Amino acid dipepetide frequency for Pedococcus cremeus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.811AlaAla: 20.811 ± 0.199	1.003AlaCys: 1.003 ± 0.028	7.679AlaAsp: 7.679 ± 0.086	7.631AlaGlu: 7.631 ± 0.105	3.604AlaPhe: 3.604 ± 0.059	12.478AlaGly: 12.478 ± 0.112	2.775AlaHis: 2.775 ± 0.05	3.87AlaIle: 3.87 ± 0.066	2.868AlaLys: 2.868 ± 0.065	14.195AlaLeu: 14.195 ± 0.149	2.859AlaMet: 2.859 ± 0.048	2.092AlaAsn: 2.092 ± 0.04	6.565AlaPro: 6.565 ± 0.088	3.962AlaGln: 3.962 ± 0.059	9.419AlaArg: 9.419 ± 0.106	6.849AlaSer: 6.849 ± 0.081	7.885AlaThr: 7.885 ± 0.084	12.842AlaVal: 12.842 ± 0.122	2.089AlaTrp: 2.089 ± 0.047	2.545AlaTyr: 2.545 ± 0.045	0.001AlaXaa: 0.001 ± 0.001
Cys	0.877CysAla: 0.877 ± 0.027	0.084CysCys: 0.084 ± 0.008	0.464CysAsp: 0.464 ± 0.016	0.368CysGlu: 0.368 ± 0.019	0.213CysPhe: 0.213 ± 0.012	0.871CysGly: 0.871 ± 0.028	0.182CysHis: 0.182 ± 0.014	0.178CysIle: 0.178 ± 0.012	0.096CysLys: 0.096 ± 0.007	0.681CysLeu: 0.681 ± 0.024	0.106CysMet: 0.106 ± 0.009	0.127CysAsn: 0.127 ± 0.011	0.443CysPro: 0.443 ± 0.018	0.165CysGln: 0.165 ± 0.012	0.536CysArg: 0.536 ± 0.021	0.416CysSer: 0.416 ± 0.018	0.487CysThr: 0.487 ± 0.02	0.589CysVal: 0.589 ± 0.023	0.098CysTrp: 0.098 ± 0.008	0.139CysTyr: 0.139 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.429AspAla: 7.429 ± 0.085	0.346AspCys: 0.346 ± 0.016	3.706AspAsp: 3.706 ± 0.064	3.999AspGlu: 3.999 ± 0.062	1.557AspPhe: 1.557 ± 0.032	5.782AspGly: 5.782 ± 0.076	1.469AspHis: 1.469 ± 0.031	1.812AspIle: 1.812 ± 0.032	1.078AspLys: 1.078 ± 0.036	6.663AspLeu: 6.663 ± 0.075	0.778AspMet: 0.778 ± 0.023	0.994AspAsn: 0.994 ± 0.032	4.135AspPro: 4.135 ± 0.058	1.702AspGln: 1.702 ± 0.04	4.501AspArg: 4.501 ± 0.071	2.383AspSer: 2.383 ± 0.047	2.848AspThr: 2.848 ± 0.049	5.607AspVal: 5.607 ± 0.07	0.868AspTrp: 0.868 ± 0.028	1.169AspTyr: 1.169 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	7.481GluAla: 7.481 ± 0.107	0.333GluCys: 0.333 ± 0.014	2.75GluAsp: 2.75 ± 0.055	3.362GluGlu: 3.362 ± 0.066	1.329GluPhe: 1.329 ± 0.037	4.482GluGly: 4.482 ± 0.06	1.667GluHis: 1.667 ± 0.038	1.794GluIle: 1.794 ± 0.042	1.321GluLys: 1.321 ± 0.039	5.945GluLeu: 5.945 ± 0.083	0.905GluMet: 0.905 ± 0.03	0.902GluAsn: 0.902 ± 0.029	3.169GluPro: 3.169 ± 0.058	2.434GluGln: 2.434 ± 0.052	5.254GluArg: 5.254 ± 0.069	2.528GluSer: 2.528 ± 0.052	2.582GluThr: 2.582 ± 0.052	5.667GluVal: 5.667 ± 0.078	0.794GluTrp: 0.794 ± 0.026	0.882GluTyr: 0.882 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.67PheAla: 3.67 ± 0.058	0.214PheCys: 0.214 ± 0.013	1.881PheAsp: 1.881 ± 0.032	1.47PheGlu: 1.47 ± 0.031	0.93PhePhe: 0.93 ± 0.028	3.098PheGly: 3.098 ± 0.05	0.575PheHis: 0.575 ± 0.018	0.848PheIle: 0.848 ± 0.027	0.484PheLys: 0.484 ± 0.02	2.581PheLeu: 2.581 ± 0.051	0.45PheMet: 0.45 ± 0.019	0.602PheAsn: 0.602 ± 0.022	1.312PhePro: 1.312 ± 0.029	0.637PheGln: 0.637 ± 0.027	1.694PheArg: 1.694 ± 0.037	1.521PheSer: 1.521 ± 0.032	1.961PheThr: 1.961 ± 0.044	2.589PheVal: 2.589 ± 0.045	0.447PheTrp: 0.447 ± 0.02	0.606PheTyr: 0.606 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	10.835GlyAla: 10.835 ± 0.115	0.741GlyCys: 0.741 ± 0.025	5.153GlyAsp: 5.153 ± 0.067	4.984GlyGlu: 4.984 ± 0.064	2.923GlyPhe: 2.923 ± 0.05	8.498GlyGly: 8.498 ± 0.103	2.286GlyHis: 2.286 ± 0.045	3.503GlyIle: 3.503 ± 0.053	2.383GlyLys: 2.383 ± 0.053	9.659GlyLeu: 9.659 ± 0.108	2.119GlyMet: 2.119 ± 0.038	1.658GlyAsn: 1.658 ± 0.044	4.71GlyPro: 4.71 ± 0.061	2.871GlyGln: 2.871 ± 0.049	7.294GlyArg: 7.294 ± 0.082	5.753GlySer: 5.753 ± 0.084	5.918GlyThr: 5.918 ± 0.077	8.281GlyVal: 8.281 ± 0.092	1.92GlyTrp: 1.92 ± 0.036	2.186GlyTyr: 2.186 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.545HisAla: 2.545 ± 0.049	0.198HisCys: 0.198 ± 0.013	1.541HisAsp: 1.541 ± 0.037	1.357HisGlu: 1.357 ± 0.035	0.59HisPhe: 0.59 ± 0.021	2.307HisGly: 2.307 ± 0.043	0.773HisHis: 0.773 ± 0.024	0.595HisIle: 0.595 ± 0.02	0.315HisLys: 0.315 ± 0.015	2.533HisLeu: 2.533 ± 0.054	0.35HisMet: 0.35 ± 0.015	0.366HisAsn: 0.366 ± 0.017	1.661HisPro: 1.661 ± 0.04	0.687HisGln: 0.687 ± 0.023	1.85HisArg: 1.85 ± 0.039	0.961HisSer: 0.961 ± 0.028	1.246HisThr: 1.246 ± 0.031	2.036HisVal: 2.036 ± 0.048	0.379HisTrp: 0.379 ± 0.015	0.46HisTyr: 0.46 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.496IleAla: 4.496 ± 0.077	0.254IleCys: 0.254 ± 0.014	2.139IleAsp: 2.139 ± 0.046	1.963IleGlu: 1.963 ± 0.041	0.752IlePhe: 0.752 ± 0.026	3.419IleGly: 3.419 ± 0.064	0.577IleHis: 0.577 ± 0.021	0.956IleIle: 0.956 ± 0.031	0.669IleLys: 0.669 ± 0.026	2.326IleLeu: 2.326 ± 0.049	0.419IleMet: 0.419 ± 0.019	0.665IleAsn: 0.665 ± 0.025	1.677IlePro: 1.677 ± 0.032	0.686IleGln: 0.686 ± 0.023	2.02IleArg: 2.02 ± 0.036	1.631IleSer: 1.631 ± 0.038	2.074IleThr: 2.074 ± 0.045	2.84IleVal: 2.84 ± 0.053	0.391IleTrp: 0.391 ± 0.018	0.595IleTyr: 0.595 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	2.932LysAla: 2.932 ± 0.062	0.093LysCys: 0.093 ± 0.009	1.316LysAsp: 1.316 ± 0.038	1.081LysGlu: 1.081 ± 0.036	0.45LysPhe: 0.45 ± 0.021	1.911LysGly: 1.911 ± 0.051	0.396LysHis: 0.396 ± 0.018	0.692LysIle: 0.692 ± 0.024	0.747LysLys: 0.747 ± 0.037	1.608LysLeu: 1.608 ± 0.044	0.37LysMet: 0.37 ± 0.018	0.468LysAsn: 0.468 ± 0.02	1.295LysPro: 1.295 ± 0.038	0.699LysGln: 0.699 ± 0.027	1.361LysArg: 1.361 ± 0.033	1.104LysSer: 1.104 ± 0.04	1.286LysThr: 1.286 ± 0.036	2.065LysVal: 2.065 ± 0.048	0.217LysTrp: 0.217 ± 0.015	0.432LysTyr: 0.432 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.043LeuAla: 15.043 ± 0.137	0.739LeuCys: 0.739 ± 0.023	6.42LeuAsp: 6.42 ± 0.065	5.25LeuGlu: 5.25 ± 0.079	2.603LeuPhe: 2.603 ± 0.051	9.868LeuGly: 9.868 ± 0.091	2.14LeuHis: 2.14 ± 0.039	2.691LeuIle: 2.691 ± 0.052	1.885LeuLys: 1.885 ± 0.048	11.11LeuLeu: 11.11 ± 0.114	1.708LeuMet: 1.708 ± 0.039	1.537LeuAsn: 1.537 ± 0.037	6.025LeuPro: 6.025 ± 0.071	2.645LeuGln: 2.645 ± 0.052	8.074LeuArg: 8.074 ± 0.088	5.512LeuSer: 5.512 ± 0.061	6.251LeuThr: 6.251 ± 0.078	10.684LeuVal: 10.684 ± 0.118	1.344LeuTrp: 1.344 ± 0.042	1.582LeuTyr: 1.582 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.494MetAla: 2.494 ± 0.043	0.134MetCys: 0.134 ± 0.011	0.868MetAsp: 0.868 ± 0.027	0.784MetGlu: 0.784 ± 0.028	0.463MetPhe: 0.463 ± 0.02	1.567MetGly: 1.567 ± 0.04	0.343MetHis: 0.343 ± 0.017	0.549MetIle: 0.549 ± 0.023	0.406MetLys: 0.406 ± 0.018	1.745MetLeu: 1.745 ± 0.042	0.285MetMet: 0.285 ± 0.015	0.386MetAsn: 0.386 ± 0.016	1.244MetPro: 1.244 ± 0.028	0.494MetGln: 0.494 ± 0.02	1.415MetArg: 1.415 ± 0.033	1.496MetSer: 1.496 ± 0.035	1.707MetThr: 1.707 ± 0.033	1.67MetVal: 1.67 ± 0.037	0.226MetTrp: 0.226 ± 0.014	0.3MetTyr: 0.3 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.204AsnAla: 2.204 ± 0.044	0.142AsnCys: 0.142 ± 0.012	0.961AsnAsp: 0.961 ± 0.031	0.83AsnGlu: 0.83 ± 0.027	0.472AsnPhe: 0.472 ± 0.02	1.751AsnGly: 1.751 ± 0.047	0.435AsnHis: 0.435 ± 0.018	0.62AsnIle: 0.62 ± 0.024	0.386AsnLys: 0.386 ± 0.021	1.826AsnLeu: 1.826 ± 0.033	0.274AsnMet: 0.274 ± 0.015	0.408AsnAsn: 0.408 ± 0.021	1.417AsnPro: 1.417 ± 0.03	0.505AsnGln: 0.505 ± 0.019	1.207AsnArg: 1.207 ± 0.03	0.803AsnSer: 0.803 ± 0.027	1.067AsnThr: 1.067 ± 0.03	1.472AsnVal: 1.472 ± 0.037	0.275AsnTrp: 0.275 ± 0.014	0.396AsnTyr: 0.396 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.563ProAla: 7.563 ± 0.093	0.288ProCys: 0.288 ± 0.016	4.006ProAsp: 4.006 ± 0.057	3.867ProGlu: 3.867 ± 0.062	1.57ProPhe: 1.57 ± 0.033	5.838ProGly: 5.838 ± 0.078	1.355ProHis: 1.355 ± 0.039	1.379ProIle: 1.379 ± 0.036	1.156ProLys: 1.156 ± 0.031	5.146ProLeu: 5.146 ± 0.08	1.09ProMet: 1.09 ± 0.026	0.938ProAsn: 0.938 ± 0.03	2.915ProPro: 2.915 ± 0.066	1.816ProGln: 1.816 ± 0.043	3.693ProArg: 3.693 ± 0.056	3.465ProSer: 3.465 ± 0.047	3.725ProThr: 3.725 ± 0.061	5.469ProVal: 5.469 ± 0.064	0.96ProTrp: 0.96 ± 0.029	1.058ProTyr: 1.058 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.921GlnAla: 3.921 ± 0.059	0.184GlnCys: 0.184 ± 0.012	1.337GlnAsp: 1.337 ± 0.032	1.479GlnGlu: 1.479 ± 0.036	0.755GlnPhe: 0.755 ± 0.027	2.452GlnGly: 2.452 ± 0.045	0.753GlnHis: 0.753 ± 0.024	0.964GlnIle: 0.964 ± 0.031	0.609GlnLys: 0.609 ± 0.025	3.096GlnLeu: 3.096 ± 0.044	0.603GlnMet: 0.603 ± 0.023	0.508GlnAsn: 0.508 ± 0.022	1.909GlnPro: 1.909 ± 0.044	1.395GlnGln: 1.395 ± 0.041	2.708GlnArg: 2.708 ± 0.044	1.407GlnSer: 1.407 ± 0.036	1.485GlnThr: 1.485 ± 0.034	2.913GlnVal: 2.913 ± 0.041	0.553GlnTrp: 0.553 ± 0.021	0.491GlnTyr: 0.491 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.056ArgAla: 9.056 ± 0.109	0.517ArgCys: 0.517 ± 0.022	4.414ArgAsp: 4.414 ± 0.061	4.596ArgGlu: 4.596 ± 0.064	2.228ArgPhe: 2.228 ± 0.047	5.923ArgGly: 5.923 ± 0.074	2.004ArgHis: 2.004 ± 0.047	2.503ArgIle: 2.503 ± 0.05	1.391ArgLys: 1.391 ± 0.035	8.327ArgLeu: 8.327 ± 0.096	1.718ArgMet: 1.718 ± 0.035	1.208ArgAsn: 1.208 ± 0.029	4.386ArgPro: 4.386 ± 0.077	2.356ArgGln: 2.356 ± 0.05	7.317ArgArg: 7.317 ± 0.099	4.201ArgSer: 4.201 ± 0.068	4.452ArgThr: 4.452 ± 0.065	6.508ArgVal: 6.508 ± 0.08	1.484ArgTrp: 1.484 ± 0.039	1.668ArgTyr: 1.668 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.95SerAla: 6.95 ± 0.081	0.405SerCys: 0.405 ± 0.018	2.763SerAsp: 2.763 ± 0.055	2.45SerGlu: 2.45 ± 0.044	1.664SerPhe: 1.664 ± 0.038	5.926SerGly: 5.926 ± 0.077	1.099SerHis: 1.099 ± 0.029	1.66SerIle: 1.66 ± 0.037	1.025SerLys: 1.025 ± 0.032	5.41SerLeu: 5.41 ± 0.069	1.208SerMet: 1.208 ± 0.03	0.973SerAsn: 0.973 ± 0.027	3.233SerPro: 3.233 ± 0.051	1.44SerGln: 1.44 ± 0.033	3.971SerArg: 3.971 ± 0.056	3.448SerSer: 3.448 ± 0.071	3.71SerThr: 3.71 ± 0.069	4.612SerVal: 4.612 ± 0.055	1.012SerTrp: 1.012 ± 0.029	1.087SerTyr: 1.087 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	8.106ThrAla: 8.106 ± 0.088	0.435ThrCys: 0.435 ± 0.022	3.364ThrAsp: 3.364 ± 0.049	2.929ThrGlu: 2.929 ± 0.056	1.746ThrPhe: 1.746 ± 0.038	6.314ThrGly: 6.314 ± 0.08	1.206ThrHis: 1.206 ± 0.03	2.001ThrIle: 2.001 ± 0.043	1.237ThrLys: 1.237 ± 0.034	5.717ThrLeu: 5.717 ± 0.069	1.078ThrMet: 1.078 ± 0.029	1.082ThrAsn: 1.082 ± 0.035	4.049ThrPro: 4.049 ± 0.058	1.485ThrGln: 1.485 ± 0.035	4.0ThrArg: 4.0 ± 0.058	3.728ThrSer: 3.728 ± 0.069	4.605ThrThr: 4.605 ± 0.092	6.099ThrVal: 6.099 ± 0.08	1.059ThrTrp: 1.059 ± 0.026	1.276ThrTyr: 1.276 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	12.967ValAla: 12.967 ± 0.121	0.71ValCys: 0.71 ± 0.027	5.903ValAsp: 5.903 ± 0.074	5.439ValGlu: 5.439 ± 0.082	2.578ValPhe: 2.578 ± 0.054	8.103ValGly: 8.103 ± 0.092	1.984ValHis: 1.984 ± 0.042	3.033ValIle: 3.033 ± 0.053	1.76ValLys: 1.76 ± 0.048	10.543ValLeu: 10.543 ± 0.115	1.732ValMet: 1.732 ± 0.039	1.782ValAsn: 1.782 ± 0.039	5.289ValPro: 5.289 ± 0.065	2.357ValGln: 2.357 ± 0.039	7.014ValArg: 7.014 ± 0.079	4.891ValSer: 4.891 ± 0.065	6.193ValThr: 6.193 ± 0.079	11.23ValVal: 11.23 ± 0.14	1.279ValTrp: 1.279 ± 0.034	1.546ValTyr: 1.546 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.845TrpAla: 1.845 ± 0.037	0.151TrpCys: 0.151 ± 0.011	0.853TrpAsp: 0.853 ± 0.03	0.69TrpGlu: 0.69 ± 0.023	0.52TrpPhe: 0.52 ± 0.023	1.204TrpGly: 1.204 ± 0.032	0.399TrpHis: 0.399 ± 0.015	0.409TrpIle: 0.409 ± 0.018	0.343TrpLys: 0.343 ± 0.018	1.951TrpLeu: 1.951 ± 0.041	0.304TrpMet: 0.304 ± 0.015	0.36TrpAsn: 0.36 ± 0.019	0.862TrpPro: 0.862 ± 0.026	0.609TrpGln: 0.609 ± 0.022	1.352TrpArg: 1.352 ± 0.034	1.028TrpSer: 1.028 ± 0.032	1.012TrpThr: 1.012 ± 0.033	1.502TrpVal: 1.502 ± 0.037	0.437TrpTrp: 0.437 ± 0.018	0.317TrpTyr: 0.317 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.798TyrAla: 2.798 ± 0.053	0.152TyrCys: 0.152 ± 0.01	1.309TyrAsp: 1.309 ± 0.034	1.051TyrGlu: 1.051 ± 0.029	0.623TyrPhe: 0.623 ± 0.022	1.886TyrGly: 1.886 ± 0.036	0.334TyrHis: 0.334 ± 0.017	0.491TyrIle: 0.491 ± 0.022	0.364TyrLys: 0.364 ± 0.02	2.049TyrLeu: 2.049 ± 0.039	0.216TyrMet: 0.216 ± 0.013	0.394TyrAsn: 0.394 ± 0.02	1.004TyrPro: 1.004 ± 0.027	0.576TyrGln: 0.576 ± 0.02	1.575TyrArg: 1.575 ± 0.035	0.92TyrSer: 0.92 ± 0.029	1.022TyrThr: 1.022 ± 0.034	1.655TyrVal: 1.655 ± 0.033	0.318TyrTrp: 0.318 ± 0.015	0.39TyrTyr: 0.39 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 4010 proteins (1306711 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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