys: 0.662 ± 0.028	3.318GlnLeu: 3.318 ± 0.054	0.883GlnMet: 0.883 ± 0.03	0.71GlnAsn: 0.71 ± 0.03	2.035GlnPro: 2.035 ± 0.046	1.316GlnGln: 1.316 ± 0.04	2.771GlnArg: 2.771 ± 0.055	1.873GlnSer: 1.873 ± 0.048	1.557GlnThr: 1.557 ± 0.043	2.203GlnVal: 2.203 ± 0.053	0.598GlnTrp: 0.598 ± 0.024	0.547GlnTyr: 0.547 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	8.595ArgAla: 8.595 ± 0.097	0.513ArgCys: 0.513 ± 0.021	4.314ArgAsp: 4.314 ± 0.072	3.914ArgGlu: 3.914 ± 0.07	3.092ArgPhe: 3.092 ± 0.065	5.088ArgGly: 5.088 ± 0.092	1.781ArgHis: 1.781 ± 0.053	4.316ArgIle: 4.316 ± 0.071	1.779ArgLys: 1.779 ± 0.049	8.325ArgLeu: 8.325 ± 0.123	2.166ArgMet: 2.166 ± 0.051	1.908ArgAsn: 1.908 ± 0.051	3.834ArgPro: 3.834 ± 0.074	2.641ArgGln: 2.641 ± 0.053	5.624ArgArg: 5.624 ± 0.104	3.858ArgSer: 3.858 ± 0.071	3.6ArgThr: 3.6 ± 0.06	4.738ArgVal: 4.738 ± 0.082	1.354ArgTrp: 1.354 ± 0.041	1.837ArgTyr: 1.837 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.675SerAla: 6.675 ± 0.091	0.443SerCys: 0.443 ± 0.024	3.229SerAsp: 3.229 ± 0.062	2.654SerGlu: 2.654 ± 0.052	2.149SerPhe: 2.149 ± 0.049	5.929SerGly: 5.929 ± 0.089	1.061SerHis: 1.061 ± 0.032	2.932SerIle: 2.932 ± 0.057	1.207SerLys: 1.207 ± 0.042	5.452SerLeu: 5.452 ± 0.074	1.299SerMet: 1.299 ± 0.039	1.489SerAsn: 1.489 ± 0.044	2.888SerPro: 2.888 ± 0.061	1.516SerGln: 1.516 ± 0.041	3.757SerArg: 3.757 ± 0.066	2.864SerSer: 2.864 ± 0.059	2.645SerThr: 2.645 ± 0.063	3.853SerVal: 3.853 ± 0.075	0.861SerTrp: 0.861 ± 0.034	1.288SerTyr: 1.288 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.721ThrAla: 6.721 ± 0.095	0.415ThrCys: 0.415 ± 0.023	2.869ThrAsp: 2.869 ± 0.052	2.277ThrGlu: 2.277 ± 0.049	1.713ThrPhe: 1.713 ± 0.047	5.509ThrGly: 5.509 ± 0.087	1.029ThrHis: 1.029 ± 0.037	3.048ThrIle: 3.048 ± 0.062	1.099ThrLys: 1.099 ± 0.035	5.75ThrLeu: 5.75 ± 0.076	1.288ThrMet: 1.288 ± 0.04	1.427ThrAsn: 1.427 ± 0.04	3.346ThrPro: 3.346 ± 0.065	1.435ThrGln: 1.435 ± 0.041	3.374ThrArg: 3.374 ± 0.058	2.77ThrSer: 2.77 ± 0.062	2.765ThrThr: 2.765 ± 0.077	4.127ThrVal: 4.127 ± 0.079	0.572ThrTrp: 0.572 ± 0.026	1.08ThrTyr: 1.08 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	9.839ValAla: 9.839 ± 0.116	0.526ValCys: 0.526 ± 0.024	4.533ValAsp: 4.533 ± 0.081	4.361ValGlu: 4.361 ± 0.076	1.934ValPhe: 1.934 ± 0.048	5.768ValGly: 5.768 ± 0.081	1.382ValHis: 1.382 ± 0.037	3.878ValIle: 3.878 ± 0.062	1.752ValLys: 1.752 ± 0.053	6.115ValLeu: 6.115 ± 0.095	1.815ValMet: 1.815 ± 0.043	2.109ValAsn: 2.109 ± 0.056	4.186ValPro: 4.186 ± 0.064	1.993ValGln: 1.993 ± 0.049	5.377ValArg: 5.377 ± 0.085	4.173ValSer: 4.173 ± 0.072	4.703ValThr: 4.703 ± 0.072	5.036ValVal: 5.036 ± 0.093	0.909ValTrp: 0.909 ± 0.038	1.294ValTyr: 1.294 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.484TrpAla: 1.484 ± 0.039	0.157TrpCys: 0.157 ± 0.013	0.812TrpAsp: 0.812 ± 0.031	0.57TrpGlu: 0.57 ± 0.026	0.611TrpPhe: 0.611 ± 0.028	1.036TrpGly: 1.036 ± 0.036	0.373TrpHis: 0.373 ± 0.023	0.685TrpIle: 0.685 ± 0.028	0.387TrpLys: 0.387 ± 0.021	1.988TrpLeu: 1.988 ± 0.053	0.419TrpMet: 0.419 ± 0.02	0.445TrpAsn: 0.445 ± 0.025	0.786TrpPro: 0.786 ± 0.029	0.779TrpGln: 0.779 ± 0.025	1.469TrpArg: 1.469 ± 0.041	0.948TrpSer: 0.948 ± 0.035	0.858TrpThr: 0.858 ± 0.032	0.915TrpVal: 0.915 ± 0.035	0.296TrpTrp: 0.296 ± 0.018	0.327TrpTyr: 0.327 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.657TyrAla: 2.657 ± 0.049	0.253TyrCys: 0.253 ± 0.019	1.39TyrAsp: 1.39 ± 0.046	1.062TyrGlu: 1.062 ± 0.036	0.798TyrPhe: 0.798 ± 0.03	2.178TyrGly: 2.178 ± 0.051	0.499TyrHis: 0.499 ± 0.025	0.788TyrIle: 0.788 ± 0.033	0.415TyrLys: 0.415 ± 0.024	1.861TyrLeu: 1.861 ± 0.046	0.419TyrMet: 0.419 ± 0.023	0.529TyrAsn: 0.529 ± 0.028	1.018TyrPro: 1.018 ± 0.038	0.716TyrGln: 0.716 ± 0.03	1.82TyrArg: 1.82 ± 0.048	1.159TyrSer: 1.159 ± 0.042	0.946TyrThr: 0.946 ± 0.036	1.55TyrVal: 1.55 ± 0.044	0.354TyrTrp: 0.354 ± 0.021	0.555TyrTyr: 0.555 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2780 proteins (898970 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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