Amino acid dipepetide frequency for Roseovarius nanhaiticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.93AlaAla: 17.93 ± 0.223
1.184AlaCys: 1.184 ± 0.034
7.135AlaAsp: 7.135 ± 0.074
8.356AlaGlu: 8.356 ± 0.109
4.17AlaPhe: 4.17 ± 0.066
11.05AlaGly: 11.05 ± 0.109
2.586AlaHis: 2.586 ± 0.059
6.186AlaIle: 6.186 ± 0.086
3.7AlaLys: 3.7 ± 0.056
14.668AlaLeu: 14.668 ± 0.168
4.043AlaMet: 4.043 ± 0.07
2.713AlaAsn: 2.713 ± 0.051
6.838AlaPro: 6.838 ± 0.107
4.882AlaGln: 4.882 ± 0.08
9.822AlaArg: 9.822 ± 0.133
6.107AlaSer: 6.107 ± 0.085
5.591AlaThr: 5.591 ± 0.071
8.056AlaVal: 8.056 ± 0.086
1.527AlaTrp: 1.527 ± 0.043
2.599AlaTyr: 2.599 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
1.157CysAla: 1.157 ± 0.035
0.102CysCys: 0.102 ± 0.011
0.66CysAsp: 0.66 ± 0.028
0.447CysGlu: 0.447 ± 0.02
0.317CysPhe: 0.317 ± 0.018
0.934CysGly: 0.934 ± 0.03
0.309CysHis: 0.309 ± 0.019
0.463CysIle: 0.463 ± 0.024
0.219CysLys: 0.219 ± 0.013
0.839CysLeu: 0.839 ± 0.026
0.167CysMet: 0.167 ± 0.012
0.246CysAsn: 0.246 ± 0.014
0.492CysPro: 0.492 ± 0.025
0.227CysGln: 0.227 ± 0.015
0.548CysArg: 0.548 ± 0.024
0.422CysSer: 0.422 ± 0.02
0.469CysThr: 0.469 ± 0.021
0.591CysVal: 0.591 ± 0.029
0.109CysTrp: 0.109 ± 0.01
0.234CysTyr: 0.234 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
8.144AspAla: 8.144 ± 0.099
0.557AspCys: 0.557 ± 0.026
3.594AspAsp: 3.594 ± 0.092
3.721AspGlu: 3.721 ± 0.06
2.198AspPhe: 2.198 ± 0.045
5.654AspGly: 5.654 ± 0.097
1.347AspHis: 1.347 ± 0.038
3.406AspIle: 3.406 ± 0.058
1.673AspLys: 1.673 ± 0.034
6.446AspLeu: 6.446 ± 0.091
1.886AspMet: 1.886 ± 0.039
1.155AspAsn: 1.155 ± 0.041
3.489AspPro: 3.489 ± 0.063
1.78AspGln: 1.78 ± 0.037
3.998AspArg: 3.998 ± 0.072
2.101AspSer: 2.101 ± 0.044
3.126AspThr: 3.126 ± 0.069
4.398AspVal: 4.398 ± 0.074
1.171AspTrp: 1.171 ± 0.032
1.452AspTyr: 1.452 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
8.801GluAla: 8.801 ± 0.114
0.392GluCys: 0.392 ± 0.019
3.559GluAsp: 3.559 ± 0.066
3.466GluGlu: 3.466 ± 0.07
1.826GluPhe: 1.826 ± 0.046
5.257GluGly: 5.257 ± 0.073
1.066GluHis: 1.066 ± 0.034
3.457GluIle: 3.457 ± 0.053
1.887GluLys: 1.887 ± 0.043
4.741GluLeu: 4.741 ± 0.075
2.01GluMet: 2.01 ± 0.042
1.66GluAsn: 1.66 ± 0.04
2.31GluPro: 2.31 ± 0.051
1.808GluGln: 1.808 ± 0.042
4.188GluArg: 4.188 ± 0.068
1.975GluSer: 1.975 ± 0.045
3.599GluThr: 3.599 ± 0.051
4.228GluVal: 4.228 ± 0.062
0.784GluTrp: 0.784 ± 0.028
1.088GluTyr: 1.088 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
4.379PheAla: 4.379 ± 0.071
0.423PheCys: 0.423 ± 0.017
2.724PheAsp: 2.724 ± 0.05
2.059PheGlu: 2.059 ± 0.045
1.363PhePhe: 1.363 ± 0.047
3.693PheGly: 3.693 ± 0.063
0.706PheHis: 0.706 ± 0.027
1.601PheIle: 1.601 ± 0.046
0.862PheLys: 0.862 ± 0.028
3.248PheLeu: 3.248 ± 0.067
0.822PheMet: 0.822 ± 0.027
0.935PheAsn: 0.935 ± 0.027
1.403PhePro: 1.403 ± 0.042
1.034PheGln: 1.034 ± 0.029
2.005PheArg: 2.005 ± 0.04
1.946PheSer: 1.946 ± 0.049
1.958PheThr: 1.958 ± 0.039
2.475PheVal: 2.475 ± 0.049
0.55PheTrp: 0.55 ± 0.023
0.915PheTyr: 0.915 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
11.565GlyAla: 11.565 ± 0.113
0.847GlyCys: 0.847 ± 0.029
5.15GlyAsp: 5.15 ± 0.087
4.63GlyGlu: 4.63 ± 0.066
3.387GlyPhe: 3.387 ± 0.059
7.955GlyGly: 7.955 ± 0.123
2.019GlyHis: 2.019 ± 0.044
4.738GlyIle: 4.738 ± 0.071
2.973GlyLys: 2.973 ± 0.065
9.105GlyLeu: 9.105 ± 0.106
2.755GlyMet: 2.755 ± 0.057
2.112GlyAsn: 2.112 ± 0.061
3.829GlyPro: 3.829 ± 0.061
3.203GlyGln: 3.203 ± 0.064
6.017GlyArg: 6.017 ± 0.079
4.246GlySer: 4.246 ± 0.079
5.035GlyThr: 5.035 ± 0.076
6.054GlyVal: 6.054 ± 0.083
1.496GlyTrp: 1.496 ± 0.038
2.35GlyTyr: 2.35 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
2.488HisAla: 2.488 ± 0.053
0.245HisCys: 0.245 ± 0.016
1.347HisAsp: 1.347 ± 0.029
1.053HisGlu: 1.053 ± 0.031
0.808HisPhe: 0.808 ± 0.027
1.977HisGly: 1.977 ± 0.048
0.559HisHis: 0.559 ± 0.025
1.028HisIle: 1.028 ± 0.031
0.505HisLys: 0.505 ± 0.021
2.109HisLeu: 2.109 ± 0.046
0.549HisMet: 0.549 ± 0.026
0.442HisAsn: 0.442 ± 0.017
1.368HisPro: 1.368 ± 0.036
0.578HisGln: 0.578 ± 0.023
1.328HisArg: 1.328 ± 0.038
1.018HisSer: 1.018 ± 0.033
0.844HisThr: 0.844 ± 0.028
1.559HisVal: 1.559 ± 0.042
0.341HisTrp: 0.341 ± 0.018
0.567HisTyr: 0.567 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
7.552IleAla: 7.552 ± 0.088
0.673IleCys: 0.673 ± 0.025
3.564IleAsp: 3.564 ± 0.069
3.735IleGlu: 3.735 ± 0.056
1.802IlePhe: 1.802 ± 0.045
5.101IleGly: 5.101 ± 0.069
0.914IleHis: 0.914 ± 0.032
2.47IleIle: 2.47 ± 0.045
1.501IleLys: 1.501 ± 0.037
4.916IleLeu: 4.916 ± 0.068
1.265IleMet: 1.265 ± 0.04
1.393IleAsn: 1.393 ± 0.034
2.404IlePro: 2.404 ± 0.047
1.13IleGln: 1.13 ± 0.035
3.06IleArg: 3.06 ± 0.054
3.009IleSer: 3.009 ± 0.052
3.066IleThr: 3.066 ± 0.055
3.819IleVal: 3.819 ± 0.065
0.756IleTrp: 0.756 ± 0.025
1.245IleTyr: 1.245 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
3.597LysAla: 3.597 ± 0.064
0.201LysCys: 0.201 ± 0.013
1.758LysAsp: 1.758 ± 0.042
1.434LysGlu: 1.434 ± 0.038
0.934LysPhe: 0.934 ± 0.032
2.631LysGly: 2.631 ± 0.064
0.616LysHis: 0.616 ± 0.024
1.529LysIle: 1.529 ± 0.035
1.127LysLys: 1.127 ± 0.036
2.816LysLeu: 2.816 ± 0.045
0.881LysMet: 0.881 ± 0.027
0.729LysAsn: 0.729 ± 0.027
1.723LysPro: 1.723 ± 0.048
0.766LysGln: 0.766 ± 0.026
2.112LysArg: 2.112 ± 0.043
1.818LysSer: 1.818 ± 0.043
1.769LysThr: 1.769 ± 0.041
2.072LysVal: 2.072 ± 0.046
0.401LysTrp: 0.401 ± 0.018
0.603LysTyr: 0.603 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
13.022LeuAla: 13.022 ± 0.135
0.924LeuCys: 0.924 ± 0.032
6.075LeuAsp: 6.075 ± 0.084
5.267LeuGlu: 5.267 ± 0.074
3.221LeuPhe: 3.221 ± 0.059
8.662LeuGly: 8.662 ± 0.098
1.815LeuHis: 1.815 ± 0.046
5.675LeuIle: 5.675 ± 0.081
3.001LeuLys: 3.001 ± 0.052
8.565LeuLeu: 8.565 ± 0.123
2.888LeuMet: 2.888 ± 0.061
2.595LeuAsn: 2.595 ± 0.044
5.516LeuPro: 5.516 ± 0.073
2.616LeuGln: 2.616 ± 0.051
7.339LeuArg: 7.339 ± 0.089
6.507LeuSer: 6.507 ± 0.093
6.017LeuThr: 6.017 ± 0.079
6.374LeuVal: 6.374 ± 0.087
1.287LeuTrp: 1.287 ± 0.037
2.023LeuTyr: 2.023 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
3.712MetAla: 3.712 ± 0.058
0.219MetCys: 0.219 ± 0.014
1.594MetAsp: 1.594 ± 0.038
1.362MetGlu: 1.362 ± 0.039
0.818MetPhe: 0.818 ± 0.03
2.527MetGly: 2.527 ± 0.043
0.518MetHis: 0.518 ± 0.023
1.742MetIle: 1.742 ± 0.038
1.05MetLys: 1.05 ± 0.029
2.711MetLeu: 2.711 ± 0.048
0.901MetMet: 0.901 ± 0.027
0.814MetAsn: 0.814 ± 0.029
1.679MetPro: 1.679 ± 0.039
1.13MetGln: 1.13 ± 0.035
2.187MetArg: 2.187 ± 0.045
1.935MetSer: 1.935 ± 0.044
2.235MetThr: 2.235 ± 0.044
1.828MetVal: 1.828 ± 0.037
0.256MetTrp: 0.256 ± 0.016
0.359MetTyr: 0.359 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.149AsnAla: 3.149 ± 0.052
0.228AsnCys: 0.228 ± 0.016
1.43AsnAsp: 1.43 ± 0.05
1.188AsnGlu: 1.188 ± 0.038
0.974AsnPhe: 0.974 ± 0.032
2.294AsnGly: 2.294 ± 0.064
0.47AsnHis: 0.47 ± 0.022
1.301AsnIle: 1.301 ± 0.035
0.615AsnLys: 0.615 ± 0.025
2.408AsnLeu: 2.408 ± 0.049
0.688AsnMet: 0.688 ± 0.026
0.596AsnAsn: 0.596 ± 0.024
1.653AsnPro: 1.653 ± 0.037
0.646AsnGln: 0.646 ± 0.027
1.496AsnArg: 1.496 ± 0.039
1.205AsnSer: 1.205 ± 0.037
1.263AsnThr: 1.263 ± 0.04
1.845AsnVal: 1.845 ± 0.046
0.381AsnTrp: 0.381 ± 0.019
0.61AsnTyr: 0.61 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
5.913ProAla: 5.913 ± 0.09
0.371ProCys: 0.371 ± 0.021
3.892ProAsp: 3.892 ± 0.058
4.276ProGlu: 4.276 ± 0.07
1.903ProPhe: 1.903 ± 0.039
4.84ProGly: 4.84 ± 0.073
1.08ProHis: 1.08 ± 0.032
2.299ProIle: 2.299 ± 0.047
1.647ProLys: 1.647 ± 0.044
4.735ProLeu: 4.735 ± 0.066
1.407ProMet: 1.407 ± 0.031
1.269ProAsn: 1.269 ± 0.037
2.232ProPro: 2.232 ± 0.052
1.694ProGln: 1.694 ± 0.046
2.987ProArg: 2.987 ± 0.059
2.519ProSer: 2.519 ± 0.048
2.256ProThr: 2.256 ± 0.047
3.898ProVal: 3.898 ± 0.056
0.669ProTrp: 0.669 ± 0.022
1.149ProTyr: 1.149 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
3.658GlnAla: 3.658 ± 0.062
0.187GlnCys: 0.187 ± 0.013
1.783GlnAsp: 1.783 ± 0.037
1.524GlnGlu: 1.524 ± 0.044
1.017GlnPhe: 1.017 ± 0.031
2.632GlnGly: 2.632 ± 0.055
0.623GlnHis: 0.623 ± 0.025
2.115GlnIle: 2.115 ± 0.051
1.034GlnLys: 1.034 ± 0.027
2.893GlnLeu: 2.893 ± 0.051
1.237GlnMet: 1.237 ± 0.039
0.936GlnAsn: 0.936 ± 0.028
1.659GlnPro: 1.659 ± 0.043
1.018GlnGln: 1.018 ± 0.034
2.341GlnArg: 2.341 ± 0.045
1.861GlnSer: 1.861 ± 0.042
1.885GlnThr: 1.885 ± 0.042
2.149GlnVal: 2.149 ± 0.045
0.38GlnTrp: 0.38 ± 0.018
0.557GlnTyr: 0.557 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
9.096ArgAla: 9.096 ± 0.114
0.486ArgCys: 0.486 ± 0.021
4.216ArgAsp: 4.216 ± 0.069
3.808ArgGlu: 3.808 ± 0.066
2.425ArgPhe: 2.425 ± 0.047
5.038ArgGly: 5.038 ± 0.07
1.621ArgHis: 1.621 ± 0.035
4.142ArgIle: 4.142 ± 0.065
2.086ArgLys: 2.086 ± 0.042
7.144ArgLeu: 7.144 ± 0.098
2.164ArgMet: 2.164 ± 0.043
1.674ArgAsn: 1.674 ± 0.043
3.346ArgPro: 3.346 ± 0.06
2.359ArgGln: 2.359 ± 0.047
5.353ArgArg: 5.353 ± 0.079
3.283ArgSer: 3.283 ± 0.056
3.047ArgThr: 3.047 ± 0.054
4.609ArgVal: 4.609 ± 0.063
0.921ArgTrp: 0.921 ± 0.031
1.595ArgTyr: 1.595 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
6.317SerAla: 6.317 ± 0.079
0.421SerCys: 0.421 ± 0.022
3.399SerAsp: 3.399 ± 0.062
2.951SerGlu: 2.951 ± 0.058
1.996SerPhe: 1.996 ± 0.042
5.475SerGly: 5.475 ± 0.078
1.067SerHis: 1.067 ± 0.029
2.591SerIle: 2.591 ± 0.049
1.449SerLys: 1.449 ± 0.038
5.032SerLeu: 5.032 ± 0.08
1.401SerMet: 1.401 ± 0.038
1.319SerAsn: 1.319 ± 0.039
2.461SerPro: 2.461 ± 0.048
1.639SerGln: 1.639 ± 0.038
3.114SerArg: 3.114 ± 0.056
2.659SerSer: 2.659 ± 0.053
2.418SerThr: 2.418 ± 0.046
3.593SerVal: 3.593 ± 0.063
0.666SerTrp: 0.666 ± 0.024
1.395SerTyr: 1.395 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
6.34ThrAla: 6.34 ± 0.084
0.476ThrCys: 0.476 ± 0.022
3.131ThrAsp: 3.131 ± 0.058
2.982ThrGlu: 2.982 ± 0.054
1.897ThrPhe: 1.897 ± 0.041
5.495ThrGly: 5.495 ± 0.063
1.127ThrHis: 1.127 ± 0.035
2.653ThrIle: 2.653 ± 0.051
1.379ThrLys: 1.379 ± 0.047
5.995ThrLeu: 5.995 ± 0.08
1.291ThrMet: 1.291 ± 0.035
1.201ThrAsn: 1.201 ± 0.037
3.37ThrPro: 3.37 ± 0.057
1.542ThrGln: 1.542 ± 0.038
3.58ThrArg: 3.58 ± 0.058
2.801ThrSer: 2.801 ± 0.056
2.602ThrThr: 2.602 ± 0.058
3.941ThrVal: 3.941 ± 0.058
0.702ThrTrp: 0.702 ± 0.023
1.252ThrTyr: 1.252 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
8.23ValAla: 8.23 ± 0.086
0.645ValCys: 0.645 ± 0.026
3.86ValAsp: 3.86 ± 0.076
3.998ValGlu: 3.998 ± 0.059
2.642ValPhe: 2.642 ± 0.047
5.152ValGly: 5.152 ± 0.075
1.373ValHis: 1.373 ± 0.035
4.257ValIle: 4.257 ± 0.068
1.862ValLys: 1.862 ± 0.045
7.073ValLeu: 7.073 ± 0.09
2.263ValMet: 2.263 ± 0.047
1.698ValAsn: 1.698 ± 0.042
3.446ValPro: 3.446 ± 0.058
2.158ValGln: 2.158 ± 0.045
4.275ValArg: 4.275 ± 0.066
3.989ValSer: 3.989 ± 0.063
4.591ValThr: 4.591 ± 0.075
4.946ValVal: 4.946 ± 0.071
0.903ValTrp: 0.903 ± 0.031
1.407ValTyr: 1.407 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
1.454TrpAla: 1.454 ± 0.038
0.141TrpCys: 0.141 ± 0.011
0.793TrpAsp: 0.793 ± 0.028
0.611TrpGlu: 0.611 ± 0.026
0.526TrpPhe: 0.526 ± 0.02
0.994TrpGly: 0.994 ± 0.031
0.35TrpHis: 0.35 ± 0.02
0.728TrpIle: 0.728 ± 0.023
0.391TrpLys: 0.391 ± 0.019
1.666TrpLeu: 1.666 ± 0.038
0.425TrpMet: 0.425 ± 0.02
0.389TrpAsn: 0.389 ± 0.019
0.71TrpPro: 0.71 ± 0.026
0.612TrpGln: 0.612 ± 0.023
1.137TrpArg: 1.137 ± 0.034
0.813TrpSer: 0.813 ± 0.029
0.829TrpThr: 0.829 ± 0.029
0.81TrpVal: 0.81 ± 0.028
0.219TrpTrp: 0.219 ± 0.016
0.255TrpTyr: 0.255 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.64TyrAla: 2.64 ± 0.054
0.23TyrCys: 0.23 ± 0.014
1.63TyrAsp: 1.63 ± 0.039
1.235TyrGlu: 1.235 ± 0.038
0.874TyrPhe: 0.874 ± 0.031
2.104TyrGly: 2.104 ± 0.047
0.544TyrHis: 0.544 ± 0.026
0.994TyrIle: 0.994 ± 0.031
0.558TyrLys: 0.558 ± 0.022
2.278TyrLeu: 2.278 ± 0.046
0.534TyrMet: 0.534 ± 0.022
0.564TyrAsn: 0.564 ± 0.023
1.11TyrPro: 1.11 ± 0.036
0.666TyrGln: 0.666 ± 0.025
1.526TyrArg: 1.526 ± 0.043
1.147TyrSer: 1.147 ± 0.039
1.158TyrThr: 1.158 ± 0.034
1.523TyrVal: 1.523 ± 0.041
0.336TyrTrp: 0.336 ± 0.017
0.589TyrTyr: 0.589 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3516 proteins (1111941 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski