Amino acid dipepetide frequency for Cloacimonas acidaminovorans (strain Evry)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.631AlaAla: 3.631 ± 0.109
0.722AlaCys: 0.722 ± 0.036
3.489AlaAsp: 3.489 ± 0.076
5.038AlaGlu: 5.038 ± 0.106
2.904AlaPhe: 2.904 ± 0.06
4.509AlaGly: 4.509 ± 0.106
0.977AlaHis: 0.977 ± 0.036
5.631AlaIle: 5.631 ± 0.094
4.721AlaLys: 4.721 ± 0.113
6.938AlaLeu: 6.938 ± 0.125
1.597AlaMet: 1.597 ± 0.056
3.433AlaAsn: 3.433 ± 0.095
2.041AlaPro: 2.041 ± 0.069
2.341AlaGln: 2.341 ± 0.062
2.384AlaArg: 2.384 ± 0.063
3.592AlaSer: 3.592 ± 0.085
3.603AlaThr: 3.603 ± 0.123
4.182AlaVal: 4.182 ± 0.087
0.735AlaTrp: 0.735 ± 0.031
2.662AlaTyr: 2.662 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
0.699CysAla: 0.699 ± 0.033
0.12CysCys: 0.12 ± 0.014
0.571CysAsp: 0.571 ± 0.035
0.608CysGlu: 0.608 ± 0.033
0.562CysPhe: 0.562 ± 0.03
0.984CysGly: 0.984 ± 0.046
0.225CysHis: 0.225 ± 0.019
0.773CysIle: 0.773 ± 0.037
0.662CysLys: 0.662 ± 0.034
1.274CysLeu: 1.274 ± 0.048
0.214CysMet: 0.214 ± 0.019
0.612CysAsn: 0.612 ± 0.032
0.619CysPro: 0.619 ± 0.037
0.365CysGln: 0.365 ± 0.025
0.491CysArg: 0.491 ± 0.03
0.787CysSer: 0.787 ± 0.034
0.424CysThr: 0.424 ± 0.032
0.627CysVal: 0.627 ± 0.037
0.129CysTrp: 0.129 ± 0.013
0.547CysTyr: 0.547 ± 0.033
0.0CysXaa: 0.0 ± 0.0
Asp
3.048AspAla: 3.048 ± 0.075
0.567AspCys: 0.567 ± 0.033
2.334AspAsp: 2.334 ± 0.066
3.275AspGlu: 3.275 ± 0.074
3.019AspPhe: 3.019 ± 0.069
2.811AspGly: 2.811 ± 0.086
0.628AspHis: 0.628 ± 0.028
4.815AspIle: 4.815 ± 0.088
3.627AspLys: 3.627 ± 0.089
5.35AspLeu: 5.35 ± 0.101
1.027AspMet: 1.027 ± 0.037
3.047AspAsn: 3.047 ± 0.094
2.181AspPro: 2.181 ± 0.068
1.265AspGln: 1.265 ± 0.046
1.707AspArg: 1.707 ± 0.053
3.065AspSer: 3.065 ± 0.075
2.443AspThr: 2.443 ± 0.067
2.562AspVal: 2.562 ± 0.056
0.707AspTrp: 0.707 ± 0.035
2.867AspTyr: 2.867 ± 0.07
0.0AspXaa: 0.0 ± 0.0
Glu
3.925GluAla: 3.925 ± 0.084
0.487GluCys: 0.487 ± 0.029
3.125GluAsp: 3.125 ± 0.077
5.242GluGlu: 5.242 ± 0.149
2.663GluPhe: 2.663 ± 0.07
3.698GluGly: 3.698 ± 0.072
1.111GluHis: 1.111 ± 0.045
6.103GluIle: 6.103 ± 0.129
5.585GluLys: 5.585 ± 0.127
7.471GluLeu: 7.471 ± 0.147
1.793GluMet: 1.793 ± 0.06
4.167GluAsn: 4.167 ± 0.088
2.198GluPro: 2.198 ± 0.062
2.5GluGln: 2.5 ± 0.068
2.56GluArg: 2.56 ± 0.076
2.94GluSer: 2.94 ± 0.072
3.634GluThr: 3.634 ± 0.077
3.546GluVal: 3.546 ± 0.075
0.593GluTrp: 0.593 ± 0.032
2.586GluTyr: 2.586 ± 0.068
0.0GluXaa: 0.0 ± 0.0
Phe
3.322PheAla: 3.322 ± 0.074
0.705PheCys: 0.705 ± 0.034
2.278PheAsp: 2.278 ± 0.062
2.446PheGlu: 2.446 ± 0.054
2.109PhePhe: 2.109 ± 0.07
2.88PheGly: 2.88 ± 0.066
0.759PheHis: 0.759 ± 0.035
3.55PheIle: 3.55 ± 0.076
2.238PheLys: 2.238 ± 0.063
4.291PheLeu: 4.291 ± 0.099
1.026PheMet: 1.026 ± 0.04
2.634PheAsn: 2.634 ± 0.068
2.089PhePro: 2.089 ± 0.06
1.562PheGln: 1.562 ± 0.051
1.794PheArg: 1.794 ± 0.047
3.803PheSer: 3.803 ± 0.107
2.78PheThr: 2.78 ± 0.076
2.466PheVal: 2.466 ± 0.066
0.632PheTrp: 0.632 ± 0.031
2.155PheTyr: 2.155 ± 0.071
0.0PheXaa: 0.0 ± 0.0
Gly
3.55GlyAla: 3.55 ± 0.092
0.716GlyCys: 0.716 ± 0.041
2.85GlyAsp: 2.85 ± 0.081
3.623GlyGlu: 3.623 ± 0.076
3.036GlyPhe: 3.036 ± 0.065
3.976GlyGly: 3.976 ± 0.116
0.935GlyHis: 0.935 ± 0.037
6.16GlyIle: 6.16 ± 0.107
5.029GlyLys: 5.029 ± 0.11
5.553GlyLeu: 5.553 ± 0.127
1.62GlyMet: 1.62 ± 0.051
3.765GlyAsn: 3.765 ± 0.114
1.323GlyPro: 1.323 ± 0.048
1.66GlyGln: 1.66 ± 0.059
2.263GlyArg: 2.263 ± 0.065
3.983GlySer: 3.983 ± 0.096
4.17GlyThr: 4.17 ± 0.141
3.443GlyVal: 3.443 ± 0.082
0.9GlyTrp: 0.9 ± 0.039
2.899GlyTyr: 2.899 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
0.365HisAla: 0.365 ± 0.024
0.307HisCys: 0.307 ± 0.023
0.508HisAsp: 0.508 ± 0.025
0.555HisGlu: 0.555 ± 0.032
0.967HisPhe: 0.967 ± 0.04
0.639HisGly: 0.639 ± 0.031
0.43HisHis: 0.43 ± 0.028
1.73HisIle: 1.73 ± 0.049
1.234HisLys: 1.234 ± 0.05
2.126HisLeu: 2.126 ± 0.064
0.137HisMet: 0.137 ± 0.014
1.252HisAsn: 1.252 ± 0.048
1.135HisPro: 1.135 ± 0.043
0.755HisGln: 0.755 ± 0.033
0.767HisArg: 0.767 ± 0.039
1.456HisSer: 1.456 ± 0.055
0.96HisThr: 0.96 ± 0.04
0.197HisVal: 0.197 ± 0.02
0.217HisTrp: 0.217 ± 0.019
1.032HisTyr: 1.032 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
6.047IleAla: 6.047 ± 0.11
1.087IleCys: 1.087 ± 0.044
4.807IleAsp: 4.807 ± 0.084
5.077IleGlu: 5.077 ± 0.111
3.441IlePhe: 3.441 ± 0.084
5.048IleGly: 5.048 ± 0.106
1.334IleHis: 1.334 ± 0.049
7.129IleIle: 7.129 ± 0.139
5.357IleLys: 5.357 ± 0.112
7.883IleLeu: 7.883 ± 0.155
1.765IleMet: 1.765 ± 0.049
4.556IleAsn: 4.556 ± 0.097
4.428IlePro: 4.428 ± 0.087
2.595IleGln: 2.595 ± 0.068
3.527IleArg: 3.527 ± 0.089
6.064IleSer: 6.064 ± 0.117
4.935IleThr: 4.935 ± 0.132
4.834IleVal: 4.834 ± 0.102
0.821IleTrp: 0.821 ± 0.037
3.615IleTyr: 3.615 ± 0.078
0.0IleXaa: 0.0 ± 0.0
Lys
4.538LysAla: 4.538 ± 0.115
0.579LysCys: 0.579 ± 0.032
3.631LysAsp: 3.631 ± 0.088
5.37LysGlu: 5.37 ± 0.131
2.235LysPhe: 2.235 ± 0.063
3.98LysGly: 3.98 ± 0.091
1.252LysHis: 1.252 ± 0.044
5.967LysIle: 5.967 ± 0.101
5.209LysLys: 5.209 ± 0.116
6.027LysLeu: 6.027 ± 0.113
2.176LysMet: 2.176 ± 0.065
3.919LysAsn: 3.919 ± 0.101
2.662LysPro: 2.662 ± 0.073
2.746LysGln: 2.746 ± 0.07
3.022LysArg: 3.022 ± 0.089
3.298LysSer: 3.298 ± 0.084
3.919LysThr: 3.919 ± 0.089
4.236LysVal: 4.236 ± 0.089
0.604LysTrp: 0.604 ± 0.033
2.882LysTyr: 2.882 ± 0.073
0.0LysXaa: 0.0 ± 0.0
Leu
7.414LeuAla: 7.414 ± 0.141
1.294LeuCys: 1.294 ± 0.051
4.766LeuAsp: 4.766 ± 0.098
6.2LeuGlu: 6.2 ± 0.114
4.262LeuPhe: 4.262 ± 0.105
5.748LeuGly: 5.748 ± 0.125
1.828LeuHis: 1.828 ± 0.059
8.03LeuIle: 8.03 ± 0.133
7.398LeuLys: 7.398 ± 0.142
9.73LeuLeu: 9.73 ± 0.173
2.292LeuMet: 2.292 ± 0.072
5.735LeuAsn: 5.735 ± 0.104
4.753LeuPro: 4.753 ± 0.097
4.33LeuGln: 4.33 ± 0.102
3.828LeuArg: 3.828 ± 0.094
7.293LeuSer: 7.293 ± 0.12
5.399LeuThr: 5.399 ± 0.109
5.123LeuVal: 5.123 ± 0.095
1.049LeuTrp: 1.049 ± 0.045
3.951LeuTyr: 3.951 ± 0.099
0.0LeuXaa: 0.0 ± 0.0
Met
1.636MetAla: 1.636 ± 0.056
0.209MetCys: 0.209 ± 0.018
1.274MetAsp: 1.274 ± 0.048
1.571MetGlu: 1.571 ± 0.059
0.756MetPhe: 0.756 ± 0.038
1.386MetGly: 1.386 ± 0.051
0.451MetHis: 0.451 ± 0.028
1.657MetIle: 1.657 ± 0.051
1.885MetLys: 1.885 ± 0.051
2.415MetLeu: 2.415 ± 0.062
0.505MetMet: 0.505 ± 0.034
1.352MetAsn: 1.352 ± 0.051
1.126MetPro: 1.126 ± 0.041
1.218MetGln: 1.218 ± 0.05
1.058MetArg: 1.058 ± 0.043
1.155MetSer: 1.155 ± 0.042
0.918MetThr: 0.918 ± 0.037
1.197MetVal: 1.197 ± 0.042
0.162MetTrp: 0.162 ± 0.018
0.534MetTyr: 0.534 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.752AsnAla: 3.752 ± 0.081
0.755AsnCys: 0.755 ± 0.032
2.505AsnAsp: 2.505 ± 0.082
3.182AsnGlu: 3.182 ± 0.076
2.711AsnPhe: 2.711 ± 0.067
3.57AsnGly: 3.57 ± 0.109
0.863AsnHis: 0.863 ± 0.036
5.074AsnIle: 5.074 ± 0.097
3.41AsnLys: 3.41 ± 0.084
6.2AsnLeu: 6.2 ± 0.123
1.111AsnMet: 1.111 ± 0.042
3.655AsnAsn: 3.655 ± 0.126
3.518AsnPro: 3.518 ± 0.079
2.072AsnGln: 2.072 ± 0.079
2.46AsnArg: 2.46 ± 0.07
3.603AsnSer: 3.603 ± 0.095
2.951AsnThr: 2.951 ± 0.099
2.91AsnVal: 2.91 ± 0.078
0.803AsnTrp: 0.803 ± 0.044
3.27AsnTyr: 3.27 ± 0.092
0.0AsnXaa: 0.0 ± 0.0
Pro
3.053ProAla: 3.053 ± 0.093
0.417ProCys: 0.417 ± 0.027
2.672ProAsp: 2.672 ± 0.065
4.023ProGlu: 4.023 ± 0.093
2.112ProPhe: 2.112 ± 0.058
2.474ProGly: 2.474 ± 0.056
0.682ProHis: 0.682 ± 0.032
2.656ProIle: 2.656 ± 0.069
2.415ProLys: 2.415 ± 0.07
4.057ProLeu: 4.057 ± 0.129
0.729ProMet: 0.729 ± 0.04
2.307ProAsn: 2.307 ± 0.077
1.607ProPro: 1.607 ± 0.071
1.691ProGln: 1.691 ± 0.045
1.174ProArg: 1.174 ± 0.048
2.446ProSer: 2.446 ± 0.061
2.055ProThr: 2.055 ± 0.07
3.612ProVal: 3.612 ± 0.085
0.514ProTrp: 0.514 ± 0.033
1.985ProTyr: 1.985 ± 0.059
0.0ProXaa: 0.0 ± 0.0
Gln
2.297GlnAla: 2.297 ± 0.071
0.291GlnCys: 0.291 ± 0.022
1.805GlnAsp: 1.805 ± 0.046
2.939GlnGlu: 2.939 ± 0.081
1.459GlnPhe: 1.459 ± 0.047
2.042GlnGly: 2.042 ± 0.059
0.595GlnHis: 0.595 ± 0.03
3.458GlnIle: 3.458 ± 0.103
2.979GlnLys: 2.979 ± 0.087
3.376GlnLeu: 3.376 ± 0.077
0.918GlnMet: 0.918 ± 0.041
2.569GlnAsn: 2.569 ± 0.067
1.282GlnPro: 1.282 ± 0.043
1.489GlnGln: 1.489 ± 0.059
1.491GlnArg: 1.491 ± 0.051
1.975GlnSer: 1.975 ± 0.057
2.016GlnThr: 2.016 ± 0.061
2.052GlnVal: 2.052 ± 0.061
0.359GlnTrp: 0.359 ± 0.022
1.61GlnTyr: 1.61 ± 0.052
0.0GlnXaa: 0.0 ± 0.0
Arg
2.106ArgAla: 2.106 ± 0.062
0.427ArgCys: 0.427 ± 0.03
1.921ArgAsp: 1.921 ± 0.056
2.8ArgGlu: 2.8 ± 0.077
2.001ArgPhe: 2.001 ± 0.059
2.035ArgGly: 2.035 ± 0.064
0.636ArgHis: 0.636 ± 0.031
3.621ArgIle: 3.621 ± 0.087
3.232ArgLys: 3.232 ± 0.09
3.983ArgLeu: 3.983 ± 0.089
0.941ArgMet: 0.941 ± 0.04
2.417ArgAsn: 2.417 ± 0.059
1.246ArgPro: 1.246 ± 0.043
1.496ArgGln: 1.496 ± 0.056
1.554ArgArg: 1.554 ± 0.054
2.095ArgSer: 2.095 ± 0.056
1.844ArgThr: 1.844 ± 0.058
2.019ArgVal: 2.019 ± 0.06
0.434ArgTrp: 0.434 ± 0.025
2.036ArgTyr: 2.036 ± 0.068
0.0ArgXaa: 0.0 ± 0.0
Ser
4.772SerAla: 4.772 ± 0.094
0.752SerCys: 0.752 ± 0.037
3.135SerAsp: 3.135 ± 0.085
3.885SerGlu: 3.885 ± 0.08
3.383SerPhe: 3.383 ± 0.079
4.951SerGly: 4.951 ± 0.1
1.067SerHis: 1.067 ± 0.037
4.592SerIle: 4.592 ± 0.095
3.261SerLys: 3.261 ± 0.081
6.08SerLeu: 6.08 ± 0.11
1.152SerMet: 1.152 ± 0.04
3.027SerAsn: 3.027 ± 0.085
2.822SerPro: 2.822 ± 0.11
2.235SerGln: 2.235 ± 0.063
2.4SerArg: 2.4 ± 0.065
4.461SerSer: 4.461 ± 0.107
3.312SerThr: 3.312 ± 0.09
3.626SerVal: 3.626 ± 0.085
0.864SerTrp: 0.864 ± 0.042
2.951SerTyr: 2.951 ± 0.081
0.0SerXaa: 0.0 ± 0.0
Thr
4.143ThrAla: 4.143 ± 0.117
0.53ThrCys: 0.53 ± 0.029
2.991ThrAsp: 2.991 ± 0.092
3.455ThrGlu: 3.455 ± 0.082
2.32ThrPhe: 2.32 ± 0.073
4.399ThrGly: 4.399 ± 0.139
0.909ThrHis: 0.909 ± 0.039
4.479ThrIle: 4.479 ± 0.117
3.004ThrLys: 3.004 ± 0.073
5.906ThrLeu: 5.906 ± 0.097
1.115ThrMet: 1.115 ± 0.042
2.959ThrAsn: 2.959 ± 0.113
2.685ThrPro: 2.685 ± 0.098
1.804ThrGln: 1.804 ± 0.061
1.844ThrArg: 1.844 ± 0.055
3.101ThrSer: 3.101 ± 0.093
3.278ThrThr: 3.278 ± 0.129
3.555ThrVal: 3.555 ± 0.122
0.659ThrTrp: 0.659 ± 0.044
2.252ThrTyr: 2.252 ± 0.085
0.0ThrXaa: 0.0 ± 0.0
Val
3.48ValAla: 3.48 ± 0.091
0.678ValCys: 0.678 ± 0.034
2.81ValAsp: 2.81 ± 0.075
3.336ValGlu: 3.336 ± 0.081
2.765ValPhe: 2.765 ± 0.077
3.05ValGly: 3.05 ± 0.073
0.944ValHis: 0.944 ± 0.041
4.841ValIle: 4.841 ± 0.091
3.594ValLys: 3.594 ± 0.084
5.562ValLeu: 5.562 ± 0.09
1.36ValMet: 1.36 ± 0.042
3.17ValAsn: 3.17 ± 0.094
2.451ValPro: 2.451 ± 0.078
2.129ValGln: 2.129 ± 0.065
1.995ValArg: 1.995 ± 0.059
4.029ValSer: 4.029 ± 0.091
3.537ValThr: 3.537 ± 0.131
3.213ValVal: 3.213 ± 0.1
0.628ValTrp: 0.628 ± 0.04
2.531ValTyr: 2.531 ± 0.064
0.0ValXaa: 0.0 ± 0.0
Trp
0.608TrpAla: 0.608 ± 0.03
0.089TrpCys: 0.089 ± 0.012
0.668TrpAsp: 0.668 ± 0.035
0.887TrpGlu: 0.887 ± 0.039
0.544TrpPhe: 0.544 ± 0.031
0.718TrpGly: 0.718 ± 0.035
0.251TrpHis: 0.251 ± 0.02
0.861TrpIle: 0.861 ± 0.039
0.746TrpLys: 0.746 ± 0.034
1.302TrpLeu: 1.302 ± 0.05
0.307TrpMet: 0.307 ± 0.021
0.809TrpAsn: 0.809 ± 0.043
0.162TrpPro: 0.162 ± 0.016
0.784TrpGln: 0.784 ± 0.035
0.411TrpArg: 0.411 ± 0.027
0.575TrpSer: 0.575 ± 0.046
0.712TrpThr: 0.712 ± 0.055
0.584TrpVal: 0.584 ± 0.032
0.139TrpTrp: 0.139 ± 0.016
0.414TrpTyr: 0.414 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.743TyrAla: 2.743 ± 0.067
0.562TyrCys: 0.562 ± 0.032
2.204TyrAsp: 2.204 ± 0.068
2.414TyrGlu: 2.414 ± 0.064
2.274TyrPhe: 2.274 ± 0.073
2.554TyrGly: 2.554 ± 0.069
0.89TyrHis: 0.89 ± 0.041
3.225TyrIle: 3.225 ± 0.071
2.665TyrLys: 2.665 ± 0.07
4.9TyrLeu: 4.9 ± 0.114
0.681TyrMet: 0.681 ± 0.033
2.99TyrAsn: 2.99 ± 0.083
2.355TyrPro: 2.355 ± 0.065
1.964TyrGln: 1.964 ± 0.059
2.113TyrArg: 2.113 ± 0.064
3.005TyrSer: 3.005 ± 0.079
2.5TyrThr: 2.5 ± 0.088
2.119TyrVal: 2.119 ± 0.064
0.621TyrTrp: 0.621 ± 0.036
2.605TyrTyr: 2.605 ± 0.075
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1813 proteins (649216 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski